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Search Results for " tau protein "

Targets Recommended: Others

38

抑制剂 & 化合物

1

天然产物

2

化合物库

21

重组蛋白

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Cat. No.	Product Name
L9840	抗阿尔茨海默症化合物库		986 compounds
	986 种阿尔茨海默症相关的化合物集合，可用于高通量和高内涵筛选；
L1310	细胞骨架化合物库		759 compounds
	759 种细胞骨架相关的化合物，可以用于高通量和高内涵筛选；

化合物库

抗阿尔茨海默症化合物库

Cat.No: L9840

Compounds: 986

细胞骨架化合物库

Cat.No: L1310

Compounds: 759

Cat. No.	Product Name	Target	Signaling Pathways
TP1453	Tau protein (592-597), Human TFA	Others	Others
	Tau protein (592-597), Human TFA 是人 Tau 蛋白的肽片段。
TP1420	Microtubule-associated protein tau (26-44)
	Microtubule-associated protein tau (26-44) is a synthetic peptide with an amino group conjugated to glutamine and a carboxyl group conjugated to lysine.
T79038	Tau protein aggregation-IN-1	Others	Others
	Tau protein aggregation-IN-1（化合物 0c）是一种针对Tau protein聚集的抑制剂。该化合物主要应用于研究蛋白质折叠障碍类疾病，包括阿尔茨海默病、痴呆、帕金森病、亨廷顿舞蹈病及基于朊病毒引起的海绵状脑病。
T81031	tau protein/α-synuclein-IN-1	Others	Others
	tau protein/α-synuclein-IN-1为tau protein与α-synuclein双重抑制剂，能够抑制M17D神经母细胞瘤细胞中α-syn包涵体的形成，适用于阿尔茨海默病相关研究。
T9611	PF-04802367	GSK-3	PI3K/Akt/mTOR signaling; Stem Cells
	PF-04802367是 GSK-3高选择性抑制剂，对 GSK-3β酶的 IC50为 2.1 nM。它抑制两种 GSK-3 亚型（GSK-3α和GSK-3β）效果差不多，IC50值分别为 10.0 和 9.0 nM。它具有理想的中枢神经系统特性和效力。
T22118	NQTrp	Microtubule Associated	Cytoskeletal Signaling
	NQTrp 是芳香萘醌-色氨酸杂交分子，可以抑制 tau 蛋白的聚集，具有抗淀粉样蛋白活性。NQTrp 对六肽 (41GCWMLY46，γD-crystallin 的 N 端)和全长 γD-crystallin 的体外聚集有抑制作用。
T62899	Tau-aggregation and neuroinflammation-IN-1	Microtubule Associated; NO Synthase	Cytoskeletal Signaling; Immunology/Inflammation
	Tau-aggregation and neuroinflammation-IN-1 是一种有效的 Tau 蛋白聚集体抑制剂，对 AcPHF6 和全长 tau 蛋白聚集体显示出显著的抑制活性。Tau-aggregation and neuroinflammation-IN-1具有抗炎活性且可减少 NO 释放。Tau-aggregation and neuroinflammation-IN-1 对 LSP 刺激的 BV2 细胞具有低细胞毒性。Tau-aggregation and neuroinflammation-IN-1 可逆转冈田酸诱导的大鼠记忆障碍。
T67834	C004019	Microtubule Associated; PROTACs	Cytoskeletal Signaling; PROTAC
	C004019是一种小分子 PROTAC ，能够靶向tau，用于从细胞内选择性降解蛋白质，同时招募tau 和E3连接酶（Vhl），选择性增强tau 蛋白的泛素化和蛋白水解。C004019是AD 及相关tau 蛋白疾病的候选药物。
T76726	Zagotenemab LY33003560	Microtubule Associated	Cytoskeletal Signaling
	Zagotenemab 是一种人源化抗微管相关蛋白 tau 抗体，能选择性地调节大脑中的 tau 沉积物。Zagotenemab 可用于研究阿尔兹海默症等神经系统疾病。
T61360	ARN25068	GSK-3; DYRK; Microtubule Associated; Src	Angiogenesis; Cell Cycle/Checkpoint; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Stem Cells; Tyrosine Kinase/Adaptors
	ARN25068是三种蛋白激酶(GSK-3β、FYN和DYRK1A)的亚微摩尔抑制剂，可用于治疗tau相关神经系统疾病。
T61661	LY3372689 Formulaic Ia	Microtubule Associated	Cytoskeletal Signaling
	LY3372689 (Formulaic Ia) 是一种具有口服活性的O-GlcNAcase (OGA)酶抑制剂,可用于包括阿尔茨海默病在内的 tau 蛋白类疾病。
T37621	Ezeprogind disulfate	Beta Amyloid	Neuroscience
	Ezeprogind disulfate 是一种神经营养诱导剂。 Ezeprogind disulfate 针对所有神经退行性变，包括 Abeta 蛋白或 tau 蛋白。 Ezeprogind disulfate 可用于神经系统疾病相关研究，包括进行性核上性麻痹（PSP）、tau 蛋白病、阿尔茨海默病和帕金森病等。
