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Search Results for " urokinase inhibitor "

Targets Recommended: OX Receptor

20

抑制剂 & 化合物

7

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T3722	MK-1064 Urokinase inhibitor 1,MK 1064	OX Receptor	GPCR/G Protein; Neuroscience
	MK-1064 (Urokinase inhibitor 1) 是一种选择性食欲素 2 (2-SORA)受体拮抗剂，可用于失眠患者的研究。
T13408	ZK824190	Others; Serine Protease	Others; Proteases/Proteasome
	ZK824190 是具有口服活性尿激酶型纤溶酶原激活剂 (uPA) 选择性抑制剂，对 uPA，tPA 和 Plasmin 的IC50分别为 237，1600 和 1850 nM。ZK824190在多发性硬化症中有研究价值。
T8362	Benzamidine hydrochloride Benzamidine HCl,苄脒盐酸盐	Serine/threonin kinase; Serine Protease	Cell Cycle/Checkpoint; Metabolism; Proteases/Proteasome
	Benzamidine hydrochloride (Benzamidine HCl) 是可逆的胰蛋白酶样丝氨酸蛋白酶 (trypsin-like serine proteases) 竞争性抑制剂，对 uPA、类胰蛋白酶、胰蛋白酶和 Xa 因子作用的Ki 分别为 97 µM、20 µM、21 µM 和 110 µM。
T21703	4-Chlorophenylguanidine hydrochloride	Others	Others
	4-Chlorophenylguanidine hydrochloride 是一种有效的尿激酶选择性抑制剂。
T13257	Upamostat	PAI-1; Serine/threonin kinase; Serine Protease	Cell Cycle/Checkpoint; Metabolism; Proteases/Proteasome
	Upamostat 是一种丝氨酸蛋白酶抑制剂，也是一种具有口服活性的 WX-UK1 前药，是一种尿激酶型纤溶酶原激活剂 (uPA) 抑制剂。
TP2338L	Cenupatide acetate Cenupatide acetate(1006388-38-0 Free base)	Others	Others
	Cenupatide acetate 是一种尿激酶纤溶酶原激活物受体 (uPAR) 抑制剂，用于治疗与细胞迁移改变相关的疾病，例如癌症。
T60248	4-Aminobenzamidine dihydrochloride p-Aminobenzamidine dihydrochloride	Serine Protease	Proteases/Proteasome
	4-Aminobenzamidine dihydrochloride (p-Aminobenzamidine dihydrochloride) 是一种强胰蛋白酶 (trypsin)抑制剂，也是一种相对较弱的尿激酶型纤溶酶原激活剂 (uPA) 抑制剂 (Ki=82 μM)。4-Aminobenzamidine 可抑制 SCID 小鼠体内前列腺肿瘤的生长。
T13251	UKI-1 UKI-1C	Others	Others
	UKI-1 is a urokinase-type plasminogen activator system synthetic inhibitor.
T13409	ZK824859	Others	Others
	ZK824859 is an oral available and selective inhibitor of urokinase plasminogen activator (uPA)(IC50s of 79 nM, 1580 nM and 1330 nM for human uPA, tPA, and plasmin, respectively).
T70927	UCD74A HCl	Others	Others
	UCD74A HCl is a cell impermeant homolog of UCD38B, inhibitor of uPA (urokinase plasminogen activator).
T35931	GGACK (hydrochloride)	Others	Others
	GGACK is an inhibitor of urokinase-type plasminogen activator (uPA) and factor Xa (Kis = 1.8 and 8.7 μM, respectively).1,2 1.Kettner, C., and Shaw, E.The susceptibility of urokinase to affinity labeling by peptides of arginine chloromethyl ketoneBiochim. Biophys. Acta569(1)31-40(1979) 2.Kettner, C., and Shaw, E.The selective affinity labeling of factor Xa by peptides of arginine chloromethyl ketoneThromb. Res.22(5-6)645-652(1981)
T22451	UK-371804 HCl	Serine Protease	Proteases/Proteasome
	UK-371804 is a potent and selective urokinase-type plasmogen activator (uPA) inhibitor with excellent enzyme potency (Ki=10 nM) and selectivity profile (2700-fold versus plasmin and 4000-fold versus tPA).
T13409L	ZK824859 hydrochloride (2271122-53-1 free base) ZK824859 hydrochloride	Others	Others
	ZK824859 hydrochloride is an oral available and selective inhibitor of urokinase plasminogen activator (uPA)(IC50s of 79 nM, 1580 nM and 1330 nM for human uPA, tPA, and plasmin, respectively).
TP2338	Cenupatide UPARANT,Cenupatide trifluoroacetic acid salt,Ac-Arg-Aib-Arg-α(Me)Phe-NH2)
	Cenupatide is a urokinase plasminogen activator receptor (uPAR) inhibitor. Cenupatide inhibits uPAR binding to the formyl peptide receptors (FPRs) can improve kidney lesions in a rat model of STZ-induced diabetes. Cenupatide reverted STZ-induced up-regula
T69028	CJ-463	Others	Others
	CJ-463 is a potent ans selective uPA inhibitor. Treatment with CJ-463 resulted in a significant inhibition of primary tumor growth, with the highest efficacy seen in the 100 mg/kg group. Urokinase (uPA) plays a crucial role in carcinogenesis by facilitating tumor cell invasion and metastasis. CJ-463 may be a novel agent for treatment of lung cancer.
T41085	UK122 UK122	Others	Others
	UK122 is a highly effective and specific inhibitor of urokinase-type plasminogen activator (uPA) with an IC50 value of 0.2 μM. It displays negligible to minimal inhibition towards tissue-type plasminogen activator (tPA), plasmin, thrombin, and trypsin (all IC50 >100 μM). Functioning as a 4-oxazolidinone analogue, UK122 is an anticancer agent that effectively inhibits cancer cell migration and invasion.
T62961	ZK824859 hydrochloride	Others	Others
	ZK824859 hydrochloride 是一种选择性的、口服具有活力的尿激酶型纤溶酶原激活剂 (uPA) 抑制剂。ZK824859 hydrochloride 对人 uPA，tPA 和纤溶酶的 IC50 值分别为 79 nM，1580 nM 和 1330 nM。
T35579	PKSI-527	Others	Others
	PKSI-527 is an inhibitor of plasma kallikrein (Ki = 0.81 μM). It is selective for plasma kallikrein over glandular kallikrein, plasmin, thrombin, urokinase, and Factor Xa (Kis = >500, 390, >500, 200, and >500 μM, respectively). PKSI-527 reduces bradykinin generation induced by kaolin and λ-carrageenan ex vivo in human plasma. It also prolongs partial thromboplastin and euglobulin clot lysis times. In vivo, PKSI-527 (300 mg/kg per day) reduces hyperplasia, pannus formation, and infiltration of in...
T62731	ZK824190 hydrochloride	Others	Others
	ZK824190 hydrochloride 是一种选择性的、口服具有活力的尿激酶型纤溶酶原激活剂 (uPA) 抑制剂，能够作用于 uPA (IC50: 237 nM)、tPA (IC50: 1600 nM) 和 Plasmin (IC50: 1850 nM)。ZK824190 hydrochloride 能够用于研究多发性硬化症的研究
T80859	Vitronectin
	Vitronectin为一类多功能糖蛋白，广泛分布于血液及细胞外基质。该蛋白质与糖胺聚糖、胶原蛋白、纤溶酶原及尿激酶受体发生结合，并对纤溶酶原激活抑制剂1的抑制构象起稳定作用。Vitronectin常用于促进伤口愈合和肿瘤进展研究领域。

