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Search Results for " tofacitinib "

Targets Recommended: ROCK Apoptosis JAK Src

12

抑制剂 & 化合物

1

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T6321	Tofacitinib 托法替尼,Tasocitinib,CP-690550	ROCK; Apoptosis; JAK; Src	Angiogenesis; Apoptosis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors
	Tofacitinib (Tasocitinib) 是口服小分子 Janus 激酶抑制剂，用于治疗中度至重度类风湿性关节炎。
T2398	Tofacitinib Citrate CP-690550 citrate,柠檬酸托法替尼,枸橼酸托法替尼,Tasocitinib citrate,Tofacitinib (CP-690550) Citrate	Apoptosis; Influenza Virus; JAK; Antibacterial; Antifungal	Angiogenesis; Apoptosis; Chromatin/Epigenetic; JAK/STAT signaling; Microbiology/Virology; Stem Cells
	Tofacitinib Citrate (CP-690550 citrate) 是 JAK1/2/3抑制剂，IC50分别为112，20 和 1 nM。它具有抗菌，抗真菌和抗病毒活性。
T70168	Tofacitinib HCl	Others	Others
	Tofacitinib HCl, also known as tasocitinib, CP-690550, is a Janus kinase (JAK) inhibitor. Tofacitinib HCl modulates the signaling pathway at the point of JAKs, preventing the phosphorylation and activation of STATs. JAK enzymes transmit cytokine signaling through pairing of JAKs (e.g., JAK1/JAK3, JAK1/JAK2, JAK1/TyK2, JAK2/JAK2). Tofacitinib HCl inhibited the in vitro activities of JAK1/JAK2, JAK1/JAK3, and JAK2/JAK2 combinations with IC50 of 406, 56, and 1377 nM, respectively.
T37638	Tofacitinib metabolite-1	Others	Others
	Tofacitinib metabolite-1, a derivative of Tofacitinib, which is a JAK inhibitor, is employed in studies focused on the pharmacokinetics and metabolism of tofacitinib[1][2].
T13426	(3R,4S)-Tofacitinib	Others	Others
	(3R,4S)-Tofacitinib is an less active enantiomer of Tofacitinib. Tofacitinib is a JAK3 inhibitor(IC50 : 1 nM).
T13426L	(3S,4S)-Tofacitinib (3S,4S)-托法替尼	Others	Others
	(3S,4S)-Tofacitinib, a less active enantiomer of tofacitinib, is a Janus kinases inhibitor.
T69958	Tofacitinib maleate	Others	Others
	Tofacitinib maleate, also known as tasocitinib, CP-690550, is a Janus kinase (JAK) inhibitor. Tofacitinib maleate modulates the signaling pathway at the point of JAKs, preventing the phosphorylation and activation of STATs. JAK enzymes transmit cytokine signaling through pairing of JAKs (e.g., JAK1/JAK3, JAK1/JAK2, JAK1/TyK2, JAK2/JAK2). Tofacitinib maleate inhibited the in vitro activities of JAK1/JAK2, JAK1/JAK3, and JAK2/JAK2 combinations with IC50 of 406, 56, and 1377 nM, respectively.
T13427	(3S,4R)-Tofacitinib	Others	Others
	(3S,4R)-Tofacitinib is an less active enantiomer of Tofacitinib. Tofacitinib is a JAK3 inhibitor(IC50 : 1 nM).
T72406	Tofacitinib Prodrug-1	Others	Others
	Tofacitinib Prodrug-1 是减轻托法替尼 (Tofacitinib) 全身性不良反应的口服有效前药。Tofacitinib Prodrug-1 能在小鼠模型有效减轻恶唑酮诱导的结肠炎，具有低毒性，是治疗溃疡性结肠炎的潜在候选药物。
T31074	CP-690550A Tofacitinib metabolite M2,CP-690,550A,UNII-Q7ZOK859UK	Others	Others
	Cp-690550a is a novel JAK3 inhibitor, which is used to treat rheumatoid arthritis, graft rejection, psoriasis, and other immune-mediated diseases.
T69957	Quoromycin	Others	Others
	Quoromycin is a novel antivirulence agent against Vibrio vulnificus, inhibiting the quorum-sensing signaling pathway by controlling the DNA-binding affinity of SmcR and thus effectively alleviating the virulence of V. vulnificus in vitro and in vivo.
T70167	BP-5-087	Others	Others
	BP-5-087 is a STAT3 inhibitor, combining with BCR-ABL1 inhibition to overcome kinase-independent resistance in chronic myeloid leukemia.

化合物

Cat.No: T6321

Synonym: 托法替尼,Tasocitinib,CP-690550

Target: ROCK, Apoptosis, JAK, Src

Tofacitinib Citrate

Cat.No: T2398

Synonym: CP-690550 citrate,柠檬酸托法替尼,枸橼酸托法替尼,Tasocitinib citrate,Tofacitinib (CP-690550) Citrate

Target: Apoptosis, Influenza Virus, JAK, Antibacterial, Antifungal

Tofacitinib HCl

Cat.No: T70168

Target: Others

Tofacitinib metabolite-1

Cat.No: T37638

Target: Others

(3R,4S)-Tofacitinib

Cat.No: T13426

Target: Others

(3S,4S)-Tofacitinib

Cat.No: T13426L

Synonym: (3S,4S)-托法替尼

Target: Others

Tofacitinib maleate

Cat.No: T69958

Target: Others

(3S,4R)-Tofacitinib

Cat.No: T13427

Target: Others

Tofacitinib Prodrug-1

Cat.No: T72406

Target: Others

Cat.No: T31074

Synonym: Tofacitinib metabolite M2,CP-690,550A,UNII-Q7ZOK859UK

Target: Others

Cat.No: T69957

Target: Others

Cat.No: T70167

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
TMIJ-0137	Tofacitinib-d3 Citrate
	Tofacitinib-d3 Citrate 是 Tofacitinib Citrate 的氘代化合物。Tofacitinib Citrate 的 CAS 号为 540737-29-9。Tofacitinib citrate是JAK1/2/3抑制剂，IC50分别为112，20 和 1 nM。它具有抗菌，抗真菌和抗病毒活性。

同位素标记化合物

Tofacitinib-d3 Citrate

Cat.No: TMIJ-0137

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