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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T84705 |
Tyrosinase-IN-22
5-Chloro-2-mercaptobenzimidazole |
Others | Others |
Tyrosinase-IN-22(compound 4)是L-酪氨酸和L-多巴的抑制剂,IC50值分别为60 nM和30 nM。具备显著的抗氧化及抗黑素生成特性,适合相关领域研究。 | |||
T37832 |
CAY10761
CAY10761 |
Others | Others |
CAY10761 is an inhibitor of ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1; IC50s = 467 and 429 μM for the human and snake venom enzymes, respectively).1,2 It also inhibits mushroom tyrosinase (Ki = 1.9 μM) and urease from jack bean, P. mirabilis, and B. pasteurii (IC50s = 0.093, <0.125, and 0.089 mM, respectively, at pH 8.2).3,4 |1. Khan, K.M., Fatima, N., Rasheed, M., et al. 1,3,4-Oxadiazole-2(3H)-thione and its analogues: A new class of non-competitive nucleotide pyrophosphatases/p... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T72803 |
Norartocarpetin
|
Others | Others |
Norartocarpetin 是一种酪氨酸酶抑制剂。Norartocarpetin 具有较强的酪氨酸酶抑制活性,其抑制活性 IC50值为 0.47 μM。Norartocarpetin 作为一种抗褐变剂可用于食品体系的研究。Norartocarpetin 对肺癌细胞 (NCI-H460) 也具有显著的抗癌活性,其 IC50值为 22 μM。Norartocarpetin 的抗增殖作用是通过靶向 Ras/Raf/MAPK 信号通路、线粒体介导的细胞凋亡、S 期细胞周期阻滞和抑制细胞迁移和侵袭实现的。 |