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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T0213 |
Thalidomide
Thalomid,沙利度胺,Sedoval |
Apoptosis; TNF; Autophagy; Ligand for E3 Ligase; Molecular Glues | Apoptosis; Autophagy; PROTAC |
Thalidomide (Thalomid) 能够抑制 cereblon,即 cullin-4 E3 泛素连接酶复合物 CUL4-RBX1-DDB1 的一部分,Kd 值约为 250 nM,具有免疫调节、抗炎、抗肿瘤作用。它可以作为分子胶来增强底物。 | |||
T12644L |
(S)-Thalidomide
(S)-(-)-Thalidomide |
Apoptosis | Apoptosis |
(S)-Thalidomide ((S)-(-)-Thalidomide) 是 Thalidomide 的 S 型异构体,具有免疫调节,抗炎,抗癌,抗血管生成活性和促凋亡活性,可用于研究麻风结节性红斑和骨髓瘤。 | |||
T9389 |
Thalidomide-PEG4-Propargyl
Thalidomide-O-PEG4-Propargyl |
E3 Ligase Ligand-Linker Conjugate | PROTAC |
Thalidomide-PEG4-Propargyl (Thalidomide-O-PEG4-Propargyl) 包含基于 Thalidomide 的 cereblon 配体和 1 个 linker,是一种合成的 E3 连接酶配体-linker 偶联物,。 | |||
T18831 |
Thalidomide-propargyl
|
Others; Ligand for E3 Ligase | Others; PROTAC |
Thalidomide-propargyl 是一种基于 Thalidomide 的 Cereblon 配体,可用于募集 CRBN 蛋白。它能够利用 linker 与靶蛋白配体连接,得到含 IMiD 的 PROTAC。 | |||
T40503 |
Thalidomide-5-methyl
|
Ligand for E3 Ligase | PROTAC |
Thalidomide-5-methyl 是基于 Thalidomide 的 CRBN 配体,可以用于CRBN 的招募。 | |||
T40011 |
Thalidomide-CH2CONH-C3-COOH
|
Others | Others |
Thalidomide-CH2CONH-C3-COOH 是一种合成的 E3 连接酶配体-接头偶联物,它结合了 PROTAC 技术中使用的基于Thalidomide 的CRBN 配体和接头。 | |||
T40013 |
Thalidomide-O-CH2CONH-CH2COOH
|
Others | Others |
Thalidomide-O-CH2CONH-CH2COOH 是一种合成的 E3 连接酶配体-接头偶联物,它结合了 PROTAC 技术中使用的基于 Thalidomide 的 CRBN 配体和接头。 | |||
T40012 |
Thalidomide-CH2CONH-C2-COOH
|
Others | Others |
Thalidomide-CH2CONH-C2-COOH 是一种合成的 E3 连接酶配体-接头偶联物,它结合了 PROTAC 技术中使用的基于Thalidomide 的CRBN 配体和接头。 | |||
T9402 |
Thalidomide-O-C4-NH2 hydrochloride
|
E3 Ligase Ligand-Linker Conjugate | PROTAC |
Thalidomide-O-C4-NH2 hydrochloride 包含基于 Thalidomide 的 cereblon 配体和 PROTAC 技术中使用的接头,是一种合成的 E3 连接酶配体-接头偶联物。 | |||
T18807 |
Thalidomide-NH-C4-NH-Boc
|
E3 Ligase Ligand-Linker Conjugate; Ligand for E3 Ligase | PROTAC |
Thalidomide-NH-C4-NH-Boc 包含基于 Thalidomide 的 cereblon 配体和 1 个 linker,是一种合成的 E3 连接酶配体-linker 偶联物。 | |||
T7755 |
Thalidomide 4-fluoride
E3 ligase Ligand 4,2-(2,6-二氧代-哌啶-3-基)-4-氟基-异吲哚-1,3-二酮 |
IRAK; Ligand for E3 Ligase | Immunology/Inflammation; NF-κB; PROTAC |
Thalidomide 4-fluoride (E3 ligase Ligand 4) 是一种基于 Thalidomide 的 Cereblon 配体,可用于募集 CRBN 蛋白。它能够利用 linker 与 IRAK4 靶蛋白配体连接,得到 PROTAC IRAK4 degrader-1。 | |||
T9381 |
Thalidomide 5-fluoride
2-(2,6-二氧代 - 哌啶-3-基)-5-氟 - 异吲哚-1,3-二酮,H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-fluoro- |
Ligand for E3 Ligase | PROTAC |
Thalidomide 5-fluoride (H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-fluoro-) 是一种基于沙利度胺的 Cereblon 配体,通过 linker 与 IRAK4 蛋白配体结合形成 PROTACIRAK4 degrader-1。 | |||
T7763 |
Thalidomide-4-OH
Cereblon ligand 2,E3 ligase Ligand 2 |
Ligand for E3 Ligase | PROTAC |
Thalidomide-4-OH (E3 ligase Ligand 2) 是一种基于 Thalidomide 的 Cereblon 配体,可用于募集 CRBN 蛋白。它能够利用 linker 与靶蛋白配体连接,得到 PROTAC 分子。 | |||
T7753 |
Thalidomide-O-COOH
