135
130
3
13
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T31894 |
Furothiazole
C 132,NSC 523298,C 132 (VAN),CCRIS 1194 |
Others | Others |
Furothiazole is a bioactive chemical. | |||
T6946 |
Pimavanserin tartrate
ACP-103,ACP-103 tartrate,Nuplazid,Pimavanserin,匹莫范色林 |
5-HT Receptor | GPCR/G Protein; Neuroscience |
Pimavanserin tartrate (Nuplazid) 是一种有效的5-HT 2A 受体反向激动剂,pIC50和 pKi 值分别为8.73和9.3,用于治疗与帕金森病相关的精神病。 | |||
T9247 |
Vanilloid receptor antagonist 1
4-(7-Hydroxy-2-isopropyl-4-oxoquinazolin-3(4H)-yl)benzonitrile |
TRP/TRPV Channel | Membrane transporter/Ion channel |
Vanilloid receptor antagonist 1 (4-(7-Hydroxy-2-isopropyl-4-oxoquinazolin-3(4H)-yl)benzonitrile) 是香草酸受体的有效拮抗剂。 | |||
T12225L |
Nevanimibe hydrochloride
PD-132301 hydrochloride,ATR101 hydrochloride |
Apoptosis; Acyltransferase | Apoptosis; Metabolism |
Nevanimibe hydrochloride (PD-132301 hydrochloride) 是一种口服有效的,选择性酰基辅酶 A:胆固醇 O-酰基转移酶 1 抑制剂,EC50为 9 nM。它抑制 ACAT2,EC50为 368 nM。它诱导细胞凋亡,具有抗肾上腺皮质癌的潜力。 | |||
T7153 |
Vanoxerine dihydrochloride
GBR-12909 dihydrochloride,伐诺司林二盐酸盐,I893 dihydrochloride |
Dopamine Receptor | GPCR/G Protein; Neuroscience |
Vanoxerine dihydrochloride (GBR-12909 dihydrochloride) 是一种竞争性的、有效的、选择性的多巴胺再摄取抑制剂,能够与多巴胺转运体 (DAT) 上的靶点结合。 | |||
T6117 |
Tivantinib
ARQ 197 |
Apoptosis; c-Met/HGFR | Apoptosis; Tyrosine Kinase/Adaptors |
Tivantinib (ARQ 197) 是一种高选择性c-Met 酪氨酸激酶抑制剂,Ki 为 355 nM。 | |||
T6247 |
Onvansertib
NMS-P937,NMS-1286937 |
Apoptosis; PLK | Apoptosis; Cell Cycle/Checkpoint |
Onvansertib (NMS-1286937) 是一种可口服的高选择性PLK1抑制剂,IC50值为 2 nM。 | |||
T37979 |
N-Desmethyl Pimavanserin
AC-279 |
5-HT Receptor | GPCR/G Protein; Neuroscience |
N-Desmethyl Pimavanserin (AC-279) 是 Pimavanserin (一种 5-HT2A 受体反向激动剂)的活性代谢物,可用于治疗失眠等睡眠障碍。 | |||
T6036 |
Brivanib
BMS-540215,布立尼布 |
EGFR; VEGFR; FGFR; Autophagy | Angiogenesis; Autophagy; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
Brivanib (BMS-540215) 是一种针对 VEGFR2 的 ATP 竞争性抑制剂,IC50 为 25 nM。它对 VEGFR-1 和 FGFR-1 具有中等效力,对 VEGFR2 的选择性是对 PDGFR-β 的 240 倍。 | |||
T2189 |
Sodium orthovanadate
Sodium vanadate,钒酸钠,Trisodium vanadate,Sodium pervanadate |
ATPase; Phosphatase | Membrane transporter/Ion channel; Metabolism |
Sodium orthovanadate 是一种蛋白酪氨酸磷酸酶,碱性磷酸酶和一些ATP 酶的抑制剂,有可能充当磷酸盐类似物。它具有胰岛素样作用、对心室肌的正性肌力作用和其他代谢作用。 | |||
T67926 |
(S)-(+)-N-3-Benzylnirvanol
ZSN-76403 |
P450; HIV Protease | Metabolism; Microbiology/Virology; Proteases/Proteasome |
(S)-(+)-N-3-Benzylnirvanol (ZSN-76403) 是一种细胞色素P450 CYP2C19抑制剂,IC50值为0.179 µM,可用于研究艾滋病毒感染。 | |||
T2576 |
Brivanib (alaninate)
丙氨酸布立尼布,BMS-582664,Brivanib Alaninate |
VEGFR; FGFR; Autophagy | Angiogenesis; Autophagy; Tyrosine Kinase/Adaptors |
Brivanib Alaninate (BMS-582664) 是一种血管内皮生长因子受体 2 (VEGFR2) 抑制剂的丙氨酸盐,IC50值为 25 nM,具有潜在的抗肿瘤活性。它对 VEGFR1 和 FGFR1 适度抑制,对 VEGFR2 的选择性是对 PDGFRβ 的 240 倍。 | |||
T23106 |
Olvanil
N-Vanillyloleamide,奥伐尼,N-Vannilyloleoylamide |
TRP/TRPV Channel | Membrane transporter/Ion channel |
Olvanil (N-Vannilyloleoylamide) 是一种vanilloid 受体激动剂,EC50为0.7nM。 | |||
T1656 |
Vandetanib
ZD6474,凡德他尼 |
Apoptosis; EGFR; VEGFR; Autophagy | Angiogenesis; Apoptosis; Autophagy; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
