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Search Results for " th17 cell "

Targets Recommended: ROR

8

抑制剂 & 化合物

2

天然产物

10

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T7388	GSK805	ROR	Metabolism
	GSK805 是能够生物利用的、具有 CNS 穿透性的 RORγt 抑制剂。
T9195	SHR0302 ARQ252	Apoptosis; JAK	Angiogenesis; Apoptosis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	SHR0302 (ARQ252) 是一种具有口服活性的 JAK 抑制剂。它对 JAK1的结合力是 JAK2的 10 倍以上，是 JAK3的 77 倍，是 Tyk2的 420 倍。它抑制JAK1-STAT3磷酸化并诱导肝星状细胞凋亡，具有抗增殖和抗炎作用。
T19710	Ciglitazone Ciglitazona,U 63287,ADD3878,ADD-3878,U-63287,ADD 3878	Apoptosis; p38 MAPK; PPAR	Apoptosis; DNA Damage/DNA Repair; MAPK; Metabolism
	Ciglitazone (ADD 3878) 是一种强效和选择性的PPARγ激动剂(EC50：3μM)和口服降糖药。Ciglitazone 抑制th17细胞的增殖和分化，降低胰岛素水平、血管内皮生长因子的产生和血压，诱导胃癌细胞的细胞周期停止。Ciglitazone 能诱导负鼠肾上皮细胞的凋亡，激活p38 MAPK 和凋亡诱导因子(AIF)的核转位。 Ciglitazone 在肥胖症和高血糖症的动物模型中表现出降血糖活性。
T79527	BET BD2-IN-1	Epigenetic Reader Domain	Chromatin/Epigenetic
	BET BD2-IN-1（compound 45）为BETBD2选择性抑制剂，IC50值为1.6 nM，通过抑制STAT3与NF-κB活性，阻断Th17细胞的分化，适用于银屑病与炎症性肠病研究。
T72254	RORγt inverse agonist 26	Others	Others
	RORγt inverse agonist 26 是一种有效的 RORγt 反向激动剂。RORγt inverse agonist 26 调节 Th17 细胞的分化并抑制 IL-17的产生。RORγt inverse agonist 26 具有研究炎症和自身免疫性疾病的潜力。
T64017	RORγt agonist 3	Others	Others
	RORγt agonist 3 是 RORγt 的有效激动剂。RORγt agonist 3 能够促使 Th17 细胞分化，增加促炎细胞因子水平，进而提高淋巴细胞的细胞毒性。RORγt agonist 3 能够阻碍调节性 T 细胞的产生，并免疫反应产生抑制作用。
T64140	RORγt agonist 2	Others	Others
	RORγt agonist 2 是 RORγt 的有效的激动剂。RORγt agonist 2 能够诱导 Th17 细胞分化，增加促炎细胞因子水平，进而增强淋巴细胞的细胞毒性。RORγt agonist 2 对调节性 T 细胞的产生表现出抑制作用，能够抑制免疫反应。
T35797	Lithocholic acid 3-sulfate disodium Sulfolithocholic acid disodium	Others	Others
	Lithocholic acid 3-sulfate disodium (Sulfolithocholic acid disodium) 可作为 RORgammat 配体，抑制 Th17 细胞分化。Lithocholic acid 3-sulfate disodium 是石胆酸（LCA）的硫酸化产物，可诱导细胞损伤。

化合物

Cat.No: T7388

Target: ROR

Cat.No: T9195

Synonym: ARQ252

Target: Apoptosis, JAK

Cat.No: T19710

Synonym: Ciglitazona,U 63287,ADD3878,ADD-3878,U-63287,ADD 3878

Target: Apoptosis, p38 MAPK, PPAR

Cat.No: T79527

Target: Epigenetic Reader Domain

RORγt inverse agonist 26

Cat.No: T72254

Target: Others

RORγt agonist 3

Cat.No: T64017

Target: Others

RORγt agonist 2

Cat.No: T64140

Target: Others

Lithocholic acid 3-sulfate disodium

Cat.No: T35797

Synonym: Sulfolithocholic acid disodium

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T13502	3-Oxo-5β-cholanoic acid 3-氧代-5β-胆烷酸,Dehydrolithocholic acid	ROR	Metabolism
	3-Oxo-5β-cholanoic acid (Dehydrolithocholic acid) 是胆汁酸的一种代谢产物。3-Oxo-5β-cholanoic acid 直接与关键转录因子RORγt(Kd=1.13 μM) 结合抑制TH17细胞分化。
TN1778	Isoformononetin 异刺芒柄花素,黄豆苷元杂质	IL Receptor; Antifection	Immunology/Inflammation; Microbiology/Virology
	Isoformononetin shows fungitoxic activity against Cladosporium sphaerospermum; it also has immunomodulatory activity, it inhibits the differentiation of Th17 cells and B-cell lymphopoesis to promote osteogenesis in estrogen-deficient bone loss conditions.

