259
100
3
38
6
Cat. No. | Product Name | ||
---|---|---|---|
L4700 | 免疫/炎症分子化合物库 | 4720 compounds | |
4720 种具有抗炎症活性的化合物的特有集合,可用于高通量筛选和高内涵筛选; | |||
L3800 | NF-κB 通路分子库 | 729 compounds | |
729 个 NF-κB 信号通路相关的小分子化合物的特有集合,用于高通量、高内涵筛选; | |||
L9840 | 抗阿尔茨海默症化合物库 | 986 compounds | |
986 种阿尔茨海默症相关的化合物集合,可用于高通量和高内涵筛选; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T77494 |
TNF-α-IN-9
|
TNF | Apoptosis |
TNF-α-IN-9 是一种 NDM-1 inhibitor-3类似物,是一种 TNF-α 抑制剂。TNF-α-IN-9 显示低抑制活性。 | |||
T19584L |
TNF-α (31-45), human acetate
TNF-α (31-45), human acetate(144796-71-4 free base) |
Others | Others |
TNF-α (31-45), human acetate(144796-71-4 free base) 是一种肿瘤坏死因子-α 的肽。 | |||
T36127 |
TNF-α Antagonist
|
||
TNF-α antagonist is an exocyclic peptide that mimics the critical TNF-α recognition loop on TNF receptor I complex and, thus, prevents ligand interaction with the receptor. By blocking the TNF receptor ligand contact site, this peptide interferes with both activating receptor activator of NF-κB (RANK) and TNF-α's recruitment and activation of osteoclasts. TNF-α antagonist has been used to block bone resorption in the study of systemic bone loss in rheumatoid arthritis and inflammatory bone destr... | |||
T40321 |
TNF-α-IN-6
|
Others | Others |
TNF-α-IN-6 is an orally efficacious allosteric inhibitor of TNFα ( K D = 6.8 nM). | |||
T36097 |
TNF-α-IN-2
|
Others | Others |
TNF-α-IN-2 is a highly potent and orally bioavailable inhibitor of tumor necrosis factor alpha (TNFα), exhibiting an IC50 of 25 nM in the HTRF assay. It exerts its inhibitory effects by inducing conformational changes in the TNFα trimer upon binding, resulting in disrupted signaling when the trimer interacts with TNFR1. TNF-α-IN-2 holds promise as a valuable tool for investigating the pathogenesis of rheumatoid arthritis[1]. | |||
T13175 |
TNF-α-IN-1
|
TNF | Apoptosis |
TNF-α-IN-1是 TNF-α 抑制剂。 | |||
T4637 |
R-7050
TNF-α Antagonist III |
TNF | Apoptosis |
R-7050 (TNF-α Antagonist III) 是一种肿瘤坏死因子受体拮抗剂,对 TNFα具有更高选择性。 | |||
TP1537 |
TNF-α (10-36), human
|
||
TNF-α (10-36), human is a potent pro-inflammatory cytokine involved in the acute phase stress response. | |||
T19584 |
TNF-α (31-45), human
|
Others | Others |
TNF-α (31-45), human is a peptide of tumor necrosis factor-α. | |||
TP1626 |
TNF-α (46-65), human
|
||
Human TNF alpha (46-65) peptide. | |||
TP1479 |
TNF-α (10-36), human (TFA) (144796-70-3 free base)
TNF-α (10-36), human (TFA) |
||
TNF-α (10-36), human (TFA) is a peptide of human TNF-α. | |||
TP1669 |
TNF-α (46-65), human TFA (144796-72-5 free base)
TNF-α (46-65), human TFA |
||
TNF-α (46-65), human (TFA) is a peptide of human TNF-α. | |||
TP1636 |
TNF-α (31-45), human TFA (144796-71-4 free base)
TNF-α (31-45), human TFA |
||
TNF-α (31-45), human (TFA) is a peptide of tumor necrosis factor-α. | |||
T8692 |
(Rac)-Benpyrine
|
TNF | Apoptosis |
(Rac)-Benpyrine 是一种有效且具有口服活性的 TNF-α 抑制剂,是Benpyrine 的外消旋体。它可研究TNF-α介导的炎症和自身免疫性疾病。 | |||
T7495 |
Hexa-D-arginine
|
Others | Others |
Hexa-D-arginine 是稳定的furin 抑制剂,能够作用于 furin (Ki:106 nM)、PACE4 (Ki:580 nM)、PC1 (Ki:13.2 nM)。它在体外和体内均可阻断假单胞菌外毒素 A 和炭疽毒素的毒性。 | |||
T8477 |
IQ-3
|
JNK | MAPK |
IQ3 是c-JNK 家族选择性抑制剂,对JNK3 的选择性更好。它对JNK1、JNK2 和 JNK3 的Kd 值分别为0.24 μM、0.29 μM 和 0.066 μM。 | |||
T2343 |
AS601245
|
JNK | MAPK |
AS601245 是 c-Jun NH2-末端激酶 (JNK) 的抑制剂,具有神经保护特性。 | |||
T40423 |
L48H37
|
Others | Others |
L48H37是Curcumin的一个化学稳定类似物。它对髓系分化蛋白2 (MD2) 表现出强效的抑制性质,作为一个特异性抑制剂。其机制包括抑制LPS-TLR4/MD2的相互作用和信号传导。L48H37主要用于脓血症和肺损伤研究[1]。 | |||
T8727 |
TH1020
|
TLR; Antibacterial | Immunology/Inflammation; Microbiology/Virology |
TH1020 是一种选择性 Toll 样受体 5 /鞭毛蛋白复合拮抗剂,IC50为 0.85 μM。它抑制鞭毛蛋白诱导的TLR5信号传导。 | |||
T13018 |
SU3327
halicin |
JNK | MAPK |
SU3327 (halicin) 是具有底物竞争性的 JNK 选择性抑制剂,IC50为 0.7 μM。它还抑制 JNK 和 JIP 之间的蛋白相互作用,IC50值为 239 nM。 | |||
T8798 |
MSA-2
|
STING | Immunology/Inflammation |
MSA-2 是可口服的非核苷酸 STING 激动剂,以具有纳摩尔亲和力的非共价二聚体形式与 STING 结合。它在同基因小鼠肿瘤模型中显示抗肿瘤活性,与抗 PD-1 协同作用,可刺激肿瘤分泌干扰素-β,诱导肿瘤消退,具有持久的抗肿瘤免疫。 | |||
T83628 |
TNF/IFNγ-IN-1
|
Antioxidant; TNF; COX | Apoptosis; Immunology/Inflammation; Neuroscience; oxidation-reduction |
TNF/IFNγ-IN-1(TGA) 是 TNF 和 IFN-γ 的双重抑制剂。TNF/IFNγ-IN-1 具有潜在的抗氧化和抗炎活性,可用于类似阿尔茨海默等的神经退行性疾病。 | |||
T79025 |
TNF-α-IN-10
|
Others | Others |
TNF-α-IN-10 (compound 8a) 作为IL-6与TNF-α的抑制剂,表现出抗炎活性。 | |||
T22115 |
SM-7368
|
NF-κB | NF-κB |
NF-κB Activation Inhibitor III 是一种NF-kB 抑制剂,抑制 TNF-α 诱导的MMP-9上调,靶向抑制下游的MAPK p38,可用于靶向 TNF-α 介导的肿瘤侵袭和转移的化疗研究。 | |||
T4328 |
OSS_128167
SIRT6-IN-1 |
HBV; Sirtuin | Chromatin/Epigenetic; DNA Damage/DNA Repair; Microbiology/Virology |
OSS_128167 (SIRT6-IN-1) 是一种选择性沉默调节蛋白 6 (SIRT6) 抑制剂,对 SIRT6,SIRT1 和 SIRT2 的 IC50分别为 89 μM,1578 μM 和 751 μM。它具有抗 HBV、抗癌、抗炎和抗病毒活性,可抑制 HBV 的转录和复制。 | |||
T13324 |
VUF11207 fumarate
|
CXCR; Arrestin | Autophagy; GPCR/G Protein; Immunology/Inflammation |
VUF11207 fumarate 是一种 CXCR7激动剂和高效CXCR7配体,pKi 为 8.1。它可诱导CXCR7的β-arrestin2募集和随后的内在化,pEC50分别为 8.8 和 7.9。 | |||
T3185 |
R112
|