Vandetanib (ZD6474) 是一种具有口服活性的VEGFR2/KDR 酪氨酸激酶抑制剂,IC50值为40 nM。它也抑制VEGFR3/FLT4和EGFR/HER1,IC50值分别为110和500 nM。 | |||
T8143 |
Bevantolol hydrochloride
贝凡洛尔盐酸盐,NC-1400 hydrochloride,盐酸贝凡洛尔 |
Calcium Channel; Adrenergic Receptor | GPCR/G Protein; Membrane transporter/Ion channel; Metabolism; Neuroscience |
Bevantolol hydrochloride (NC-1400 hydrochloride) 是一种 β1-肾上腺素受体拮抗剂,可治疗心绞痛和高血压,在大鼠大脑皮层中的pKi 值分别为 7.83、6.9。 | |||
T21358 |
Dalbavancin
BI 397,BI-397,VER 001,A-A 1,BI397,VER-001,Dalbavancin HCl,达巴万星 |
Antibacterial; Antibiotic | Microbiology/Virology |
Dalbavancin (BI-397) HCl 是一种半合成的脂糖肽抗生素,对革兰氏阳性细菌有杀菌活性。Dalbavancin 抑制金黄色葡萄球菌和炭疽芽孢杆菌的 MIC90分别为 0.06 μg/mL 和 0.25 μg/mL。 | |||
T14130 |
Adomeglivant
LY2409021 |
Glucagon Receptor | GPCR/G Protein |
Adomeglivant (LY2409021) 是一种高效的选择性胰高血糖素受体 (GluR) 变构拮抗剂,主要用于2型糖尿病的研究。 | |||
T2691 |
Oritavancin diphosphate
奥利万星二磷酸盐,LY333328 diphosphate |
Others; Antibacterial; Antibiotic | Microbiology/Virology; Others |
Oritavancin diphosphate (LY333328 diphosphate) 是一种新型半合成的糖肽抗生素, 可研究革兰氏阳性菌感染。 | |||
T37332 |
(±)-N-3-Benzylnirvanol
|
P450 | Metabolism |
(±)-N-3-Benzylnirvanol 是由(+)-N-3-Benzylnirvanol 和 (-)-N-3-Benzylnirvanoll 混装在一起的外消旋混合物。(+)-N-3-Benzylnirvanol 和 (-)-N-3-Benzylnirvanoll 是细胞色素 P450的选择性抑制剂,对 CYP2C19具有抑制作用,(±)- n -3-苄基壬烷醇可降低小鼠血浆胆固醇水平。 | |||
T0491 |
Ethylvanillin
Ethylprotal,Bourbonal,乙基香兰素,Rhodiarome,Ethyl vanillin |
Others | Others |
Ethylvanillin (Rhodiarome) 是一种食用香料,效果是 Vanillin 的三倍,可用于巧克力的生产。 | |||
T12738L1 |
Rivanicline 2HCl
Rivanicline 2HCl(15585-43-0 Free base) |
AChR | Neuroscience |
Rivanicline 2HCl 是一种选择性神经元烟碱受体(neuronal nicotinic receptor) 的抑制剂,对α4β2 亚型的亲和力较高。 | |||
T2076 |
Pimavanserin
ACP-103,匹莫范色林 |
5-HT Receptor | GPCR/G Protein; Neuroscience |
Pimavanserin (ACP-103) 是特异性的 5-HT2A 受体反向激动剂,在基于细胞的功能测定中,平均 pIC50值为8.7。它是非典型抗精神病药,用于治疗帕金森病患者的幻觉和精神病。 | |||
T8218 |
Vanin-1-IN-1
VUN34002 |
Others | Others |
Vanin-1-IN-1 (VUN34002) 是 vanin-1 酶抑制剂。其中 vanin-1 是细胞表面相关的肌醇锚定蛋白,在代谢和炎症中具有重要的作用。 | |||
T11217 |
Eplivanserin
依利色林,SR-46349 |
5-HT Receptor | GPCR/G Protein; Neuroscience |
Eplivanserin (SR-46349) 是一种有效和特异性的 5-HT2A 受体拮抗剂,Kd 值为 1.14 nM,在大鼠皮质膜中 IC50 值为 5.8 nM。 | |||
T0313 |
Evans blue
Direct Blue 53,C.I. 23860,伊文思蓝 |
GluR | Neuroscience |
Evans blue (C.I. 23860) 是一种突触泡谷氨酸吸收的有效抑制剂,同时也是一种AMPA/kainate 受体拮抗剂。 | |||
T12242 |
Norvancomycin hydrochloride
Desmethyl-vancomycin hydrochloride,盐酸去甲万古霉素 |
Antibacterial | Microbiology/Virology |
Norvancomycin hydrochloride (Desmethyl-vancomycin hydrochloride) 可用于葡萄球菌所致的心内膜炎、骨髓炎、肺炎、败血症或软组织感染。 | |||
T22276 |
Bis(maltolato)oxovanadium(IV)
双(麦芽醇)氧钒(IV),BMOV,Bis maltolato oxovanadium,Bis(maltolato)oxovanadium (IV),bis maltolato oxo vanadium,Bis(maltolato)oxovanadium (IV) |
Phosphatase; Others | Metabolism; Others |
Bis(maltolato)oxovanadium(IV) (BMOV) 是一种有效的胰岛素增敏剂,也是一种有效的、竞争性的、可逆的、口服具有活性的光谱蛋白酪氨酸磷酸酶 (PTP) 抑制剂。它抑制HCPTPA,PTP1B,HPTPβ和SHP2的IC50分别为 126 nM,109 nM,26 nM 和 201 nM。 | |||
T16545 |
Pivanex
Pivalyloxymethyl butyrate,AN-9 |
Apoptosis; HDAC; Bcr-Abl | Angiogenesis; Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; Tyrosine Kinase/Adaptors |