Cereblon ligand 3,E3 ligase Ligand 3,TCE35031 |
Others; Ligand for E3 Ligase | Others; PROTAC |
Thalidomide-O-COOH (Cereblon ligand 3) 是一种基于 Thalidomide 的 Cereblon 配体,可用于募集 CRBN 蛋白。它能够利用 linker 与靶蛋白配体连接,得到 PROTAC 分子。 | |||
T9291 |
Thalidomide-5-OH
4 - 羟基沙利度胺,2-(2,6-dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione |
Others; Ligand for E3 Ligase | Others; PROTAC |
Thalidomide-5-OH (2-(2,6-dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione) 是基于 Thalidomide 的的cereblon 配体,可用于募集CRBN 蛋白。它能够利用 linker 与靶蛋白配体连接,得到 PROTAC 分子。 | |||
T40003 |
Thalidomide-NH-C6-NH2 hydrochloride
|
Others; E3 Ligase Ligand-Linker Conjugate | Others; PROTAC |
Thalidomide-NH-C6-NH2 hydrochloride 包含基于 Thalidomide 的 cereblon 配体和 1 个 linker,是合成的 E3 连接酶配体-linker 偶联物,可用于 PROTAC 的合成。 | |||
T15189 |
Thalidomide-O-amido-C4-N3
E3 ligase Ligand-Linker Conjugates 18,Cereblon Ligand-Linker Conjugates 4 |
Others; Ligand for E3 Ligase | Others; PROTAC |
Thalidomide-O-amido-C4-N3 (Cereblon Ligand-Linker Conjugates 4) 是一种 E3 连接酶配体- linker 偶联物,包含基于 Thalidomide 的 cereblon 配体和 linker。 | |||
T18819 |
Thalidomide-O-amido-PEG2-C2-NH2 hydrochloride
|
Others; Ligand for E3 Ligase | Others; PROTAC |
Thalidomide-O-amido-PEG2-C2-NH2 hydrochloride 包含一个 E3 连接酶配体和一个 linker。 Thalidomide-O-amido-PEG2-C2-NH2 盐酸盐可用作治疗癌症的免疫调节剂。 | |||
T40019 |
Thalidomide-5-NH2-CH2-COOH
|
Others | Others |
Thalidomide-5-NH2-CH2-COOH (compound 114) 是原肌球蛋白受体激酶的选择性抑制剂。它是 E3 连接酶的配体,具有研究一种或多种疾病的潜力。 | |||
T40016 |
Thalidomide-NH-CH2-COOH
2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]acetic acid,(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycine |
Ligand for E3 Ligase | PROTAC |
Thalidomide-NH-CH2-COOH ((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycine) 是一种基于 Thalidomide 的 Cereblon 配体,可用于募集 CRBN 蛋白。它能够利用 linker 与靶蛋白配体连接,得到 PROTAC 分子。 | |||
T18816 |
Thalidomide-O-amido-C6-NH2 hydrochloride
|
Others; E3 Ligase Ligand-Linker Conjugate | Others; PROTAC |
Thalidomide-O-amido-C6-NH2 hydrochloride 包含基于 Thalidomide 的 cereblon 配体和 1 个 linker,是一种合成的 E3 连接酶配体-linker 偶联物,。它可用于 PROTAC 分子的合成。 | |||
T40030 |
Thalidomide 4'-ether-alkylC2-amine hydrochloride
halidomide-linker 6 |
E3 Ligase Ligand-Linker Conjugate | PROTAC |
Thalidomide 4'-ether-alkylC2-amine hydrochloride (halidomide-linker 6) 包含基于 Thalidomide 的 cereblon 配体和 linker,是合成的 E3 连接酶配体-linker 偶联物,可应用于 PROTAC 技术。 | |||
T12644 |
(R)-Thalidomide
(R)-(+)-Thalidomide |
Others | Others |
(R)-Thalidomide is the R-enantiomer of Thalidomide, has sedative properties. | |||
T7760 |
Thalidomide-O-amido-C3-NH2 TFA
Cereblon Ligand-Linker Conjugates 16 TFA,E3 Ligase Ligand-Linker Conjugates 52 TFA |
E3 Ligase Ligand-Linker Conjugate; Ligand for E3 Ligase | PROTAC |
Thalidomide-O-amido-C3-NH2 TFA (Cereblon Ligand-Linker Conjugates 16 TFA) 包含基于 Thalidomide 的 cereblon 配体和 1 个 linker,是一种合成的 E3 连接酶配体-linker 偶联物,。 | |||
T18818 |
Thalidomide-O-amido-PEG-C2-NH2 hydrochloride
|
Others; E3 Ligase Ligand-Linker Conjugate | Others; PROTAC |
