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TMPY-02904
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TLR4 Protein, Human, Recombinant (His)
TLR-4,TOLL,toll-like receptor 4,A...
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Human
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Baculovirus Insect Cells
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TLR4, also known as TLR-4, is a member of the Toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. TLR4 is most abundantly expressed... |
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TMPY-02794
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TLR2 Protein, Human, Recombinant (aa 1-587, His)
TIL4,CD282,toll-like receptor 2
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Human
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Baculovirus Insect Cells
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TLR2 Protein, Human, Recombinant (aa 1-587, His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 65.5 kDa and the accession number is O60603-1. |
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TMPY-03042
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TLR2 Protein, Rat, Recombinant (His)
toll-like receptor 2
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Rat
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Baculovirus Insect Cells
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TLR2 Protein, Rat, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 67.5 kDa and the accession number is Q6YGU2. |
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TMPY-02930
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TLR2 Protein, Mouse, Recombinant (His)
toll-like receptor 2,Ly105
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Mouse
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Baculovirus Insect Cells
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TLR2 Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 64.8 kDa and the accession number is Q9QUN7. |
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TMPY-01396
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TLR3 Protein, Mouse, Recombinant (His)
toll like receptor 3,Tlr3,AI957183
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Mouse
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HEK293 Cells
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TLR3 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 78.7 kDa and the accession number is Q99MB1. |
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TMPH-02937
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TLR11 Protein, Mouse, Recombinant (His & Myc)
Toll-like receptor 11,Toll-li...
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Mouse
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E. coli
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Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. TLR11 Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 25.7 kDa and the accession number is Q6R5P0. |
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TMPH-02211
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TLR7 Protein, Human, Recombinant (His & Myc)
TLR7,Toll-like receptor 7
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Human
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E. coli
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Endosomal receptor that plays a key role in innate and adaptive immunity. Controls host immune response against pathogens through recognition of uridine-containing single strand RNAs (ssRNAs) of viral origin or guanosine analogs. Upon binding to agonists, undergoes dimerization that brings TIR domains from the two molecules into direct contact, leading to the recruitment of TIR-containing downstream adapter MYD88 through homotypic interaction. In turn, the Myddosome signaling complex is formed i... |
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TMPH-02938
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TLR7 Protein, Mouse, Recombinant (His & Myc)
Tlr7,Toll-like receptor 7
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Mouse
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E. coli
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TLR7 Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 43.8 kDa and the accession number is P58681. |
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TMPY-06410
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TLR3 Protein, Human, Recombinant (His)
CD283,IIAE2,toll like receptor 3
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Human
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Baculovirus Insect Cells
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TLR3 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 79.38 kDa and the accession number is Q6PCD4. |
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TMPH-02212
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TLR8 Protein, Human, Recombinant (His)
TLR8,Toll-like receptor 8
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Human
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P. pastoris (Yeast)
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Endosomal receptor that plays a key role in innate and adaptive immunity. Controls host immune response against pathogens through recognition of RNA degradation products specific to microorganisms that are initially processed by RNASET2. Recognizes GU-rich single-stranded RNA (GU-rich RNA) derived from SARS-CoV-2, SARS-CoV-1 and HIV-1 viruses. Upon binding to agonists, undergoes dimerization that brings TIR domains from the two molecules into direct contact, leading to the recruitment of TIR-con... |
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TMPY-04483
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IRAK4 Protein, Human, Recombinant (His)
IPD1,NY-REN-64,REN64,interleukin-1 receptor-associated kinas...
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Human
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Baculovirus Insect Cells
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Interleukin-1 receptor-associated kinase 4, also known as Renal carcinoma antigen NY-REN-64, IRAK-4, and IRAK4, is a member of the protein kinase superfamily, TKL Ser/Thr protein kinase family, and Pelle subfamily. IRAK4 contains one death domain and one protein kinase domain. IRAK4 is required for the efficient recruitment of IRAK1 to the IL-1 receptor complex following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. ... |
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TMPH-02271
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BTK Protein, Human, Recombinant (His)
BPK,AGMX1,ATK,B-cell progenitor kinase,Tyrosine-protein kina...
