96
31
6
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T39503 |
Hepatitis Virus C NS3 Protease Inhibitor 2
|
||
Hepatitis Virus C NS3 Protease Inhibitor 2 is a peptide inhibitor derived from a product that targets the NS3 protease of the hepatitis C virus (HCV). Its inhibitory activity against the NS3 protease is characterized by a Ki value of 41 nM. | |||
T6327 |
Tubacin
|
Virus Protease; HDAC | Chromatin/Epigenetic; DNA Damage/DNA Repair; Microbiology/Virology |
Tubacin 是一种高效、选择性、可逆、可渗透细胞的 HDAC6 抑制剂,IC50 为 4 nM,选择性是 HDAC1 的约 350 倍。 | |||
T1848 |
Dynasore
Dynamin Inhibitor I |
Dynamin; Virus Protease; Autophagy; HSV | Autophagy; Cytoskeletal Signaling; Microbiology/Virology |
Dynasore (Dynamin Inhibitor I) 是一种可渗透细胞的化学物质,可逆且非竞争性地抑制 dynamin 1/2 的 GTPase 活性。 它还抑制线粒体动力蛋白 Drp1,对其他小 GTPase 没有影响。 | |||
T14044 |
4E2RCat
|
PERK | Apoptosis |
4E2RCat 是一种 eIF4E-eIF4G 相互作用的抑制剂,IC50为13.5 μM。 | |||
T13397 |
ZINC03129319
|
Virus Protease | Microbiology/Virology |
ZINC03129319 是有效的登革病毒 NS2B-NS3蛋白酶抑制剂,抑制常数 Ki1和 Ki3分别为 92 μM 和 20 μM。 | |||
T2244 |
ESI-09
|
cAMP; Virus Protease | GPCR/G Protein; Microbiology/Virology |
ESI-09是一种新型非环状核苷酸EPAC 的拮抗剂,对EPAC1和EPAC2的IC50值分别为3.2和1.4 μM。 | |||
T1307 |
Carmofur
HCFU,卡莫氟 |
Nucleoside Antimetabolite/Analog; Virus Protease; SARS-CoV; DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology |
Carmofur (HCFU) 是 5-氟尿嘧啶的衍生物,是一种抗肿瘤药物。它是一种酸性神经酰胺酶抑制剂,用于治疗乳腺癌和结直肠癌。它抑制 SARS-CoV-2主要蛋白酶,还抑制 Vero E6 细胞 SARS-CoV-2,EC50为 24.3 μM。 | |||
T1883 |
Des(benzylpyridyl) Atazanavi
|
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Des(benzylpyridyl) Atazanavi 是 Atazanavir 的 N-脱烷基代谢物 (M1),一种 HIV 蛋白酶抑制剂。 | |||
T8936 |
Proteinase K
proteinase K for tritirachium album,Protease K,蛋白酶 K |
Others | Others |
Proteinase K (proteinase K for tritirachium album) 是一种非特异性丝氨酸蛋白酶,可用于蛋白消化。它在有 SDS 或尿素存在的情况下,在很大 pH 值 (4-12)、盐浓度和温度单位内均有活性。 | |||
T6309 |
AZ960
AZ 960 |
Apoptosis; Virus Protease; JAK; Parasite | Angiogenesis; Apoptosis; Chromatin/Epigenetic; JAK/STAT signaling; Microbiology/Virology; Stem Cells |
AZ960 是一种高效选择性的 JAK2激酶抑制剂,Ki 值为0.45 nM。 | |||
T7779 |
Nelfinavir
AG1341,甲磺酸萘非那韦 |
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Nelfinavir (AG1341) 是一种口服活性的 HIV-1 蛋白酶抑制剂,用于抑制 HIV 感染,是一种广谱抗癌剂。 | |||
T4197 |
HZ-1157
HZ1157,DHFR-inhibitor |
HCV Protease | Microbiology/Virology; Proteases/Proteasome |
HZ-1157 (DHFR-inhibitor) 是一种丙型肝炎病毒抑制剂,对 HCV NS3/4A 蛋白酶具有抑制活性。 | |||
T8371 |
ML188
|
Virus Protease; SARS-CoV | Microbiology/Virology |
ML188是一种选择性非共价 SARS-CoV3CLpro 抑制剂,具有抗病毒活性,IC50为 1.5 μM。 | |||
T6605 |
NH125
|
CaMK; Virus Protease; PKA; Antibacterial; PKC; Autophagy; Antifungal | Autophagy; Chromatin/Epigenetic; Cytoskeletal Signaling; Microbiology/Virology; Neuroscience; Tyrosine Kinase/Adaptors |
NH125 是一种真核延长因子 2 激酶(eEF-2K/CaMKIII)的高效选择性抑制剂,诱导 eEF2 磷酸化,对 eEF-2K 作用的 IC50值为 60 nM。 | |||
T5126 |
Glecaprevir
ABT-493 |
HCV Protease; SARS-CoV | Microbiology/Virology; Proteases/Proteasome |