化合物

Cat.No: T3722

Synonym: Urokinase inhibitor 1,MK 1064

Target: OX Receptor

Cat.No: T13408

Target: Others, Serine Protease

Benzamidine hydrochloride

Cat.No: T8362

Synonym: Benzamidine HCl,苄脒盐酸盐

Target: Serine/threonin kinase, Serine Protease

4-Chlorophenylguanidine hydrochloride

Cat.No: T21703

Target: Others

Cat.No: T13257

Target: PAI-1, Serine/threonin kinase, Serine Protease

Cenupatide acetate

Cat.No: TP2338L

Synonym: Cenupatide acetate(1006388-38-0 Free base)

Target: Others

4-Aminobenzamidine dihydrochloride

Cat.No: T60248

Synonym: p-Aminobenzamidine dihydrochloride

Target: Serine Protease

Cat.No: T13251

Synonym: UKI-1C

Target: Others

Cat.No: T13409

Target: Others

Cat.No: T70927

Target: Others

GGACK (hydrochloride)

Cat.No: T35931

Target: Others

Cat.No: T22451

Target: Serine Protease

ZK824859 hydrochloride (2271122-53-1 free base)

Cat.No: T13409L

Synonym: ZK824859 hydrochloride

Target: Others

Cat.No: TP2338

Synonym: UPARANT,Cenupatide trifluoroacetic acid salt,Ac-Arg-Aib-Arg-α(Me)Phe-NH2)

