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Search Results for " ubiquitin activating enzyme "

Targets Recommended: E1/E2/E3 Enzyme

42

抑制剂 & 化合物

5

天然产物

1

化合物库

16

重组蛋白

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Cat. No.	Product Name
L8600	泛素化化合物库		210 compounds
	210 种泛素化相关的小分子，用于高通量和高内涵筛选；

化合物库

泛素化化合物库

Cat.No: L8600

Compounds: 210

Cat. No.	Product Name	Target	Signaling Pathways
T24136	Heclin	E1/E2/E3 Enzyme	Ubiquitination
	Heclin 是一种 HECT E3 泛素连接酶抑制剂，通过抑制 Smurf2、Nedd4 和 WWP1 起作用，IC50 值分别为 6.8、6.3 和 6.9 μM。
T5374	NAcM-OPT	E1/E2/E3 Enzyme; NEDD8	Metabolism; Ubiquitination
	NAcM-OPT 是口服活性、有效的 cullin neddylation 1 抑制剂，可以抑制 DCN1-UBE2M 相互作用。
T16901	SMIP004	Apoptosis; Others; E1/E2/E3 Enzyme	Apoptosis; Others; Ubiquitination
	SMIP004 是一种 SKP2 E3 连接酶抑制剂。 SMIP004 是人前列腺癌细胞的癌细胞特异性凋亡诱导剂。
T16102	ML-792	E1/E2/E3 Enzyme	Ubiquitination
	ML-792 是特异性的小泛素样修饰物活化酶抑制剂。ML-792选择性抑制SAE/SUMO1和SAE/SUMO2，IC50分别为 3 和 11 nM，对 NAE/NEDD8 和 UAE/ubiquitin 抑制作用微弱，IC50分别为 32 μM 和 >100 μM。
T5199	COH000	E1/E2/E3 Enzyme	Ubiquitination
	COH000 是不可逆的泛素样激活酶1 共价变构抑制剂，体外测得对 SUMO 化修饰的IC50=0.2 μM。
T16699	PYZD-4409	Others; E1/E2/E3 Enzyme	Others; Ubiquitination
	PYZD-4409 是一种特异性 UBA1 抑制剂，IC50 为 20 μM。 PYZD-4409 在恶性细胞中诱导细胞死亡，并且对恶性细胞的细胞毒性优于对正常造血细胞的细胞毒性。
T12261	NSC232003	E1/E2/E3 Enzyme	Ubiquitination
	NSC232003 是高效的UHRF1抑制剂，能够抑制 DNA 甲基化，并破坏 DNMT1/UHRF1 相互作用。
T2158	Nutlin-3 Nutlin3	E1/E2/E3 Enzyme	Ubiquitination
	Nutlin-3 是一种 MDM2 拮抗剂，抑制 MDM2-p53 相互作用，Ki 为 90 nM，并激活 p53。
T7415	DKM 2-93	E1/E2/E3 Enzyme	Ubiquitination
	DKM 2-93是相对选择性 UBA5抑制剂，IC50=430 μM。
T8564	BC-1382	Others; E1/E2/E3 Enzyme	Others; Ubiquitination
	BC-1382 是E3泛素连接酶HECTD2抑制剂，能够特异性破坏 HECTD2/PIAS1 相互作用 (IC50≈ 5 nM)。BC-1382具有抗炎活性。
T16888	SJ-172550	Mdm2; E1/E2/E3 Enzyme	Apoptosis; Ubiquitination
	SJ-172550 是 MDMX 的小分子抑制剂，EC50为5 μM。
T3517	RO8994	Mdm2; E1/E2/E3 Enzyme; p53	Apoptosis; Ubiquitination
	RO8994是一种高效且特异性的螺吲哚酮小分子 MDM2 抑制剂，MTT 增殖试验和HTRF 结合试验的IC50 为 20 nM 和 5 nM。
T8428	Subasumstat TAK-981	E1/E2/E3 Enzyme	Ubiquitination
	Subasumstat (TAK-981) 是SUMOylation 酶联反应的选择性抑制剂，具有潜在的免疫激活和抗肿瘤特性。
T23371	SMER3 SMER 3	Others; Ligand for E3 Ligase	Others; PROTAC
	SMER3 是选择性的 Skp1-Cullin-F-box (SCF)Met30泛素连接酶抑制剂。SMER 3 通过抑制 SCFMet30来增强 Rapamycin 的生长抑制作用。
T6629	PYR-41 PYR41,PYR 41	Apoptosis; E1/E2/E3 Enzyme	Apoptosis; Ubiquitination
	PYR-41 是一种选择性，可透过细胞的泛素活化酶 E1抑制剂，IC50值小于10 μM。
T10703	Mezigdomide CC-92480	Apoptosis; E1/E2/E3 Enzyme; Molecular Glues	Apoptosis; PROTAC; Ubiquitination
