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Search Results for " vdr "

Targets Recommended: Others

26

抑制剂 & 化合物

5

天然产物

2

重组蛋白

2

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T13292	VDR agonist 1	Others	Others
	VDR agonist 1 (compound 28) 是一种非甾体类维生素 D 受体 (VDR)的激动剂，在MCF-7 细胞中测得其IC50值为 690 nM。VDR agonist 1 通过上调 p21 和 p27 的表达来抑制细胞周期，通过增加 BAX 的表达来促进细胞凋亡，降低 Bcl-2 的表达，具有治疗乳腺癌的潜力。
T78944	VDR agonist 2	Others	Others
	VDR agonist 2（化合物16i）作为VDR（vitamin D receptor）激动剂，能有效抑制TGF-β1诱导的肝星状细胞（HSC）活化，并在体外和体内展现出显著的抗肝纤维化效果。
TQ0200	Paricalcitol	Others	Others
	Paricalcitol 是一种 vitamin D receptor 激活剂，是一种 vitamin D 类似物，用于研究继发性甲状旁腺功能亢进，该疾病与慢性肾功能衰竭有关。
T24166	Inecalcitol TX 522,TX-522,TX522,伊奈骨化醇	Apoptosis	Apoptosis
	Inecalcitol (TX 522) 是一种独特的维生素 D3 类似物，可诱导细胞凋亡，有抗癌活性。它是一种具有口服活性维生素 D 受体激动剂，Kd 为 0.53 nM。
T16015	Maxacalcitol 马沙骨化醇,22-Oxacalcitriol	Others	Others
	Maxacalcitol (22-Oxacalcitriol) 是非血钙维生素 D3的一种类似物，是 VDR 样受体的配体。
T14856	Calcipotriol MC 903,卡泊三醇,Calcipotriene	Others	Others
	Calcipotriol (MC 903) 是一种合成的 VitD3类似物，对维他命 D 受体具有高亲和力。
TQ0244	Calcipotriol monohydrate 钙泊三醇一水合物,卡泊三醇一水合物	Others	Others
	Calcipotriol monohydrate 是维生素 D3 的类似物，对维生素 D 受体具有高亲和力。Calcipotriol monohydrate 可用于银屑病研究。
T6430L	Calcifediol monohydrate 骨化二醇一水合物,25-hydroxy Vitamin D3 monohydrate	Endogenous Metabolite	Metabolism
	Calcifediol monohydrate (25-hydroxy Vitamin D3 monohydrate) 是维生素 D3 在肝中经羟基化后得到的前激素，是有效的 VDR 抑制剂。
T6112	Doxercalciferol TSA 840,度骨化醇,Hectorol,1.alpha.-Hydroxyvitamin D2,1α-hydroxyvitamin D2	Others	Others
	Doxercalciferol (TSA 840) 是一种维生素 D2 类似物，是一种维生素 D 受体激活剂，能够阻碍肾病的进程。
T6374	Alfacalcidol Bondiol,Etalpha,阿法骨化醇,1-hydroxy Vitamin D3,1.alpha.-Hydroxyvitamin D3,1-hydroxycholecalciferol	Others	Others
	Alfacalcidol (Etalpha) 是一种维生素 D3 衍生物，是非选择性的维生素 D 受体活化剂，有用于骨质疏松研究的潜力。
T13404	ZK168281	Others	Others
	ZK168281 is a 25-carboxylic ester 1α,25(OH)2D3 analog and a pure antagonist of VDR (Kd of 0.1 nM). ZK168281 is an effective inhibitor of the coactivator (CoA) interaction of its receptor.
T69676	LG190155	Others	Others
	LG190155 is a moderately potent VDR agonist. Vitamin D receptor (VDR) agonists are well known for their capacity to control calcium and bone metabolism and to regulate growth and differentiation of many cell types.
T17292	ZK159222	Others	Others
	ZK159222 is an effective 1α,25-(OH)2D3 receptor (VDR) agonist. ZK159222 has a partial agonistic character.
T24675	PS121912 PS-121912,PS 121912	Others	Others
	PS121912 is a potent and selective inhibitor of VDR-coactivator.
T70151	MeTC7	Others	Others
	MeTC7 is a VDR antagonist, which can be synthesized from 7-dehydrocholesterol (6) in two steps, inhibits VDR selectively, suppresses the viability of cancer cell-lines, and reduces the growth of the spontaneous transgenic TH-MYCN neuroblastoma and xenografts in vivo.
