Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T70391 |
AMG151 HCl
|
Others | Others |
ARRY-403, also known as AMG-151, is an orally available allosteric glucokinase (GK) activator developed for the treatment of type 2 diabetes mellitus (T2DM). ARRY-403 has many favorable physicochemical characteristics and ADME properties (low potential to cause drug–drug interactions (DDIs). ARRY-403 potently activates human glucokinase (GK) in vitro (EC50 = 79 nM at 5 mM glucose), with an S0.5 = 0.93 mM glucose (ARRY-403 at 5 mM) and Vmax = 134% compared to the no activator control. It possesse... | |||
T70392 |
Tyrphostin AG-808
|
Others | Others |
Tyrphostin AG-808 is a 15-human lipoxygenase inhibitor. |