Thalidomide-O-amido-PEG-C2-NH2 hydrochloride 包含基于 Thalidomide 的 cereblon 配体和 1 个 linker,是一种合成的 E3 连接酶配体-linker 偶联物。它可用于 PROTAC 的合成分子。 | |||
T40031 |
Thalidomide-O-C6-NH2 hydrochloride
4-((6-aminohexyl)oxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochloride,萨力多胺-O-C6-氨基盐酸盐 |
E3 Ligase Ligand-Linker Conjugate | PROTAC |
Thalidomide-O-C6-NH2 hydrochloride (4-((6-aminohexyl)oxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochloride) 是一种合成的E3 连接酶配体 -linker 偶联物,用于 PROTAC dTAG-13 的合成。其中 dTAG-13 是一种 FKBP12F36V 和 BET 的降解剂。 | |||
T9401 |
Thalidomide-NH-PEG1-NH2 hydrochloride
4-[(2-(2-Aminoethoxy)ethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl |
E3 Ligase Ligand-Linker Conjugate | PROTAC |
Thalidomide-NH-PEG1-NH2 hydrochloride (4-[(2-(2-Aminoethoxy)ethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl) 包含基于 Thalidomide 的 cereblon 配体和 1 个 linker,是合成的 E3 连接酶配体-linker 偶联物,可用于 PROTAC 的合成。 | |||
T77912 |
Tz-Thalidomide
|
Epigenetic Reader Domain | Chromatin/Epigenetic |
Tz-Thalidomide 是一种四嗪修饰的 Thalidomide(E3连接酶配体),对 BRD4 具有一定的亲和力。 | |||
T39925 |
Thalidomide-NH-PEG3-COOH
Thalidomide-NH-PEG3-COOH |
Others | Others |
Thalidomide-NH-PEG3-COOH is a conjugate of the E3 ligase ligand-linker synthesized compound, which integrates a cereblon ligand based on Thalidomide and a linker employed in PROTAC technology. | |||
T39496 |
Thalidomide-O-C5-acid
Thalidomide-O-C5-acid |
Others | Others |
Thalidomide-O-C5-acid is a chemically synthesized conjugate that acts as an E3 ligase ligand-linker and combines the cereblon ligand derived from Thalidomide with a linker commonly utilized in PROTAC technology. | |||
T40149 |
Thalidomide-NH-PEG8-Ts
Thalidomide-NH-PEG8-Ts |
Others | Others |
Thalidomide-NH-PEG8-Ts is a chemically synthesized conjugate consisting of a Thalidomide-based cereblon ligand and an 8-unit PEG linker. This conjugate serves as an E3 ligase ligand-linker in PROTAC technology applications, including the degradation of IDO1 by a PROTAC degrader. | |||
T9382 |
Thalidomide-NH-C2-PEG3-OH
H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl]amino]- |
E3 Ligase Ligand-Linker Conjugate | PROTAC |
Thalidomide-NH-C2-PEG3-OH (H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl]amino]-) 包含基于 Thalidomide 的 cereblon 配体和 1 个 linker,是 E3 连接酶配体-linker 偶联物,可用于合成 PROTAC BCL-XL 降解剂 XZ739。 | |||
T40023 |
Pomalidomide-PEG3-CO2H
Thalidomide-NH-PEG3-propionic acid |
E3 Ligase Ligand-Linker Conjugate | PROTAC |
Pomalidomide-PEG3-CO2H (Thalidomide-NH-PEG3-propionic acid) 是一种由 E3 连接酶配体和连接体组成的偶联物,结合了基于 Thalidomide 的 Cereblon 配体和 3 个单元 PEG Linker。 | |||
T39379 |
Thalidomide-PEG3-NH2
Thalidomide-PEG3-NH2 |
Others | Others |
Thalidomide-PEG3-NH2 is a synthesized conjugate comprising an E3 ligase ligand-linker conjugate that integrates a cereblon ligand based on Thalidomide and a linker employed in PROTAC technology. | |||
T39377 |
Thalidomide-PEG2-NH2
