|
TMPJ-01035
|
UBE2G2 Protein, Human, Recombinant (GST)
Ubiquitin-Conjugating Enzyme E2 G2,Ubiquitin
|
Human
|
E. coli
|
|
Ubiquitin-Conjugating Enzyme E2 G2 (UBE2G2) is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation, which belong to the ubiquitin-conjugating enzyme family. It shares 60% and 100% sequence identity with S.cerevisiae Ubc7 and mouse respectively. The UBE2G2 enzyme and the GP78 E3 ligase are active components of endoplasmic reticulum-associated degradation pathway which is essential for the degradation of misfolded ER proteins. The mechanism of K48-linked ... |
|
TMPY-00361
|
Pellino-1 Protein, Human, Recombinant (His & GST)
pellino E3 ubiquitin protein ligase 1,PRIS...
|
Human
|
Baculovirus Insect Cells
|
|
PELI is a family of E3 ubiquitin ligases that regulate protein activity through a post-translational modification, ubiquitination. PELI1 may function to control inadvertent activation of RIP3, thus preventing aberrant cell death and maintaining cellular homeostasis. PELI1 might participate in B-cell maturation or oncogenic activation of aggressive B-cell lymphomas, both during and after germinal center stages. |
|
TMPH-02631
|
PRKN Protein, Mouse, Recombinant (GST)
E3 ubiquitin-protein ligase parkin,Prkn,Pa...
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Mouse
|
E. coli
|
|
Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Substrates include SYT11 and VDAC1. Other substrates are BCL2, CCNE1, GPR37, RHOT1/MIRO1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, MIRO1 and AIMP2. Mediates monoubiquitination as well as 'Lys-6', 'Lys-11', 'Lys-48'-linked and 'Lys-63'-linked polyubiquitination of substrates depending on the context. Participates in the removal and/or det... |
|
TMPH-03281
|
PRKN Protein, Rat, Recombinant (His & Myc)
E3 ubiquitin-protein ligase parkin,Parkin ...
|
Rat
|
Baculovirus Insect Cells
|
|
PRKN Protein, Rat, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 55.6 kDa and the accession number is Q9JK66. |
|
TMPH-01263
|
PRKN Protein, Human, Recombinant (His & SUMO)
PRKN,Parkin RBR E3 ubiquitin-protein ligase
|
Human
|
E. coli
|
|
Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Substrates include SYT11 and VDAC1. Other substrates are BCL2, CCNE1, GPR37, RHOT1/MIRO1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, MIRO1 and AIMP2. Mediates monoubiquitination as well as 'Lys-6', 'Lys-11', 'Lys-48'-linked and 'Lys-63'-linked polyubiquitination of substrates depending on the context. Participates in the removal and/or det... |
|
TMPK-01001
|
RNF43 Protein, Mouse, Recombinant (hFc)
Rnf43,RING finger protein 43,RING-type E3 ubiquitin...
|
Mouse
|
HEK293 Cells
|
|
RNF43 (E3 ubiquitin-protein ligase RNF43 or RING-type E3 ubiquitin transferase RNF43) functions as a tumor suppressor, by exerting a predominant negative feedback mechanism in the Wnt/β-catenin signaling pathway. RNF43 inhibits Wnt/beta-catenin signaling by ubiquitinating Frizzled receptor and targeting it to the lysosomal pathway for degradation. |
|
TMPJ-01053
|
UBE2I Protein, Human, Recombinant (GST)
SUMO-Protein Ligase,Ubiquitin-Conjugating ...
|
Human
|
E. coli
|
|
SUMO-Conjugating Enzyme UBC9 (UBC9) belongs to the ubiquitin-conjugating enzyme family. UBC9 is homologous to ubiquitin-conjugating enzymes (E2s). However, instead of conjugating ubiquitin, UBC9 conjugates a ubiquitin homologue, Small Ubiquitin-Like Modifier 1 (SUMO-1). The conjugation of ubiquitin requires the activities of ubiquitin-activating (E1) and conjugating (E2) enzymes. It is suggested that UBC9 might play a role in DNA repair and perhaps even in aging. |
|
TMPJ-01403
|
UBE2D4 Protein, Human, Recombinant (GST)
Ubiquitin-Conjugating Enzyme E2 D4,Ubiquitin
|
Human
|
E. coli
|
|
Ubiquitin-Conjugating Enzyme E2 D4 (UBE2D4) is a ligase that belongs to the Ubiquitin-Conjugating Enzyme family. UBE2D4 has been proposed to participate in Ubl conjugation pathway. UBE2D4 takes part in post-translational protein modification, protein K6-linked ubiquitination, protein K11-linked ubiquitination, protein K27-linked ubiquitination, protein K29-linked ubiquitination, protein K48-linked ubiquitination, and protein K63-linked ubiquitination. UBE2D4 regulate of protein metabolic process... |
|
TMPJ-01198
|
UBE2R2 Protein, Human, Recombinant (His)
UBC3B,Ubiquitin-Conjugating Enzyme E2-CDC34B,CDC34B...