Syk | Angiogenesis; Tyrosine Kinase/Adaptors |
R112 是 ATP 竞争性的 Syk 激酶抑制剂,它能够抑制 Syk 激酶活性,Ki=6 nM,IC50=226 nM。 | |||
T6150 |
TAK-715
|
p38 MAPK; Casein Kinase; JNK | MAPK; Metabolism; Stem Cells |
TAK-715 是一种具有口服活性的p38 MAPK 抑制剂,对 p38α 和 p38β 的IC50分别为 7.1 nM 和200 nM。它抑制酪蛋白激酶 I (CK1δ/ε),调节 Wnt/β-catenin 信号传导的激活,有抗炎活性。 | |||
T80973 |
TNF-α-IN-8
|
Others | Others |
TNF-α-IN-8 (compound I-42) 作为一种TNF-α抑制剂,属于异吲哚-亚胺类化合物,适用于肿瘤、心脏病、骨质疏松、炎症、过敏及自身免疫性疾病的研究。作为点击化学试剂,其Azide基团能与含Alkyne的分子配对,通过铜催化的叠氮-炔环加成反应(CuAAc)产生反应,也可与含DBCO或BCN基团的分子进行菌株促进的炔-叠氮环加成反应(SPAAC)。 | |||
T78730 |
TNF-α-IN-11
|
Others | Others |
TNF-α-IN-11 (Compound 10)是一种TNF-α抑制剂, KD值为12.06 μM。该化合物通过结合TNF-α并阻断其诱发的caspase和NF-κB信号通路激活,来实现其抑制作用。其具体机制包括抑制IκBα磷酸化和NF κB p65的核转位,适用于研究TNF-α介导的自身免疫性疾病。 | |||
T1781 |
GW9508
GW 9508 |
GPR; Potassium Channel | Endocrinology/Hormones; GPCR/G Protein; Membrane transporter/Ion channel |
GW 9508 是一种选择性 G 蛋白偶联受体FFA1(GPR40) 和GPR120激动剂。它是一种葡萄糖敏感性胰岛素促分泌剂和 ATP 敏感性钾通道开放剂,具有抗炎和抗动脉粥样硬化活性。 | |||
T22698 |
TLR3-IN-1
CU CPT 4a |
TLR | Immunology/Inflammation |
TLR3-IN-1 (CU CPT 4a) 是一种选择性的TLR3信号抑制剂,在 RAW 264.7 细胞中 IC50 为 3.44 μM。它可以抑制 TLR3/dsRNA 复合物介导的下游信号通路,并抑制全细胞中 TNF-α 和 IL-1β 的产生。 | |||
T6927 |
Pamapimod
R1503,帕吡莫德,Ro4402257 |
p38 MAPK; Autophagy | Autophagy; MAPK |
Pamapimod (R1503) 是一种新型的选择性 p38 丝裂原活化蛋白激酶抑制剂,对于p38α和p38β的IC50分别为 14 nM 和 480 nM,Ki 分别为 1.3 nM 和 120 nM,对 p38δ 或 p38γ 亚型没有活性,可研究类风湿关节炎和其他自身免疫性疾病。 | |||
T6950 |
PNU-120596
NSC 216666 |
AChR | Neuroscience |
PNU-120596 (NSC-216666) 是一种选择性α7 nAChR 阳性变构调节剂,EC50为 216 nM,可用于精神病和神经疾病的研究。 | |||
T77778 |
KP-457
TNF‐α‐converting enzyme |
Others | Others |
KP-457(TNF-α-转化酶)为ADAM17的选择性抑制剂,无细胞试验中IC50值为11.1 nM/L。该化合物亦能裁剪多种分子,包括GPIbα、GPV及TNF-α。 | |||
T76026 |
TNF-α (31-45), human TFA
|
||
TNF-α (31-45), human TFA 是人肿瘤坏死因子-α 的多肽片段。TNF α 是一种炎性细胞因子,可诱导坏死或凋亡。 | |||
T8505 |
SC-236
4-(5-(4-氯苯基)-3-(三氟甲基)-1H-,Sc 236 |
Apoptosis; COX; PPAR | Apoptosis; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; Neuroscience |
SC-236 (Sc 236) 是一种具有口服活性的COX-2特异性抑制剂和PPARγ激动剂。它可通过 c-Jun 氨基端抑制激活蛋白-1活性,在小鼠模型中通过抑制 ERK 的磷酸化发挥抗炎作用。 | |||
T4403 |
AX-024 hydrochloride
AX-024 HCl |
IL Receptor; TNF; COX; IFNAR; Interleukin | Apoptosis; Immunology/Inflammation; Neuroscience |
AX-024 hydrochloride (AX-024 HCl) 是一种细胞因子释放抑制剂,可强烈抑制 IL-6、TNFα、IFN-γ、IL-10 和 IL-17A 的产生。它是口服可利用的 TCR-Nck 相互作用抑制剂,可选择性地抑制 TCR 触发的 T 细胞活化。它通过靶向 SH3结构域调节细胞信号传导,具有低毒、高效和高选择性的特点。 | |||
T2036 |
6-OAU
GTPL5846 |
GPR | Endocrinology/Hormones; GPCR/G Protein |
6-OAU (GTPL5846) 是 GPR84 的替代激动剂,在 Gqi5 嵌合体存在的情况下,在 HEK293 细胞中激活人 GPR84,在 PI 测定中 EC50 为 105 nM。 | |||
T27695 |
JTE-607
JTE-607 dihydrochloride,JTE-607 HCl,甲氧番荔枝碱 |
Cysteine Protease | Proteases/Proteasome |
JTE-607 HCl 是高选择性的炎性细胞因子合成抑制剂,可保护小鼠免受内毒素休克。它作用于 LPS 刺激的人 PBMC,抑制TNF-α(IC50:11 nM)、IL-1β(IC50:5.9 nM)、IL-6(IC50:8.8 nM)、IL-8(IC50:7.3 nM)和IL-10(IC50:9.1 nM)。 | |||
T3147 |
Pyrrolidinedithiocarbamate ammonium
PDTC,Pyrrolidinedithiocarbamate,吡咯烷二硫代氨基甲酸铵,APDC,1-Pyrrolidinedithiocarboxylic acid ammonium salt,Ammonium pyrrolidinedithiocarbamate,吡咯烷二硫代甲酸铵 |
NF-κB | NF-κB |
Pyrrolidinedithiocarbamate ammonium (1-Pyrrolidinedithiocarboxylic acid ammonium salt) 是一种选择性的、能透过血脑屏障的NF-κB 抑制剂。 | |||
T6823 |
E3330
|
HIF/HIF Prolyl-Hydroxylase; DNA/RNA Synthesis | Cell Cycle/Checkpoint; Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism |
E3330 是一种口服有效的选择性 AP 内切核酸酶 1 (APE1; REF-1) 抑制剂,可抑制NF-κB DNA 结合活性。它阻断 TNF-α 诱导的肝癌细胞系中 IL-8 的激活,可以抑制癌细胞的生长和迁移,具有抗癌活性。 | |||
T4543 |
Telithromycin
HMR3647,泰利霉素,Ketek,RU66647 |
Antibacterial; Antibiotic | Microbiology/Virology |
Telithromycin (HMR3647) 是一种社区获得性肺炎抗生素。 | |||
T78272 |
Anti-Mouse TNF alpha Antibody (TN3-19.12)
|
||
Anti-Mouse TNF alpha Antibody为Rat宿主源的IgG类针对小鼠TNF alpha的抗体抑制剂。 | |||
T78434 |
Mca-(endo-1a-Dap(Dnp))-TNF-Alpha (-5 to +6) amide (human) TFA
|
||
Mca-(endo-1a-Dap(Dnp))-TNF-Alpha (-5 to +6) amide (human) TFA 为基于荧光共振能量转移的多肽底物,通过裂解引起的荧光强度变化来确定其活性。 | |||
T81838 |
Mca-(endo-1a-Dap(Dnp))-TNF-Alpha (-5 to +6) amide (human)
|
||
Mca-(endo-1a-Dap(Dnp))-TNF-Alpha (-5 to +6) amide (human) 为一种基于FRET (荧光共振能量转移) 原理的多肽底物,通过其裂解引起的荧光强度变化来评估其活性。 | |||
T6204 |
QNZ
CAY10470,EVP4593 |
TNF; NF-κB | Apoptosis; NF-κB |
QNZ (EVP4593) 是 NF-κB 活化和 TNF-α 产生的一种有效抑制剂。 QNZ 对 NF-κB 和 TNF-α 的 IC50 分别为 11 nM 和 7 nM。 | |||
T14848 |
C 87
|
Others; TNF | Apoptosis; Others |
C 87 是一种小分子 TNF-α 抑制剂。 C 87 直接与 TNFα 结合,有效抑制 TNF-α 诱导的细胞毒性 (IC50 = 8.73 μM),并有效阻断 TNF-α 触发的信号传导活动。 | |||
T12985 |
SPD304 dihydrochloride
|
TNF | Apoptosis |
SPD304 dihydrochloride 是 TNF-α 的特异性抑制剂,IC50 为 22 µM。 SPD304 dihydrochloride 促进 TNF 三聚体的解离。 | |||
T10730 |
CDC801
CDC-801 |
TNF; PDE | Apoptosis; Metabolism |
CDC801 是一种 PDE4 和 TNF-α 抑制剂,IC50 分别为 1.1 μM 和 2.5 μM。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T6S1572 |
Sauchinone
|
ERK; p38 MAPK; NF-κB | MAPK; NF-κB |
Sauchinone 是一种从Saururus chinensis 中获得的非对映异构的木脂素。它通过抑制I-κBα磷酸化和p65核易位来抑制 LPS 诱导的 iNOS,TNF-α 和 COX-2 表达。它具有抗炎和抗氧化活性。 | |||
T15686 |
L-741626
3-(4-(4-Chlorophenyl-4-hydroxypiperidino)methyl)indole |