Pivanex (Pivalyloxymethyl butyrate) 是丁酸的一种衍生物,是具有口服活性的 HDAC 抑制剂。Pivanex 通过下调 bcr-abl 蛋白增强凋亡。Pivanex 显示出抗转移和抗血管生成的活性。 | |||
T2334 |
Avanafil
阿伐那非,TA1790 |
PDE | Metabolism |
Avanafil (TA1790) 是一种高活性PDE-5抑制剂,IC50=5.2 nM,对PDE1,PDE6和PDE11活性较低。 | |||
T78068 |
O-allylvanillin
|
Others | Others |
O-allylvanillin为o-烯丙基查尔酮衍生物,呈现抗癌活性。该化合物对THP-1、HL60、Hep-G2、MCF-7细胞系生长抑制作用显著,其IC50值依次为74.76 μM、63.52 μM、90.99 μM、90.11 μM。 | |||
T12738 |
Rivanicline hemioxalate
RJR-2403 hemioxalate,(E)-Metanicotine hemioxalate |
Others | Others |
Rivanicline hemioxalate (RJR-2403 hemioxalate; (E)-Metanicotine hemioxalate) 是一种神经元烟碱受体 (neuronal nicotinic receptor) 激动剂,对 α4β2 亚型有高度选择性(Ki= 26 nM),比对于 α7 受体的选择性高1000倍(Ki=3.6 μM)。 | |||
T75270 |
Genevant CL1
|
Others | Others |
Genevant CL1 是一种脂质,可用于 mRNA 脂质纳米颗粒 (LNP) 疫苗递送。 | |||
T125451 |
Dracoflavan C2
|
Others | Others |
Dracoflavan C2 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T125451。 | |||
T123947 |
3',5-Dihydroxy-4',6,7-trimethoxyflavanone
|
Others | Others |
3',5-Dihydroxy-4',6,7-trimethoxyflavanone 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T123947。 | |||
T129450 |
6-O-Vanilloylsucrose
|
Others | Others |
6-O-Vanilloylsucrose 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T129450。 | |||
T130446 |
7-Hydroxyflavanone-glucoside
|
Others | Others |
7-Hydroxyflavanone-glucoside 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T130446。 | |||
T32606 |
Lavandulyl Senecioate
(+-)-Lavandulyl senecioate,(S)-(+-)-Lavandulyl senecioate |
Others | Others |
Lavandulyl Senecioate is a sex pheromone of the vine mealybug Planococcus ficus Signoret. | |||
T35037 |
Vanilmandelic acid, L-(+)-
Vanilmandelic acid L-form,(+)-Vanilmandelic acid |
Others | Others |
Vanilmandelic acid, L-(+)- is a chemical intermediate in the synthesis of artificial vanilla flavorings and is an end-stage metabolite of the catecholamines, epinephrine, and norepinephrine. It is produced via intermediary metabolites. | |||
T39267 |
5,6-Dichlorovanillin
|
Others | Others |
5,6-Dichlorovanillin undergoes chlorination, resulting in the formation of 4,5,6-trichloroguaiacol, tetrachloroguaiacol, and residual starting materials. | |||
T131489 |
5-Hydroxy-7-methoxy-8-methylflavanone
|
Others | Others |
5-Hydroxy-7-methoxy-8-methylflavanone 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T131489。 | |||
T83536 |
(R)-Avanafil
(R)-TA1790 |
Others | Others |
(R)-Avanafil ((R)-TA1790),为选择性PDE5抑制剂,IC50值为5.2 nM,主要用于勃起功能障碍研究。 | |||
T124392 |
8-Epiivangustin
|
Others | Others |
8-Epiivangustin 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T124392,CAS号为 68776-48-7。 | |||
T68472 |
Adomeglivant, (+)-
|
Others | Others |
Adomeglivant, (+)-, is a potent and selective glucagon receptor antagonist. LY2409021 lowers blood glucose in healthy people and in those with type 2 diabetes. | |||
T125452 |
Dracoflavan C1
|
Others | Others |
T37181 |
Avanafil metabolite M4
Avanafil metabolite M4 |
Others | Others |