T27825	LG190178 LG-190178,LG 190178	Others	Others
	LG190178, a vitamin D receptor (VDR) ligand, is a therapeutic agent used for the treatment of psoriasis, osteoporosis, and secondary hyperparathyroidism.
T36593	TEI-9648	Others	Others
	TEI-9648, a Vitamin D3 Lactone analogue, is a potent and specific vitamin D receptor (VDR) antagonist. TEI-9648 inhibits VDR/VDRE-mediated genomic actions of 1α,25(OH)2D3. TEI-9648 also inhibits HL-60 cell differentiation induced by of 1α,25(OH)2D3. TEI-9648 has the potential for bone metabolism research[1][2]. TEI-9648 (10-1000 nM) dose-dependently blocks the reciprocal changes of CD11b and CD71 expression associated with HL-60 cell differentiation induced by 1α,25(OH)2D3[1]. TEI-9648 has cons...
T17031	TEI-9647	Others	Others
	TEI-9647 is a 1α,25-dihydroxy vitamin D3-26,23-lactone (1α,25-lactone) analog and is an effective VDR/vitamin D-responsive element (DRE)-mediated genomic actions antagonist.
TQ0123	MC 1046 Impurity A of Calcipotriol	Others	Others
	MC 1046 is an impurity of Calcipotriol. Calcipotriol is a ligand of VDR-like receptors.
T13590	Calcipotriol Impurity C	Others	Others
	Calcipotriol Impurity C is the impurity of Calcipotriol. Calcipotriol is a VDR-like receptors ligand.
T11644	Impurity C of Alfacalcidol	Others	Others
	Impurity of Alfacalcidol is an impurity of Alfacalcidol. Alfacalcidol is a non-selective VDR activator medication.
T10088	24R-Calcipotriol PRI 2202	Others	Others
	24R-Calcipotriol(PRI 2202) is an impurity of Calcipotriol which is a ligand of VDR-like receptors.
T11646	Impurity F of Calcipotriol	Others	Others
	Impurity F of Calcipotriol is a impurity of Calcipotriol. Calcipotriol (MC 903; Calcipotriene) is a ligand of VDR-like receptors.
T9644	Triciferol	Others	Others
	Triciferol 作为具有结合了 VDR 激动剂和 HDAC 拮抗剂活性的多重配体发挥作用。Triciferol 直接与 VDR 结合 (IC50=87 nM)，在一些 1,25D 靶基因上作为具有 1,25D 样效力的激动剂发挥作用。Triciferol 诱导显著的微管蛋白高乙酰化，并增强组蛋白乙酰化。Triciferol 在体外癌细胞模型中也表现出有效的抗增殖和细胞毒性活性。
T11643	Impurity B of Calcitriol 1β,25-Dihydroxyvitamin-D3,1-Epicalcitriol	Others	Others
	Impurity B of Calcitriol is an impurity of Calcitriol. Calcitriol is the hormonally active form of vitamin D, Calcitriol is the active metabolite of vitamin D3 that activates the vitamin D receptor (VDR).
T83765	Dendrogenin A DDA	Others	Others
	Dendrogenin A (DDA) 作为一种选择性肝X受体(LXR)调节剂(SLiM)、胆固醇环氧水解酶(ChEH; Ki = 120 nM)的抑制剂及胆固醇的活性代谢产物，通过DDA合成酶将5,6α-环氧胆固醇与组胺结合形成。DDA在非癌性人乳腺上皮细胞和上皮黑色素细胞中存在，但在多种乳腺癌细胞或黑色素瘤细胞中未发现，且在分离的人乳腺肿瘤组织中仅以低水平存在。它抑制22(R)-羟基胆固醇诱导的LXRβ和LXRα激活(分别以IC50 = 76和362 nM)，但也是LXR的部分激动剂，在B16/F10小鼠黑色素瘤细胞中增加Nur77、NOR-1、LC3-I和LC3-II的蛋白水平。DDA选择性调节LXRα和LXRβ，而非孕烯X受体(PXR)、芳香烃受体(AhR)、维生素D受体(VDR)、维甲酸X受体γ(RXRγ)、维甲酸受体α(RARα)、过氧化物酶体增殖物激活受体α(PPARα)、PPARγ、糖皮质激素受体、雄激素受体、雌激素受体α(ERα)及ERβ在2.5 µM下。此外，DDA在2.5和5 µM的浓度下增加B16/F10和SK-MEL-28癌细胞中LC3-II的蛋白水平，并在2...