|
Human
|
E. coli
|
|
Ubiquitin-Conjugating Enzyme E2 R2 (UBE2R2) is a modification enzyme that belongs to the ubiquitin-conjugating enzyme family. UBE2R2 is involved in cell growth and transformation. It accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro, UBE2R2 catalyzes monoubiquitination and 'Lys-48'-linked polyubiquitination. It may be involved in degradation of katenin. |
|
TMPH-01262
|
PRKN Protein, Human, Recombinant (His & Myc)
Parkinson juvenile disease protein 2,E3 ubiquitin-p...
|
Human
|
Baculovirus Insect Cells
|
|
PRKN Protein, Human, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 55.6 kDa and the accession number is O60260. |
|
TMPJ-01047
|
UBE2H Protein, Human, Recombinant (GST)
UBE2H,UbcH2,Ubiquitin-Conjugating Enzyme E2 H,U...
|
Human
|
E. coli
|
|
Ubiquitin-Conjugating Enzyme E2 H (UBE2H) belongs to the E2 Ubiquitin-Conjugating Enzyme family. The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. It has been shown to conjugate ubiquitin to histone H2A in an E3 dependent manner in ... |
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TMPH-01273
|
TRIP12 Protein, Human, Recombinant (His & Myc)
Thyroid receptor-interacting protein 12,E3 ubiquitin
|
Human
|
E. coli
|
|
E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardless of the presence of lysine residues in target proteins. Acts as a key regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damag... |
|
TMPH-01269
|
SMURF2 Protein, Human, Recombinant (His)
SMAD ubiquitination regulatory factor 2,E3 ubiq...
|
Human
|
E. coli
|
|
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD7 to trigger SMAD7-mediated transforming growth factor beta/TGF-beta receptor ubiquitin-dependent degradation, thereby downregulating TGF-beta signaling. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with AIMP1. Also forms a stable com... |
|
TMPJ-00985
|
UBE2A Protein, Human, Recombinant (GST, His)
RAD6A,HR6A,Ubiquitin-Protein Ligase A,UBE2...
|
Human
|
E. coli
|
|
Ubiquitin-Conjugating Enzyme E2 (UBE2A) is a member of the E2 Ubiquitin-Conjugating Enzyme family. The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. UBE2A catalyzes the covalent attachment of ubiquitin to other proteins. UBE2A is re... |
|
TMPJ-01138
|
UBE2S Protein, Human, Recombinant (GST)
UBE2S,Ubiquitin-Conjugating Enzyme E2-24 kDa,E2-EPF...
|
Human
|
E. coli
|
|
Ubiquitin-Conjugating Enzyme E2 S (UBE2S) is a member of the Ubiquitin-Conjugating Enzyme family. UBE2S interacts with CDC20, FZR1/CDH1 and VHL. UBE2S can form a thiol ester linkage with Ubiquitin in an Ubiquitin Activating Enzyme-Dependent manner, a characteristic property of Ubiquitin Carrier Proteins. UBE2S acts as an essential factor of the Anaphase Promoting Complex/Cyclosome, a cell cycle-regulated Ubiquitin ligase that controls progression through mitosis. UBE2S is also involved in ubiqui... |
|
TMPH-00109
|
UBC8 Protein, Arabidopsis thaliana, Recombinant (His & Myc)
E2 ubiquitin-conjugating enzyme 8,Ubiquitin
|
Arabidopsis thaliana
|
E. coli
|
|
Accepts the ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. UBC8 Protein, Arabidopsis thaliana, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 24.0 kDa and the accession number is P35131. |
|
TMPH-03074
|
UBC5A Protein, Japonica rice, Recombinant (His & Myc)
E2 ubiquitin-conjugating enzyme 5A,Ubiquitin
|
Rice
|
E. coli
|
|
E2 conjugating enzyme that associates with the E3 ubiquitin-protein ligase EL5 to mediates ubiquitination of target proteins. UBC5A Protein, Japonica rice, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 23.6 kDa and the accession number is Q8S920. |
|
TMPJ-00571
|
UBE2D3 Protein, Human, Recombinant
Ubiquitin-protein ligase D3,Ubiquitin<...