T77342	GSK-3 inhibitor 3	GSK-3; Microtubule Associated	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Stem Cells
	GSK-3 inhibitor 3 是一种具有选择性、具有口服活性和脑渗透性的 GSK-3 抑制剂，对 GSK-3α 和 GSK-3β 具有抑制作用， IC50s 分别为 0.35 nM 和 0.25 nM。GSK-3 inhibitor 3 在三重转基因小鼠阿尔茨海默病模型中降低 Tau 蛋白 (tau protein) S396 磷酸化水平，IC50为 10 nM。GSK-3 inhibitor 3 可用于研究神经系统疾病。
T77341	GSK-3 inhibitor 4	GSK-3; CDK	Cell Cycle/Checkpoint; PI3K/Akt/mTOR signaling; Stem Cells
	GSK-3 inhibitor 4 是一种具有口服活性和脑渗透性的 GSK-3，CDK2 和 CDK5 三重抑制剂，对 GSK-3β，GSK-3α，CDK2 和 CDK5 具有抑制作用，IC50 值分别为 0.56 nM ，0.45 nM ，0.47 μM，0.68 μM。GSK-3 inhibitor 4 可有效降低 Tau protein 水平。GSK-3 inhibitor 4 可用于研究阿尔茨海默症。
T7003	Leucomethylene blue mesylate N3,N3,N7,N7-四甲基-10H-吩噻嗪-3,7-二胺二甲磺酸盐,TRx0237 mesylate,TRx0237 (LMTX) mesylate,Methylene blue leuco base mesylate salt,Leucomethylene Blue Dimesylate	Beta Amyloid; Microtubule Associated	Cytoskeletal Signaling; Neuroscience
	Leucomethylene blue mesylate (TRx0237 mesylate) 是一种 Methylene blue (亚甲基蓝)的还原形式, 亚甲基蓝是一种化学指示剂和生物染色剂。它是一种具有口服活性的二代 tau 蛋白聚集的抑制剂 (Ki=为0.12 μM)，可用于阿尔兹海默症的研究。
T111959	IFB-088 acetate	Others	Others
	IFB-088 acetate 是一种苄基胍衍生物，可用于治疗与PPP1R15A 途径相关并与蛋白质错误折叠应激相关的疾病和癌症，如tau 病、突触核蛋白病、多谷氨酰胺和多丙氨酸疾病、白质营养不良、囊性纤维化、多发性硬化症、溶酶体储存障碍、淀粉样变性疾病、炎症、代谢障碍、心血管疾病、骨质疏松症、神经系统创伤等等。
T30438	BF-158	Others	Others
	BF-158 is used for imaging tau protein.
T39660	Tau tracer 1	Others	Others
	Tau tracer 1 is a radiopharmaceutical agent designed specifically for visualizing Tau protein aggregates, commonly associated with neurodegenerative diseases. Its primary application lies in the diagnosis of these conditions.
T40409	Tau Peptide (275-305) (Repeat 2 domain)
	Tau Peptide (275-305), also known as the R2 domain fragment, represents the second repeat unit of the microtubule-binding domain of the Alzheimer's tau peptide. Tau Peptide (275-305) is considered crucial in determining the biochemical characteristics of the complete tau protein.
T37051	Tau tracer 2	Others	Others
	Tau tracer 2 (Pl-2620) is a specific imaging agent designed to detect and visualize Tau protein aggregates. Its primary application lies in the diagnosis of neurodegenerative diseases [1].
T76652	PHF6
	PHF6 (VQIVYK) 为一自组装序列，能启动全长tau蛋白聚集，其定位于tau蛋白第三个微管结合重复区。
T80616	Posdinemab
	Posdinemab为一种针对微管相关蛋白tau (MAPT)的人源化IgG1κ抗体。
T61087	THK-5105	Others	Others
	THK-5105为芳基喹啉衍生物，具备与tau原纤维高度结合的亲和力。它对tau蛋白聚集体及含tau的阿尔茨海默病(AD)脑匀浆显示出显著的结合能力。18F-THK-5105展现出作为tau成像PET探针的潜能。
T60907	THK-5117	Others	Others
	THK-5117 是一种芳基喹啉衍生物，具有作为 tau 成像 PET 探针的潜力。THK-5117 对 tau 原纤维表现出高结合亲和力，Ki 值为 10.5 nM。THK-5117 还显示出对 tau 蛋白聚集体和富含 tau 的阿尔茨海默病 (AD) 脑匀浆的高结合亲和力。
T76886	Semorinemab
	Semorinemab (RG 6100) 是一种抗 Tau 人源化 IgG4单克隆抗体，靶向 Tau 蛋白的 N 端部分(氨基酸残基 6-23)。Semorinemab 与人 Tau 蛋白结合的 Kd 值为 3.8 nM。Semorinemab 可用于阿尔茨海默病的研究。
T63481	Tau-aggregation-IN-1	Others	Others
	Tau-aggregation-IN-1 是一种 dopamine D2和 D3受体激动剂，也是 tau441 蛋白聚合抑制剂 (IC50: 21 μM)。
T62307	Aha1/Hsp90-IN-1	Others	Others
	Aha1/Hsp90-IN-1 (Compound 17) 是一种 Aha1/Hsp90 complex 抑制剂，对 tau 蛋白聚集具有抑制作用。Aha1/Hsp90-IN-1 能够破坏 Aha1/Hsp90 的相互作用 (IC50: 3.32 μM)。