Glecaprevir (ABT-493) 是一种新型的 HCV NS3/4A 蛋白酶抑制剂,其 IC50值在 3.5 和 11.3 nM 之间。它也是 SARS-CoV 3CLpro 的抑制剂,IC50为 4.09 μM。 | |||
T7366 |
NGI-1
ML414 |
Virus Protease | Microbiology/Virology |
NGI-1 (ML414) 是一种可渗透细胞的寡糖转移酶 (OST) 抑制剂,直接靶向和阻断 OST 催化亚基 STT3A 和 STT3B 的功能,可有效降低病毒感染性而不影响细胞活力。 | |||
T1954 |
SRPIN340
SRPK inhibitor |
Virus Protease; Serine/threonin kinase | Cell Cycle/Checkpoint; Metabolism; Microbiology/Virology |
SRPIN340 (SRPK inhibitor) 是 ATP 竞争性 SRPK 抑制剂,能够抑制 SRPK1 活性,Ki 值为 0.89 μM。 | |||
T4547 |
Grazoprevir
MK-5172 |
HCV Protease; SARS-CoV | Microbiology/Virology; Proteases/Proteasome |
Grazoprevir (MK-5172) 是一种丙型肝炎病毒 NS3/4a 蛋白酶的选择性抑制剂,具有跨基因型和耐药变体的广泛活性,对 gt1b、gt1a、gt2a、gt2b 和 gt3a 的Ki 分别为 0.01 nM、0.01 nM、0.08 nM、0.15 nM 和 0.90 nM。它也是 SARS-CoV-2 3CLpro 抑制剂。 | |||
T1822 |
Clemizole
克立咪唑,吡咯咪唑 |
HCV Protease; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology; Neuroscience; Proteases/Proteasome |
Clemizole 是一种 H1 组胺受体拮抗剂,可抑制 NS4B 的 RNA 结合和丙型肝炎病毒复制。它也是TRP5通道抑制剂。 | |||
T2616 |
PIK-93
PIK 93 |
ATM/ATR; DNA-PK; Virus Protease; PI3K; Carbonic Anhydrase; PI4K; mTOR; HSV | DNA Damage/DNA Repair; Metabolism; Microbiology/Virology; PI3K/Akt/mTOR signaling |
PIK-93 是一种合成的PI4KIIIβ抑制剂,IC50值为 19 nM,同时可抑制PI3Kγ和PI3Kα的活性,IC50值分别为 16 nM 和 39 nM。 | |||
T9716 |
Ensitrelvir
S-217622 |
SARS-CoV | Microbiology/Virology |
Ensitrelvir (S-217622) 是首个口服有效的、非共价的、非肽的SARS-CoV-2 3CL 蛋白酶抑制剂,IC50为13 nM。 | |||
T25268L |
Coblopasvir dihydrochloride
Coblopasvir dihydrochloride(1312608-46-0 Free base) |
HCV Protease | Microbiology/Virology; Proteases/Proteasome |
Coblopasvir dihydrochloride 是一种泛基因型非结构蛋白 5A(NS5A)抑制剂。本品可用于慢性丙型肝炎病毒感染的研究。 | |||
T7903 |
Saquinavir
Ro 31-8959,沙奎那韦 |
SARS-CoV; HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Saquinavir (Ro 31-8959) 是一种 HIV 蛋白酶抑制剂,可研究逆转录病毒。它也是 SARS-CoV 3CLpro 抑制剂,IC50为 1.36 μM。 | |||
T12711 |
Retro-2 cycl
RN 1-001 |
Virus Protease | Microbiology/Virology |
Retro-2 cycl 是一种抗病毒剂,是一种逆行运输抑制剂,抑制 JCPyV(IC50s:54 μM)和 HPV16 假病毒(IC50s:160 μM)。 | |||
T6370 |
AEBSF hydrochloride
AEBSF HCl,Pefabloc SC |
Thrombin; Serine Protease; Influenza Virus | Microbiology/Virology; Proteases/Proteasome |
AEBSF hydrochloride (Pefabloc SC) 是一种丝氨酸蛋白酶的不可逆抑制剂。 | |||
T4474 |
Asunaprevir
BMS-650032,阿那匹韦 |
HCV Protease; SARS-CoV | Microbiology/Virology; Proteases/Proteasome |
Asunaprevir (BMS-650032) 是一种有口服活性的 HCV NS3 蛋白酶抑制剂,IC50值为 0.2 nM-3.5 nM。它也是 SARS-CoV-2 3CLpro 抑制剂。 | |||
T12437 |
PF429242 dihydrochloride
|
S1P Receptor | GPCR/G Protein |
PF429242 dihydrochloride 是一种可逆的竞争性 SREBP 位点 1 蛋白酶抑制剂,IC50值为175 nM。 | |||
T0220 |
Foscarnet sodium
Phosphonoformate,膦甲酸钠 |
Virus Protease; Reverse Transcriptase; DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology |
Foscarnet sodium (Phosphonoformate) 是一种病毒 DNA 聚合酶活性抑制剂,可逆地抑制病毒复制。它是一种用于治疗巨细胞病毒性视网膜炎的抗病毒剂。 | |||
T0939 |
Phenytoin
苯妥英,Diphenylhydantoin,5,5-Diphenylhydantoin |