|
Human
|
E. coli
|
|
UBE2D3 is an enzyme that belongs to the ubiquitin-conjugating enzyme family. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This enzyme functions in the ubiquitination of the tumor-suppressor protein p53, which is induced by an E3 ubiquitin-protein ligase. |
|
TMPH-00108
|
UBC11 Protein, Arabidopsis thaliana, Recombinant (His)
Ubiquitin-conjugating enzyme E2-17 kDa 11,Ubiqu...
|
Arabidopsis thaliana
|
E. coli
|
|
Accepts the ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. UBC11 Protein, Arabidopsis thaliana, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 20.6 kDa and the accession number is P35134. |
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TMPY-01654
|
ITCH Protein, Human, Recombinant (aa 526-903)
itchy E3 ubiquitin protein ligase,NAPP1,dJ...
|
Human
|
E. coli
|
|
E3 ubiquitin-protein ligase Itchy homolog, also known as Atrophin-1-interacting protein 4, NFE2-associated polypeptide 1, NAPP1, and ITCH, is a cell membrane protein that contains one C2 domain, one HECT (E6AP-type E3 ubiquitin-protein ligase) domain and contains four WW domains. ITCH acts as an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It catalyzes 'Lys-... |
|
TMPJ-00033
|
UBE2B Protein, Human, Recombinant (His)
Ubiquitin-Conjugating Enzyme E2 B,hHR6B,Ubiquit...
|
Human
|
HEK293 Cells
|
|
Ubiquitin-Conjugating Enzyme E2 B (UBE2B) is a member of the ubiquitin-conjugating enzyme family. UBE2B accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. It is shown that UBE2B interacts with RAD18, UBR2, and WAC. UBE2B is required for post-replicative DNA damage repair. Additional, UBE2B plays a role in sepsis-induced muscle protein proteolysis and cancer-induced cachexia. |
|
TMPH-01265
|
PELI3 Protein, Human, Recombinant (His)
PELI3,E3 ubiquitin-protein ligase pellino ...
|
Human
|
E. coli
|
|
E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1. Can activate AP1/JUN and ELK1. Not required for NF-kappa-B activation. PELI3 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 54.8 kDa and the access... |
|
TMPJ-01039
|
UBE2K Protein, Human, Recombinant (His & SUMO)
Ubiquitin-Conjugating Enzyme E2-25 kDa,Huntingtin-I...
|
Human
|
E. coli
|
|
UBE2K Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis and SUMO tag. The predicted molecular weight is 38 KDa and the accession number is P61086. |
|
TMPJ-01334
|
UBE2Z Protein, Human, Recombinant (His)
Uba6-Specific E2 Conjugating Enzyme 1,Ubiquitin Car...
|
Human
|
E. coli
|
|
Ubiquitin-Conjugating Enzyme E2 Z (ZUBE2Z) is a member of the E2 ubiquitin-conjugating enzyme family. ZUBE2Z is widely expressed in many tissues, with high expression found in the placenta, pancreas, spleen, and testis. It is ubiquitinates proteins that catalyze the covalent attachment of ubiquitin to other proteins. It has shown that ZUBE2Z participate in signaling pathways, and may be involved in apoptosis regulation. |
|
TMPH-00107
|
UBC10 Protein, Arabidopsis thaliana, Recombinant (His)
Ubiquitin carrier protein 10/12,Ubiquitin-...
|
Arabidopsis thaliana
|
E. coli
|
|
Accepts the ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. UBC10 Protein, Arabidopsis thaliana, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 20.6 kDa and the accession number is P35133. |
|
TMPH-03391
|
TRIM2 Protein, Rat, Recombinant (His)
Trim2,Tripartite motif-containing protein 2,E3 ubiquitin...
|
Rat
|
E. coli
|
|
E3 ubiquitin-protein ligase that mediates the ubiquitination of phosphorylated BCL2L11. Also mediates the UBE2D1-dependent ubiquitination of NEFL. Plays a neuroprotective function. May play a role in neuronal rapid ischemic tolerance. TRIM2 Protein, Rat, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 85.5 kDa and the accession number is D3ZQG6. |
|
TMPJ-01038
|
UBE2K Protein, Human, Recombinant (GST)
Ubiquitin-Conjugating Enzyme E2(25K),Ubiquitin<...
|
Human
|
E. coli
|
|
UBE2K Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 45 KDa and the accession number is P61086. |
|
TMPH-01266
|
RNF13 Protein, Human, Recombinant (His)
RING finger protein 13,E3 ubiquitin-protein lig...