T40701	Ezeprogind AZP-2006	Others	Others
	Ezeprogind (AZP-2006) is an orally active neurotrophic inducer that effectively addresses the underlying factors contributing to neurodegeneration, with a broad scope extending beyond the conventional targets like Abeta protein and tau protein. Exhibiting potent neuroprotective properties, Ezeprogind is a valuable tool for studying a range of neurological disorders, including progressive supranuclear palsy (PSP), tauopathies, Alzheimer's disease, Parkinson's disease, and others.
T78173	Aβ/tau aggregation-IN-3	Others	Others
	Aβ/tau aggregation-IN-3为一种高效的抗Aβ聚集剂，经Aβ-硫黄素T (Aβ-ThT) 聚集测定显示，其半抑制浓度(IC50)为0.85 μM，表现出显著的抗淀粉样蛋白活性。
T61579	BuChE-IN-5	Others	Others
	BuChE-IN-5 (compound 25b) is a highly potent BuChE inhibitor, displaying an IC50 value of 1.94 μM. It effectively inhibits aggregation of Aβ and tau protein in Escherichia coli. Furthermore, BuChE-IN-5 exhibits considerable free radical scavenging capacity and antioxidant activity. Given these properties, it holds promise as a valuable tool for Alzheimer's disease research [1].
T75361	BSB	Others	Others
	BSB，一种刚果红衍生的荧光探针，既与细胞外淀粉样β蛋白发生结合，也能与由异常tau蛋白与突触核蛋白组成的细胞内病变相结合，是作为阿尔茨海默病原型成像剂的代表。
T84747	(R,S,S)-VH032	Others	Others
	(R,S,S)-VH032 为E3 Ligase用于PROTACs合成的Ligand。作为VHL配体及VHL/HIF-1α相互作用抑制剂，该化合物用于募集von Hippel-Lindau (VHL)蛋白，进而可合成针对tau的小分子PROTACC004019。
T39183	Okadaic acid ammonium salt	Others	Others
	Okadaic acid ammonium salt, a marine toxin, serves as an inhibitor of protein phosphatases (PP), displaying a higher affinity for PP2A (IC 50 =0.1-0.3 nM) alongside inhibitory effects on PP1 (IC 50 =15-50 nM), PP3 (IC 50 =3.7-4 nM), PP4 (IC 50 =0.1 nM), and PP5 (IC 50 =3.5 nM), but does not affect PP2C. By inhibiting PPs, this compound promotes protein phosphorylation and acts as a tumor promoter. Additionally, it is involved in inducing tau phosphorylation.
T74812	hBChE-IN-1	Others	Others
	hBChE-IN-1 (compound 4) 是一种喹啉基衍生物，是一种有效的 hBChE 抑制剂 (IC50=7 nM) 并且具有高选择性超过 hAChE。 hBChE-IN-1 对tau 和Aβ40蛋白聚集具有抑制活性，IC50值分别为 20 和 4.3 μM。 hBChE-IN-1 可用于阿尔茨海默病的研究。
T78874	GSK-3β inhibitor 15	Others	Others
	GSK-3β inhibitor15（Compound 54）是一种高效GSK-3β抑制剂（IC50: 3.4 nM），能够抑制Aβ1-42诱导的GSK-3β与tau蛋白的磷酸化并阻止LPS诱导的iNOS表达，显示出对Aβ1-42引起的神经毒性的神经保护效应。该化合物在阿尔茨海默病（AD）研究中具有潜在应用价值。
T82242	hAChE-IN-6	Others	Others
	hAChE-IN-6（化合物51）是一种能够穿透血脑屏障的AChE抑制剂，具有0.16 μM的IC50。该化合物同时对hBuChE与GSK3β显示出抑制活性，其IC50分别为0.69 μM和0.26 μM。hAChE-IN-6亦能抑制tau蛋白与Aβ1-42的自聚集，适用于阿尔茨海默病（AD）的相关研究。
T82243	hAChE-IN-5	GSK-3	PI3K/Akt/mTOR signaling; Stem Cells
	hAChE-IN-5（化合物49）是一种同时针对hAChE和hBuChE的有效抑制剂，其IC50值均为0.17 μM。此外，hAChE-IN-5对GSK3β同样展现出良好的抑制活性，IC50值为0.21 μM。作为tau蛋白聚集和Aβ1-42自聚集的抑制剂，hAChE-IN-5能够结合PAS，进而阻止Aβ依赖的神经毒性。其能穿透血脑屏障（BBB），显示出成为多靶点抗阿尔茨海默病药物研究的潜力。
T75339	Methylene blue hydrate	Others	Others
	亚甲蓝（Basic Blue 9）水合物，作为鸟苷酸环化酶（sGC）、单胺氧化酶A（MAO-A）及NO合酶（NOS）的抑制剂，常用于医疗作为血管加压剂及染料。该化合物通过影响一氧化氮合成酶/鸟苷酸环化酶信号通路，能够减少脉冲前抑制，同时作为一种氧化还原循环化合物，具有穿透血脑屏障的能力，并作为Tau蛋白聚集的抑制剂，有助于缓解脑水肿、减轻小胶质细胞活化和神经炎症。