化合物

VDR agonist 1

Cat.No: T13292

Target: Others

VDR agonist 2

Cat.No: T78944

Target: Others

Cat.No: TQ0200

Target: Others

Cat.No: T24166

Synonym: TX 522,TX-522,TX522,伊奈骨化醇

Target: Apoptosis

Cat.No: T16015

Synonym: 马沙骨化醇,22-Oxacalcitriol

Target: Others

Cat.No: T14856

Synonym: MC 903,卡泊三醇,Calcipotriene

Target: Others

Calcipotriol monohydrate

Cat.No: TQ0244

Synonym: 钙泊三醇一水合物,卡泊三醇一水合物

Target: Others

Calcifediol monohydrate

Cat.No: T6430L

Synonym: 骨化二醇一水合物,25-hydroxy Vitamin D3 monohydrate

Target: Endogenous Metabolite

Doxercalciferol

Cat.No: T6112

Synonym: TSA 840,度骨化醇,Hectorol,1.alpha.-Hydroxyvitamin D2,1α-hydroxyvitamin D2

Target: Others

Cat.No: T6374

Synonym: Bondiol,Etalpha,阿法骨化醇,1-hydroxy Vitamin D3,1.alpha.-Hydroxyvitamin D3,1-hydroxycholecalciferol

Target: Others

Cat.No: T13404

Target: Others

Cat.No: T69676

Target: Others

Cat.No: T17292

Target: Others

Cat.No: T24675

Synonym: PS-121912,PS 121912

Target: Others

Cat.No: T70151

Target: Others

Cat.No: T27825

Synonym: LG-190178,LG 190178

Target: Others

Cat.No: T36593

Target: Others

Cat.No: T17031

Target: Others

Cat.No: TQ0123

Synonym: Impurity A of Calcipotriol

Target: Others

Calcipotriol Impurity C

Cat.No: T13590

Target: Others

Impurity C of Alfacalcidol

Cat.No: T11644

Target: Others

24R-Calcipotriol

Cat.No: T10088

Synonym: PRI 2202

Target: Others

Impurity F of Calcipotriol

Cat.No: T11646

Target: Others

Cat.No: T9644

Target: Others

Impurity B of Calcitriol

Cat.No: T11643

Synonym: 1β,25-Dihydroxyvitamin-D3,1-Epicalcitriol

Target: Others

Cat.No: T83765

Synonym: DDA

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T1086	Vitamin D2 Calciferol,Ergocalciferol,Ercalciol,维生素D2	DNA/RNA Synthesis; Endogenous Metabolite	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism
	Vitamin D2 (Calciferol) 来源于植物或膳食补充剂，能够用作维生素 D 的补充剂。
T1135	Vitamin D3 维生素D3,Cholecalciferol,Colecalciferol	Endogenous Metabolite	Metabolism
	Vitamin D3 (Cholecalciferol) 是维生素 D 的一种天然存在形式，代谢激活后可以诱导细胞分化和癌细胞增殖。
T6316	Calcitriol Topitriol,Rocaltrol,Calcijex,RO215535,骨化三醇,1,25-Dihydroxyvitamin D3	Endogenous Metabolite	Metabolism
	Calcitriol (1,25-Dihydroxyvitamin D3) 是一种维他命 D 的代谢物，一种维他命 D 受体 (VDR) 的激动剂 (IC50=0.4 nM)。Calcitriol 增加肠道对钙和磷的吸收，并与甲状旁腺激素一起增加了骨吸收。
T6430	Calcifediol 25-羟基维生素 D3,U 32070E,25-hydroxy Vitamin D3,RO 8-8892,骨化二醇	Endogenous Metabolite	Metabolism
	Calcifediol (U 32070E) 是由维生素 D3 在肝中经羟基化后得到的前激素，是 VDR 的有效抑制剂。