|
Human
|
E. coli
|
|
RNF13 Protein, Human, Recombinant (His) is expressed in E. coli with N-terminal 10xHis tag. The predicted molecular weight is 26.2 kDa. Accession number: O43567 |
|
TMPH-01267
|
RNF13 Protein, Human, Recombinant (His & Myc)
RING finger protein 8,RNF8,E3 ubiquitin-protein
|
Human
|
E. coli
|
|
E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of hist... |
|
TMPH-01261
|
NEDD4L Protein, Human, Recombinant (GST)
NEDD4L,HECT-type E3 ubiquitin transferase NED4L,Ned...
|
Human
|
E. coli
|
|
NEDD4L Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 138.5 kDa and the accession number is Q96PU5. |
|
TMPH-03508
|
IpaH9.8 Protein, Shigella flexneri, Recombinant (His)
E3 ubiquitin-protein ligase ipaH9.8,ipaH9....
|
Shigella flexneri
|
P. pastoris (Yeast)
|
|
Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is an E3 ubiquitin ligase that interferes with host's ubiquitination pathway and modulates the acute inflammatory responses, thus facilitating bacterial colonization within the host cell. IpaH9.8 Protein, Shigella flexneri, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 64.0 kDa and the accession number is D2AJU0. |
|
TMPH-02288
|
UBE2D3 Protein, Human, Recombinant (His & SUMO)
(E3-independent) E2 ubiquitin-conjugating enzyme D3...
|
Human
|
E. coli
|
|
UBE2D3 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 32.7 kDa and the accession number is P61077. |
|
TMPJ-00999
|
UBE2D1 Protein, Human, Recombinant (GST)
Ubiquitin-conjugating enzyme E2(17)KB 1,UB,UbcH5,UB...
|
Human
|
E. coli
|
|
Ubiquitin-conjugating enzyme E2 D1（UBE2D1）belongs to the ubiquitin-conjugating enzyme family. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This enzyme is closely related to a stimulator of iron transport (SFT), and is up-regulated in hereditary hemochromatosis. It also functions in the ubiquitination of the tumor-suppressor protein p53 and the hypoxia-inducible transc... |
|
TMPY-02950
|
WWP2 Protein, Human, Recombinant (His & GST)
WW domain containing E3 ubiquitin protein ligas...
|
Human
|
Baculovirus Insect Cells
|
|
WWP2 contains 1 C2 domain, 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain and 4 WW domains. It is an E3 ubiquitin-protein ligase that accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. WWP2 can be detected in heart, throughout the brain, placenta, lung, liver, muscle, kidney and pancreas. It is also expressed in spleen and peripheral blood leukocytes. WWP2 polyubiquitinates POU5F1 by 'Lys-6... |
|
TMPY-03510
|
Cbl-c Protein, Human, Recombinant (His & GST)
Cbl proto-oncogene C, E3 ubiquitin protein liga...
|
Human
|
Baculovirus Insect Cells
|
|
CBL proteins, such as Cbl-c, are phosphorylated upon activation of a variety of receptors that signal via protein tyrosine kinases. Through interactions with proteins containing SRC homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling. Cbl-c is a member of the Cbl family of E3 ubiquitin ligases. Expression of Cbl-c gene may be restricted to epithelial cells, and alternatively spliced transcript variants encoding multiple isoforms have been observed for Cbl-c g... |
|
TMPH-01274
|
ZNRF3 Protein, Human, Recombinant (His & SUMO)
RING-type E3 ubiquitin transferase ZNRF3,E3 ubi...
|
Human
|
E. coli
|
|
E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone. Along with RSPO2 and RNF43, constitutes a master switch that governs ... |
|
TMPH-01268
|
SIAH1 Protein, Human, Recombinant (GST)
SIAH1,RING-type E3 ubiquitin transferase SIAH1,Siah...
|
Human
|
E. coli
|
|
SIAH1 Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 61.6 kDa and the accession number is Q8IUQ4. |
|
TMPH-01272
|
TRIM9 Protein, Human, Recombinant (His & SUMO)
RING finger protein 91,RING-type E3 ubiquitin trans...
|
Human
|
E. coli
|
|
E3 ubiquitin-protein ligase which ubiquitinates itself in cooperation with an E2 enzyme UBE2D2/UBC4 and serves as a targeting signal for proteasomal degradation. May play a role in regulation of neuronal functions and may also participate in the formation or breakdown of abnormal inclusions in neurodegenerative disorders. May act as a regulator of synaptic vesicle exocytosis by controlling the availability of SNAP25 for the SNARE complex formation. |
|
TMPH-02630
|
MDM2 Protein, Mouse, Recombinant (His)
E3 ubiquitin-protein ligase Mdm2,RING-type...