	Mezigdomide (CC-92480) 是一种有效的、新型的、具有选择性的和具有活性的 cereblon E3 泛素连接酶调节剂 (CELMoD)，常以分子胶的方式发挥作用。Mezigdomide 具有抗骨髓瘤活性。
T7379	2-D08	E1/E2/E3 Enzyme; TAM Receptor	Tyrosine Kinase/Adaptors; Ubiquitination
	2-D08是小泛素样修饰蛋白抑制剂。2-D08也能抑制 Axl，IC50=0.49 nM。
T6149	YH239-EE	Apoptosis; E1/E2/E3 Enzyme	Apoptosis; Ubiquitination
	YH239-EE 是 YH239 的乙酯，是 p53-MDM2 拮抗剂和凋亡诱导剂。
T3653	MX69	Mdm2; E1/E2/E3 Enzyme; IAP	Apoptosis; Ubiquitination
	MX69 是用于抗癌研究的一种MDM2/XIAP 抑制剂。
T13244	Ubiquitination-IN-1	Others	Others
	Ubiquitination-IN-1 是一种有效的泛素化和Cksl-Skp2蛋白互作抑制剂 (IC50=0.17 μM) 抑制剂，增加 p27 水平，可通过阻断肿瘤抑制因子的降解发挥作用。
T9236	WSB1 Degrader 1	Others; E1/E2/E3 Enzyme	Others; Ubiquitination
	WSB1 Degrader 1 是具有口服活性的 WSB1降解剂，具有抗癌活性。
T7889	C25-140	Others; TNF; E1/E2/E3 Enzyme; NF-κB	Apoptosis; NF-κB; Others; Ubiquitination
	C25-140 是一种具有口服活性和一定选择性的 TRAF6-Ubc13相互作用抑制剂。它直接与 TRAF6 结合，阻断 TRAF6 和 Ubc13 的相互作用，降低 TRAF6 和 NF-κB 的活性，并与自身免疫对抗。
T3317	SZL P1-41	Apoptosis; Others; E1/E2/E3 Enzyme	Apoptosis; Others; Ubiquitination
	SZL P1-41 是 Skp2 抑制剂，可以阻止 Skp2-Skp1 复合物的组装。它选择性地抑制 Skp2 SCF E3 连接酶活性，还在体内外抑制 Skp2 介导的 p27 和 Akt 泛素化。它通过触发细胞衰老和抑制糖酵解来抑制 Y 细胞和 Y 干细胞的存活，有抗肿瘤作用。
T13349	WS-383	E1/E2/E3 Enzyme	Ubiquitination
	WS-383 是高效、选择性、可逆的DCN1-UBC12相互作用抑制剂，IC50为11 nM。它抑制 Cul3/1 的类泛素化修饰，引起 NRF2，p21和p27 的积累。
T11980	MD-224	Mdm2; E1/E2/E3 Enzyme; PROTACs	Apoptosis; PROTAC; Ubiquitination
	MD-224是一种基于蛋白水解靶向嵌合体（PROTAC）概念的高效、高效的MDM2降解剂，是一类新型抗癌剂。
T4253	Skp2 Inhibitor C1 SKPin C1	Others; E1/E2/E3 Enzyme	Others; Ubiquitination
	Skp2 Inhibitor C1 (SKPin C1)(SKPin C1)是Skp2介导p27降解的特异性抑制剂。
T3110	PRT4165 NSC600157,PRT 4165	BMI-1; Others; E1/E2/E3 Enzyme	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Others; Ubiquitination
	PRT4165 (NSC600157) 是有效的 PRC1介导 H2A 泛素化的抑制剂。
T5555	Siremadlin NVP-HDM 201	E1/E2/E3 Enzyme	Ubiquitination
	Siremadlin (NVP-HDM 201) 是一种有效的、可口服的、高度特异性的 p53-MDM2 相互作用抑制剂。
T6254	Idasanutlin RG7388,Ro 5503781,依达奴林	Mdm2; E1/E2/E3 Enzyme	Apoptosis; Ubiquitination
	Idasanutlin (Ro 5503781) 是一种有效且特异性的 p53-MDM2 抑制剂，IC50值为 6 nM。
T3549	Avadomide CC 122	Apoptosis; E1/E2/E3 Enzyme; Ligand for E3 Ligase	Apoptosis; PROTAC; Ubiquitination
	Avadomide (CC 122) 是口服有效的cereblon 调节剂，可以调节 cereblon E3 连接酶活性，诱导弥漫性大 B 细胞淋巴瘤细胞凋亡，具有抗肿瘤和免疫调节活性。
T6965	RG7112 RG-7112,RG 7112,RO5045337	Mdm2; E1/E2/E3 Enzyme	Apoptosis; Ubiquitination
	RG7112 (RO5045337) 是一种口服生物可利用的选择性 p53-MDM2 抑制剂。
TQ0127	Navtemadlin AMG232,CS-1300	Mdm2; E1/E2/E3 Enzyme	Apoptosis; Ubiquitination
	Navtemadlin (AMG232) 是一种有效的、选择性的、可口服的 p53-MDM2 相互作用抑制剂，IC50值为 0.6 nM。它以 0.045 nM 的 Kd 与 MDM2 结合。