Virus Protease; Sodium Channel | Membrane transporter/Ion channel; Microbiology/Virology |
Phenytoin (5,5-Diphenylhydantoin) 是一种有效的电压门控钠离子通道阻滞剂,可减少小鼠乳腺肿瘤的生长和转移,具有抗癫痫活性。 | |||
T0495 |
Aminothiazole
2-Aminothiazole,2-氨基噻唑,2-Thiazolylamine,氨噻唑 |
Virus Protease; Antibacterial; Antibiotic; Antifungal | Microbiology/Virology |
Aminothiazole (2-Aminothiazole) 是一种甲状腺抑制剂,具有抗菌活性。它是一种典型的杂环胺,是合成多种生物活性分子的前体,包括染料,抗生素,硫磺药物,杀真菌剂和化学反应促进剂。 | |||
T1822L |
Clemizole hydrochloride
克立咪唑盐酸,盐酸克立咪唑 |
HCV Protease; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology; Neuroscience; Proteases/Proteasome |
Clemizole hydrochloride 是一种 TRPC5通道的抑制剂。它还是一种 H1 组胺受体拮抗剂,抑制 HCV 复制。 | |||
T5158 |
N-Desmethylclozapine
N-去甲基氯氮平,Desmethylclozapine,Normethylclozapine,Norclozapine |
Virus Protease; Dopamine Receptor; 5-HT Receptor; Opioid Receptor; AChR; Drug Metabolite | Endocrinology/Hormones; GPCR/G Protein; Metabolism; Microbiology/Virology; Neuroscience |
N-Desmethylclozapine (Desmethylclozapine) 是非典型抗精神病药 Clozapine 的主要活性代谢产物。它是血清素受体亚型 5-HT2C 的拮抗剂,IC50值为7.1 nM。 它也是多巴胺 D4 受体的拮抗剂和δ-阿片受体的激动剂。 | |||
T21900 |
ML-336
(E)-2-((1,4-二甲基哌嗪-2-亚基)氨基)-5-硝基-N-苯基苯甲酰胺 |
Others | Others |
ML-336 是一种喹唑啉酮类的委内瑞拉马脑炎病毒 (VEEV) 抑制剂,其VEEV TC-83 CPE(IC50:32 nM)、VEEV V3526 CPE(IC50:20 nM)、VEEV 野生型 CPE (IC50:42 nM),有效抑制 VEEV 诱导的三种病毒株 (V3526、TC-83和野生型) 细胞病变效应。 | |||
T5886 |
4-Phenylbutyric acid
苯丁酸,4-苯基丁酸,Benzenebutyric acid |
Virus Protease; HDAC | Chromatin/Epigenetic; DNA Damage/DNA Repair; Microbiology/Virology |
4-Phenylbutyric acid (Benzenebutyric acid) 是一种组蛋白去乙酰化酶和内质网应激抑制剂,可研究癌症和感染等疾病。 | |||
T1623 |
Lopinavir
ABT-378,洛匹那韦 |
SARS-CoV; HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Lopinavir (ABT-378) 是一种选择性肽模拟 HIV-1 蛋白酶的高效抑制剂。它通过阻止 HIV-1 的成熟而起作用,从而阻断其感染性。它也是 SARS-CoV 3CLpro 的抑制剂。 | |||
T8328 |
STING agonist-1
G10 |
Virus Protease; STING | Immunology/Inflammation; Microbiology/Virology |
STING agonist-1 (G10)是一种人类特异性 STING 激动剂,可引发针对新兴甲病毒的抗病毒活性。它抑制甲病毒属 VEEV 复制,IC90值为 24.57 μM。 | |||
T6001 |
Nelfinavir Mesylate
Viracept,Nelfin,AG1343,AG 1343 Mesylate,甲磺酸奈非那韦 |
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Nelfinavir Mesylate (Viracept) 是一种口服活性的 HIV-1蛋白酶抑制剂,用于抑制 HIV 感染,是一种广谱抗癌剂。 | |||
T23004 |
ML-SA1
Mucolipin synthetic agonist 1 |
Others; TRP/TRPV Channel | Membrane transporter/Ion channel; Others |
ML-SA1 (Mucolipin synthetic agonist 1) 是一种选择性的TRPML 激动剂,通过促进溶酶体的酸化和蛋白酶活性抑制登格病毒 2 和寨卡病毒,抗 DENV2 RNA 和 ZIKV RNA 的IC50分别为 8.3 μM 和 52.99 μM。ML SA1可诱发自噬。ML SA1可用于广谱抗病毒研究。 | |||
T2324 |
Darunavir
地瑞那韦,达芦那韦,TMC114 |
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Darunavir (TMC114) 是一种 HIV 蛋白酶抑制剂,用于治疗艾滋病和 HIV 感染。 由于单独使用时会出现抗病毒药物耐药性,因此与其他抗 HIV 药物联合使用。 | |||
T4686 |
Simeprevir
TMC435,西咪匹韦,TMC-435350,Olysio |
HCV Protease; SARS-CoV | Microbiology/Virology; Proteases/Proteasome |
Simeprevir (TMC435) 是一种有效的 HCV NS3/4A 蛋白酶抑制剂,抑制 HCV 复制,EC50 为 7.8 nM。它也是 SARS-CoV-2 3CLpro 抑制剂。 | |||
T3359 |
Aprotinin
抑酶肽,抑肽酶,Bovine Pancreatic Trypsin Inhibitor,Traskolan,Antilysin |