Avanafil metabolite M4 is a major active metabolite of the phosphodiesterase 5 (PDE5) inhibitor avanafil . Avanafil is metabolized by the cytochrome P450 (CYP450) isoforms CYP3A4 and CYP2C to the major metabolites avanafil metabolite M4 and avanafil metabolite M16 , as well as minor metabolites. Avanafil metabolite M4 inhibits PDE5 with 18% of the potency of avanafil. | |||
T124352 |
Dihydrocitflavanone
|
Others | Others |
Dihydrocitflavanone 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T124352。 | |||
T25004 |
Advantame anhydrous
Advantame |
Others | Others |
Advantame anhydrous is a non-caloric sweetener, synthesized from isovanillin and aspartame. The U.S. Food and Drug Administration has approved Advantame for general use in foods and beverages except for meat and poultry as a food additive. | |||
T70020 |
Vancomycin monohydrochloride
|
Others | Others |
Vancomycin monohydrochloride is an amphoteric glycopeptide antibiotic that inhibits bacterial cell wall synthesis by binding to peptidoglycan. | |||
T8675 |
Vaniprevir
|
Others | Others |
Vaniprevir is a macrocyclic hepatitis C virus NS3/4a protease inhibitor and is active against both the genotype 1 and genotype 2 NS3/4a protease enzymes. vaniprevir has good plasma exposure and excellent liver exposure in multiple species. | |||
T11294 |
Flavanone hydrazone
|
Others | Others |
Flavanone hydrazine is a potent non-steroidal anti-inflammatory agent that effectively inhibits lens protein-induced ocular inflammation. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T20911 |
Dibutyl maleate
AI3-00644,Butyl maleate,DBM (VAN),马来酸二丁酯 |
Others | Others |
Dibutyl maleate (DBM (VAN)) 是马来酸的二酯,可用作合成抗菌化合物的中间体。 | |||
T2860 |
Vanillyl Alcohol
4-Hydroxy-3-methoxybenzenemethanol,3-Methoxy-4-hydroxybenzyl alcohol,4-Hydroxy-3-methoxybenzyl alcohol,香兰醇,Vanillin alcohol,Vanillic alcohol |
Apoptosis; Others | Apoptosis; Others |
Vanillyl Alcohol (3-Methoxy-4-hydroxybenzyl alcohol) 是一种酚类醇,具有抗血管生成、抗惊厥、抗炎、抗氧化、神经保护和抗伤害活性。它由香兰素衍生而来,在食品和饮料中用作调味剂。 | |||
T7999 |
7-Hydroxyflavanone
|
Anti-infection | Microbiology/Virology |
7-Hydroxyflavanone 对肺炎链球菌临床分离株显示出抗菌活性。 | |||
T5767 |
Isovanillic acid
3-羟基-4-甲氧基苯甲酸,3-Hydroxy-4-methoxybenzoic acid |
Others | Others |
Isovanillic acid (3-Hydroxy-4-methoxybenzoic acid) 是一种酚醛酸化合物,从 S. frutescens 中分离得到,具有抗炎作用。 | |||
T9115 |
Vanillic Acid
4-hydroxy-3-methoxybenzoic acid,Acide vanillique,香草酸,Vanillate |
Others; NF-κB; Endogenous Metabolite; Antibacterial | Metabolism; Microbiology/Virology; NF-κB; Others |
Vanillic Acid (Acide vanillique) 是一种在食用植物和水果中发现的调味剂,可抑制NF-κB 活化,具有抗菌,抗炎等活性。 | |||
TN1742 |
Homovanillyl alcohol
高香草醇,4-羟基-3-甲氧基苯乙醇 |
TNF; Drug Metabolite | Apoptosis; Metabolism |
Homovanillyl alcohol 是羟基酪醇的生物代谢物。Hydroxytyrosol 是存在于原始橄榄油和葡萄酒中的酚类化合物。它能够保护红细胞免受氧化损伤,并对心血管具有保护作用。 | |||
T7992 |
4-Hydroxyflavanone
|
NO Synthase | Immunology/Inflammation |
4-Hydroxyflavanone 是一种黄酮的合成类似物,是 SREBP 成熟和脂质合成的抑制剂。它具有研究肝脏脂肪变性及血脂异常的潜力。 | |||
T0542 |
Isohomovanillic acid
3-羟基-4-甲氧基苯乙酸,Homoisovanillic acid |
Others; Endogenous Metabolite | Metabolism; Others |
Isohomovanillic acid (Homoisovanillic acid) 是一种由乙酸乙酯在 pH 值为 2 的条件下从尿液中提取而来,在许多正常人尿中并不明显。 | |||
T0530 |
Flavanone