T16974	TAK-243 MLN7243	Apoptosis; E1/E2/E3 Enzyme; NF-κB	Apoptosis; NF-κB; Ubiquitination
	TAK-243 (MLN7243) 是一种泛素激活酶 UAE 的抑制剂 (IC50=1 nM)，具有选择性。TAK-243 可阻断泛素结合，破坏单泛素信号传导以及整体蛋白质泛素化。TAK-243 具有抗肿瘤活性，可以促进细胞凋亡。
TQ0231	NVP-CGM097 CGM097	Mdm2; E1/E2/E3 Enzyme	Apoptosis; Ubiquitination
	NVP-CGM097 (CGM097) 是一种选择性MDM2抑制剂，对hMDM2的IC50为 1.7 nM。
T1493	BH3I-1 BHI1	BCL; E1/E2/E3 Enzyme	Apoptosis; Ubiquitination
	BH3I-1 (BHI1) 是一种Bcl-2家族拮抗剂，作用于p53/mDM2，Kd 为 5.3 μM。它抑制BakBH3 肽与Bcl-xL 结合，Ki 为 2.6 μM。
T6611	NSC697923 2-[(4-methylphenyl)sulfonyl]-5-nitrofuran	E1/E2/E3 Enzyme	Ubiquitination
	NSC-697923 (2-[(4-methylphenyl)sulfonyl]-5-nitrofuran), a potent inhibitor of UBE2N (ubiquitin-conjugating enzyme E2 N, Ubc13), exhibits its role in inducing cell death in neuroblastoma (NB) cells through two distinct mechanisms. In p53 wild-type NB cells, NSC-697923 promotes the nuclear importation of p53, thereby triggering cell death. Meanwhile, in p53 mutant NB cells, NSC-697923 activates the JNK-mediated apoptotic pathway, leading to cell death. Additionally, NSC-697923 inhibits DNA damage ...
T2243	Serdemetan JNJ-26854165,N-[2-(1H-吲哚-3-基)乙基]-N'-(4-吡啶基)-1,4-苯二胺	Apoptosis; Mdm2; E1/E2/E3 Enzyme; p53	Apoptosis; Ubiquitination
	Serdemetan (JNJ-26854165) 是一种 HDM2泛素连接酶拮抗剂，能诱导 p53野生型细胞的早期凋亡。
T6023	Nutlin-3a (-)-Nutlin-3,Nutlin-3a chiral,(−)-Nutlin-3	Apoptosis; E1/E2/E3 Enzyme; Autophagy	Apoptosis; Autophagy; Ubiquitination
	Nutlin-3a ((−)-Nutlin-3) 是 Nutlin-3 的活性对映体，是一种 MDM2抑制剂，可抑制 MDM2-p53相互作用，稳定 p53 蛋白，从而诱导细胞自噬和凋亡，有潜力研究 TP53野生型卵巢癌。
T25465	GS143 GS-143,GS 143	IκB/IKK; E1/E2/E3 Enzyme; NF-κB	NF-κB; Ubiquitination
	GS-143 是选择性的IκBα泛素化抑制剂，抑制 SCFβTrCP1介导的IκBα泛素化作用，IC50=5.2 μM。GS143 抑制NF-κB 的活化和靶基因的转录，并且不抑制蛋白酶体的特性，并具有抗哮喘作用。
T6585	SAR405838 MI773,MI 773,MI-77301,MI-773	Mdm2; E1/E2/E3 Enzyme	Apoptosis; Ubiquitination
	SAR405838 (MI 773) 是 MI-773 的类似物，具有抗肿瘤活性。它是一种高效、选择性的MDM2-p53相互作用抑制剂，与 MDM2 结合的Ki 值为 0.88 nM。
T8929	BC1618 2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]-	Mitophagy; Others; E1/E2/E3 Enzyme; AMPK	Autophagy; Chromatin/Epigenetic; Others; PI3K/Akt/mTOR signaling; Ubiquitination
	BC1618 (2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]-) 是一种具有口服活性的 Fbxo48 抑制剂，可刺激 Ampk 依赖性信号传导。它促进线粒体分裂，促进自噬并提高肝脏胰岛素敏感性。
T6614	Nutlin-3b (+)-Nutlin-3,4-[[(4R,5S)-4,5-双(4-氯苯基)-4,5-二氢-2-[4-甲氧基-2-(1-甲基乙氧基)苯基]-1H-咪唑-1-基]羰基]-2-哌嗪酮	Mdm2; E1/E2/E3 Enzyme	Apoptosis; Ubiquitination
	Nutlin-3b ((+)-Nutlin-3) 是一种 p53/MDM2 拮抗剂或抑制剂，IC50为 13.6 μM。它与 MDM2 的结合活性比 Nutlin-3a 低 150 倍。