Others; Serine Protease; Influenza Virus; Proteasome | Microbiology/Virology; Others; Proteases/Proteasome; Ubiquitination |
Aprotinin (Traskolan) 是分离自牛肺的一种广谱丝氨酸蛋白酶抑制剂,可抑制多种不同酯酶和蛋白酶的活性。 | |||
T9567 |
Samatasvir
ATOLIHZIXHZSBA-BTSKBWHGSA-N,IDX719 |
HCV Protease | Microbiology/Virology; Proteases/Proteasome |
Samatasvir (ATOLIHZIXHZSBA-BTSKBWHGSA-N) 是 NS5A HCV 复制抑制剂。它能够有效的选择复制子及感染性 HCV,在基因型 1至5 复制子中,EC50= 2~24 pM。 | |||
T4988 |
Boceprevir
SCH 503034,EBP 520,波普瑞韦 |
HCV Protease; SARS-CoV | Microbiology/Virology; Proteases/Proteasome |
Boceprevir (SCH 503034) 是一种口服有效的选择性 HCV NS3 蛋白酶抑制剂。在酶试验中的 Ki 为 14 nM,在基于细胞的复制子试验中 EC90 为 350 nM。它也是 SARS-CoV-2 3CLpro 抑制剂。 | |||
T22394 |
Paritaprevir
ABT450,ABT-450,帕利普韦,Veruprevir |
HCV Protease | Microbiology/Virology; Proteases/Proteasome |
Paritaprevir (ABT450) 是一种非结构蛋白 3/4A 蛋白酶抑制剂,对 HCV 1a 和 HCV 1b 的 EC50 值分别为 1 和 0.21 nM。它也是SARS-CoV 3CLpro 的抑制剂,IC50为 1.31 μM。 | |||
T5013 |
Brequinar
Bipenquinate,NSC 368390,DUP785,布喹那 |
Virus Protease; Dehydrogenase; DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology |
Brequinar (NSC-368390) 是二氢乳清酸脱氢酶的一种强效抑制剂,对广谱病毒具有强效活性。 | |||
T6388 |
Amprenavir
141W94,安普那韦,Prozei,KVX-478,VX-478,安瑞那韦 |
SARS-CoV; HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Amprenavir (KVX-478) 是一种 HIV 蛋白酶抑制剂,Ki 为0.6 nM。它也是 SARS-CoV 3CLpro 抑制剂,IC50为 1.09 μM。 | |||
T6190 |
Telaprevir
VX-950,LY-570310,Incivek,MP-424,特拉匹韦 |
HCV Protease; SARS-CoV | Microbiology/Virology; Proteases/Proteasome |
Telaprevir (Incivek) 是一种选择性可逆的HCV NS3-4A 蛋白酶抑制剂,作用于基因 1型 (H 株) NS3 蛋白酶结构域和 NS4A 辅因子肽,Ki 为 7 nM。它也是 SARS-CoV-2 3CLpro 抑制剂。 | |||
T0825 |
Ebselen
SPI-1005,PZ-51,依布硒,CCG-39161 |
Phosphatase; Virus Protease; Calcium Channel; COX; HIV Protease | Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Neuroscience; Proteases/Proteasome |
Ebselen (CCG-39161) 是一种谷胱甘肽过氧化物酶模拟物,是电压依赖性钙通道阻断剂。它抑制Mpro 和COVID-19病毒,是HIV-1衣壳 CTD 二聚化的抑制剂,具有抗炎、抗癌和抗氧化活性。 | |||
T1525 |
Ritonavir
RTV,利托那韦,Abbott 84538,A 84538,ABT 538 |
Apoptosis; SARS-CoV; HIV Protease | Apoptosis; Microbiology/Virology; Proteases/Proteasome |
Ritonavir (ABT 538) 是一种 HIV 蛋白酶抑制剂,可研究 HIV 感染和 AIDS 。它也是 SARS-CoV 3CLpro 的抑制剂,IC50为 1.61 μM。 | |||
T3335 |
Darunavir Ethanolate
地瑞那韦乙醇盐,UIC 94017,Darunavir Ethanolate,TMC114,达芦那韦乙醇 |
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Darunavir Ethanolate (UIC 94017) 是一种HIV 蛋白酶抑制剂,可以用于 HIV/AIDS 的相关研究。对野生型 HIV-1 蛋白酶的Ki 值为1 nM。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TMO2787 |
Anthraquinone
dioxoanthracene,Anthradione,anthracenedione,蒽醌 |
Virus Protease | Microbiology/Virology |
Anthraquinone (Anthradione) 是常用于缓解便秘的草药中的主要活性成分,可用作染料形成前体。 | |||
T5666 |
Dipotassium glycyrrhizinate
|
Virus Protease | Microbiology/Virology |
Dipotassium glycyrrhizinate 是一种具有抗过敏和抗炎活性的阴离子表面活性剂。 | |||
T2741 |
Glycyrrhizic acid
Glycyrrhizin,甘草酸 |
Virus Protease; Dehydrogenase; MAO | Metabolism; Microbiology/Virology; Neuroscience |