Thalidomide-PEG2-NH2 |
Others | Others |
Thalidomide-PEG2-NH2 is a chemically synthesized E3 ligase ligand-linker conjugate consisting of a ligand derived from Thalidomide-based cereblon and a linker commonly employed in PROTAC technology. | |||
T39644 |
Thalidomide-O-C6-COOH
Thalidomide-O-C6-COOH |
Others | Others |
Thalidomide-O-C6-COOH is a synthetic conjugate comprising an E3 ligase ligand-linker, which combines the Thalidomide derived cereblon ligand with a PROTAC technology linker. | |||
T39645 |
Thalidomide-O-C7-acid
Thalidomide-O-C7-acid |
Others | Others |
Thalidomide-O-C7-acid is a compound created through the synthesis of an E3 ligase ligand-linker conjugate. It consists of a cereblon ligand derived from Thalidomide, combined with a linker that is commonly employed in PROTAC technology. | |||
T39642 |
Thalidomide-O-C3-acid
Thalidomide-O-C3-acid |
Others | Others |
Thalidomide-O-C3-acid is a chemically derived conjugate that combines a cereblon ligand based on Thalidomide and a linker commonly employed in PROTAC technology. This synthesized E3 ligase ligand-linker conjugate serves to facilitate targeted protein degradation. | |||
T39604 |
Thalidomide-NH-PEG4-Ms
Thalidomide-NH-PEG4-Ms |
Others | Others |
Thalidomide-NH-PEG4-Ms is a conjugate that consists of a cereblon ligand based on Thalidomide and a linker molecule, which serves as a ligand-linker moiety for E3 ligase. This conjugate is specifically designed as a degrader for PROTAC BCL-XL, known as XZ739. | |||
T40036 |
Thalidomide-NH-PEG4-COOH
Thalidomide-NH-PEG4-COOH |
Others | Others |
Thalidomide-NH-PEG4-COOH is a conjugate comprising an E3 ligase ligand-linker, utilized in the synthesis of dCBP-1. dCBP-1 itself functions as a powerful and selective heterobifunctional degrader targeting p300/CBP. | |||
T39382 |
Thalidomide-NH-C8-NH2
Thalidomide-NH-C8-NH2 |
Others | Others |
Thalidomide-NH-C8-NH2 is a synthetic conjugate of an E3 ligase ligand-linker, which combines a cereblon ligand based on Thalidomide with a specific linker utilized in PROTAC technology. | |||
T39376 |
Thalidomide-O-C8-NH2
Thalidomide-O-C8-NH2 |
Others | Others |
Thalidomide-O-C8-NH2 is a chemically synthesized conjugate that combines a cereblon ligand derived from Thalidomide with a linker utilized in PROTAC technology. It functions as an E3 ligase ligand-linker conjugate. | |||
T17918 |
Thalidomide-O-amido-PEG2-C2-NH2 TFA
E3 Ligase Ligand-Linker Conjugates 24 TFA,Cereblon Ligand-Linker Conjugates 10 TFA |
Others; E3 Ligase Ligand-Linker Conjugate | Others; PROTAC |
Thalidomide-O-amido-PEG2-C2-NH2 TFA (E3 Ligase Ligand-Linker Conjugates 24 TFA) 包含基于 Thalidomide 的 cereblon 配体和 2 个单元的 PEG linker,是一种合成的 E3 连接酶配体-linker 偶联物。 | |||
T39893 |
Thalidomide-Piperazine-PEG2-NH2
Thalidomide-Piperazine-PEG2-NH2 |
Others | Others |
Thalidomide-Piperazine-PEG2-NH2 is a synthetic E3 ligase ligand-linker conjugate that combines the cereblon ligand derived from Thalidomide with a linker commonly utilized in PROTAC technology. | |||