Dopamine Receptor | GPCR/G Protein; Neuroscience |
L-741626 (3-(4-(4-Chlorophenyl-4-hydroxypiperidino)methyl)indole) 是D2多巴胺受体选择性拮抗剂,对人 D2、D3 和 D4 受体的Ki 分别为 2.4、100 和 220 nM。 | |||
T2893 |
Muscone
3-Methylcyclopentadecanone,Methylexaltone,麝香酮 |
MMP; TNF; NF-κB; NOD-like Receptor (NLR); P-gp; Interleukin | Apoptosis; Immunology/Inflammation; Membrane transporter/Ion channel; Neuroscience; NF-κB; Proteases/Proteasome |
Muscone (3-Methylcyclopentadecanone) 是中药麝香的一种主要活性单体。它抑制NF-κB 和NLRP3炎性小体的活化,显著降低炎性细胞因子水平,并最终改善心脏功能和存活率。 | |||
TN2130 |
Manghaslin
槲皮素-3-O-芸香糖-(1→2)-O-鼠李糖苷,Quercetin 3-O-rutinoside-(1->2)-O-rhamnoside |
AChE; Glucosidase | Metabolism; Neuroscience |
Manghaslin (Quercetin 3-O-rutinoside-(1->2)-O-rhamnoside) 是具有抗炎活性的黄酮苷,对 AChE 具有抑制活性,IC50=94.92 µM。 | |||
T2P2870 |
Damascenone
trans-damascenone,Beta-Damascenone,大马烯酮,大马酮 |
Others; NF-κB; Endogenous Metabolite | Metabolism; NF-κB; Others |
Damascenone 是一种 E-和 Z-异构体大马士革酮的混合物,源于Epipremnum pinnatum的具有抗炎特性的特性化合物。 | |||
T2A2481 |
Taurochenodeoxycholic Acid
Chenodeoxycholyltaurine,TCDCA,Chenyltaurine,Taurochenodeoxycholate,12-Deoxycholyltaurine,牛磺鹅去氧胆酸 |
Apoptosis; TNF; Caspase; Endogenous Metabolite | Apoptosis; Metabolism; Proteases/Proteasome |
Taurochenodeoxycholic Acid (12-Deoxycholyltaurine) 是动物胆汁酸的主要生物活性物质之一,可诱导细胞凋亡,具有明显的抗炎和免疫调节作用。 | |||
TN2215 |
Taurochenodeoxycholic acid sodium
牛磺鹅去氧胆酸钠盐,Sodium taurochenodeoxycholate,牛磺鹅去氧胆酸钠 |
Apoptosis; Endogenous Metabolite | Apoptosis; Metabolism |
Taurochenodeoxycholic acid sodium (Sodium taurochenodeoxycholate) 是动物胆汁酸的主要生物活性物质之一。它可诱导细胞凋亡,具有抗炎和免疫调节作用。 | |||
T13808 |
p-Coumaric Acid Ethyl Ester
对香豆酸乙酯,Ethyl (E)-p-hydroxycinnamate,Ethyl trans-4-hydroxycinnamate |
Others; Drug Metabolite | Metabolism; Others |
p-Coumaric Acid Ethyl Ester (Ethyl (E)-p-hydroxycinnamate) 是 p-Coumaric acid 的乙酯形式。p-Coumaric Acid 是一种免疫抑制剂, 能够用于自身免疫性炎性疾病 (如类风湿关节炎) 的研究。 | |||
TCS2170 |
2,5-Dihydroxyacetophenone
Quinacetophenone,2-Acetylhydroquinone,2-5-dihydroxyacetophenone,2 ',5'-二羟基苯乙酮,Acetylhydroquinone,2,5-二羟基苯乙酮,DHAP |
ERK; NF-κB; Tyrosinase | MAPK; NF-κB; Proteases/Proteasome |
2,5-Dihydroxyacetophenone (Quinacetophenone) 是从熟地黄中分离出的一种天然产物,通过阻断 ERK1/2和 NF-κB 信号通路,抑制活化巨噬细胞中炎症介质的产生。 | |||
T5779 |
MOSLOFLAVONE
|
IL Receptor; Virus Protease; TNF; Antibacterial | Apoptosis; Immunology/Inflammation; Microbiology/Virology |
Mosloflavone 从Scutellaria baicalensis Georgi 中分离出的类黄酮,具有抗EV71活性。它可抑制铜绿假单胞菌的毒力和生物膜形成,有作为杀菌剂的潜力。它在病毒感染的初始阶段抑制 VP2 病毒复制和蛋白质表达,并抑制病毒 VP2 衣壳蛋白合成。 | |||
TN2539 |
1beta-Hydroxyalantolactone
|
IL Receptor; TNF | Apoptosis; Immunology/Inflammation |
1beta-Hydroxyalantolactone 是从药用植物大英花的花头中分离出的小分子化合物,可抑制细胞中TNF-α、IL-17、IFN-γ的表达,促进TNF-α、IFN-γ、IL-17的分泌,可防治类风湿性关节炎。 | |||
TN1520 |
Isoforskolin
Coleonol B |
IL Receptor; TNF | Apoptosis; Immunology/Inflammation |
Isoforskolin 源自毛喉鞘蕊花,可减少人单核白细胞中 TNF-α、IL-1β、IL-6 和 IL-8 的分泌。Isoforskolin 可用于治疗莱姆关节炎的研究。 | |||
T8288 |
14-Deoxyandrographolide
去氧穿心莲内酯,14-去氧穿心莲内酯 |
Apoptosis; Others | Apoptosis; Others |
14-Deoxyandrographolide 是穿心莲中的一种天然产物,是一种钙通道阻断剂,具有保肝功效。它通过诱导 TNFRSF1A 的释放,使肝细胞对 TNF-α 介导的凋亡脱敏。 | |||
TQ0218 |
Deoxyandrographolide
去氧穿心莲内酯,14-deoxyandrographolide |
IL Receptor; TNF | Apoptosis; Immunology/Inflammation |
Deoxyandrographolide (14-deoxyandrographolide) 抑制 LPS 诱导的 iNOS mRNA 水平升高以及促炎症介质 TNF-α 和 IL-6 的产生。它增强 NGF 诱导的神经突起生长。 | |||
T3889 |
Platycodin D
|
Prostaglandin Receptor; AMPK | Chromatin/Epigenetic; GPCR/G Protein; Immunology/Inflammation; PI3K/Akt/mTOR signaling |
Platycodin D 是从桔梗中分离得到的一种皂苷类天然产物,是AMPKα的激活剂,具有抗肥胖活性。它可刺激 TNF-α 合成或抑制 TNF-α mRNA 的降解。 | |||
T2720 |
Ginsenoside Rc
Panaxoside Rc,人参皂苷Rc,人参皂苷 Rc |
Others; TNF; GABA Receptor; Interleukin | Apoptosis; Immunology/Inflammation; Membrane transporter/Ion channel; Neuroscience; Others |
Ginsenoside Rc (Panaxoside Rc) 是人参中的一种人参皂苷,可抑制 TNF-α 和 IL-1β 的表达。它增强 GABA 受体 A 介导的离子通道电流。 | |||
TN1511 |
Cleomiscosin A
|
LDL; Antioxidant; TNF | Apoptosis; Metabolism; oxidation-reduction |
Cleomiscosin A 来源于 Acer okamotoanum 的叶和树枝,对小鼠腹腔巨噬细胞的 TNF-α 分泌具有抑制活性。 Cleomiscosin A 可用于预防动脉粥样硬化病变中 LDL 氧化的研究。 | |||
TN1507 |
Clematichinenoside AR
|
TNF; Autophagy | Apoptosis; Autophagy |
Clematichinenoside AR 是从中药威灵仙中提取的一种天然产物,具有抗炎和免疫抑制特性,对 PI3K/Akt 信号通路和与胶原诱导的关节炎相关的 TNF-α± 具有抗关节炎作用。 | |||
TC0036 |
Compound Lup-20(29)-en-3-yl acetate
|
IL Receptor; VEGFR; Others; TNF; COX | Angiogenesis; Apoptosis; Immunology/Inflammation; Neuroscience; Others; Tyrosine Kinase/Adaptors |
Lup-20(29)-en-3-yl acetate 是 Lupeol 的衍生物,通过下调 TNF-α、IL-1β、MCP-1、COX-2、VEGF 和颗粒酶 B 来抑制类风湿性关节炎的进展。 | |||
T13864 |
Resolvin D1
RvD1 |
Apoptosis | Apoptosis |
Resolvin D1 (RvD1) 是一种内源性促进炎症消解介质,可通过调节肌动蛋白聚合阻断促进炎症的中性粒细胞迁移,减少 TNF-α 介导的炎症在巨噬细胞中的作用,并增强巨噬细胞对凋亡细胞的吞噬作用。 | |||
T0131 |
Cepharanthine
NSC-623442,千金藤碱,千金藤素 |
Apoptosis; TNF; HIV Protease; Autophagy | Apoptosis; Autophagy; Microbiology/Virology; Proteases/Proteasome |
Cepharanthine (NSC-623442) 是从Stephania cepharanthaHayata 中提取的一种生物碱,具有抗炎、抗氧化作用。它可抑制肿瘤坏死因子 (TNF)-α 介导的 NFκB 刺激、质膜脂质过氧化和血小板聚集,并抑制细胞因子的产生。 | |||