Glycyrrhizic acid (Glycyrrhizin) 是甘草里面的活性成分三萜皂苷,为 HMGB1的拮抗剂,有用于肿瘤、糖尿病等研究的潜力。 | |||
T2875 |
Angelicin
Isopsoralen,异补骨脂素 |
Apoptosis; Virus Protease; Antiviral | Apoptosis; Immunology/Inflammation; Microbiology/Virology |
Angelicin (Isopsoralen) 是一种三环芳烃天然产物,结构上跟补骨脂素有关,具有抗癌、抗炎、抗病毒等活性。 | |||
T2926 |
Schizandrin A
|
P450; Virus Protease; Autophagy | Autophagy; Metabolism; Microbiology/Virology |
Schisandrin A 是一种从东方药物五味子中提取的主要有效成分,抑制 CYP3A 活性,IC50 分别为 6.60 μM 和 Ki 为 5.83 μM。 | |||
T0122 |
Bergenin
Cuscutin,Bengenin,岩白菜素 |
Apoptosis; IL Receptor; Virus Protease; TNF; NF-κB; Antibacterial; NOD; Autophagy; Antifungal | Apoptosis; Autophagy; Immunology/Inflammation; Microbiology/Virology; NF-κB |
Bergenin (Bengenin) 是一种在许多药用植物中发现的多酚,有细胞保护和抗氧化作用。它还具有广泛的保肝、抗炎、抗肿瘤、抗病毒、抗真菌以及免疫调节作用。 | |||
T0254 |
Probucol
DH-581,普罗布考 |
Virus Protease; ABC; Lipid | Membrane transporter/Ion channel; Metabolism; Microbiology/Virology |
Probucol (DH-581) 是一种抗高脂血症药物,可通过增加 LDL 分解代谢率来降低血液中的胆固醇水平。 | |||
T0433 |
Artesunate
WR-256283,青蒿琥酯 |
Virus Protease; Ferroptosis; STAT; Parasite | Apoptosis; JAK/STAT signaling; Microbiology/Virology; Stem Cells |
Artesunate (WR-256283) 是治疗疟疾的青蒿素组药物的一部分。 它是青蒿素的半合成衍生物,具有水溶性。 | |||
T2718 |
Palmatine chloride
|
Others; Indoleamine 2,3-Dioxygenase (IDO); Aurora Kinase | Cell Cycle/Checkpoint; Chromatin/Epigenetic; Metabolism; Others |
Palmatine chloride 是口服具有活力的不可逆 IDO-1抑制剂。它能够减轻结肠损伤,预防肠道菌群失调和调节色氨酸分解代谢,并改善 DSS 诱发的结肠炎。 | |||
T5S0802 |
Palmatine
巴马汀,Berbericinine,Burasaine |
Indoleamine 2,3-Dioxygenase (IDO); AChR; AChE; Aurora Kinase | Cell Cycle/Checkpoint; Chromatin/Epigenetic; Metabolism; Neuroscience |
Palmatine (Burasaine) 是口服具有活力的、不可逆IDO-1抑制剂。它可以减轻结肠损伤,预防肠道菌群失调和调节色氨酸分解代谢,从而改善DSS (Dextran Sulphate Sodium Salt) 诱发的结肠炎。它有用于结肠炎的研究潜力。 | |||
T4850 |
PCL 016
2-吡啶甲酸,2-Picolinic acid |
Virus Protease; Endogenous Metabolite | Metabolism; Microbiology/Virology |
PCL 016 (2-Picolinic acid) 是一种局部抗病毒剂,可抑制兔体内的腺病毒复制。 | |||
T5429 |
Theaflavin 3,3'-digallate
茶黄素-3,3'-双没食子酸,8-Gingerol,TFDG |
Virus Protease; Antioxidant; HIV Protease; HSV | Microbiology/Virology; oxidation-reduction; Proteases/Proteasome |
Theaflavin 3,3'-digallate (8-Gingerol) 是一种寨卡病毒蛋白酶抑制剂,IC50为 2.3 μM。它直接与 ZIKVpro 结合并抑制 ZIKV 复制,可抑制 gp41 和 NS2B-3 蛋白酶的活性,并具有抗 HSV 和 HIV-1病毒活性。它是红茶中的主要多酚,有抗肿瘤作用。 | |||
T1717 |
alpha-Mangostin
α-倒捻子素,α-Mangostin,Mangostin |
Apoptosis; Virus Protease; Dehydrogenase; Reactive Oxygen Species; Antibacterial; Antifungal | Apoptosis; Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB |
alpha-Mangostin (Mangostin) 是有多种生物活性的膳食呫吨酮。它是一种IDH1突变体的抑制剂,Ki 值为 2.85 μM。 | |||
T2A2498 |
L-Lysine
Aminutrin,Lysine Acid,lysine,L-赖氨酸,赖氨酸 |
Virus Protease; Endogenous Metabolite; Antifection | Metabolism; Microbiology/Virology |
L-Lysine (Aminutrin) 是一种人类必需氨基酸,能增加钙吸收,减少糖尿病相关疾病和改善肠道健康,可用于疱疹的研究。 | |||
T6S0095 |
Genkwanin
7-O-Methylapigenin,Puddumetin,Apigenin 7-methyl ether,芫花素 |
Virus Protease | Microbiology/Virology |
