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Search Results for " thymidylate kinase "

Targets Recommended: Others

12

抑制剂 & 化合物

2

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T8864	Thymidylate Kinase Inhibitor, YMU1	Others	Others
	YMU1 是一种选择性抑制剂，特异性作用于人胸苷酸激酶 (IC50: 610 nM) 。
T61781	MtTMPK-IN-6	Others	Others
	MtTMPK-IN-6 (compound 1) is a highly effective inhibitor (IC 50 = 29 μM) of M. tuberculosis thymidylate kinase (Mtb TMPK). It is a valuable compound for tuberculosis research [1].
T61780	MtTMPK-IN-4	Others	Others
	MtTMPK-IN-4 (compound 2), a para-piperidine, is a highly potent inhibitor of thymidylate kinase (MtTMPK) in Mycobacterium tuberculosis, exhibiting an IC50 value of 6.1 μM. Additionally, it possesses remarkable inhibitory activity against tyrosinase. Furthermore, MtTMPK-IN-4 exhibits potent antibacterial properties [1] [2].
T61796	MtTMPK-IN-1	Others	Others
	MtTMPK-IN-1 (compound 3) is a highly effective inhibitor of Mycobacterium tuberculosis thymidylate kinase (Mt TMPK), exhibiting an IC50 value of 2.5 μM. It displays moderate to weak activity against Mtb H37Rv while demonstrating low cytotoxicity in human fibroblast cells MRC-5. MtTMPK-IN-1 is a valuable tool for tuberculosis research [1].
T35652	2'-Deoxyguanosine 5'-monophosphate (sodium salt hydrate)	Others	Others
	2'-Deoxyguanosine 5'-monophosphate (dGMP) is used as a substrate of guanylate kinases to generate dGDP, which in turn is phosphorylated to dGTP, a nucleotide precursor used in DNA synthesis. In addition, dGMP can be efficiently phosphorylated by the type I thymidylate kinase of the malarial agent P. falciparum. In humans, deficiency of mitochondrial deoxyguanosine kinase, which synthesizes dGMP from ATP and deoxyguanosine, contributes to mitochondrial DNA depletion syndrome.
T63657	MtTMPK-IN-9	Others	Others
	MtTMPK-IN-9 是中等效力的分支杆菌胸苷酸激酶 (MtbTMPK)抑制剂 (IC50: 48 μM)。MtTMPK-IN-9 对抗分枝杆菌具有亚微摩尔活性，但没有显著的细胞毒性。MtTMPK-IN-9 能够用于研究结核病。
T63491	MtTMPK-IN-8	Others	Others
	MtTMPK-IN-8 是具有中等效力的分支杆菌胸苷酸激酶 (MtbTMPK)抑制剂，没有显著的细胞毒性，对抗分枝杆菌表现出亚微摩尔活性 (MICs = 0.78~9.4 μM)，能够用于研究结核病。
T61573	MtTMPK-IN-5	Others	Others
	MtTMPK-IN-5 (compound 17) is a highly effective inhibitor of M. tuberculosis thymidylate kinase (Mtb TMPK), demonstrating remarkable enzyme inhibitory activity with an IC50 value of 34 μM. Additionally, MtTMPK-IN-5 exhibits notable activity against M. tuberculosis, as evidenced by a minimum inhibitory concentration (MIC) of 12.5 μM. Given its potent properties, MtTMPK-IN-5 serves as a valuable tool for tuberculosis research [1].
T63639	MtTMPK-IN-7	Others	Others
	MtTMPK-IN-7 是中等效力的分支杆菌胸苷酸激酶 (MtbTMPK) 抑制剂 (IC50: 47 μM)。MtTMPK-IN-7 对抗分枝杆菌表现出亚微摩尔活性，其 MICs 值为 2.3~4.7 μM。MtTMPK-IN-7 能够用于研究结核病。
T62305	MtTMPK-IN-2	Others	Others
	MtTMPK-IN-2 (compound 15)为一高效MtbTMPK抑制剂，IC50值达1.1 μM。该化合物对MtbH37Rv表现出抑制活性（MIC = 12.5 μM），同时对人成纤维细胞MRC-5显示出一定细胞毒性（EC50= 6.1 μM）。MtTMPK-IN-2适用于结核病研究。
T73980	Thymidine 5′-diphosphate	Others	Others
	Thymidine 5′-diphosphate (dTDP) 是合成嘧啶的关键产物，通过胸苷酸激酶 (TMPK) 对 5'-单磷酸胸苷 (dTMP) 进行磷酸化反应生成，此过程需 ATP 与 Mg2+。进一步，dTDP 可被 TMPK 催化转化为胸苷 5'-三磷酸 (dTTP)。通过测量 dTDP 水平，可以评估 TMPK 活性。
T62897	MtTMPK-IN-3	Others	Others
	MtTMPK-IN-3（compound 25）是一种针对结核分枝杆菌胸苷酸激酶（MtbTMPK）的有效抑制剂，具有0.12 μM的IC50值。该化合物对MtbH37Rv展示出了抑制效果（MIC=12.5 μM），同时对人成纤维细胞MRC-5显示出一定的细胞毒性（EC50=12.5 μM）。MtTMPK-IN-3适用于结核病研究领域。

化合物

Thymidylate Kinase Inhibitor, YMU1

Cat.No: T8864

Target: Others

Cat.No: T61781

Target: Others

Cat.No: T61780

Target: Others

Cat.No: T61796

Target: Others

2'-Deoxyguanosine 5'-monophosphate (sodium salt hydrate)

Cat.No: T35652

Target: Others

Cat.No: T63657

Target: Others

Cat.No: T63491

Target: Others

Cat.No: T61573

Target: Others

Cat.No: T63639

Target: Others

Cat.No: T62305

Target: Others

Thymidine 5′-diphosphate

Cat.No: T73980

Target: Others

Cat.No: T62897

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-00157	Thymidylate kinase Protein, Bacillus anthracis, Recombinant (His) dTMP kinase,tmk,Thymidylate kinase	Bacillus anthracis	E. coli
	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis. Thymidylate kinase Protein, Bacillus anthracis, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 27.8 kDa and the accession number is C3LJ02.
TMPJ-00905	DTYMK Protein, Human, Recombinant (His) DTYMK,TMPK,dTMP kinase,Thymidylate kin...	Human	HEK293 Cells
	Thymidylate kinase (DTYMK) is a ubiquitous enzyme of about 25 kD which belongs to thymidylate kinase family. DTYMK is important in the dTTP synthesis pathway for DNA synthesis. It participated in the pyrimidine metabolism pathway and dTTP biosynthesis pathway. DTYMK catalyzes the conversion of dTMP to dTDP and catalyzes the phosphorylation of thymidine 5'-monophosphate (dTMP) to form thymidine 5'-diphosphate (dTDP) in the presence of ATP and magnesium. Structural and functional analyses suggest ...

重组蛋白

Thymidylate kinase Protein, Bacillus anthracis, Recombinant (His)

Cat.No: TMPH-00157

Species: Bacillus anthracis

Expression System: E. coli

DTYMK Protein, Human, Recombinant (His)

Cat.No: TMPJ-00905

Species: Human

Expression System: HEK293 Cells

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