首页工具

登录

搜索结果

Search Results for " wee1 "

Targets Recommended: Wee1 Wee1

19

抑制剂 & 化合物

1

天然产物

2

重组蛋白

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name	Target	Signaling Pathways
T8916	WEE1-IN-3 JUN76288	Wee1	Cell Cycle/Checkpoint
	WEE1-IN-3 (JUN76288) 是一种有效的 Wee1激酶抑制剂，IC50小于 10 nM。它治疗癌症和其他增殖性疾病。
T23869	WEE1-IN-4 Wee1-Inhibitor-I,Wee1 Inhibitor-I,Wee1 Inhibitor I,Wee1-Inhibitor I	Others	Others
	Wee1 Inhibitor I is an ATP-binding site-targeting Wee1 inhibitor.
T9864	Debio-0123 WEE1-IN-5	Wee1	Cell Cycle/Checkpoint
	Debio-0123 (WEE1-IN-5) 是一种口服有效且高度特异性的WEE1抑制剂，IC50值在低纳摩尔范围内。Debio-0123 抑制磷酸化 CDC2。Debio-0123 可增强卡铂在体内的抗肿瘤活性，而这两种药物单独使用都没有活性。
T23881	Wee1 Inhibitor II Wee1-Inhibitor II,Wee1-Inhibitor-II,Wee1 Inhibitor-II	Others	Others
	Wee1 Inhibitor II is an ATP-binding site-targeting Wee1 inhibitor.
T6931	PD0166285 PD-166285	Apoptosis; Wee1; Chk	Apoptosis; Cell Cycle/Checkpoint
	PD0166285是 P-gp 的底物，是一种有效的 Wee1 和 Chk1 抑制剂弱抑制。
T2077	Adavosertib AZD1775,MK-1775,Adavosertib (MK-1775)	Wee1	Cell Cycle/Checkpoint
	Adavosertib (MK-1775) 是一种细胞周期调节蛋白 Wee1 的抑制剂 (IC50=5.2 nM)，具有选择性。Adavosertib 具有抗肿瘤活性，可以阻滞细胞周期，抑制肿瘤细胞增殖。
T16446	PD 407824 PD-407824	Wee1; Chk	Cell Cycle/Checkpoint
	PD 407824 是一种化学 BMP 增敏剂，能促进细胞对亚阈值量 BMP4 的敏感性提高。PD 407824 是一种高效的检查点激酶 Chk1 和 WEE1 抑制剂（IC50 分别为 47 和 97 nM）。
T9643	ZN-c3	Wee1	Cell Cycle/Checkpoint
	ZN-c3 是一种有效的选择性 Wee1 抑制剂，具有平衡的效力、ADME 和药代动力学特性。
T41163	ZNL 02-096 Pomalidomide-C3-adavosertib	Apoptosis; Wee1	Apoptosis; Cell Cycle/Checkpoint
	ZNL 02-096 (Pomalidomide-C3-adavosertib) 是一种快速和选择性的 Wee1 降解剂 (IC50=3.58 nM)。ZNL 02-096 可在亚摩尔浓度下选择性降解 Wee1，而不损伤 AZD 1775 的二级靶点 PLK1。在体外 MOLT-4 细胞中，ZNL 02-096 可诱导 Wee1 降解、DNA 损伤积累、细胞周期停滞在 G2/M 期和细胞凋亡。ZNL 02-096 在 300 种癌症细胞系中显示出抗增殖作用。
T71067	MK-1775 hemihydrate	Others	Others
	MK-1775 hemihydrate is a WEE1 inhibitor with potential antineoplastic sensitizing activity.
T70126	CJM-061	Others	Others
	CJM-061 is a Wee1 inhibitor.
T74371	LEB-03-146	Others	Others
	LEB-03-146是一种WEE1DUBTAC（去泛素化酶靶向嵌合体），通过PEG2连接剂把AZD1775 (Adavosertib) 和OTUB1招募者EN523相连。在HEP3B肝癌细胞中，LEB-03-146能显著增强WEE1的稳定性。
T74275	LEB-03-144	Others	Others
	LEB-03-144 是一个 WEE1DUBTAC (去泛素化酶靶向嵌合体)，通过 C3 烷基连接剂将 AZD1775 (Adavosertib) 与 OTUB1招募者 EN523 连接起来。LEB-03-144 在 HEP3B 肝癌细胞中可显著稳定WEE1。
T74276	LEB-03-153	Others	Others
	LEB-03-153 是一个WEE1DUBTAC (去泛素化酶靶向嵌合体)，通过无连接剂将 AZD1775 (Adavosertib) 连接到OTUB1的招募者 EN523。
T71462	GUN94110	Others	Others
	GUN94110 is a WEE1 kinase inhibitors useful in treatment of cancer and other proliferative diseases. GUN94110 was reported in WO 2019028008. This product has no formal name at the moment. For the convenience of communication, a temporary code name was therefore proposed according to MedKoo Chemical Nomenclature (see web page: https://www.medkoo.com/page/naming).
T74274	LEB-03-145	Others	Others
	LEB-03-145 是一个WEE1DUBTAC (去泛素化酶靶向嵌合体)，通过 C5 烷基连接剂将 AZD1775 (Adavosertib) 与OTUB1招募者 EN523 连接起来。
T82385	FMF-06-098-1	PROTACs	PROTAC
	FMF-06-098-1是一种多靶点蛋白降解剂。通过专一性降解作用，FMF-06-098-1针对多种激酶，能够有效降解AAK1, ABL2, AURKA, AURKB, BUB1B, CDC7, CDK1, CDK12, CDK13, CDK2, CDK4, CDK6, CDK7, CDK9, CHEK1, CSNK1D, EPHA1, PER, FGFR1, GAK, IRAK4, ITK, LIMK2, MAP4K2, MAP4K3, MAPK6, MAPK7, MARK4, MELK, PKN3, PLK4, PRKAA1, PTK2, PTK6, RPS6KA4, S1K2, STK35, TNK2, UHMK1, ULK1及WEE1等关键蛋白。
T74644	DB0614	PROTACs	PROTAC
	DB1113 (Example 24) 是一种靶向蛋白激酶降解的双功能化合物。DB1113 可降解ABL1，ABL2，BLK，CDK11B，CDK4，CSK，EPHA3，FER，GAK，LIMK1，MAP3K20，MAP4K1，MAP4K2，MAP4K3，MAP4K5，MAPK14，MAPK7，MAPK8，MAPK9，MAPKAPK2，MAPKAPK3，NLK，PDIK1L，PTK2B，RIPK1，RPS6KA1，RPS6KA3，SIK2，SIK3，STK35，TNK2 和ULK1。DB1113 可用于研究异常激酶活性介导的疾病或紊乱。
T6931L	PD0166285 dihydrochloride PD-166285	Others	Others
	PD-166285 is an effective and broadly active inhibitor of protein tyrosine kinase.