Genkwanin (Apigenin 7-methyl ether) 是一种O-甲基化黄酮,有抗炎活性,通过被动扩散和多药耐药蛋白介导的外排机制转运。 | |||
T8071 |
L-Lysine hydrochloride
赖氨酸盐酸盐,Lysine hydrochloride,L-赖氨酸盐酸盐 |
Virus Protease | Microbiology/Virology |
L-Lysine hydrochloride 是一种人类必需氨基酸,能增加钙吸收,减少糖尿病相关疾病和改善肠道健康,可用于疱疹的研究。 | |||
T3717 |
Hinokitiol
4-Isopropyltropolone,桧木醇,β-thujaplicin,β-桧木醇 |
DNA Methyltransferase; Virus Protease; Estrogen/progestogen Receptor; Nrf2 | Chromatin/Epigenetic; Endocrinology/Hormones; Immunology/Inflammation; Microbiology/Virology |
Hinokitiol (4-Isopropyltropolone) 是从日本扁柏中分离到的一种挥发油成分,可抑制紫外线 B 诱导的角质形成细胞凋亡,可调节雌激素受体信号传导并抑制人乳腺癌细胞的增殖。它具有抗感染、抗氧化及抗肿瘤等活性。 | |||
T5S1923 |
Schisandrin C
五味子丙素,Schizandrin-C,Wuweizisu-C |
Apoptosis; Others; Virus Protease | Apoptosis; Microbiology/Virology; Others |
Schisandrin C (Wuweizisu-C) 是从五味子中分离得到的一种植物化学木脂素。它具有抗癌、抗炎和抗氧化等多种生物活性,可研究癌症、阿尔茨海默病、肝病。 | |||
T0800 |
Danthron
Dantron,1,8-Dihydroxyanthraquinone,1,8-二羟基蒽醌,丹蒽醌,Chrysazin,Antrapurol |
Virus Protease; Antibacterial; AMPK; Autophagy | Autophagy; Chromatin/Epigenetic; Microbiology/Virology; PI3K/Akt/mTOR signaling |
Danthron (Antrapurol) 是一种从中药 rhubarb 中提取的天然产物,可通过激活 AMPK 来调节葡萄糖和脂质代谢。 | |||
T6S1315 |
Oroxylin A
千层纸素A,6-Methoxybaicalein,Baicalein 6-methyl ether |
Virus Protease; HIF/HIF Prolyl-Hydroxylase; Autophagy | Autophagy; Chromatin/Epigenetic; Metabolism; Microbiology/Virology |
Oroxylin A (Baicalein 6-methyl ether) 是一种有活性的黄酮,具有较强的抗癌作用。 | |||
TN1202 |
(-)-α-Pinene
左旋-α-蒎烯,左旋-alpha-蒎烯,(1S)-(-)-Alpha-Pinene |
Virus Protease; GABA Receptor; Endogenous Metabolite; Antibacterial | Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Neuroscience |
(-)-α-Pinene ((1S)-(-)-Alpha-Pinene) 是一种单萜类化合物,通过延长 GABAergic 突触传递、作为 GABAA-BZD 受体的部分调节剂并直接与 GABAA 受体的 BZD 结合位点结合来增强 NREMS 的数量而不影响 NREMS 的强度。 | |||
T0011 |
2-Phenylethanol
苯乙醇,Phenethyl alcohol,2-Phenylethyl alcohol,Benzyl carbinol,Phenylethanol,Benzeneethanol |
Others; Virus Protease; Antibacterial; Antibiotic | Microbiology/Virology; Others |
2-Phenylethanol (Phenylethanol) 是从玫瑰、风笛、阿勒颇松、桔子花等多种物种中提取得到的一种无色液体。它有一种使人感到愉悦的气味,也是一种从真菌Candida albicans 产生的自体抗生素。它可用作香皂中的防腐剂,也用作香烟添加剂。 | |||
T2774 |
Lycorine hydrochloride
石蒜碱,Licorine hydrochloride,Galanthidine hydrochloride,Narcissine hydrochloride,Lycorine chloride,Amarylline hydrochloride,盐酸石蒜碱 |
Virus Protease; HCV Protease; Antibacterial; Autophagy | Autophagy; Microbiology/Virology; Proteases/Proteasome |
Lycorine hydrochloride (Narcissine hydrochloride) 是黑色素瘤血管生成抑制剂,是一种来自石蒜的主要活性成分,抑制 Hey1B 细胞的有丝分裂增殖,IC50值为 1.2 μM,具有抗肿瘤活性。 | |||
T3759 |
3,4-Dimethoxycinnamic acid
Dimethylcaffeic acid,3,4-二甲氧基肉桂酸,Caffeic acid dimethyl ether,O-Methylferulic acid |
Apoptosis; Virus Protease; Reactive Oxygen Species | Apoptosis; Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB |
3,4-Dimethoxycinnamic acid (O-Methylferulic acid) 是从 Securidaca inappendiculata Hassk 中提取和纯化的单体。 3,4-Dimethoxycinnamic acid 通过 ROS 介导的信号通路对 L-02 细胞发挥抗凋亡作用。抗凋亡作用。 | |||
T3324 |
Lycorine