化合物

Cat.No: T24136

Target: E1/E2/E3 Enzyme

Cat.No: T5374

Target: E1/E2/E3 Enzyme, NEDD8

Cat.No: T16901

Target: Apoptosis, Others, E1/E2/E3 Enzyme

Cat.No: T16102

Target: E1/E2/E3 Enzyme

Cat.No: T5199

Target: E1/E2/E3 Enzyme

Cat.No: T16699

Target: Others, E1/E2/E3 Enzyme

Cat.No: T12261

Target: E1/E2/E3 Enzyme

Cat.No: T2158

Synonym: Nutlin3

Target: E1/E2/E3 Enzyme

Cat.No: T7415

Target: E1/E2/E3 Enzyme

Cat.No: T8564

Target: Others, E1/E2/E3 Enzyme

Cat.No: T16888

Target: Mdm2, E1/E2/E3 Enzyme

Cat.No: T3517

Target: Mdm2, E1/E2/E3 Enzyme, p53

Cat.No: T8428

Synonym: TAK-981

Target: E1/E2/E3 Enzyme

Cat.No: T23371

Synonym: SMER 3

Target: Others, Ligand for E3 Ligase

Cat.No: T6629

Synonym: PYR41,PYR 41

Target: Apoptosis, E1/E2/E3 Enzyme

Cat.No: T10703

Synonym: CC-92480

Target: Apoptosis, E1/E2/E3 Enzyme, Molecular Glues

Cat.No: T7379

Target: E1/E2/E3 Enzyme, TAM Receptor

Cat.No: T6149

Target: Apoptosis, E1/E2/E3 Enzyme

Cat.No: T3653

Target: Mdm2, E1/E2/E3 Enzyme, IAP

Ubiquitination-IN-1

Cat.No: T13244

Target: Others

WSB1 Degrader 1

Cat.No: T9236

Target: Others, E1/E2/E3 Enzyme

Cat.No: T7889

Target: Others, TNF, E1/E2/E3 Enzyme, NF-κB

Cat.No: T3317

Target: Apoptosis, Others, E1/E2/E3 Enzyme

Cat.No: T13349

Target: E1/E2/E3 Enzyme

Cat.No: T11980

Target: Mdm2, E1/E2/E3 Enzyme, PROTACs

Skp2 Inhibitor C1

Cat.No: T4253

Synonym: SKPin C1

Target: Others, E1/E2/E3 Enzyme

Cat.No: T3110

Synonym: NSC600157,PRT 4165

Target: BMI-1, Others, E1/E2/E3 Enzyme

Cat.No: T5555

Synonym: NVP-HDM 201

Target: E1/E2/E3 Enzyme

Cat.No: T6254

Synonym: RG7388,Ro 5503781,依达奴林

Target: Mdm2, E1/E2/E3 Enzyme

Cat.No: T3549

Synonym: CC 122

Target: Apoptosis, E1/E2/E3 Enzyme, Ligand for E3 Ligase

Cat.No: T6965

Synonym: RG-7112,RG 7112,RO5045337

Target: Mdm2, E1/E2/E3 Enzyme

Cat.No: TQ0127

Synonym: AMG232,CS-1300

Target: Mdm2, E1/E2/E3 Enzyme

Cat.No: T16974

Synonym: MLN7243

Target: Apoptosis, E1/E2/E3 Enzyme, NF-κB

Cat.No: TQ0231

Synonym: CGM097