化合物

Cat.No: T8916

Synonym: JUN76288

Target: Wee1

Cat.No: T23869

Synonym: Wee1-Inhibitor-I,Wee1 Inhibitor-I,Wee1 Inhibitor I,Wee1-Inhibitor I

Target: Others

Cat.No: T9864

Synonym: WEE1-IN-5

Target: Wee1

Wee1 Inhibitor II

Cat.No: T23881

Synonym: Wee1-Inhibitor II,Wee1-Inhibitor-II,Wee1 Inhibitor-II

Target: Others

Cat.No: T6931

Synonym: PD-166285

Target: Apoptosis, Wee1, Chk

Cat.No: T2077

Synonym: AZD1775,MK-1775,Adavosertib (MK-1775)

Target: Wee1

Cat.No: T16446

Synonym: PD-407824

Target: Wee1, Chk

Cat.No: T9643

Target: Wee1

Cat.No: T41163

Synonym: Pomalidomide-C3-adavosertib

Target: Apoptosis, Wee1

MK-1775 hemihydrate

Cat.No: T71067

Target: Others

Cat.No: T70126

Target: Others

Cat.No: T74371

Target: Others

Cat.No: T74275

Target: Others

Cat.No: T74276

Target: Others

Cat.No: T71462

Target: Others

Cat.No: T74274

Target: Others

Cat.No: T82385

Target: PROTACs

Cat.No: T74644

Target: PROTACs

PD0166285 dihydrochloride

Cat.No: T6931L

Synonym: PD-166285

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T3S0737	Flavokawain A 2'-羟基-4,4',6'-三甲氧基查耳酮,Flavokavain A	Apoptosis; p38 MAPK	Apoptosis; MAPK
	Flavokawain A (Flavokavain A) 是 kava 提取物中的查耳酮，是一种抗癌试剂，具有抗肿瘤活性。它通过 Bax 蛋白依赖和线粒体依赖的凋亡途径诱导细胞凋亡，有潜力用于膀胱癌的相关研究。

天然产物

Cat.No: T3S0737

Synonym: 2'-羟基-4,4',6'-三甲氧基查耳酮,Flavokavain A

Target: Apoptosis, p38 MAPK

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-02884	CTDP1 Protein, Mouse, Recombinant (His & Myc) Fcp1,Ctdp1,RNA polymerase II subunit A C-t...	Mouse	E. coli
	Processively dephosphorylates 'Ser-2' and 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit. This promotes the activity of RNA polymerase II. Plays a role in the exit from mitosis by dephosphorylating crucial mitotic substrates (USP44, CDC20 and WEE1) that are required for M-phase-promoting factor (MPF)/CDK1 inactivation. CTDP1 Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The p...
TMPY-04542	CDK2 Protein, Human, Recombinant (His) CDKN2,cyclin-dependent kinase 2,p33(CDK2)	Human	Baculovirus Insect Cells
	CDK2 is a member of the Ser/Thr protein kinase family. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. Cdks (cyclin-dependent kinases) are heteromeric serine/threonine kinases that control progression through the cell cycle in concert with their regulatory subunits, the c...

重组蛋白

CTDP1 Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02884

Species: Mouse

Expression System: E. coli

CDK2 Protein, Human, Recombinant (His)

Cat.No: TMPY-04542

Species: Human

Expression System: Baculovirus Insect Cells

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

Copyright © 2015-2024 TargetMol Chemicals Inc. All rights reserved. 沪ICP备20019793号-4

沪公网安备 31010602006700号

沪公网安备 31010602006700号

TargetMol Loading

联系我们

电话：

400-820-0310

邮箱：

service@tsbiochem.com

QQ：

2881945090（终端用户）

2885109491（经销商）

经销：

终端：

地址：

上海市静安区江场三路238号8楼