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Human
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Baculovirus Insect Cells
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Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members. PLCG2 phosphorylation is performed in... |
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TMPJ-01325
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TOLLIP Protein, Human, Recombinant (His)
Toll-Interacting Protein,TOLLIP
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Human
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E. coli
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Toll-Interacting Protein (TOLLIP) is a member of the tollip family. TOLLIP localizes to the cytoplasm. It contains one C2 domain and one CUE domain. TOLLIP is an inhibitory adaptor protein for Toll-like receptors (TLR). The Toll-like receptors pathway is a part of the immune system that recognize structurally conserved molecular patterns of microbial pathogens, resulting in an inflammatory immune response. TOLLIP constitutes a complex with Tom1 to regulate endosomal transferring of ubiquitinated... |
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TMPH-02738
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IRAK3 Protein, Mouse, Recombinant (His & Myc)
Irak3,Inactive IL-1 receptor-associated kinase 3,IL-1 recept...
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Mouse
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Baculovirus Insect Cells
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Putative inactive protein kinase which regulates signaling downstream of immune receptors including IL1R and Toll-like receptors. Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex. Upon IL33-induced lung inflammation, positively regulates expression of IL6, CSF3, CXCL2 and CCL5 mRNAs in dendritic cells. IRAK3 Protein, Mouse, Recombinant (His & Myc) is expressed in ... |
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TMPY-03606
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ECSIT Protein, Human, Recombinant (His)
ECSIT signalling integrator,SITPEC
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Human
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E. coli
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ECSIT is an adapter protein of the toll-like and IL-1 receptor signaling pathway that is involved in the activation of NF-kappa-B via MAP3K1. Activation of NF-kappaB as a consequence of signaling through the Toll and IL-1 receptors is a major element of innate immune responses. ECSIT is specific for the Toll/IL-1 pathways and is a regulator of MEKK-1 processing. It bridges TRAF6 to MEKK-1. Expression of wild-type ECSIT accelerates processing of MEKK-1, whereas a dominant-negative fragment of ECS... |
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TMPK-01177
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CD28 Protein, Canine, Recombinant (mFc)
CD28 molecule,CD28 antigen (Tp44),CD28,MGC138290
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Canine
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HEK293 Cells
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CD28 is the receptor for CD80 (B7-1) and CD86 (B7-2) proteins.When activated by Toll-like receptor ligands, the CD80 expression is upregulated in antigen presenting cells (APCs). The CD86 expression on antigen presenting cells is constitutive. CD28 is the only B7 receptor constitutively expressed on naive T cells. CD28 Protein, Canine, Recombinant (mFc) is expressed in HEK293 mammalian cells with C-mFc tag. The predicted molecular weight is 41.6 kDa and the accession number is Q9GKP3. |
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TMPK-00110
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CD28 Protein, Human/Cynomolgus/Rhesus macaque, Recombinant (His & Avi)
CD28 molecule,MGC138290,CD28,CD28 antigen (Tp44)
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Human,Cynomolgus,Rhesus
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HEK293 Cells
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CD28 is the receptor for CD80 (B7-1) and CD86 (B7-2) proteins.When activated by Toll-like receptor ligands, the CD80 expression is upregulated in antigen presenting cells (APCs). The CD86 expression on antigen presenting cells is constitutive. CD28 is the only B7 receptor constitutively expressed on naive T cells. CD28 Protein, Human/Cynomolgus/Rhesus macaque, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with N-His-Avi tag. The predicted molecular weight is 18.2 kDa and the acc... |
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TMPK-01176
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CD28 Protein, Canine, Recombinant (His)
CD28 antigen (Tp44),MGC138290,CD28,CD28 molecule
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Canine
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HEK293 Cells
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CD28 is the receptor for CD80 (B7-1) and CD86 (B7-2) proteins.When activated by Toll-like receptor ligands, the CD80 expression is upregulated in antigen presenting cells (APCs). The CD86 expression on antigen presenting cells is constitutive. CD28 is the only B7 receptor constitutively expressed on naive T cells. CD28 Protein, Canine, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 16.7 kDa and the accession number is Q9GKP3. |
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TMPJ-00099
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CD28 Protein, Mouse, Recombinant (hFc & His)
T-cell-specific surface glycoprotein CD28,CD28
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Mouse
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HEK293 Cells
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T-cell-specific surface glycoprotein CD28, contains an Ig-like V-type domain. CD28 is one of the proteins expressed on T cells that provide co-stimulatory signals, which are required for their activation. It is the receptor for CD80 and CD86. When activated by Toll-like receptor ligands, the CD80 expression is upregulated in antigen presenting cells (APCs). The CD86 expression on antigen presenting cells is constitutive. CD28 is the only B7 receptor constitutively expressed on naive T cells. It ... |