Target: Mdm2, E1/E2/E3 Enzyme

Cat.No: T1493

Synonym: BHI1

Target: BCL, E1/E2/E3 Enzyme

Cat.No: T6611

Synonym: 2-[(4-methylphenyl)sulfonyl]-5-nitrofuran

Target: E1/E2/E3 Enzyme

Cat.No: T2243

Synonym: JNJ-26854165,N-[2-(1H-吲哚-3-基)乙基]-N'-(4-吡啶基)-1,4-苯二胺

Target: Apoptosis, Mdm2, E1/E2/E3 Enzyme, p53

Cat.No: T6023

Synonym: (-)-Nutlin-3,Nutlin-3a chiral,(−)-Nutlin-3

Target: Apoptosis, E1/E2/E3 Enzyme, Autophagy

Cat.No: T25465

Synonym: GS-143,GS 143

Target: IκB/IKK, E1/E2/E3 Enzyme, NF-κB

Cat.No: T6585

Synonym: MI773,MI 773,MI-77301,MI-773

Target: Mdm2, E1/E2/E3 Enzyme

Cat.No: T8929

Synonym: 2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]-

Target: Mitophagy, Others, E1/E2/E3 Enzyme, AMPK

Cat.No: T6614

Synonym: (+)-Nutlin-3,4-[[(4R,5S)-4,5-双(4-氯苯基)-4,5-二氢-2-[4-甲氧基-2-(1-甲基乙氧基)苯基]-1H-咪唑-1-基]羰基]-2-哌嗪酮

Target: Mdm2, E1/E2/E3 Enzyme

Cat. No.	Product Name	Target	Signaling Pathways
T4S0181	Hinokiflavone 日本扁柏黄酮,扁柏双黄酮	MMP; BCL; E1/E2/E3 Enzyme	Apoptosis; Proteases/Proteasome; Ubiquitination
	Hinokiflavone 是pre-mRNA 剪接活性的新型调节剂，通过抑制剪接体装配来阻止pre-mRNA 底物的剪接，特别是阻止 B complex 的形成。它是SUMO protease 蛋白酶抑制剂，能够抑制前哨蛋白特异性蛋白酶 1 的活性。
T9352	hydrocotarnine	Others	Others
	hydrocotarnine 是 Cbl 的抑制剂。
T4036	Solasodine Solancarpidine,Purapuridine,澳洲茄铵,Solasodin	Apoptosis; Others; E1/E2/E3 Enzyme; Antifungal	Apoptosis; Microbiology/Virology; Others; Ubiquitination
	Solasodine (Purapuridine) 是存在于茄科植物中的一种类固醇生物碱。它具有神经保护、降压、抗真菌、抗癌、抗动脉粥样硬化、抗雄激素和抗炎活性。
T2947	Indole-3-carbinol 吲哚-3-甲醇,I3C,3-Indolemethanol,3-吲哚甲醇,Indole-3-Methanol	E1/E2/E3 Enzyme; NF-κB; Aryl Hydrocarbon Receptor; Endogenous Metabolite; p53	Apoptosis; Immunology/Inflammation; Metabolism; NF-κB; Ubiquitination
	Indole-3-carbinol (I3C) 是樟子松中的一种天然产物，是可口服的硫代葡萄糖苷葡糖苷酶裂解产物。它是芳烃受体 (AhR) 的激动剂，可抑制 NF-κB 和 IκBα 激酶活化。
T6S2123	Ginkgolic Acid Romanicardic acid,Ginkgolic acid I,Ginkgolic acid (15:1),银杏酸C15:1,银杏酸,Ginkgolic acid C15:1	Others; E1/E2/E3 Enzyme	Others; Ubiquitination
	Ginkgolic Acid (Romanicardic acid) 是一种天然化合物，在体外实验中抑制SUMOylation，IC50=3.0 μM。