Galanthidine,Narcissine,石蒜碱,Amarylline,Belamarine,Licorine,番石榴碱 |
Apoptosis; Virus Protease; Antibacterial; AChR; Fatty Acid Synthase | Apoptosis; Metabolism; Microbiology/Virology; Neuroscience |
Lycorine (Narcissine) 是从金眼科植物科中提取的一种天然生物碱。它是一种具有口服活性的SCAP 抑制剂,Kd 值 15.24 nM。它也是黑色素瘤血管生成抑制剂,有用于前列腺癌和代谢疾病的研究潜力。 | |||
T2732 |
(-)-Epicatechin gallate
表儿茶素没食子酸酯,(−)-Epicatechin 3-gallate,Epicatechin gallate,(-)-Epicatechin 3-gallate,(-)-Epicatechin 3-O-gallate,ECG |
Virus Protease; COX; Autophagy | Autophagy; Immunology/Inflammation; Microbiology/Virology; Neuroscience |
(-)-Epicatechin gallate ((-)-Epicatechin 3-O-gallate) 抑制环加氧酶-1 的IC50值为 7.5 μM。 | |||
TN1059 |
Ganoderic acid B
|
IL Receptor; HIV Protease; JAK; STAT | Angiogenesis; Chromatin/Epigenetic; Immunology/Inflammation; JAK/STAT signaling; Microbiology/Virology; Proteases/Proteasome; Stem Cells |
Ganoderic acid B 是从灵芝中分离的一种三萜类天然产物。它是端粒酶抑制剂,抑制 Epstein-Barr 病毒抗原的活化。它是 HIV-1 蛋白酶抑制剂。 | |||
TN7388 |
Ganoderic acid GS-2
|
Others | Others |
Ganoderic acid GS-2 inhibits the activity of the human immunodeficiency virus-1 (HIV-1) protease. | |||
TN4109 |
Ganolucidic acid A
|
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Ganolucidic acid A exhibits cytotoxicity, has inhibitory activities against human HeLa cervical cancer cell lines. It shows significant anti-human immunodeficiency virus (anti-HIV)-1 protease activity with IC50 values of 20-90 microM. | |||
TMA1012 |
Ganoderiol F
|
Androgen Receptor; HIV Protease; Autophagy | Autophagy; Endocrinology/Hormones; Microbiology/Virology; Proteases/Proteasome |
Ganoderiol F has anti-inflammatory, cytotoxic and anti-HIV activity, it inhibits activity of topoisomerases in vitro, and it inhibits human immunodeficiency virus-1 protease with IC(50) values of 20-40 microM. It induced HO-1 expression, activation of the mitogen-activated protein kinase EKR and up-regulation of cyclin-dependent kinase inhibitor p16 and suppressed lipopolysaccharide (LPS)-induced nitric oxide (NO) production. | |||
T72508 |
Palmatine hydroxide
|
Others | Others |
Palmatine hydroxide 是不可逆的口服活性IDO-1抑制剂,其对HEK 293-hIDO-1 和 rhIDO-1的IC50值分别为3 μM和157 μM。该化合物还能非竞争性抑制(WNV)NS2B-NS3蛋白酶,IC50值为96 μM。Palmatine hydroxide展现了抗癌、抗炎、神经保护、抗细菌和抗病毒的活性。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-00323 |
Hepatitis C virus (HCV-1a) NS3 protease/helicase immunodominant region Protein (aa 1356-1459, GST)
NS3 |
HCV | E. coli |
HCV NS3 displays three enzymatic activities: serine protease, NTPase, and RNA helicase. HCV NS3 serine protease, in association with NS4A, is responsible for the cleavages of NS3-NS4A, NS4A-NS4B, NS4B-NS5A, and NS5A-NS5B. HCV NS3 RNA helicase binds to RNA and unwinds dsRNA in the 3' to 5' direction, and likely RNA stable secondary structure in the template strand (By similarity). Cleaves and inhibits the host antiviral protein MAVS. NS3/NS4A complex also prevents phosphorylation of human IRF3, t... | |||