2-Phenyl-4-chromanone,4-Flavanone,2,3-Dihydroflavone,黄烷酮,2-Phenylchroman-4-one |
Others; Aromatase | Endocrinology/Hormones; Others |
Flavanone (2-Phenylchroman-4-one) 是天然的黄酮类化合物,对人类雌激素合成酶芳香化酶具有抑制作用。 | |||
TN7242 |
5-Hydroxyvanillin
3,4-Dihydroxy-5-methoxybenzaldehyde |
Antifungal | Microbiology/Virology |
5-Hydroxyvanillin (3,4-Dihydroxy-5-methoxybenzaldehyde) 可从籼稻中就分离得到对金黄色葡萄球菌具有抑制作用,可用于治疗和预防骨质疏松症。 | |||
T3740 |
Isovanillin
3-羟基-4-甲氧基苯甲醛,3-Hydroxy-p-anisaldehyde,3-Hydroxy-4-methoxybenzaldehyde,5-Formylguaiacol |
Others | Others |
Isovanillin (5-Formylguaiacol) 是一种醛氧化酶抑制剂,具有解痉挛和止泻活性。 | |||
TN1644 |
Flavanomarein
|
Others | Others |
Flavanomarein 是Coreopsis tinctoria Nutt 的主要黄酮类化合物,对糖尿病性肾病具有保护作用。它具有很好的抗氧化,降糖,降压和降血脂作用。 | |||
TN1558 |
N-Vanillyldecanamide
癸酸香草酰胺,Decylic acid vanillylamide |
Others | Others |
N-Vanillyldecanamide (Decylic acid vanillylamide) 分离自辣椒果实,以剂量依赖的方式显著减小紫花苜蓿幼苗的自由基长度。 | |||
T5S1000 |
Sophoraflavanone G
Kushenol F,槐黄烷酮 G,Vexibinol |
Apoptosis | Apoptosis |
Sophoraflavanone G (Kushenol F) 是从苦参中提取到的一种天然产物,通过抑制 MAPK 相关通路诱导 MDA-MB-231 和 HL-60 细胞凋亡,具有抗肿瘤和抗炎特性。 | |||
TN6791 |
Palvanil
Hexadecanamide |
TRP/TRPV Channel | Membrane transporter/Ion channel |
Palvanil (Hexadecanamide) 是一种快速脱敏的 TRPV1 激动剂。它可能是治疗 IBS 的有前途的药物,因为它可以调节肠道蠕动并减轻内脏疼痛。 | |||
T2948 |
Ethylvanillin acetate
乙酰乙基香兰酯,4-Acetoxy-3-ethoxybenzaldehyde,AKOS B004453,Ethyl vanillin acetate |
Others | Others |
Ethyl vanillin acetate 是香兰素乙酯的乙酸乙酯形式,可用作巧克力或糖果的调味剂。 | |||
T4513 |
Vanillyl butyl ether
4-(Butoxymethyl)-2-methoxyphenol,香兰醇丁醚,Butyl vanillyl ether,香草醇丁醚 |
Others | Others |
Vanillyl butyl ether (Butyl vanillyl ether) 是香草特有风味和香气的来源。它是辣椒素类似物,对人体有感官刺激作用。它是环保且无毒的物质。它是烷氧基取代的苄基衍生物,主要用作调味剂。 | |||
TN3174 |
6-Methoxyflavanone
NSC50184 |
GABA Receptor | Membrane transporter/Ion channel; Neuroscience |
6-Methoxyflavanone(6-MeOF)是人重组GABA A受体GABA反应的正变构调节剂,具有抗焦虑活性和抗炎活性,可用于减轻顺铂诱导的神经性疼痛。 | |||
T8163 |
Glucovanillin
葡萄糖香草醛,Vanillin 4-O-β-D-Glucoside,4-(β-D-葡萄糖氧基)-3-甲氧基苯甲醛 |
Others | Others |
Glucovanillin (Vanillin 4-O-β-D-Glucoside) 是提取于青荚中,通过细胞壁降解和葡萄糖酐水解的酶联合作用可转化为香草醛。 | |||
TN7126 |
N-Vanillyloctanamide
|
Others | Others |
N-Vanillyloctanamide 是一种来自 Capsicum annuum L. var. 果实的辣椒素。年鉴。 N-Vanillyloctanamide 减少 Lactuca sativa 幼苗的自由基长度,这种抑制是剂量依赖性的。 | |||
T7984 |
2-Hydroxyflavanone
|
Others | Others |
2-Hydroxyflavanone 是一种天然存在的黄酮类化合物,存在于许多植物和水果中。它具有抗氧化、抗炎和抗肿瘤的活性,可以清除自由基,减少炎症,并抑制肿瘤细胞的生长,还具有治疗糖尿病、肥胖症、心血管疾病和神经系统疾病等多种疾病的潜力。 | |||
T2977 |
Vanillin acetate
Acetovanillin,乙酰香兰酯,Acetylvanillin,4-Formyl-2-methoxyphenyl acetate,乙酰香兰素,4-Acetoxy-3-methoxybenzaldehyde |
Others | Others |
Acetylvanillin 可由香草醛用乙酸酐处理后得到。 | |||
T8641 |
Vancomycin
|
Antibacterial; Antibiotic; Autophagy | Autophagy; Microbiology/Virology |
Vancomycin 是一种糖肽类抗生素,可以通过改变细胞膜的渗透性并选择性地抑制核糖核酸的合成以发挥抗菌活性。Vancomycin 可以用于治疗所有抗生素均无效的严重感染。 | |||
T0243 |
Vanitiolide
Vanitiolid,香草吗啉 |
Others | Others |
Vanitiolide (Vanitiolid) 是一种具有利胆作用的药物。 | |||
T2929 |
Ethyl Vanillate
香兰酸乙酯,Ethylprotal,香草酸乙酯,Bourbonal |
Antioxidant; Antifungal | Microbiology/Virology; oxidation-reduction |
Ethyl Vanillate (Bourbonal) 是一种杀菌剂,抑制17β-HSD2,其IC50为 1.3 µM。它是一种香草醛类似物,是一种调味剂,具有很强的抗氧化活性。 | |||