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TMPK-00111
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CD28 Protein, Human/Cynomolgus/Rhesus macaque, Recombinant (His & Avi), Biotinylated
CD28 antigen (Tp44),CD28 molecule,CD28,MGC138290
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Human,Cynomolgus,Rhesus
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HEK293 Cells
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CD28 is the receptor for CD80 (B7-1) and CD86 (B7-2) proteins.When activated by Toll-like receptor ligands, the CD80 expression is upregulated in antigen presenting cells (APCs). The CD86 expression on antigen presenting cells is constitutive. CD28 is the only B7 receptor constitutively expressed on naive T cells. CD28 Protein, Human/Cynomolgus/Rhesus macaque, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with N-His-Avi tag. The predicted molecular weight is 18.2 k... |
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TMPJ-00789
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Flagellin Protein, Salmonella Typhimurium, Recombinant
flaF,Phase 1-I flagellin,Flagellin,fliC,hag
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Salmonella typhimurium
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E. coli
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Flagellin is the major structural protein monomer of bacterial flagella. Flagellin through binding to its receptor and activation of antigen presenting cells stimulates the innate and adaptive immune responses. Flagellin is used as an effective systemic or mucosal adjuvant to stimulate the immune system. Flagellin is an agonist of Toll-like receptor 5 (TLR5), a pattern recognition receptor (PRR) of the innate immune system expressed on the basolateral surface of intestinal epithelial cells and o... |
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TMPH-02585
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ACOD1 Protein, Mouse, Recombinant (His & Myc)
Cis-aconitate decarboxylase,Cis-aconitic acid decarboxylase,...
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Mouse
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Baculovirus Insect Cells
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Cis-aconitate decarboxylase that catalyzes production of itaconate and is involved in the inhibition of the inflammatory response. Acts as a negative regulator of the Toll-like receptors (TLRs)-mediated inflammatory innate response by stimulating the tumor necrosis factor alpha-induced protein TNFAIP3 expression via reactive oxygen species (ROS) in LPS-tolerized macrophages. Involved in antimicrobial response of innate immune cells; ACOD1-mediated itaconic acid production contributes to the anti... |
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TMPJ-00983
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ARRB1 Protein, Human, Recombinant (His)
Arrestin β-1,β-Arrestin-1,Beta-Arrestin-1,ARR1,ARRB1,Arresti...
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Human
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E. coli
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β-Arrestin-1 (ARRB1) is a cytoplasmic protein that belongs to the arrestin family. ARRB1 is expressed at high levels in peripheral blood leukocytes and the central nervous system. ARRB1 regulates agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. ARRB1 acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. ARRB1 is believed to play a major role in r... |
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TMPJ-00527
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SP-D Protein, Human, Recombinant (His)
Lung Surfactant Protein D,SFTP4,COLEC7,SFTPD,PSP-D,SP-D,Pulm...
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Human
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HEK293 Cells
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Surfactant Pulmonary-Associated Protein D (SP-D) is a 43 kDa member of the collectin family of innate immune modulators. Its principal components consist of a collagen-like region and a C-terminal carbohydrate recognition domain (CRD), a structure that places it in a subset of pattern recognition proteins termed defense collagens. SP-D is constitutively secreted by alveolar lining cells and epithelium associated with tubular structures and induced in cardiac smooth muscle and endothelial cells. ... |
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TMPH-01551
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IFNLR1 Protein, Human, Recombinant (His & SUMO)
Cytokine receptor class-II member 12,Likely interle...
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Human
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E. coli
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The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Determines the cell type specificity of the lambda interferon action. Shows a more restricted pattern of expression in the epithelial tissues thereby limiting responses to lambda interferons primar... |
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TMPJ-00177
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BAFF/TNFSF13B Protein, Human, Recombinant (Avi & hFc), Biotinylated
BAFF,Dendritic cell-derived TNF-like molecule,CD257...
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Human
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HEK293 Cells
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B-cell activating factor (BAFF), also known as BLyS, TALL-1, THANK, and TNFSF13B, is a transmembrane glycoprotein in the TNF ligand superfamily. BAFF is a cytokine and serves as a ligand for receptors TNFRSF13B (TACI), TNFRSF17 (BCMA), and TNFRSF13C (BAFFR). BAFF can promotes the survival, proliferation and maturation of B lymphocytes, which are key elements in the pathogenesis of systemic lupus erythematosus (SLE). This cytokine is encoded on TNFSF13B gene, and diverse single-nucleotide polymor... |
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TMPH-03267
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CD300f/CD300LF Protein, Rat, Recombinant (His & Myc & SUMO)
Clm1,Cd300lf,CD300 antigen-like family member F,CLM...
