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Search Results for " toxoplasma gondii "

Targets Recommended: Antibiotic Parasite

8

抑制剂 & 化合物

3

天然产物

8

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T1172	Diclazuril 地克珠利,R-64433	Antibiotic; Parasite	Microbiology/Virology
	Diclazuril (R-64433) 是一种具有口服活性的抗球虫剂，是苯乙腈衍生物。它可用于某些传染病和寄生虫病的相关研究。
T72081	CpCDPK1/TgCDPK1-IN-2	Parasite	Microbiology/Virology
	CpCDPK1/TgCDPK1-IN-2 是 CpCDPK1 和 TgCDPK1 双重抑制剂，对 CpCDPK1 和 TgCDPK1 有抑制这样，IC50 值分别为 12 和 5 nM。CpCDPK1/TgCDPK1-IN-2 可用于研究弓形虫 (T. gondii)、细小隐孢子虫 (C. parvum) 和隐孢子虫 (C. hominus) 等顶复门原生动物感染相关疾病。
T36692	Fanotaprim	DHFR	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism
	Fanotaprim 是二氢叶酸还原酶的有效抑制剂，抑制 tgDHFR (Toxoplasma gondiiDHFR) 和 hDHFR (human DHFR)的 IC50分别为 1.57 和 308 nM。Fanotaprim 在研究弓形虫病方面具有价值。
T61671	MMV687807	Others	Others
	MMV687807 is a potent anthelmintic compound exhibiting strong efficacy against Toxoplasma gondii (T. gondii). It demonstrates an IC50 value of 0.15 μM and a CC50 value of 1.69 μM [1].
T69311	GW300657X	Others	Others
	GW300657X is a small molecule inhibitor that blocks toxoplasma gondii rhoptry kinase 18 and maintains moderate CDK2-cyclin A inhibitory activity.
T29003	TRC-19	Others	Others
	TRC-19 is a potent and selective inhibitor of Toxoplasma gondii dihydrofolate reductase. TRC-19 shows an IC50 of 9 nM and 89-fold selectivity in favor of Toxoplasma gondii dihydrofolate reductase.
T76121	Phosphoglucomutase	Endogenous Metabolite	Metabolism
	Phosphoglucomutase可促进弓形虫的囊肿发育。缺乏 Phosphoglucomutase 会引发代谢疾病。
T38269	Purfalcamine	Others	Others
	Purfalcamine is an orally active, selective Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1) inhibitor with an IC50 of 17 nM and an EC50 of 230 nM. Purfalcamine has antimalarial activity and causes malaria parasites developmental arrest at the schizont stage[1][2]. Purfalcamine has low activity against Toxoplasma gondii calcium-dependent protein kinase 3 (TgCDPK3)[1]. Purfalcamine (225, 450 nM) has no effect on the parasitemia in the first 32 hours. After about 40 hours, paras...

化合物

Cat.No: T1172

Synonym: 地克珠利,R-64433

Target: Antibiotic, Parasite

CpCDPK1/TgCDPK1-IN-2

Cat.No: T72081

Target: Parasite

Cat.No: T36692

Target: DHFR

Cat.No: T61671

Target: Others

Cat.No: T69311

Target: Others

Cat.No: T29003

Target: Others

Phosphoglucomutase

Cat.No: T76121

Target: Endogenous Metabolite

Cat.No: T38269

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
TN7103	13,21-Dihydroeurycomanone Pasakbumin C	Anti-infection; Parasite	Microbiology/Virology
	13,21-Dihydroeurycomanone (Pasakbumin C) 是从 Eurycoma longifolia 根部分离得到的一种天然产物，有抗寄生虫活性。
T0819	Spiramycin Espiramicin,螺旋霉素,Sequamycin,Rovamycin,Provamycin,Formacidine	Antibacterial; Antibiotic; Parasite	Microbiology/Virology
	Spiramycin (Rovamycin) 是一种由安博链霉菌产生的大环内酯类抗生素，具有抗细菌和弓形虫活性，并具有抗寄生虫作用。它由 16 个内酯环组成，其上附着 mycaminose，forosamine 和 mycarose 三种糖。
T35750	Trypacidin	Others	Others
	Trypacidin is a fungal metabolite originally isolated fromA. fumigatus.1It is active againstB. subtilisandM. bovis(MICs = 12.5 and 1.25 μg/ml, respectively), as well asT. cruziandT. gondii(MICs = 5-10 and 10-20 μg/ml, respectively).1,2It reduces viability and induces lysis of A549 human lung cancer cells (IC50s = 7.4 μM for both).3Trypacidin increases survival in a mouse model ofT. gondiiinfection when administered in six doses of 12.5 mg/kg each.1 1.Balan, J., Ebringer, L., Nemec, P., et al.Ant...