TMPH-00134 |
AcMNPV Viral cathepsin Protein (His & SUMO)
Cysteine proteinase,Viral cathepsin,VCATH,V-cath |
AcMNPV | E. coli |
Cysteine protease that plays an essential role in host liquefaction to facilitate horizontal transmission of the virus. Accumulates within infected cells as an inactive proenzyme (proV-CATH), which is activated by proteolytic cleavage upon cell death. AcMNPV Viral cathepsin Protein (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 39.9 kDa and the accession number is P25783. | |||
TMPH-00060 |
ApNPV Viral cathepsin Protein (His & Myc)
V-cath,Viral cathepsin,Cysteine proteinase (CP),VCATH |
ApNPV | E. coli |
Cysteine protease that plays an essential role in host liquefaction to facilitate horizontal transmission of the virus. May participate in the degradation of foreign protein expressed by the baculovirus system. ApNPV Viral cathepsin Protein (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 31.1 kDa and the accession number is Q91CL9. | |||
TMPH-02236 |
TMPRSS2 Protein, Human, Recombinant (E. coli, His)
Transmembrane protease serine 2,TMPRSS2,Serine ... |
Human | E. coli |
Plasma membrane-anchored serine protease that participates in proteolytic cascades of relevance for the normal physiologic function of the prostate. Androgen-induced TMPRSS2 activates several substrates that include pro-hepatocyte growth factor/HGF, the protease activated receptor-2/F2RL1 or matriptase/ST14 leading to extracellular matrix disruption and metastasis of prostate cancer cells. In addition, activates trigeminal neurons and contribute to both spontaneous pain and mechanical allodynia.... | |||
TMPH-02237 |
TMPRSS2 Protein, Human, Recombinant (His & Myc)
Serine protease 10,Transmembrane protease ... |
Human | HEK293 Cells |
Plasma membrane-anchored serine protease that participates in proteolytic cascades of relevance for the normal physiologic function of the prostate. Androgen-induced TMPRSS2 activates several substrates that include pro-hepatocyte growth factor/HGF, the protease activated receptor-2/F2RL1 or matriptase/ST14 leading to extracellular matrix disruption and metastasis of prostate cancer cells. In addition, activates trigeminal neurons and contribute to both spontaneous pain and mechanical allodynia.... | |||
TMPY-00818 |
Granzyme H/GZMH Protein, Human, Recombinant (His)
CTSGL2,CSP-C,CCP-X,granzyme H,CTLA1,CGL-2,GZMH |
Human | HEK293 Cells |
Granzymes are key components of the immune response that play important roles in eliminating host cells infected by intracellular pathogens. Several granzymes are potent inducers of cell death. A total of eight granzymes (A-G and M) have been identified in the mouse, but only five are known in humans (A, B, H, M, and granzyme 3), and granzyme H appears to be specifically human. Human granzyme H is a neutral serine protease that is expressed predominantly in the lymphokine-activated killer (LAK)/... |