天然产物

3-Oxo-5β-cholanoic acid

Cat.No: T13502

Synonym: 3-氧代-5β-胆烷酸,Dehydrolithocholic acid

Target: ROR

Isoformononetin

Cat.No: TN1778

Synonym: 异刺芒柄花素,黄豆苷元杂质

Target: IL Receptor, Antifection

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-01316	IL-21 Protein, Mouse, Recombinant (His) 白细胞介素,IL-21,Interleukin-21,白介素,IL21	Mouse	E. coli
	Interleukin-21(IL-21) is an approximately 14 kDa cytokine which belongs to the IL-15/IL-21 family. Mature mouse IL-21 shares 66%,59%, 58%, and 88% aa sequence identity with mature canine, human, rabbit, and rat IL-21, respectively. IL-21 is produced by activated T follicular helper cells (Tfh), Th17 cells, and NKT cells. It exerts its biological effects through a heterodimeric receptor complex (IL-21 specific IL-21 R). IL-21 is a cytokine that has potent regulatory effects on cells of the immun...
TMPK-00515	IL-1 beta/IL-1F2 Protein, Cynomolgus, Recombinant (His) Interleukin-1 β,IL-1 beta,IL1B,IL1F2,IL-1BETA,IL-1β,IL-1 β,I...	Cynomolgus	E. coli
	Interleukin-1 beta (IL-1β) is induced by inflammatory signals in a broad number of immune cell types. IL-1β (and IL-18) are the only cytokines which are processed by caspase-1 after inflammasome-mediated activation. IL-1 signaling activates innate immune cells including antigen presenting cells, and drives polarization of CD4 T cells towards T helper type (Th) 1 and Th17 cells. IL-1 beta/IL-1F2 Protein, Cynomolgus, Recombinant (His) is expressed in E. coli expression system with C-His tag. The p...
TMPK-00161	IL-1 beta/IL-1F2 Protein, Human, Recombinant (His & Avi) Interleukin-1 beta,IL-1 β,IL-1β,IL1F2,IL-1BETA,Interleukin-1...	Human	E. coli
	Interleukin-1 beta (IL-1β) is induced by inflammatory signals in a broad number of immune cell types. IL-1β (and IL-18) are the only cytokines which are processed by caspase-1 after inflammasome-mediated activation. IL-1 signaling activates innate immune cells including antigen presenting cells, and drives polarization of CD4 T cells towards T helper type (Th) 1 and Th17 cells. IL-1 beta/IL-1F2 Protein, Human, Recombinant (His & Avi) is expressed in E. coli expression system with C-His-Avi tag. ...
TMPK-00278	RGMA Protein, Human, Recombinant (His & Avi) RGMA,RGM	Human	HEK293 Cells
	Repulsive guidance molecule (RGM) is a glycosylphosphatidylinositol (GPI)-anchored glycoprotein that has diverse functions in the developing and pathological central nervous system (CNS). The binding of RGM to its receptor neogenin regulates axon guidance, neuronal differentiation, and survival during the development of the CNS. RGMa induces T cell activation in experimental autoimmune encephalomyelitis (EAE), which is the animal model of multiple sclerosis (MS). RGM is expressed in pathogenic ...
TMPK-01105	IL-22RA1 Protein, Human, Recombinant (hFc) IL-22R-alpha-1,CRF2-9,IL-TIF-R1,IL-22R-α-1,IL22R1,zcytoR11,I...	Human	HEK293 Cells
	Interleukin (IL)-22 is a member of the IL-10 family of cytokines and represents an important effector molecule of activated Th22, Th1, and Th17 cells, as well as Tc-cell subsets, gammadelta T cells, natural killer (NK), and NKT cells. IL-22 mediates its effects via a heterodimeric transmembrane receptor complex consisting of IL-22R1 and IL-10R2 and subsequent Janus kinase-signal transducers and activators of transcription (JAK-STAT) signaling pathways including Jak1, Tyk2, and STAT3. IL-22RA1 Pr...
TMPJ-00402	CD117 Protein, Human, Recombinant (hFc) KIT,CD117,v-kit Hardy-Zuckerman 4 feline sarcoma vi...	Human	HEK293 Cells
	C-Kit/SCF R is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). c-Kit contains 5 Ig-like C2-type (immunoglobulin-like) domains and 1 protein kinase domain. It belongs to the protein kinase superfamily and CSF-1/PDGF receptor subfamily. SCF R expression on mast cells enables them to infiltrate SCF-secreting tumors where they promote tumor growth and induce local immune suppression. SCF R is up-regulated on dendritic cells by Th2-orTh17-biasing sti...