Cat.No: T69028

Target: Others

Cat.No: T41085

Synonym: UK122

Target: Others

ZK824859 hydrochloride

Cat.No: T62961

Target: Others

Cat.No: T35579

Target: Others

ZK824190 hydrochloride

Cat.No: T62731

Target: Others

Cat.No: T80859

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-01869	PAI-2 Protein, Human, Recombinant (His) SERPINB2,Urokinase inhibitor,Placental pla...	Human	HEK293 Cells
	Inhibits urokinase-type plasminogen activator. The monocyte derived PAI-2 is distinct from the endothelial cell-derived PAI-1. PAI-2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with N-10xHis tag. The predicted molecular weight is 50.1 kDa and the accession number is P05120.
TMPY-01711	Serpin B2 Protein, Human, Recombinant (GST) PAI,serpin peptidase inhibitor, clade B (ovalbumin)...	Human	Baculovirus Insect Cells
	Serpins are the largest and most diverse family of serine protease inhibitors which are involved in some fundamental biological processes such as blood coagulation, complement activation, fibrinolysis, angiogenesis, inflammation and tumor suppression and are expressed in a cell-specific manner.SerpinB2, also known as Plasminogen activator inhibitor 2, Placental plasminogen activator inhibitor, Monocyte Arg-serpin, Urokinase inhibitor and PAI2, is a cytoplasm protein that belongs to the serpin fa...
TMPJ-00625	Serpin E1 Protein, Mouse, Recombinant (His) Pai1,Planh1,Plasminogen activator inhibitor 1,Serpi...	Mouse	HEK293 Cells
	Plasminogen activator inhibitor-1 (serpin E1) is a serine protease inhibitor which belongs to the serpin family. Serpin E1 acts as 'bait' for tissue plasminogen activator, urokinase, protein C and matriptase-3/TMPRSS7. Its rapid interaction with PLAT may function as a major control point in the regulation of fibrinolysis.
TMPH-02834	PAI-1 Protein, Mouse, Recombinant (His & SUMO) Endothelial plasminogen activator inhibitor,Serpine...	Mouse	E. coli
	Serine protease inhibitor. Inhibits TMPRSS7. Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots. As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading. Acts as a regulator of cell migration, independently of its role as protease inhibitor. It is required for stimulation of ...
TMPJ-01320	BSSP-4 Protein, Human, Recombinant (His) BSSP4,Tryptase ε,Serine Protease 26,BSSP-4,Serine Protease 2...	Human	HEK293 Cells
	Brain-Specific Serine Protease 4 (BSSP-4) is a serine protease that preferentially cleaves the synthetic substrate H-D-Leu-Thr-Arg-pNA compared to tosyl-Gly-Pro-Arg-pNA. BSSP-4 is expressed abundantly in the epithelial cells of the airways, including trachea, esophagus and fetal lung, but scarce in adult lung and expressed at low levels in placenta, pancreas, prostate and thyroid gland. BSSP-4 belongs to the peptidase S1 family and related to trypsin, referentially hydrolyzing substrates after a...
TMPJ-00796	Serpin E2 Protein, Human, Recombinant (His) PN-1,PI-7,Protease nexin 1,PI7,GDN,Peptidase inhibitor	Human	HEK293 Cells
	Serpin E2 is a secreted protein that belongs to the serpin family. Serpin E2 is a serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Serpin E2 expression is weak or absent in all normal pancreas and chronic pancreatitis tissue. In contrast, it was strongly over-expressed in the majority of pancreatic carcinoma as well as gastric and colorectal cancer samples. Serpin E2 promotes neurite extension by inhibiting thrombin. It also can bind heparin. It has been shown tha...
TMPJ-01083	Serpin E2 Protein, Mouse, Recombinant (His) Pi7,Protease nexin I,Spi4,Pn1,Serine protease-inhibitor<...	Mouse	HEK293 Cells
	Serpin E2 is a member of the Serpin superfamily. It is differentially expressed during neuronal differentiation and is able to transform human embryonic kidney cells into neuronlike cells. Its over-expression in mice leads to progressive neuronal and motor dysfunction in these animals. It is also over-expressed in the majority of pancreatic carcinoma as well as gastric and colorectal cancer samples whereas it is weakly expressed in all normal pancreas and chronic pancreatitis tissue samples. Ser...

重组蛋白

PAI-2 Protein, Human, Recombinant (His)

Cat.No: TMPH-01869

Species: Human

Expression System: HEK293 Cells

Serpin B2 Protein, Human, Recombinant (GST)

Cat.No: TMPY-01711

Species: Human

Expression System: Baculovirus Insect Cells

Serpin E1 Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-00625

Species: Mouse

Expression System: HEK293 Cells

PAI-1 Protein, Mouse, Recombinant (His & SUMO)

Cat.No: TMPH-02834

Species: Mouse

Expression System: E. coli

BSSP-4 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01320

Species: Human

Expression System: HEK293 Cells

Serpin E2 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00796

Species: Human

Expression System: HEK293 Cells

Serpin E2 Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-01083

Species: Mouse

Expression System: HEK293 Cells

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