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Rat
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E. coli
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Acts as an inhibitory receptor for myeloid cells and mast cells. Positively regulates the phagocytosis of apoptotic cells (efferocytosis) via phosphatidylserine (PS) recognition; recognizes and binds PS as a ligand which is expressed on the surface of apoptotic cells. Plays an important role in the maintenance of immune homeostasis, by promoting macrophage-mediated efferocytosis and by inhibiting dendritic cell-mediated efferocytosis. Negatively regulates Fc epsilon receptor-dependent mast cell ... |
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TMPY-03999
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MD2/LY96 Protein, Mouse, Recombinant (hFc)
lymphocyte antigen 96,ESOP-1,MD2,MD-2
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Mouse
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HEK293 Cells
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LY96 (Lymphocyte Antigen 96, also known as ESOP-1) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. This gene encodes a protein that associates with toll-like receptor 4 on the cell surface and confers responsiveness to lipopolysaccharide (LPS), thus providing a link between the receptor and LPS signaling. LY-96 also cooperates with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria. It enhances the TLR4-dependent activa... |
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TMPH-02803
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NRROS Protein, Mouse, Recombinant (His)
Negative regulator of reactive oxygen species,Transforming g...
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Mouse
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E. coli
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Key regulator of transforming growth factor beta-1 (TGFB1) specifically required for microglia function in the nervous system. Required for activation of latent TGF-beta-1 in macrophages and microglia: associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGFB1, and regulates integrin-dependent activation of TGF-beta-1. TGF-beta-1 activation mediated by LRRC33/NRROS is highly localized: there is little spreading of TGF-beta-1 acti... |
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TMPJ-01143
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MERTK/Mer Protein, Human, Recombinant (aa 1-323, His)
MER,Receptor tyrosine kinase MerTK,Tyrosine-protein kinase M...
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Human
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HEK293 Cells
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Tyrosine-protein kinase Mer (MERTK) is a single-pass type I membrane protein which belongs to the MER/AXL/TYRO3 receptor kinase family. MERTK include two fibronectin type-III domains, two Ig-like C2-type domains, and one tyrosine kinase domain. It can’t be expressed in normal B- and T-lymphocytes, but it is usually expressed in numerous neoplastic B- and T-cell lines. MERTK could regulate many physiological processes, such as cell survival, migration, differentiation. It was demonstrated that t... |
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TMPY-01406
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REG3G Protein, Human, Recombinant (His)
UNQ429,PAP-1B,LPPM429,REG-III,regenerating islet-derived 3 γ...
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Human
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HEK293 Cells
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Regenerating gene (Reg), first isolated from a regenerating islet cDNA library, encodes a secretory protein with a growth stimulating effect on pancreatic beta cells. Reg and Reg-related genes which were expressed in various organs have been revealed to constitute a multigene family, the Reg family, which consists of four subtypes (types I, II, III, IV) based on the primary structures of the encoded proteins of the genes, which are associated with tissue repair and have been directly implicated ... |
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TMPH-02873
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RAB10 Protein, Mouse, Recombinant (His & SUMO)
Ras-related protein Rab-10,Rab10
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Mouse
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E. coli
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The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is mainly involved in the biosynthetic transport of proteins from the Golgi to the plasma membrane. Regulates, f... |
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TMPH-02282
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Ubiquilin-1 Protein, Human, Recombinant (His & Myc)
Ubiquilin-1,UBQLN1,Protein linking IAP with cytoskeleton 1
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Human
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E. coli
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Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS), autophagy and endoplasmic reticulum-associated protein degradation (ERAD) pathway. Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome. Plays a role in the ERAD pathway via its in... |
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TMPY-01816
|
Pentraxin 3 Protein, Human, Recombinant (His)
TNFAIP5,pentraxin 3,PTX3,TSG-14
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Human
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HEK293 Cells
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Pentraxin-related protein PTX3, also known as Tumor necrosis factor alpha-induced protein 5, Tumor necrosis factor-inducible gene 14 protein, TSG-14, PTX3 and TNFAIP5, is a secreted protein that contains one pentaxin domain. PTX3 plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility. Pentraxins are a family of evolutionarily conserved multifunctional pattern-recognition proteins characterized by a cycl... |
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