T6717 |
Vanillin
Lioxin,m-Methoxy-p-hydroxybenzaldehyde,香草醛,Zimco,p-Vanillin,p-Hydroxy-m-methoxybenzaldehyde,香兰素,FEMA 3107 |
Others; Endogenous Metabolite | Metabolism; Others |
Vanillin (Zimco) 是一种天然产物,是从香草豆中提取的单个分子,是香水,食品和药物中广泛使用的气味。 | |||
TN7221 |
6-Bromovanillin
|
||
6-Bromovanillin 是一种生化试剂,可用于用于合成caridopa。Caridopa 一种芳香氨基酸脱羧酶抑制剂。 | |||
T2818 |
Methyl Vanillate
|
Reactive Oxygen Species; Wnt/beta-catenin; Endogenous Metabolite | Cytoskeletal Signaling; Immunology/Inflammation; Metabolism; NF-κB; Stem Cells |
Methyl vanillate 是一种枳椇属植物中的提取物,是Wnt/β-catenin 信号通路活化剂,是一种香草酸的甲酯。它具有抗氧化作用。 | |||
T5838 |
L-Canavanine sulfate
|
NO Synthase; NOD | Immunology/Inflammation; NF-κB |
L-Canavanine sulfate 是一种诱导型 NO 合酶的选择性抑制剂。 | |||
T0832 |
Vancomycin hydrochloride
盐酸万古霉素,Vancomycin HCl |
Cell wall; Antibacterial; Antibiotic; Autophagy | Autophagy; Immunology/Inflammation; Microbiology/Virology |
Vancomycin hydrochloride (Vancomycin HCl) 是Vancomycin 的盐酸盐,是一种支链三环糖基化肽,对大多数生物体具有杀菌活性,对肠球菌具有抑菌作用。 | |||
TN3050 |
4'-Methoxyflavanone
|
Others | Others |
4'-Methoxyflavanone 是一种从天然 Isaria fumosorosea KCH J2中分离得到的黄酮类化合物,可用于研究代谢疾病和心血管疾病。 | |||
TN4340 |
Ivangustin
|
PARP | Chromatin/Epigenetic; DNA Damage/DNA Repair |
Ivangustin exhibits remarkable cytotoxicity against HEp2, SGC-7901 and HCT116 human cancer cell lines. | |||
T3S0507 |
Homovanillic acid
Homovaniuic acid,Vanilacetic acid,高香草酸,Vanillacetic acid |
Others; Endogenous Metabolite | Metabolism; Others |
Homovanillic acid (Vanillacetic acid) 是一种多巴胺代谢物,它与乳糜泻、生长激素缺乏、芳香族氨基酸脱羧酶缺乏症以及脂联素还原酶缺乏症相关。 | |||
TN6769 |
7,8,3',4'-tetrahydroxyflavanone
|
Others | Others |
7,8,3',4'-tetrahydroxyflavanone 是一种生物活性化学物质。 | |||
T0611 |
Vanillylmandelic acid
4-Hydroxy-3-methoxymandelic acid,3-甲氧基-4-羟基扁桃酸 |
Others; Antioxidant | Others; oxidation-reduction |
Vanillylmandelic acid 是儿茶酚胺、肾上腺素和去甲肾上腺素代谢的最终产物,具有抗氧化活性,常用于帮助诊断嗜铬细胞瘤,以及其升高与抑郁症状有关。 | |||
TN1308 |
6-Hydroxyflavanone
|
Others; Lipoxygenase; COX; GABA Receptor | Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Neuroscience; Others |
6-Hydroxyflavanone 是从菖蒲叶中提取分离,通过靶向环氧合酶-2(COX-2),5-脂氧合酶(5-LOX)以及阿片类药物和 GABA-A 受体从而具有抗炎和抗神经性疼痛活性。6-Hydroxyflavanone 在链脲佐菌素诱导的糖尿病神经病变模型中具有抗伤害感受特性。 | |||
TN3144 |
6,4'-Dihydroxy-7-methoxyflavanone
檀木 |
ERK; IL Receptor; Antioxidant; TNF; NF-κB; MAPK; Prostaglandin Receptor; JNK; Autophagy | Apoptosis; Autophagy; GPCR/G Protein; Immunology/Inflammation; MAPK; NF-κB; oxidation-reduction |
6,4'-Dihydroxy-7-methoxyflavanone 是一种从 Dalbergia odorifera T. Chen (Leguminosae) 的心材中分离出来的生物活性化合物,具有抗氧化、抗炎和神经保护作用。 6,4'-二羟基-7-甲氧基黄烷酮可用于治疗破骨性骨病如骨质疏松症、类风湿性关节炎和牙周病的研究。 | |||
TN3119 |
5-Hydroxy-7,8-dimethoxyflavanone
|
IL Receptor; TNF; NF-κB; HIV Protease; NO Synthase; CCR | Apoptosis; Immunology/Inflammation; Microbiology/Virology; NF-κB; Proteases/Proteasome |
5-Hydroxy-7,8-dimethoxyflavanone 是从穿心莲叶和根中分离出来的,具有抗炎活性。 | |||
TN3232 |
7-Hydroxy-5,8-dimethoxyflavanone
|
Others | Others |
7-Hydroxy-5,8-dimethoxyflavanone是一种天然产物,属于金粟兰科金粟兰属,其产品编号为 TN3232,CAS号为 54377-24-1。7-Hydroxy-5,8-dimethoxyflavanone可用作对照参考。 | |||
TN3227 |
7-Hydroxy-2',5,8-trimethoxyflavanone