天然产物

Cat.No: T4S0181

Synonym: 日本扁柏黄酮,扁柏双黄酮

Target: MMP, BCL, E1/E2/E3 Enzyme

Cat.No: T9352

Target: Others

Cat.No: T4036

Synonym: Solancarpidine,Purapuridine,澳洲茄铵,Solasodin

Target: Apoptosis, Others, E1/E2/E3 Enzyme, Antifungal

Indole-3-carbinol

Cat.No: T2947

Synonym: 吲哚-3-甲醇,I3C,3-Indolemethanol,3-吲哚甲醇,Indole-3-Methanol

Target: E1/E2/E3 Enzyme, NF-κB, Aryl Hydrocarbon Receptor, Endogenous Metabolite, p53

Cat.No: T6S2123

Synonym: Romanicardic acid,Ginkgolic acid I,Ginkgolic acid (15:1),银杏酸C15:1,银杏酸,Ginkgolic acid C15:1

Target: Others, E1/E2/E3 Enzyme

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-02840	Ubiquitin Activating Enzyme E1/UBA1 Protein, Human, Recombinant (His & GST) UBE1,ubiquitin-like modifier activating	Human	Baculovirus Insect Cells
	UBE1, also known as UBA1, belongs to the ubiquitin-activating E1 family. UBE1 gene complements an X-linked mouse temperature-sensitive defect in DNA synthesis, and thus may function in DNA repair. It is part of a gene cluster on chromosome Xp11.23. UBE1 catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation. It also catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation by first adenylating its C-terminal glycine residue w...
TMPJ-01324	UBA5 Protein, Human, Recombinant (His) Ubiquitin-like modifier-activating enz...	Human	E. coli
	UBA5 is a member of the ubiquitin-activating E1 family and UBA5 subfamily. Ubiquitin and ubiquitin-like proteins are recognized as covalently conjugated to various cellular substrates by a three-step enzymatic pathway. The ubiquitin-activating enzyme (E1) has a vital role in the first step of ubiquitination pathway to activate ubiquitin or ubiquitin-like proteins. UBA5 activates ubiquitin-fold modifier 1, a ubiquitin-like post-translational modifier protein, via the formation of a high-energy th...
TMPY-06748	UBA6 Protein, Human, Recombinant (GST) ubiquitin-like modifier activating enz...	Human	Baculovirus Insect Cells
	UBA6 (Ubiquitin Like Modifier Activating Enzyme 6) is a Protein Coding gene. The UBA6 gene, located on 4q13.2, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog. Uba6 is a homolog of the ubiquitin-activating enzyme, Uba1, and activates two ubiquitin-like proteins (UBLs), ubiquitin and FAT10. UBA6 is an alternative enzyme for ubiquitin activation in vertebrates that plays a pivotal role in early mouse development. UBA6 is widely expressed in the lymph n...
TMPJ-00999	UBE2D1 Protein, Human, Recombinant (GST) Ubiquitin-conjugating enzyme E2(17)KB 1,UB...	Human	E. coli
	Ubiquitin-conjugating enzyme E2 D1（UBE2D1）belongs to the ubiquitin-conjugating enzyme family. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This enzyme is closely related to a stimulator of iron transport (SFT), and is up-regulated in hereditary hemochromatosis. It also functions in the ubiquitination of the tumor-suppressor protein p53 and the hypoxia-inducible transc...
TMPJ-00571	UBE2D3 Protein, Human, Recombinant Ubiquitin-protein ligase D3,Ubiquitin-conj...	Human	E. coli
	UBE2D3 is an enzyme that belongs to the ubiquitin-conjugating enzyme family. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This enzyme functions in the ubiquitination of the tumor-suppressor protein p53, which is induced by an E3 ubiquitin-protein ligase.
TMPJ-01053	UBE2I Protein, Human, Recombinant (GST) SUMO-Protein Ligase,Ubiquitin-Conjugating Enzym...	Human	E. coli
	SUMO-Conjugating Enzyme UBC9 (UBC9) belongs to the ubiquitin-conjugating enzyme family. UBC9 is homologous to ubiquitin-conjugating enzymes (E2s). However, instead of conjugating ubiquitin, UBC9 conjugates a ubiquitin homologue, Small Ubiquitin-Like Modifier 1 (SUMO-1). The conjugation of ubiquitin requires the activities of ubiquitin-activating (E1) and conjugating (E2) enzymes. It is suggested that UBC9 might play a role in DNA repair and perhaps even in aging.
TMPJ-01138	UBE2S Protein, Human, Recombinant (GST) UBE2S,Ubiquitin-Conjugating Enzyme E2-24 k...	Human	E. coli
	Ubiquitin-Conjugating Enzyme E2 S (UBE2S) is a member of the Ubiquitin-Conjugating Enzyme family. UBE2S interacts with CDC20, FZR1/CDH1 and VHL. UBE2S can form a thiol ester linkage with Ubiquitin in an Ubiquitin Activating Enzyme-Dependent manner, a characteristic property of Ubiquitin Carrier Proteins. UBE2S acts as an essential factor of the Anaphase Promoting Complex/Cyclosome, a cell cycle-regulated Ubiquitin ligase that controls progression through mitosis. UBE2S is also involved in ubiqui...
TMPJ-00985	UBE2A Protein, Human, Recombinant (GST, His) RAD6A,HR6A,Ubiquitin-Protein Ligase A,UBE2A,hHR6A,<...	Human	E. coli