T39950 |
Thalidomide-amido-PEG2-NH2
Thalidomide-amido-PEG2-NH2 |
Others | Others |
Thalidomide-amido-PEG2-NH2 is a synthetic conjugate of an E3 ligase ligand-linker that combines the Thalidomide-based cereblon ligand with a linker commonly utilized in PROTAC technology. | |||
T39511 |
Thalidomide-O-C7-NH2
Thalidomide-O-C7-NH2 |
Others | Others |
Thalidomide-O-C7-NH2 is a synthesized conjugate compound comprising an E3 ligase ligand-linker conjugate. This compound incorporates a cereblon ligand based on Thalidomide and a linker that is commonly employed in PROTAC technology. | |||
T39964 |
Thalidomide-PEG4-NH2 hydrochloride
Thalidomide-PEG4-NH2 hydrochloride |
Others | Others |
Thalidomide-PEG4-NH2 hydrochloride is a compound synthesized as an E3 ligase ligand-linker conjugate. It encompasses the cereblon ligand derived from Thalidomide and a linker utilized specifically in PROTAC technology. | |||
T39917 |
Thalidomide-O-C2-acid
Thalidomide-O-C2-acid |
Others | Others |
Thalidomide-O-C2-acid is a compound designed by synthesizing an E3 ligase ligand-linker conjugate. It comprises a cereblon ligand derived from Thalidomide and a linker commonly used in PROTAC technology. | |||
T39643 |
Thalidomide-O-C4-COOH
Thalidomide-O-C4-COOH |
Others | Others |
Thalidomide-O-C4-COOH is a synthetic conjugate compound, serving as an E3 ligase ligand-linker, which combines a cereblon ligand derived from Thalidomide and a linker utilized in PROTAC technology. | |||
T39721 |
Thalidomide-5-PEG2-Cl
Thalidomide-5-PEG2-Cl |
Others | Others |
Thalidomide-5-PEG2-Cl, a Thalidomide-derived cereblon ligand, serves as the ligand for the recruitment of CRBN protein. It can be conjugated to the protein ligand via a linker to produce PROTACs. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN3098 |
5-hydroxythalidomide
5,8,9,14-Tetraacetoxy-3-benzoyloxy-10,15-dihydroxypepluane |
Others | Others |
5-hydroxythalidomide 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN3098,CAS号为 219916-77-5。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-00541 |
LON PROTEASE Protein, E. coli, Recombinant (His)
|
E. coli | E. coli |
Lon protease, an ATP-dependent mitochondrial protease, is important in mitochondrial protein maintenance. Lon protease is a multifunctional enzyme, and its functions include the degradation of damaged proteins and naturally short-lived proteins, ATPase and chaperone-like activities, as well as DNA binding. Lon protease plays a major role in the protein quality control system in mammalian cell mitochondria. It is present in the mitochondrial matrix and degrades oxidized and misfolded proteins, th... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T13141 |
Thalidomide D4
|
Others | Others |
Thalidomide D4 is a deuterium labeled Thalidomide, has immunomodulatory, anti-inflammatory and anti-angiogenic cancer properties. |