|
Others | Others |
7-Hydroxy-2',5,8-trimethoxyflavanone是一种天然产物,属于唇形科黄芩属,其产品编号为 TN3227,CAS号为 100079-34-3。7-Hydroxy-2',5,8-trimethoxyflavanone可用作对照参考。 | |||
TN5542 |
7,4'-Dihydroxy-6,8-diprenylflavanone
5-Deoxylonchocarpol A |
||
7,4'-Dihydroxy-6,8-diprenylflavanone 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN5542,CAS号为 50939-03-2。 | |||
TN5455 |
6-Hydroxyisosativan
|
||
6-Hydroxyisosativan 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN5455,CAS号为 2172624-69-8。 | |||
TN3683 |
Clovanediol
|
Others | Others |
Clovanediol是一种天然产物,属于桃金娘科番石榴属,其产品编号为 TN3683,CAS号为 2649-64-1。Clovanediol可用作对照参考。 | |||
TN4557 |
Methyl vanillate glucoside
|
Others | Others |
Methyl vanillate glucoside 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN4557,CAS号为 72500-11-9。 | |||
TN4437 |
Licorisoflavan A
|
MMP; IL Receptor; NF-κB; DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Immunology/Inflammation; NF-κB; Proteases/Proteasome |
Licorisoflavan A shows weak scavenging activity against superoxide anion radical, it and licoricidin have potential for the development of novel host-modulating strategies for the treatment of cytokine and/or MMP-mediated disorders such as periodontitis.L | |||
TN3211 |
7,3'-Dihydroxy-4'-methoxyflavan
|
Others | Others |
7,3'-Dihydroxy-4'-methoxyflavan是一种天然产物,属于桑科构树属,其产品编号为 TN3211,CAS号为 162290-05-3。7,3'-Dihydroxy-4'-methoxyflavan可用作对照参考。 | |||
TN5543 |
Isosativanone
|
||
Isosativanone 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN5543,CAS号为 82829-55-8。 | |||
TN2942 |
3-Hydroxy-5,7-dimethoxy-3',4'-methylenedioxyflavan
|
Others | Others |
3-Hydroxy-5,7-dimethoxy-3',4'-methylenedioxyflavan 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN2942,CAS号为 162602-04-2。 | |||
TN3504 |
β-Hydroxypropiovanillone
beta-Hydroxypropiovanillone |
Others | Others |
beta-Hydroxypropiovanillone, an achiral compound, which is further degraded by lignin degradation. It shows tyrosinase inhibitory activities. | |||
TN5038 |
Sophoraflavanone I
|
Others | Others |
Sophoraflavanone I is a natural product from Sophora moorcroftiana. | |||
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Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-00163 |
Levanase Protein, Bacillus sp., Recombinant (His & SUMO)
2,6-beta-D-fructan fructanohydrolase,Endo-levanase,... |
Bacillus | E. coli |
Catalyzes the hydrolysis of levan with endo-type specificity. The products of levan hydrolysis are a mixture of fructose and a series of fructooligosaccharides up to 12-mer, with levantriose being the major oligosaccharide obtained. Is not active towards sucrose. Levanase Protein, Bacillus sp., Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 30.3 kDa and the accession number is O31411. | |||
TMPH-02460 |
nifH1 Protein, Methanobacterium ivanovii, Recombinant (His & Myc)
Nitrogenase iron protein 1,Nitrogenase reductase,Nitrogenase... |
Methanobacterium ivanovii | E. coli |
The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein. nifH1 Protein, Methanobacterium ivanovii, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 37.4 kDa and the accession number is P51602. | |||