TN1848 |
Kuwanon E
|
IL Receptor; TNF | Apoptosis; Immunology/Inflammation |
Kuwanon E 是从桑树中提取得到的黄酮类化合物,具有潜在的抗炎活性,抑制TNF-α 和 IL-1β 分泌,抑制 LPS 刺激的巨噬细胞中 NF-κB 核易位。 | |||
TN2461 |
Loganic acid 6′-O-β-D-glucoside
8-Epi-Loganic acid-6'-O-β-D-glucoside |
Others | Others |
Loganic acid 6′-O-β-D-glucoside (8-Epi-Loganic acid-6'-O-β-D-glucoside) 是 Cistanche deserticola 的天然产物,可抑制 LPS 诱导的 NO 和 TNF-α 的产生。 | |||
T3887 |
Rosarin
|
Others | Others |
Rosarin 是从玫瑰红景天中分离出来的肉桂醇糖苷。它抑制小鼠肾脏和大脑前额皮层中促炎因子 iNOS,IL-1β 和 TNF-α 的表达。它具有抗炎和神经保护作用。 | |||
TN6967 |
(R)-Isomucronulatol
(-)-Isomucronulatol,2H-1-Benzopyran-7-ol |
Apoptosis | Apoptosis |
(R)-Isomucronulatol (2H-1-Benzopyran-7-ol) 是一种可从黄芪、刺槐、虎杖和甘草叶片中提取得到的类黄酮,抑制BMSCs 在TNF-α微环境中的增殖和凋亡。(R)-Isomucronulatol 具有潜在的抗炎活性。 | |||
T5785 |
MALTOTETRAOSE
Fujioligo 450,Amylotetraose,α-1,4-Tetraglucose,麦芽四糖 |
TNF; Endogenous Metabolite | Apoptosis; Metabolism |
Maltotetraose (Fujioligo 450) 能够作为生物流体中酶联测定淀粉酶特性的底物。 | |||
T2S0843 |
Negletein
黄芩素-7-甲醚,7-O-Methylbaicalein,Baicalein-7-methylether |
IL Receptor; TNF; NOS; Interleukin | Apoptosis; Immunology/Inflammation |
Negletein (7-O-Methylbaicalein) 一种神经保护剂,可增强神经生长因子的作用并诱导 PC12 细胞中的神经突生长。它通过抑制TNF-α和IL-1β表现出抗炎活性,其 IC50值分别为 16.4 和 10.8 μM。它还具有抗菌、抗缺氧和抗阿尔茨海默病活性。 | |||
T5754 |
Kavain
|
NF-κB; GABA Receptor | Membrane transporter/Ion channel; Neuroscience; NF-κB |
Kavain 是从卡瓦胡椒中分离出来的卡瓦酸内酯,可以正向调控GABAA 受体,具有抗焦虑作用。 | |||
T3000 |
Magnolol
NSC 293099,厚朴酚,5,5'-Diallyl-2,2'-biphenyldiol |
NF-κB; Retinoid Receptor; Antibacterial; PPAR; p53; Autophagy | Apoptosis; Autophagy; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology; NF-κB |
Magnolol (5,5'-Diallyl-2,2'-biphenyldiol) 是RXRα和PPARγ的激动剂,EC50值分别为 10.4 µM 和 17.7 µM。他是从厚朴的树皮中分离得到的一种木脂素。 | |||
T2759 |
Loganin
Loganoside,马钱子苷 |
Apoptosis; NF-κB; BACE; AChR; AChE | Apoptosis; Neuroscience; NF-κB |
Loganin (Loganoside) 是山茱萸中的主要环烯醚萜苷类天然产物,具有抗炎、抗休克的作用。 | |||
T6S1597 |
Mulberroside A
桑皮苷 A,桑皮苷A |
TNF; Tyrosinase; Interleukin | Apoptosis; Immunology/Inflammation; Proteases/Proteasome |
Mulberroside A 是桑中的一种主要活性成分,可降低TNF-α、IL-1β和IL-6的表达,抑制 NALP3、caspase-1 和 NF-κB 的激活以及 ERK、JNK 和 p38 的磷酸化 。它抑制蘑菇酪氨酸酶,具有抗炎和抗细胞凋亡作用。 | |||
T3816 |
Velutin
|
NF-κB; HIF/HIF Prolyl-Hydroxylase | Chromatin/Epigenetic; Metabolism; NF-κB |
Velutin 是一种苷元,提取自槲寄生中,能够抑制黑色素生物合成。它利用 NF-κB 途径减少破骨细胞分化和下调 HIF-1α。 | |||
T3662 |
Eleutheroside E
|
NF-κB | NF-κB |
Eleutheroside E 是刺五加的重要成分,具有抗炎,保护缺血心脏的功能。 | |||
T6S1579 |
Monotropein
水晶兰苷,Monotropeine |
Others | Others |
Monotropein (Monotropeine) 是从Morinda officinalis 中获得,能够抑制硫酸葡聚糖硫酸钠诱导的结肠炎小鼠模型中炎性因子的表达。 | |||
TN1410 |
Asperulosidic acid
ASPA,车叶草苷酸 |
ERK; NF-κB | MAPK; NF-κB |
Asperulosidic acid (ASPA) 是从白花蛇舌草药中提取的一种环烯醚萜苷,具有抗肿瘤、抗氧化和抗炎作用。它通过抑制 NF-κB 和丝裂原活化蛋白激酶信号通路抑制炎性细胞因子释放发挥抗炎作用。 | |||
TN6694 |
5,6-Benzoflavone
β-Naphthoflavone,beta-NF |
Antioxidant | oxidation-reduction |
5,6-Benzoflavone (β-Naphthoflavone) 是芳烃受体的外源配体,可破坏人肝癌 HepG2 细胞中的锌稳态。5,6-Benzoflavone (β-Naphthoflavone) 具有抗炎和抗氧化活性,抑制通过 AKT/Nrf-2/HO-1-NF-kappaB 信号转导轴,抑制 LPS 诱导的炎症,抑制TNF-α诱导的ICAM-1和VCAM-1表达,可用于研究神经退行性疾病。 | |||
T5S0167 |
Atractylenolide I
白术内酯 I,白术内酯I;苍术内酯I |
IL Receptor; TNF; TLR; JAK; STAT | Angiogenesis; Apoptosis; Chromatin/Epigenetic; Immunology/Inflammation; JAK/STAT signaling; Stem Cells |
Atractylenolide I 是从白术根中得到的一种倍半萜烯,具有神经保护、抗过敏、抗炎和抗癌等多种生物活性。它是一种TLR4拮抗剂,在 A375 细胞中,能够降低JAK2和STAT3的磷酸化水平。 | |||
T2932 |
Ginsenoside Rh1
Sanchinoside B2,人参皂苷 Rh1,人参皂苷Rh1,Prosapogenin A2,20(S)-Ginsenoside Rh1,Sanchinoside Rh1 |
IL Receptor; TNF; Endogenous Metabolite; PPAR; Interleukin | Apoptosis; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism |
Ginsenoside Rh1 (Sanchinoside B2) 是人参的一种主要成分,具有抗炎作用,抑制PPAR-γ,TNF-α,IL-6和IL-1β的表达。 | |||
T3763 |
Fumaric acid
Lichenic acid,Fumarate,2-Butenedioic acid,Trans-Butenedioic acid,反丁烯二酸,Donitic acid,Allomaleic acid,富马酸 |
Endogenous Metabolite | Metabolism |
Fumaric acid (2-Butenedioic acid) 与烟酸酶缺乏症相关,是癌症相关的内源性代谢物。 | |||
T2768 |
Saikosaponin A
柴胡皂苷A,柴胡皂苷 A |
NF-κB; Antibacterial; Liver X Receptor | Metabolism; Microbiology/Virology; NF-κB |
Saikosaponin A 是银柴胡中的主要活性成分,有抗炎活性,可上调 LXRα的表达。 | |||
T4973 |
Paraxanthine
1,7-二甲基黄嘌呤,1,7-DIMETHYLXANTHINE |
Endogenous Metabolite | Metabolism |
Paraxanthine (1,7-dimethylxanthine) 是一种 caffeine 的代谢物,能够刺激Ryanodine 受体通道来抑制多巴胺能细胞的死亡。 | |||
TN1094 |
Ginsenoside Rg6
人参皂苷Rg6,人参皂苷 Rg6 |
Apoptosis; NF-κB | Apoptosis; NF-κB |
Ginsenoside Rg6 抑制人淋巴瘤 JK 细胞增殖并诱导其凋亡,在 HepG2 细胞中抑制 TNF-α 诱导的 NF-κB 转录活性,IC50为 29.34 μM。 | |||
T3826 |
Polygalasaponin F
异牡荆苷,瓜子金皂苷己 |
NF-κB; TLR; Akt; PI3K | Cytoskeletal Signaling; Immunology/Inflammation; NF-κB; PI3K/Akt/mTOR signaling |
Polygalasaponin F 是从瓜子金中提取的齐墩果烷型三萜皂苷,可通过调节TLR4-PI3K/AKT-NF-kB 信号通路减少神经炎症细胞因子的分泌,能降低炎性细胞因子肿瘤坏死因子 α 的释放。 | |||
T2794 |
Astilbin
Neoastilbin,Taxifolin 3-O-rhamnoside,Isoastilbin,Taxifolin 3-rhamnoside,落新妇苷,Neoisoastilbin |
TNF; NF-κB; Nrf2 | Apoptosis; Immunology/Inflammation; NF-κB |
