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Search Results for " ubiquitin-protein ligase 8 "

Targets Recommended: Others Ligand for E3 Ligase

2

抑制剂 & 化合物

12

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T17879	E3 ligase Ligand 8	Others; Ligand for E3 Ligase	Others; PROTAC
	E3 ligase Ligand 8 是 E3 泛素连接酶配体。它能够利用 linker 与靶蛋白配体连接，形成 PROTAC 分子。PROTAC 可诱导促癌蛋白发生泛素化降解。
T36800	EN219	Others	Others
	EN219 is a synthetic recruiter of the E3 ubiquitin ligase RNF114.1It binds to cysteine 8 (C8) in the intrinsically disordered region of RNF114 (RNF114-C8; IC50= 470 nM) and inhibits RNF114-induced autoubiquitination and p21 ubiquitination in a cell-free assay when used at a concentration of 50 μM. EN219 (1 μM) also interacts with cysteine residues in the tubulin β1 chain (TUBB1), heat shock protein 60 (Hsp60), also known as Hsp family D member 1 (HspD1), and histone H3.1 (HIST1H3A) in 231MFP hum...

化合物

E3 ligase Ligand 8

Cat.No: T17879

Target: Others, Ligand for E3 Ligase

Cat.No: T36800

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-00109	UBC8 Protein, Arabidopsis thaliana, Recombinant (His & Myc) E2 ubiquitin-conjugating enzyme 8,Ubiq...	Arabidopsis thaliana	E. coli
	Accepts the ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. UBC8 Protein, Arabidopsis thaliana, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 24.0 kDa and the accession number is P35131.
TMPH-01267	RNF13 Protein, Human, Recombinant (His & Myc) RING finger protein 8,RNF8,E3	Human	E. coli
	E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of hist...
TMPJ-01386	STUB1 Protein, Human, Recombinant Carboxy Terminus of Hsp70-Interacting Protein,STIP1...	Human	E. coli
	E3 Ubiquitin-Protein Ligase CHIP is a cytoplasmic protein. CHIP is highly expressed in skeletal muscle, heart, pancreas, brain and placenta. CHIP interacts with the molecular chaperones Hsc70-Hsp70 and Hsp90 through its TPR domain; lead to in client substrate ubiquitylation and degradation by the proteasome. CHIP targets misfolded chaperone substrates towards proteasomal degradation. CHIP mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation....
TMPY-04123	CEACAM1 Protein, Human, Recombinant (His & hFc) CEACAM‑1,carcinoembryonic antigen-related cell adhesion mole...	Human	HEK293 Cells
	CEACAM1 Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 71.4 kDa and the accession number is P13688-8.
TMPJ-00808	CD45RA Protein, Human, Recombinant (His) PTPRC,CD45R,CD45,LCA,protein tyrosine phosphatase, ...	Human	HEK293 Cells
	CD45RA Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 100-135 KDa and the accession number is P08575-8.
TMPH-01705	Mucin-1/MUC1 Protein, Human, Recombinant (Isoform 8, His) Peanut-reactive urinary mucin,Isoform 8 of Mucin-1,...	Human	E. coli
	Mucin-1/MUC1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 31.2 kDa and the accession number is P15941-8.
TMPY-00717	CEACAM1 Protein, Human, Recombinant (His) CEACAM‑1,BGP1,BGP,carcinoembryonic antigen-related cell adhe...	Human	HEK293 Cells
	CEACAM1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 44.8 kDa and the accession number is P13688-8.
TMPJ-00828	Tau-F Protein, Human, Recombinant Neurofibrillary tangle protein,Paired helical filam...	Human	E. coli
	Tau proteins are proteins which contain four Tau/MAP repeats. They promote microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. They are abundant in neurons of the central nervous system and are less common elsewhere, but are also expressed at very low levels in CNS astrocytes and oligodendrocytes. The tau proteins are the product of alternative splicing from a single gene that in humans is designated MAPT. When tau proteins are def...
TMPY-00668	APP/Protease nexin-II Protein, Human, Recombinant (hFc) CTFγ,amyloid beta (A4) precursor protein,AAA,ABPP,C...	Human	HEK293 Cells
	APP/Protease nexin-II Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 101 kDa and the accession number is P05067-8.
TMPY-06707	Mucin-1/MUC1 Protein, Human, Recombinant (aa 1-173, His) ADMCKD,PEMT,KL-6,ADMCKD1,H23AG,mucin 1, cell surface associa...	Human	HEK293 Cells
	Mucin-1/MUC1 Protein, Human, Recombinant (aa 1-173, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 17.49 kDa and the accession number is P15941-8.
TMPJ-01330	CD299 Protein, Human, Recombinant (His & Flag) DC-SIGNR,L-SIGN,CD299,CD209L,LSIGN,C-type lectin domain fami...	Human	HEK293 Cells
	CD299 is also known as DC-SIGNR and CLEC4M, is a type II integral membrane protein. DC-SIGNR exists as a homotetramer, and the tandem repeat domain, also called neck domain, mediates oligermerization. Multiple human DC-SIGN/CD209 splice forms exist, generating both membrane-bound and soluble forms. DC-SIGNR is ragarded as a pathogen-recognition receptor involved in peripheral immune surveillance in liver, and probably mediate the endocytosis of pathogens which are subsequently degraded in lysoso...
TMPH-01683	Tau-F Protein, Human, Recombinant (HEK293, His) Microtubule-associated protein tau,Paired helical f...	Human	HEK293 Cells
	Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the ...

重组蛋白

UBC8 Protein, Arabidopsis thaliana, Recombinant (His & Myc)

Cat.No: TMPH-00109

Species: Arabidopsis thaliana

Expression System: E. coli

RNF13 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01267

Species: Human

Expression System: E. coli

STUB1 Protein, Human, Recombinant

Cat.No: TMPJ-01386

Species: Human

Expression System: E. coli

CEACAM1 Protein, Human, Recombinant (His & hFc)

Cat.No: TMPY-04123

Species: Human

Expression System: HEK293 Cells

CD45RA Protein, Human, Recombinant (His)

Cat.No: TMPJ-00808

Species: Human

Expression System: HEK293 Cells

Mucin-1/MUC1 Protein, Human, Recombinant (Isoform 8, His)

Cat.No: TMPH-01705

Species: Human

Expression System: E. coli

CEACAM1 Protein, Human, Recombinant (His)

Cat.No: TMPY-00717

Species: Human

Expression System: HEK293 Cells

Tau-F Protein, Human, Recombinant

Cat.No: TMPJ-00828

Species: Human

Expression System: E. coli

APP/Protease nexin-II Protein, Human, Recombinant (hFc)

Cat.No: TMPY-00668

Species: Human

Expression System: HEK293 Cells

Mucin-1/MUC1 Protein, Human, Recombinant (aa 1-173, His)

Cat.No: TMPY-06707

Species: Human

Expression System: HEK293 Cells

CD299 Protein, Human, Recombinant (His & Flag)

Cat.No: TMPJ-01330

Species: Human

Expression System: HEK293 Cells

Tau-F Protein, Human, Recombinant (HEK293, His)

Cat.No: TMPH-01683

Species: Human

Expression System: HEK293 Cells

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