Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T37523 |
Tenofovir diphosphate (sodium salt)
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Others | Others |
Tenofovir diphosphate is an inhibitor of HIV reverse transcriptase (Kis = 0.022 and 1.55 μM for RNA and DNA, respectively) and hepatitis B virus (HBV) polymerase (Ki = 0.18 μM). It is selective for these enzymes over DNA polymerase α and β, as well as mitochondrial DNA polymerase γ (Kis = 5.2, 81.7, and 59.5 μM, respectively). Tenofovir diphosphate is formed intracellularly through phosphorylation of the prodrugs tenofovir and tenofovir disoproxil by nucleotide kinases. Increased levels of tenof... | |||
T12814 |
(S)-Tenofovir
(S)-替诺福韦,(S)-PMPA,(S)-GS 1278,(S)-TDF |
Others | Others |
(S)-Tenofovir ((S)-PMPA) 是Tenofovir 的活性较低的S-对映体,Tenofovir 是一种核苷酸逆转录酶抑制剂。 | |||
T1649 |
Tenofovir
替诺福韦,泰诺福韦,PMPA,TDF,GS 1278 |
HBV; HIV Protease; Reverse Transcriptase | Microbiology/Virology; Proteases/Proteasome |
Tenofovir (GS 1278) 是一种核苷酸逆转录酶抑制剂,可研究 HIV 和慢性乙型肝炎。 | |||
T28946 |
Tenofovir exalidex
Tenofovir,HDP-Tenofovir,CMX-157,CMX157,CMX 157 |
Antiviral | Immunology/Inflammation |
Tenofovir exalidex (CMX 157) 是一种非环核苷酸类似物 Tenofovir 的脂质结合物,对野生型和抗逆转录病毒耐药的 HIV 毒株,包括多药核苷/核苷酸类似物耐药病毒,都有活性。Tenofovir exalidex 对人外周血单个核细胞中所有主要的HIV-1和HIV-2亚型以及单核细胞来源的巨噬细胞中所有 HIV-1 菌株具有活性,EC50 范围在 0.2 和 7.2 nM 之间。Tenofovir exalidex 具有口服活性,无明显毒性。Tenofovir exalidex 对 HBV 也有活性。 |