	Ubiquitin-Conjugating Enzyme E2 (UBE2A) is a member of the E2 Ubiquitin-Conjugating Enzyme family. The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. UBE2A catalyzes the covalent attachment of ubiquitin to other proteins. UBE2A is re...
TMPJ-01047	UBE2H Protein, Human, Recombinant (GST) UBE2H,UbcH2,Ubiquitin-Conjugating Enzyme E...	Human	E. coli
	Ubiquitin-Conjugating Enzyme E2 H (UBE2H) belongs to the E2 Ubiquitin-Conjugating Enzyme family. The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. It has been shown to conjugate ubiquitin to histone H2A in an E3 dependent manner in ...
TMPY-02642	UBE2W Protein, Human, Recombinant (His) UBC16,UBC-16,ubiquitin-conjugating enzyme ...	Human	E. coli
	Ubiquitin-conjugating enzymes, also known as UBE2W, E2 enzymes and more rarely as ubiquitin-carrier enzymes, perform the second step of protein ubiquitination. The modification of protein with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. UBE2W is a member of th...
TMPY-02607	Ube2H Protein, Human, Recombinant UBC8,UBCH2,E2-20K,UBCH,ubiquitin-conjugating en...	Human	E. coli
	UBE2H is a member of the ubiquitin-conjugating E2 family whose members perform the second step in the ubiquitination reaction. Initially identified as the main process for protein degradation, ubiquitination is believed nowadays to be crucial for a wider range of cellular processes. The outcome of the ubiquitin-conjugation reaction, and thereby the fate of the substrate, is heavily dependent on the number of ubiquitin molecules attached and how these ubiquitin molecules are inter-connected. To d...
TMPY-02609	UBE2M Protein, Human, Recombinant UBC12,UBC-RS2,ubiquitin-conjugating enzyme...	Human	E. coli
	UBE2M is a member of the ubiquitin-conjugating E2 family whose members perform the second step in the ubiquitination reaction. Initially identified as the main process for protein degradation, ubiquitination is believed nowadays to be crucial for a wider range of cellular processes. The outcome of the ubiquitin-conjugation reaction, and thereby the fate of the substrate, is heavily dependent on the number of ubiquitin molecules attached and how these ubiquitin molecules are inter-connected. To d...
TMPY-02608	UBC9/UBE2I Protein, Human, Recombinant UBC9,ubiquitin-conjugating enzyme E2I,C358...	Human	E. coli
	UBE2I is a member of the ubiquitin-conjugating E2 family whose members perform the second step in the ubiquitination reaction. Initially identified as the main process for protein degradation, ubiquitination is believed nowadays to be crucial for a wider range of cellular processes. The outcome of the ubiquitin-conjugation reaction, and thereby the fate of the substrate, is heavily dependent on the number of ubiquitin molecules attached and how these ubiquitin molecules are inter-connected. To d...
TMPY-02605	UBE2F Protein, Human, Recombinant (His) ubiquitin-conjugating enzyme E2F (putative...	Human	E. coli
	UBE2F is a member of the ubiquitin-conjugating E2 family whose members perform the second step in the ubiquitination reaction. Initially identified as the main process for protein degradation, ubiquitination is believed nowadays to be crucial for a wider range of cellular processes. The outcome of the ubiquitin-conjugation reaction, and thereby the fate of the substrate, is heavily dependent on the number of ubiquitin molecules attached and how these ubiquitin molecules are inter-connected. To d...
TMPY-02606	UBE2G1 Protein, Human, Recombinant E217K,UBC7,ubiquitin-conjugating enzyme E2...	Human	E. coli
	UBE2G1 is a member of the ubiquitin-conjugating E2 family whose members perform the second step in the ubiquitination reaction. Initially identified as the main process for protein degradation, ubiquitination is believed nowadays to be crucial for a wider range of cellular processes. The outcome of the ubiquitin-conjugation reaction, and thereby the fate of the substrate, is heavily dependent on the number of ubiquitin molecules attached and how these ubiquitin molecules are inter-connected. To ...
TMPY-02604	UBE2D4 Protein, Human, Recombinant (His) HBUCE1,ubiquitin-conjugating enzyme E2D 4 ...	Human	E. coli
	UBE2D4 is a member of the ubiquitin-conjugating E2 family whose members perform the second step in the ubiquitination reaction. Initially identified as the main process for protein degradation, ubiquitination is believed nowadays to be crucial for a wider range of cellular processes. The outcome of the ubiquitin-conjugation reaction, and thereby the fate of the substrate, is heavily dependent on the number of ubiquitin molecules attached and how these ubiquitin molecules are inter-connected. To ...

