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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T63105 |
Topotecan hydrochloride hydrate
|
Others | Others |
Topotecan hydrochloride hydrate 是一种口服具有活力的拓扑异构酶 I (Topoisomerase I) 抑制剂,具有抗癌作用。Topotecan hydrochloride hydrate 能够将细胞周期阻滞在 G0/G1 和 S 期,并诱导细胞凋亡。 | |||
T73411 |
PV-1019
NSC 744039 |
Others | Others |
PV-1019 (NSC 744039) 是一种有效的选择性 Chk2抑制剂,IC50值为 24 nM。PV-1019 抑制Topotecan 诱导的Chk2自磷酸化。PV-1019 抑制 IR 诱导的细胞凋亡。 | |||
T71908 |
NU1085
|
Others | Others |
NU1085 is a potent poly(ADP-ribose) polymerase (PARP) inhibitors have been developed that potentiate the cytotoxicity of ionizing radiation and anticancer drugs. The biological effects of NU1085 [Ki = 6 nM], in combination with temozolomide (TM) or topotecan (TP) have been studied in 12 human tumor cell lines (lung, colon, ovary, and breast cancer). Cells were treated with increasing concentrations of TM or TP +/- NU1085 (10 microM) for 72 h. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T5784 |
Topotecan
NSC 609669,拓扑替康,SKF 104864A |
Topoisomerase; Autophagy | Autophagy; DNA Damage/DNA Repair |
Topotecan (NSC-609669) 是一种拓扑异构酶 I 抑制剂,通过抑制 DNA 拓扑异构酶起抗肿瘤作用,可用于治疗卵巢癌。 | |||
T1174 |
Topotecan hydrochloride
SKF 104864A,SKFS 104864A,NSC609699,Nogitecan HCl,NSC 609669,盐酸拓扑替康,Topotecan HCl |
Apoptosis; Topoisomerase; Autophagy | Apoptosis; Autophagy; DNA Damage/DNA Repair |
Topotecan hydrochloride (NSC609699) 是一种具有抗癌活性的拓扑异构酶I 抑制剂。 |