Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T37910 |
Tenofovir diphosphate triethylamine
|
Others | Others |
Tenofovir diphosphate triethylamine (TFV-DP triethylamine) is a competitive inhibitor of DNA polymerases for dATP, functioning as a substrate for HIV type 1 reverse transcriptase (HIV-1 RT)[1]. | |||
T37909 |
Tenofovir diphosphate
|
Others | Others |
Tenofovir diphosphate (TFV-DP) is a competitive inhibitor of DNA polymerases, specifically targeting dATP, and it serves as a substrate for the reverse transcriptase (RT) of human immunodeficiency virus type 1 (HIV-1)[1]. | |||
T37523 |
Tenofovir diphosphate (sodium salt)
|
Others | Others |
Tenofovir diphosphate is an inhibitor of HIV reverse transcriptase (Kis = 0.022 and 1.55 μM for RNA and DNA, respectively) and hepatitis B virus (HBV) polymerase (Ki = 0.18 μM). It is selective for these enzymes over DNA polymerase α and β, as well as mitochondrial DNA polymerase γ (Kis = 5.2, 81.7, and 59.5 μM, respectively). Tenofovir diphosphate is formed intracellularly through phosphorylation of the prodrugs tenofovir and tenofovir disoproxil by nucleotide kinases. Increased levels of tenof... |