T35524	(1S)-Calcitriol	Others	Others
	(1S)-Calcitriol (1α,25-Dihydroxy-3-epi-vitamin-D3) is a natural metabolite of 1α,25-dihydroxyvitamin D3 (1α,25(OH)2D3). (1S)-Calcitriol exhibits potent vitamin D receptor (VDR)-mediated actions such as inhibition of keratinocyte growth or suppression of parathyroid hormone secretion[1]. 3‐epi‐Calcitroic acid is an end product of (1S)-Calcitriol (1α,25-Dihydroxy-3-epi-vitamin-D3; 3‐epi‐1a,25(OH)2D3) metabolism by rat CYP24A1[1]. [1]. Steve Y Rhieu, et al. Metabolic stability of 3-epi-1α,25-dihydr...

天然产物

Cat.No: T1086

Synonym: Calciferol,Ergocalciferol,Ercalciol,维生素D2

Target: DNA/RNA Synthesis, Endogenous Metabolite

Cat.No: T1135

Synonym: 维生素D3,Cholecalciferol,Colecalciferol

Target: Endogenous Metabolite

Cat.No: T6316

Synonym: Topitriol,Rocaltrol,Calcijex,RO215535,骨化三醇,1,25-Dihydroxyvitamin D3

Target: Endogenous Metabolite

Cat.No: T6430

Synonym: 25-羟基维生素 D3,U 32070E,25-hydroxy Vitamin D3,RO 8-8892,骨化二醇

Target: Endogenous Metabolite

(1S)-Calcitriol

Cat.No: T35524

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-02706	Vitamin D Receptor/VDR Protein, Human, Recombinant (His) PPP1R163,vitamin D (1,25- dihydroxyvitamin D3) receptor,NR1I...	Human	Baculovirus Insect Cells
	Vitamin D Receptor/VDR Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 50 kDa and the accession number is P11473.
TMPY-02987	Vitamin D Receptor/VDR Protein, Mouse, Recombinant (His) vitamin D (1,25- dihydroxyvitamin D3) receptor,Nr1i1	Mouse	Baculovirus Insect Cells
	Vitamin D Receptor/VDR Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 49.28 kDa and the accession number is P48281.

重组蛋白

Vitamin D Receptor/VDR Protein, Human, Recombinant (His)

Cat.No: TMPY-02706

Species: Human

Expression System: Baculovirus Insect Cells

Vitamin D Receptor/VDR Protein, Mouse, Recombinant (His)

Cat.No: TMPY-02987

Species: Mouse

Expression System: Baculovirus Insect Cells

Cat. No.	Product Name	Target	Signaling Pathways
T11952	Maxacalcitol-D6	Others	Others
	Maxacalcitol-D6 is a non-calcemic vitamin D3 analog and VDR ligand of VDR-like receptors.Maxacalcitol-D6 is the deuterated form of Maxacalcitol (22-Oxacalcitriol).
T10279	Alfacalcidol-D6	Others	Others
	Alfacalcidol-D6 is a deuterated Alfacalcidol. Alfacalcidol is a non-selective VDR activator medication.

同位素标记化合物

Maxacalcitol-D6

Cat.No: T11952

Target: Others

Alfacalcidol-D6

Cat.No: T10279

Target: Others

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