Astilbin (Neoastilbin) 是在圣约翰草和中药草药制剂中发现的一种黄酮类天然产物,抑制TNF-α表达和NF-κB 活化,可增强NRF2活化。 | |||
T6S0653 |
Linarin
Buddleoflavonoloside,Buddleoside,Acacetin-7-O-rutinoside,Acaciin,Linarine,蒙花苷 |
TNF; AChE | Apoptosis; Neuroscience |
Linarin (Acacetin-7-O-rutinoside) 是一种选择性的乙酰胆碱酯酶 (AChE) 抑制剂,从薄荷花提取物中分离得到。 | |||
T2758 |
Madecassic acid
6-Deoxy-L-Galactose,羟基积雪草酸,L-Fucose,Brahmic acid,L-fucopyranose |
Others; TNF; COX; NO Synthase; Interleukin | Apoptosis; Immunology/Inflammation; Neuroscience; Others |
Madecassic acid (L-fucopyranose) 是分离自积雪草的一种天然产物,抑制iNOS、COX-2、TNF-α、IL-1beta 和IL-6,可通过在 RAW 264.7 巨噬细胞中下调NF-κB 激活而具有抗炎作用。 | |||
T4S2063 |
Tetrahydrocoptisine
人血草碱,STYLOPINE |
ERK; p38 MAPK; NF-κB | MAPK; NF-κB |
Tetrahydrocoptisine (STYLOPINE) 具有抑制炎症的有效作用。它通过抑制 NF-κB 信号通路对 LPS 诱导的 ALI 具有保护作用,这可能涉及抑制肺部炎症过程。它具有胃保护活性,归因于减少 NO 产生和调节促炎细胞因子,抑制中性粒细胞积累和 NF-κB 表达。它是一种活性抗炎成分,通过下调 NF-κB 活化、磷酸化 ERK1/2 和磷酸化-p38MAPK 信号通路抑制 TNF-α、IL-6 和 NO 的产生。 | |||
T6S1495 |
Ginsenoside Rk3
人参皂苷Rk3,人参皂甙 Rk3 |
Others; NF-κB | NF-κB; Others |
Ginsenoside Rk3 是存在于 Panax notoginseng 的根中。它能够抑制 HepG2 细胞中 TNF-α 诱导的 NF-κB 转录活性,IC50=14.24±1.30 μM。 | |||
T3240 |
Citronellol
dihydrogeraniol,香茅醇,β-香茅醇,(±)-β-Citronellol |
Reactive Oxygen Species | Immunology/Inflammation; Metabolism; NF-κB |
Citronellol ((±)-β-Citronellol) 是一种单萜类化合物,从头状天竺葵中分离到。它可通过上调 TNF-α,RIP1/RIP3 的活性,下调 caspase-3/caspase-8 的活性,以及增加活性氧 (ROS) 的聚集来诱导肿瘤细胞的坏死性凋亡。 | |||
T2S2264 |
Linalool
Linalol,(±)-Linalool,Phantol,沉香醇 |
Apoptosis; IL Receptor; TNF; Endogenous Metabolite; iGluR | Apoptosis; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Neuroscience |
Linalool (Linalol) 是存在芫荽等植物中的单萜类天然产物,是竞争性NMDA 受体拮抗剂,具有抗肿瘤和抗心脏毒性的作用。它通过激活 Nrf2 诱导抗氧化防御和通过抑制 NF-κB 减少炎症反应来保护其免受 LPS/GalN 诱导的肝损伤,具有镇痛、抗菌和抗炎的特性。 | |||
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Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPJ-00779 |
TNF alpha Protein, Rabbit, Recombinant
TNF-a,Tumor Necrosis Factor,TNF-α... |
Rabbit | E. coli |
Tumor necrosis factor alpha (TNFα) is the prototypic ligand of the TNF superfamily. TNFα forms a homotrimer and functions by activating two types of receptors TNF-R1 (TNF receptor type 1,p55R) and TNF-R2 (TNF receptor type 2,p75R). TNFα is a pleiotropic cytokine that is capable to promote inflammation, to induce apoptotic cell death, and to inhibit tumorigenesis and viral replication. TNFα is a potent lymphoid factor that exerts cytotoxic effects on a wide range of tumor cells and certain other ... | |||
TMPY-01294 |
TNF alpha Protein, Mouse, Recombinant
TNF-α,Tnfsf1a,TNF-alpha,... |
Mouse | E. coli |
TNF alpha Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.39 kDa and the accession number is P06804. | |||
TMPY-04146 |
TNF alpha Protein, Human, Recombinant (hFc)
DIF,TNFA,tumor necrosis factor,TNFSF2,... |
Human | HEK293 Cells |
TNF alpha Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 45.8 kDa and the accession number is P01375. | |||
TMPY-00936 |
TNF alpha Protein, Human, Recombinant
TNFA,TNFSF2,TNF-alpha,TNF |
Human | E. coli |
TNF alpha Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.5 kDa and the accession number is P01375. | |||
TMPY-02202 |
TNF alpha Protein, Rat, Recombinant
tumor necrosis factor,肿瘤坏死因子,TNF-α |
Rat | E. coli |
TNF alpha Protein, Rat, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.4 kDa and the accession number is P16599. | |||
TMPY-02153 |
TNF beta Protein, Human, Recombinant
LT,TNF β,TNFSF1,肿瘤坏死因子,TNFB,lymph... |
Human | E. coli |
Lymphotoxin-alpha, also known as LT-alpha, TNF-beta, Tumor necrosis factor ligand superfamily member 1, LTA TNFSF1, and TNFB, is a secreted protein that belongs to the tumor necrosis factor family. TNF-beta/TNFSF1/Lymphotoxin alpha is highly inducible, secreted, and exists as a homotrimeric molecule. It is a cytokine that in its homotrimeric form binds to TNFRSF1A / TNFR1, TNFRSF1B / TNFBR, and TNFRSF14 / HVEM. In its heterotrimeric form with LTB, TNF-beta/TNFSF1/Lymphotoxin alpha binds to TNFRS... | |||
TMPK-00583 |
TNF alpha Protein, Ferret, Recombinant (His)
TNF-α,DIF,TNFα,TNF |
Ferret | E. coli |
TNF alpha Protein, Ferret, Recombinant (His) is expressed in E. coli expression system with C-His tag. The predicted molecular weight is 18.88 kDa and the accession number is A3FBF1. | |||
TMPJ-00288 |
TNF RII Protein, Human, Recombinant (mFc)
Tumor necrosis factor receptor 2,TNFRSF1B,p75,T... |
Human | HEK293 Cells |
TNF RII Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with C-mFc tag. The predicted molecular weight is 60 KDa and the accession number is P20333. | |||
TMPK-00119 |
TNF alpha Protein, Cynomolgus, Recombinant (His)
TNF α,TNFα,APC1 protein,... |
Cynomolgus | HEK293 Cells |
TNF alpha Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with N-His tag. The predicted molecular weight is 18.35 kDa and the accession number is P79337. | |||
TMPK-00120 |
TNF alpha Protein, Human, Recombinant (His & Avi)
TNFα,APC1 protein,肿瘤坏死因子,TNFSF2,<... |