TMPK-01071	IL-22RA1 Protein, Mouse, Recombinant (hFc) IL-22R α1,IL22R,zcytoR11,IL-TIF-R1,CRF2-9,IL-22R-alpha-1,IL-...	Mouse	HEK293 Cells
	Interleukin (IL)-22 is a member of the IL-10 family of cytokines and represents an important effector molecule of activated Th22, Th1, and Th17 cells, as well as Tc-cell subsets, gammadelta T cells, natural killer (NK), and NKT cells. IL-22 mediates its effects via a heterodimeric transmembrane receptor complex consisting of IL-22R1 and IL-10R2 and subsequent Janus kinase-signal transducers and activators of transcription (JAK-STAT) signaling pathways including Jak1, Tyk2, and STAT3. IL-22RA1 Pr...
TMPK-00162	IL-1 beta/IL-1F2 Protein, Human, Recombinant (His & Avi), Biotinylated IL-1 β,IL-1β,IL-1 β/IL-1F2,IL-1 beta,IL1B,Interleukin-1 beta...	Human	E. coli
	Interleukin-1 beta (IL-1β) is induced by inflammatory signals in a broad number of immune cell types. IL-1β (and IL-18) are the only cytokines which are processed by caspase-1 after inflammasome-mediated activation. IL-1 signaling activates innate immune cells including antigen presenting cells, and drives polarization of CD4 T cells towards T helper type (Th) 1 and Th17 cells. IL-1 beta/IL-1F2 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in E. coli expression system with C...
TMPJ-00359	SLAMF3 Protein, Human, Recombinant (His) Signaling lymphocytic activation molecule 3,CD229,Cell	Human	HEK293 Cells
	SLAMF3 (CD229) is a type I transmembrane glycoprotein in the SLAM subgroup of the CD2 family. Mature human SLAMF3 consists of a 407 amino acid (aa) extracellular domain (ECD) with two Ig-like V-set and two Ig-like truncated C2-set domains. The ECD of human SLAMF3 shares 57% - 59% aa sequence identity with mouse and rat SLAMF3. Within the first two Ig-like domains that are common to all SLAM proteins, human SLAMF3 shares 24% - 39% aa sequence identity with human 2B4, BLAME, CD2F-10, CD84, CRACC, ...
TMPH-02841	Prohibitin Protein, Mouse, Recombinant (His) Phb1,B-cell receptor-associated protein 32,Prohibit...	Mouse	E. coli
	Protein with pleiotropic attributes mediated in a cell-compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription factors in the nucleus. Plays a role in adipose tissue and glucose Homeostasis in a sex-specific manner. Contributes to pulmonary vascular remodeling by accelerating proliferation of pulmonary arterial smooth muscle cells.; In the mitochondria, together with...

重组蛋白

IL-21 Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-01316

Species: Mouse

Expression System: E. coli

IL-1 beta/IL-1F2 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-00515

Species: Cynomolgus

Expression System: E. coli

IL-1 beta/IL-1F2 Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00161

Species: Human

Expression System: E. coli

RGMA Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00278

Species: Human

Expression System: HEK293 Cells

IL-22RA1 Protein, Human, Recombinant (hFc)

Cat.No: TMPK-01105

Species: Human

Expression System: HEK293 Cells

CD117 Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-00402

Species: Human

Expression System: HEK293 Cells

IL-22RA1 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPK-01071

Species: Mouse

Expression System: HEK293 Cells

IL-1 beta/IL-1F2 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00162

Species: Human

Expression System: E. coli

SLAMF3 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00359

Species: Human

Expression System: HEK293 Cells

Prohibitin Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02841

Species: Mouse

Expression System: E. coli

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