重组蛋白

Ubiquitin Activating Enzyme E1/UBA1 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-02840

Species: Human

Expression System: Baculovirus Insect Cells

UBA5 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01324

Species: Human

Expression System: E. coli

UBA6 Protein, Human, Recombinant (GST)

Cat.No: TMPY-06748

Species: Human

Expression System: Baculovirus Insect Cells

UBE2D1 Protein, Human, Recombinant (GST)

Cat.No: TMPJ-00999

Species: Human

Expression System: E. coli

UBE2D3 Protein, Human, Recombinant

Cat.No: TMPJ-00571

Species: Human

Expression System: E. coli

UBE2I Protein, Human, Recombinant (GST)

Cat.No: TMPJ-01053

Species: Human

Expression System: E. coli

UBE2S Protein, Human, Recombinant (GST)

Cat.No: TMPJ-01138

Species: Human

Expression System: E. coli

UBE2A Protein, Human, Recombinant (GST, His)

Cat.No: TMPJ-00985

Species: Human

Expression System: E. coli

UBE2H Protein, Human, Recombinant (GST)

Cat.No: TMPJ-01047

Species: Human

Expression System: E. coli

UBE2W Protein, Human, Recombinant (His)

Cat.No: TMPY-02642

Species: Human

Expression System: E. coli

Ube2H Protein, Human, Recombinant

Cat.No: TMPY-02607

Species: Human

Expression System: E. coli

UBE2M Protein, Human, Recombinant

Cat.No: TMPY-02609

Species: Human

Expression System: E. coli

UBC9/UBE2I Protein, Human, Recombinant

Cat.No: TMPY-02608

Species: Human

Expression System: E. coli

UBE2F Protein, Human, Recombinant (His)

Cat.No: TMPY-02605

Species: Human

Expression System: E. coli

UBE2G1 Protein, Human, Recombinant

Cat.No: TMPY-02606

Species: Human

Expression System: E. coli

UBE2D4 Protein, Human, Recombinant (His)

Cat.No: TMPY-02604

Species: Human

Expression System: E. coli

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