Human | HEK293 Cells |
TNF alpha Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 20.3 kDa and the accession number is P01375. | |||
TMPK-00121 |
TNF alpha Protein, Human, Recombinant (His & Avi), Biotinylated
TNF,TNF-alpha,TNFATNF,DI... |
Human | HEK293 Cells |
TNF alpha Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 20.3 kDa and the accession number is P01375. | |||
TMPJ-00124 |
TNF alpha Protein, Human, Recombinant (aa 77-233, His)
TNF-a,TNF-α,Tumor Necrosis Factor... |
Human | E. coli |
TNF alpha Protein, Human, Recombinant (aa 77-233, His) is expressed in E. coli expression system with C-6xHis tag. The predicted molecular weight is 16 KDa and the accession number is P01375. | |||
TMPJ-00287 |
TNF RII Protein, Human, Recombinant (hFc)
TNF-R2,Tumor necrosis factor receptor superfamily m... |
Human | HEK293 Cells |
TNF RII Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 60-90 KDa and the accession number is P20333. | |||
TMPY-05187 |
TNF alpha Protein, Mouse, Recombinant, Biotinylated
Tnfa,TNFSF2,肿瘤坏死因子,Tnfsf1a,TN... |
Mouse | E. coli |
TNF alpha Protein, Mouse, Recombinant, Biotinylated is expressed in E. coli expression system. The predicted molecular weight is 17.4 kDa and the accession number is P06804. | |||
TMPY-02069 |
TNF alpha Protein, Cynomolgus, Rhesus, Recombinant
肿瘤坏死因子,TNF-α,tumor necrosis factor |
Cynomolgus,Rhesus | E. coli |
TNF alpha Protein, Cynomolgus, Rhesus, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.4 kDa and the accession number is NP_001040614.1. | |||
TMPJ-00125 |
TNF alpha Protein, Human, Recombinant (aa 57-233, His)
TNFA,TNF-α,Cachectin,肿瘤坏死因子,T... |
Human | E. coli |
TNF alpha Protein, Human, Recombinant (aa 57-233, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 18 KDa and the accession number is P01375. | |||
TMPY-05237 |
TNF alpha Protein, Human, Recombinant, Biotinylated
TNFSF2,DIF,TNF-α,tumor necrosis f... |
Human | E. coli |
TNF alpha Protein, Human, Recombinant, Biotinylated is expressed in E. coli expression system. The predicted molecular weight is 17.5 kDa and the accession number is P01375. | |||
TMPY-05516 |
TNF alpha Protein, Cynomolgus, Recombinant, Biotinylated
肿瘤坏死因子,tumor necrosis factor,TNF-α |
Cynomolgus | E. coli |
TNF alpha Protein, Cynomolgus, Recombinant, Biotinylated is expressed in E. coli expression system. The predicted molecular weight is 17.4 kDa and the accession number is P79337. | |||
TMPY-01594 |
TNF alpha Protein, Canine, Recombinant
肿瘤坏死因子,TNF-α,tumor necrosis factor |
Canine | E. coli |
TNF alpha Protein, Canine, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.3 kDa and the accession number is A9LMQ0. | |||
TMPY-02226 |
TNF alpha Protein, Ferret, Recombinant
tumor necrosis factor,肿瘤坏死因子,TNF-α |
Ferret | E. coli |
TNF alpha Protein, Ferret, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.3 kDa and the accession number is A3FBF1. | |||
TMPJ-00546 |
EFNA1 Protein, Human, Recombinant (hFc)
TNFAIP4,LERK1,Tumor Necrosis Factor α-Indu... |
Human | HEK293 Cells |
Ephrin-A1 is a member of the A-type ephrin family of cell surface proteins that function as ligands for the A-type Eph receptor tyrosine kinase family. Ephrin-A1 can be induced by TNF and IL1B. Its expression levels can be down-regulated in primary glioma tissues compared to the normal tissues. The soluble monomeric form is expressed in the glioblastoma multiforme (GBM) and breast cancer cells. Soluble Ephrin-A1 is necessary for the transformation of HeLa and SK-BR3 cells and participates in the... | |||
TMPJ-00280 |
TNF R1 Protein, Mouse, Recombinant
Tnfrsf1a,Tumor necrosis factor receptor superfamily... |
Mouse | E. coli |
Tumor necrosis factor receptor superfamily member 1A (Tnfrsf1a) is a member of the tumor necrosis factor receptor superfamily. Tnfrsf1a is one of the major receptors for the tumor necrosis factor-alpha. It can activate the transcription factor NF-κB, mediate apoptosis, and function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the... | |||
TMPH-02770 |
TNF beta Protein, Mouse, Recombinant (His)
Lta,TNF-beta,Tumor necrosis factor ligand superfami... |
Mouse | E. coli |
Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo. TNF beta Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 23.8 kDa and the accession number is P09225. | |||
TMPH-03745 |
TNF-alpha Protein, Zebrafish, Recombinant (His)
Lymphotoxin-alpha,tnfa,Tumor necrosis factor ligand... |
Danio rerio (Zebrafish) | E. coli |
TNF-alpha Protein, Zebrafish, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 23.6 kDa and the accession number is Q08CQ3. | |||
TMPH-01620 |
TNF beta Protein, Human, Recombinant (His)
Lymphotoxin-alpha,TNF-beta,LTA,Tumor necrosis facto... |
Human | HEK293 Cells |
Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo. | |||
TMPJ-00619 |
TNF RII Protein, Rhesus macaque, Recombinant (His)
Tumor necrosis factor receptor superfamily member 1b,Tnf... |