|
Mouse
|
E. coli
|
|
MDM2 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 58.6 kDa and the accession number is P23804. |
|
TMPH-03282
|
TRIM63 Protein, Rat, Recombinant (His & Myc)
Muscle-specific RING finger protein 1,Tripartite motif-conta...
|
Rat
|
E. coli
|
|
E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids. Inhibits de novo skeletal muscle protein synthesis under amino acid starvation. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striate... |
|
TMPH-01275
|
ZNRF3 Protein, Human, Recombinant (His)
ZNRF3,RING-type E3 ubiquitin transferase ZNRF3,RING...
|
Human
|
HEK293 Cells
|
|
E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone. Along with RSPO2 and RNF43, constitutes a master switch that governs ... |
|
TMPH-02210
|
TRAF6 Protein, Human, Recombinant (His & SUMO)
RING finger protein 85,E3 ubiquitin-protein lig...
|
Human
|
E. coli
|
|
TRAF6 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 75.6 kDa and the accession number is Q9Y4K3. |
|
TMPH-01270
|
TRAIP Protein, Human, Recombinant (His)
E3 ubiquitin-protein ligase TRAIP,TRAF-int...
|
Human
|
E. coli
|
|
E3 ubiquitin ligase required to protect genome stability in response to replication stress. Acts as a key regulator of interstrand cross-link repair, which takes place when both strands of duplex DNA are covalently tethered together, thereby blocking replication and transcription. Controls the choice between the two pathways of replication-coupled interstrand-cross-link repair by mediating ubiquitination of MCM7 subunit of the CMG helicase complex. Short ubiquitin chains on MCM7 promote recruitm... |
|
TMPH-01264
|
PELI1 Protein, Human, Recombinant (His)
E3 ubiquitin-protein ligase pellino homolo...
|
Human
|
Baculovirus Insect Cells
|
|
PELI1 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with N-10xHis tag. The predicted molecular weight is 48.8 kDa and the accession number is Q96FA3. |
|
TMPH-02634
|
TRIM63 Protein, Mouse, Recombinant (His & Myc)
Trim63,Muscle-specific RING finger protein 1,Tripartite moti...
|
Mouse
|
E. coli
|
|
E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids. Inhibits de novo skeletal muscle protein synthesis under amino acid starvation. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striate... |
|
TMPH-01904
|
HERC1 Protein, Human, Recombinant (His & Myc)
HECT domain and RCC1-like domain-containing protein 1,p619,H...
|
Human
|
E. coli
|
|
HERC1 Protein, Human, Recombinant (His & Myc) is expressed in E. coli. |
|
TMPH-02050
|
RNF114 Protein, Human, Recombinant (GST)
Zinc finger protein 313,RING finger protein 114,RNF114,E3
|
Human
|
E. coli
|
|
RNF114 Protein, Human, Recombinant (GST) is expressed in E. coli. |
|
TMPH-01260
|
AMFR Protein, Human, Recombinant (hFc)
gp78,RNF45,AMF receptor,RING finger protein 45,E3 ubiqui...
|
Human
|
HEK293 Cells
|
|
E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins, such as CD3D, CYP3A4, CFTR, INSIG1, SOAT2/ACAT2 and APOB for proteasomal degradation. Component of a VCP/p97-AMFR/gp78 complex that participates in the final step of endoplasmic reticulum-associated degradation (ERAD). The VCP/p97-AMFR/gp78 complex is involved in the sterol-accelerated ERAD degradation of HMGCR through binding to the HMGCR-INSIG1 complex at the ER membrane. In add... |
|
TMPH-01259
|
AMFR Protein, Human, Recombinant (His)
Autocrine motility factor receptor,AMF receptor,gp78,RNF45,R...
|
Human
|
E. coli
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E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins, such as CD3D, CYP3A4, CFTR, INSIG1, SOAT2/ACAT2 and APOB for proteasomal degradation. Component of a VCP/p97-AMFR/gp78 complex that participates in the final step of endoplasmic reticulum-associated degradation (ERAD). The VCP/p97-AMFR/gp78 complex is involved in the sterol-accelerated ERAD degradation of HMGCR through binding to the HMGCR-INSIG1 complex at the ER membrane. In add... |
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TMPH-02221
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TRIM24 Protein, Human, Recombinant (His & SUMO)
Transcription intermediary factor 1-alpha,E3 ubiquitin
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Human
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E. coli
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Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. Promotes ubiquitination and proteasomal degradation of p53/TP53. Plays a role in the regulation of cell proliferation and apopt... |
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