天然产物

13,21-Dihydroeurycomanone

Cat.No: TN7103

Synonym: Pasakbumin C

Target: Anti-infection, Parasite

Cat.No: T0819

Synonym: Espiramicin,螺旋霉素,Sequamycin,Rovamycin,Provamycin,Formacidine

Target: Antibacterial, Antibiotic, Parasite

Cat.No: T35750

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-03631	CDPK1 Protein, Toxoplasma gondii, Recombinant (His) Calmodulin-domain protein kinase 1,CDPK1	Toxoplasma gondii	E. coli
	N/A. CDPK1 Protein, Toxoplasma gondii, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 63.3 kDa and the accession number is Q9BJF5.
TMPH-03638	Profilin Protein, Toxoplasma gondii, Recombinant (His) Profilin,PRF	Toxoplasma gondii	P. pastoris (Yeast)
	N/A. Profilin Protein, Toxoplasma gondii, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 19.4 kDa and the accession number is Q58NA1.
TMPH-03635	GRA6 Protein, Toxoplasma gondii, Recombinant (GST) Antigen p32,Dense granule protein 6,GRA6,Protein p33	TOV-Toxoplasma gondii	E. coli
	Major granular component involved in excreted-secreted antigen (ESA) immunity. May have a structural role in the membranous network of the parasitophorous vacuole (PV). GRA6 Protein, Toxoplasma gondii, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 38.6 kDa and the accession number is Q27003.
TMPH-03634	GRA3 Protein, Toxoplasma gondii, Recombinant (His) P30,GRA3,Dense granule protein 3	Toxoplasma gondii	E. coli
	Direct host-parasite interaction occurs at the cytoplasmic faces of the parasitophorous vacuole membrane (PVM) and the host endoplasmic reticulum (ER) membrane via GRA3 and host CAMLG association. Direct insertion of GRA3 ER retrieval motif into the host ER membrane contributes to the host ER recruitment to the PVM. GRA3 Protein, Toxoplasma gondii, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 10.8 kDa and the accession number is ...
TMPH-03632	GRA1 Protein, Toxoplasma gondii, Recombinant (His) Dense granule protein 1,Major antigen p24,GRA1	Toxoplasma gondii	E. coli
	N/A. GRA1 Protein, Toxoplasma gondii, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 21.9 kDa and the accession number is P13403.
TMPH-03636	HSP70 Protein, Toxoplasma gondii, Recombinant (His) HSP70,Heat shock 70 kDa protein	Toxoplasma gondii	E. coli
	N/A. HSP70 Protein, Toxoplasma gondii, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 78.9 kDa and the accession number is A0A125YXI9.
TMPH-03633	GRA2 Protein, Toxoplasma gondii, Recombinant (His & Myc) Dense granule protein 2,GRA2,GP28.5,28 kDa antigen	Toxoplasma gondii	E. coli
	Major granular component involved in excreted-secreted antigen (ESA) immunity. Possibly acts in conjunction with GRA1. GRA2 Protein, Toxoplasma gondii, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 25.0 kDa and the accession number is P13404.
TMPH-03637	Profilin Protein, Toxoplasma gondii, Recombinant (E. coli, His) PRF,Profilin	Toxoplasma gondii	E. coli
	N/A. Profilin Protein, Toxoplasma gondii, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 21.4 kDa and the accession number is Q58NA1.

重组蛋白

CDPK1 Protein, Toxoplasma gondii, Recombinant (His)

Cat.No: TMPH-03631

Species: Toxoplasma gondii

Expression System: E. coli

Profilin Protein, Toxoplasma gondii, Recombinant (His)

Cat.No: TMPH-03638

Species: Toxoplasma gondii

Expression System: P. pastoris (Yeast)

GRA6 Protein, Toxoplasma gondii, Recombinant (GST)

Cat.No: TMPH-03635

Species: TOV-Toxoplasma gondii

Expression System: E. coli

GRA3 Protein, Toxoplasma gondii, Recombinant (His)

Cat.No: TMPH-03634

Species: Toxoplasma gondii

Expression System: E. coli

GRA1 Protein, Toxoplasma gondii, Recombinant (His)

Cat.No: TMPH-03632

Species: Toxoplasma gondii

Expression System: E. coli

HSP70 Protein, Toxoplasma gondii, Recombinant (His)

Cat.No: TMPH-03636

Species: Toxoplasma gondii

Expression System: E. coli

GRA2 Protein, Toxoplasma gondii, Recombinant (His & Myc)

Cat.No: TMPH-03633

Species: Toxoplasma gondii

Expression System: E. coli

Profilin Protein, Toxoplasma gondii, Recombinant (E. coli, His)

Cat.No: TMPH-03637

Species: Toxoplasma gondii

Expression System: E. coli

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