Rhesus | HEK293 Cells |
TNF RII Protein, Rhesus macaque, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 35-45 KDa and the accession number is F7EAF8. | |||
TMPJ-00618 |
TNF RII Protein, Rhesus macaque, Recombinant (hFc)
Tnfrsf1b,Tumor necrosis factor receptor superfamily... |
Rhesus | HEK293 Cells |
TNF RII Protein, Rhesus macaque, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 60-80 KDa and the accession number is F7EAF8. | |||
TMPJ-00296 |
TNF RII Protein, Mouse, Recombinant (His & Avi), Biotinylated
Tumor necrosis factor receptor superfamily member 1b,Tnf... |
Mouse | HEK293 Cells |
TNF RII Protein, Mouse, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-6xHis-Avi tag. The predicted molecular weight is 35-50 KDa and the accession number is Q545P4. | |||
TMPK-00564 |
TNFR1/CD120a/TNFRSF1A Protein, Cynomolgus, Recombinant (His)
TBP1,TNF-RI,TNFAR,p55,p60,p55-R,TNF |
Cynomolgus | HEK293 Cells |
Tumour necrosis factor alpha (TNF-α) is a pleiotropic cytokine with both injurious and protective functions, which are thought to diverge at the level of its two cell surface receptors, TNFR1 and TNFR2. In the setting of acute injury, selective inhibition of TNFR1 is predicted to attenuate the cell death and inflammation associated with TNF-α, while sparing or potentiating the protective effects of TNFR2 signalling. | |||
TMPJ-00968 |
NAMPT Protein, Human, Recombinant (His)
PBEF,PBEF1,Nicotinamide phosphoribosyltransferase,NAmPRTase,... |
Human | E. coli |
Pre-B cell colony enhancing factor (PBEF) was originally identified as a cytokine that potentiated the clonal expansion and differentiation of pre-B cells, but it is also acknowledged to be the ubiquitous intracellular enzyme nicotinamide phosphoribosyltranferase (NAMPT) and the adipokine “visfatin”. PBEF is constitutively expressed in the fetal membranes where its greatest expression is in the amnion. It has intracellular and extracellular forms. Most of the intracellular functions of PBEF are ... | |||
TMPY-02549 |
GBP1 Protein, Human, Recombinant (His)
guanylate binding protein 1,GBP1 |
Human | HEK293 Cells |
Guanylate-binding protein 1 (GBP-1) is a member of the GBP family whose members are GTPases induced in response to interferon-λ (IFN-λ), with seven highly homologous members in humans, termed HuGBP-1 to HuGBP-7. GBP-1 expression is induced by type1 and type2 interferons, including IFN-λ and also by interleukin-1β (IL-1β), IL-1α, and tumor necrosis factor-α (TNF-α). GBP-1 is key to the protective immunity against microbial and viral pathogens. GBP-1 was only secreted from endothelial cells. Secre... | |||
TMPJ-00177 |
BAFF/TNFSF13B Protein, Human, Recombinant (Avi & hFc), Biotinylated
BAFF,Dendritic cell-derived TNF-like molecule,CD257... |
Human | HEK293 Cells |
B-cell activating factor (BAFF), also known as BLyS, TALL-1, THANK, and TNFSF13B, is a transmembrane glycoprotein in the TNF ligand superfamily. BAFF is a cytokine and serves as a ligand for receptors TNFRSF13B (TACI), TNFRSF17 (BCMA), and TNFRSF13C (BAFFR). BAFF can promotes the survival, proliferation and maturation of B lymphocytes, which are key elements in the pathogenesis of systemic lupus erythematosus (SLE). This cytokine is encoded on TNFSF13B gene, and diverse single-nucleotide polymor... | |||
TMPY-03308 |
ADAM17 Protein, Rat, Recombinant (His)
ADAM metallopeptidase domain 17 |
Rat | HEK293 Cells |
ADAM17 is a member of the ADAM protein family of disintegrins and metalloproteases. ADAM17 is ubiquitously expressed in the human colon, with increased activity in the colonic mucosa of patients with ulcerative colitis, a main form of inflammatory bowel disease. The expression of ADAM17 may be inhibited by ethanol. It is involved in the processing of tumor necrosis factor alpha (TNF-α) at the surface of the cell, and from within the intracellular membranes of the trans-Golgi network. ADAM1... | |||
TMPJ-00680 |
ANGPTL7 Protein, Human, Recombinant (His)
CDT6,Cornea-derived transcript 6 protein,Angiopoietin-like p... |
Human | HEK293 Cells |
Angiopoietin-like 7 (ANGPTL7) is a secreted glycoprotein that is structurally related to the angiopoietins. Members of this protein family contain an N-terminal coiled coil domain and a C-terminal fibrinogen-like domain. ANGPTL7 shares 89% aa sequence identity with mouse and rat ANGPTL7. It is secreted as a 45-50kDa monomer that forms disulfide-linked homotrimers and tetramers via the coiled coil domain. ANGPTL7 is expressed in the corneal stroma, trabecular meshwork, and sclera and is elevated ... | |||
TMPJ-00527 |
SP-D Protein, Human, Recombinant (His)
Lung Surfactant Protein D,SFTP4,COLEC7,SFTPD,PSP-D,SP-D,Pulm... |
Human | HEK293 Cells |