TMPH-00168 |
Levanase Protein, Bacillus subtilis, Recombinant (His)
sacC,Exo-beta-D-fructosidase,Beta-D-fructofuranosidase,Le |
Bacillus subtilis | E. coli |
Exo-fructosidase that can hydrolyze both levan and inulin, leading to the production of free fructose. Is also able to hydrolyze sucrose and to a small extent raffinose, but not melezitose, stachylose, cellobiose, maltose, and lactose. Levanase Protein, Bacillus subtilis, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 77.2 kDa and the accession number is P05656. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TMIH-0262 |
Homovanillic acid-d5
|
||
Homovanillic acid-d5 是 Homovanillic acid 的氘代化合物。 | |||
TMIH-0593 |
Vanillin-d3
|
||
Vanillin-d3 是 Vanillin 的氘代化合物。 | |||
TMIH-0338 |
Methyl vanillin-d3
|
||
Methyl vanillin-d3 是 Methyl vanillin 的氘代化合物。 | |||
TMIJ-0148 |
Avanafil-13C-d3
|
||
Avanafil-13C-d3 是 Avanafil 的 13C 和氘代化合物。Avanafil 的 CAS 号为 330784-47-9。Avanafil 是一种高活性PDE-5抑制剂,IC50=5.2 nM,对PDE1,PDE6和PDE11活性较低。 | |||
TMID-0284 |
Vancomycin-d12 TFA
|
||
Vancomycin-d12 TFA 是 Vancomycin TFA 的氘代化合物。Vancomycin TFA 的 CAS 号为 1404-90-6。Vancomycin 是一种抗生素,用于通过阻止细菌生长来治疗严重的细菌感染。它还改变细胞膜的渗透性并选择性地抑制核糖核酸的合成。 | |||
TMID-0283 |
Vancomycin-13C-d3
|
||
Vancomycin-13C-d3 是 Vancomycin 的 13C 和氘代化合物。Vancomycin 的 CAS 号为 1404-90-6。Vancomycin 是一种抗生素,用于通过阻止细菌生长来治疗严重的细菌感染。它还改变细胞膜的渗透性并选择性地抑制核糖核酸的合成。 | |||
TMIH-0435 |
Pimavanserin-d3
|
||
Pimavanserin-d3 是 Pimavanserin 的氘代化合物。Pimavanserin 的 CAS 号为 706779-91-1。Pimavanserin 是特异性的 5-HT2A 受体反向激动剂,在基于细胞的功能测定中,平均 pIC50值为8.7。它是非典型抗精神病药,用于治疗帕金森病患者的幻觉和精神病。 | |||
TMIJ-0236 |
Vandetanib-d6
|
||
Vandetanib-d6 是 Vandetanib 的氘代化合物。Vandetanib 的 CAS 号为 443913-73-3。Vandetanib 是一种具有口服活性的VEGFR2/KDR酪氨酸激酶抑制剂,IC50值为40 nM。它也抑制VEGFR3/FLT4和EGFR/HER1,IC50值分别为110和500 nM。 | |||
TMID-0012 |
Ethyl-d5 Vanillin
|
||
Ethyl-d5 Vanillin 是 Ethyl Vanillin 的氘代化合物。Ethyl Vanillin 的 CAS 号为 121-32-4。Ethyl vanillin 是一种食用香料,效果是 Vanillin 的三倍,可用于巧克力的生产。 | |||
TMIH-0261 |
Homovanillic acid-d3
|
||
Homovanillic acid-d3 是 Homovanillic acid 的氘代化合物。 | |||
TMIH-0124 |
Brivanib Alaninate-d4
|
||
Brivanib Alaninate-d4 是 Brivanib Alaninate 的氘代化合物。Brivanib Alaninate 的 CAS 号为 649735-63-7。Brivanib alaninate 是一种血管内皮生长因子受体 2 (VEGFR2) 抑制剂的丙氨酸盐,IC50值为 25 nM,具有潜在的抗肿瘤活性。它对 VEGFR1 和 FGFR1 适度抑制,对 VEGFR2 的选择性是对 PDGFRβ 的 240 倍。 | |||
TMIJ-0265 |
Homovanillic Acid-13C-d3
|
||
Homovanillic Acid-13C-d3 是 Homovanillic Acid 的 13C 和氘代化合物。Homovanillic Acid 的 CAS 号为 306-08-1。Homovanillic acid 是一种多巴胺代谢物,它与乳糜泻、生长激素缺乏、芳香族氨基酸脱羧酶缺乏症以及脂联素还原酶缺乏症相关。 | |||
T35698 |
Octanoic Acid-13C
|
||
Octanoic acid-13C is intended for use as an internal standard for the quantification of octanoic acid by GC- or LC-MS. Octanoic acid is a medium-chain saturated fatty acid. It has been found in Teleme cheeses made from goat, ovine, or bovine milk.1 Octanoic acid is active against the bacteria S. mutans, S. gordonii, F. nucleatum, and P. gingivalis (IC80s = <125, <125, 1,403, and 2,294 μM, respectively).2 Levels of octanoic acid are increased in the plasma of patients with medium-chain acyl-CoA d... |