Surfactant Pulmonary-Associated Protein D (SP-D) is a 43 kDa member of the collectin family of innate immune modulators. Its principal components consist of a collagen-like region and a C-terminal carbohydrate recognition domain (CRD), a structure that places it in a subset of pattern recognition proteins termed defense collagens. SP-D is constitutively secreted by alveolar lining cells and epithelium associated with tubular structures and induced in cardiac smooth muscle and endothelial cells. ... | |||
TMPY-03861 |
Amelotin Protein, Human, Recombinant (mFc)
amelotin,UNQ689 |
Human | HEK293 Cells |
Amelotin (AMTN) is a tooth enamel protein which is expressed in maturation-stage ameloblasts and also in the internal basal lamina of junctional epithelium, a unique epithelial structure attached to the tooth surface which protects against the constant microbiological challenge to the periodontium. TNF-α stimulates AMTN gene transcription in human gingival epithelial cells via C/EBP1, C/EBP2, and YY1 elements in the human AMTN gene promoter.AMTN mRNA levels increased at 6 h and reached maximum a... | |||
TMPJ-01370 |
EDAR Protein, Mouse, Recombinant (hFc)
Ectodysplasin-A receptor,Anhidrotic ectodysplasin receptor 1... |
Mouse | HEK293 Cells |
Ectodysplasin A receptor (EDAR) is a type I transmembrane protein of the TNF-α receptor superfamily which plays a key role in ectodermal differentiation. EDAR was encoded by the mouse downless gene and defective in human dominant and recessive forms of autosomal hypohidrotic ectodermal dysplasia (EDA) syndrome. The extracellular domain of EDAR contains 14 cysteine residues, six of which approximate the TNFRSF cysteine-rich region, the cytoplasmic domain contains a region with homology to the dea... | |||
TMPY-05353 |
CCL26 Protein, Human, Recombinant
MIP-4alpha,SCYA26,MIP-4a,chemokine (C-C motif) ligand 26,IMA... |
Human | Baculovirus Insect Cells |
The eotaxin subfamily of CC chemokines consists of eotaxin-1/CCL11, eotaxin-2/CCL24 and eotaxin-3/CCL26. All eotaxins induce the trafficking of eosinophils to the sites of inflammation via CC chemokine receptor 3 (CCR3), which is also expressed by several different cell types, including basophils, dendritic cells, smooth muscle cells, epithelial cells and fibroblasts. The sequence similarity between the three eotaxins is limited (<4%), but their functional properties are very similar. Eotaxin-1 ... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T10350 |
Apremilast-d5
Apremilast D5,CC-10004 D5 |
TNF; PDE | Apoptosis; Metabolism |
Apremilast D5 (CC-10004 D5) is a deuterium-labeled Apremilast. Apremilast is an orally available inhibitor of PDE-4 (IC50: 74 nM). Apremilast inhibits TNF-α release by lipopolysaccharide (IC50: 104 nM). | |||
T71285 |
Metaxalone-d6
|
||
Metaxalone-d6 is intended for use as an internal standard for the quantification of metaxalone by GC-or LC-MS. Metaxalone is a skeletal muscle relaxant. It inhibits the proliferation of, and induces apoptosis in, RAW 264.7 cells in vitro when used at concentrations ranging from 1 to 100 µM. Metaxalone also reduces LPS-induced increases in COX-1, COX-2, and NF-kB levels and inhibits LPS-induced production of TNF-α, IL-6, and prostaglandin E2 in RAW 264.7 cells. Formulations containing metaxalone ... | |||
T36408 |
Rhein-13C4
Rhein-13C4 |
||
Rhein-13C4 is intended for use as an internal standard for the quantification of rhein by GC- or LC-MS. Rhein is an anti-inflammatory anthraquinone found in rhubarb and is the bioactive derivative of its prodrug diacerein . At 10 μM, rhein inhibits IL-1β signaling, suppressing signaling through NF-κB, and reduces the expression of the matrix metalloproteases MMP-1 and MMP-13.1 It inhibits IKKβ (IC50 = 11.8 μM), decreasing iNOS and IL-6 expression in LPS-stimulated macrophages but paradoxically i... | |||
TMID-0254 |
Linalool-d3
|
||
Linalool-d3 是 Linalool 的氘代化合物。Linalool 的 CAS 号为 78-70-6。Linalool 是存在芫荽等植物中的单萜类天然产物,是竞争性NMDA受体拮抗剂,具有抗肿瘤和抗心脏毒性的作用。它通过激活 Nrf2 诱导抗氧化防御和通过抑制 NF-κB 减少炎症反应来保护其免受 LPS/GalN 诱导的肝损伤,具有镇痛、抗菌和抗炎的特性。 | |||
T71328 |
Theobromine-d6
|
||
Theobromine-d6 is intended for use as an internal standard for the quantification of theobromine by GC- or LC-MS. Theobromine is a methylxanthine alkaloid and derivative of caffeine that has been found in cocoa beans and has diverse biological activities. It is an adenosine A1 receptor antagonist. Theobromine increases AMPK phosphorylation and inhibits adipocyte differentiation, ERK and JNK phosphorylation, and IL-6 and TNF-α production in 3T3-L1 preadipocytes cultured in differentiation medium.... | |||
T71303 |
Flufenamic Acid-d4
|
||
Flufenamic acid-d4 is intended for use as an internal standard for the quantification of flufenamic acid by GC- or LC-MS. Flufenamic acid is a non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor (IC50s = 3 and 9.3 µM for human COX-1 and COX-2, respectively). Flufenamic acid inhibits TNF-α-induced increases in COX-2 levels and NF-κB activation in HT-29 colon cancer cells in a concentration-dependent manner. It inhibits calcium influx induced by fMLP or A23187 in human polymorphonuclear... |