化合物

Tau protein (592-597), Human TFA

Cat.No: TP1453

Target: Others

Microtubule-associated protein tau (26-44)

Cat.No: TP1420

Tau protein aggregation-IN-1

Cat.No: T79038

Target: Others

tau protein/α-synuclein-IN-1

Cat.No: T81031

Target: Others

Cat.No: T9611

Target: GSK-3

Cat.No: T22118

Target: Microtubule Associated

Tau-aggregation and neuroinflammation-IN-1

Cat.No: T62899

Target: Microtubule Associated, NO Synthase

Cat.No: T67834

Target: Microtubule Associated, PROTACs

Cat.No: T76726

Synonym: LY33003560

Target: Microtubule Associated

Cat.No: T61360

Target: GSK-3, DYRK, Microtubule Associated, Src

Cat.No: T61661

Synonym: Formulaic Ia

Target: Microtubule Associated

Ezeprogind disulfate

Cat.No: T37621

Target: Beta Amyloid

GSK-3 inhibitor 3

Cat.No: T77342

Target: GSK-3, Microtubule Associated

GSK-3 inhibitor 4

Cat.No: T77341

Target: GSK-3, CDK

Leucomethylene blue mesylate

Cat.No: T7003

Synonym: N3,N3,N7,N7-四甲基-10H-吩噻嗪-3,7-二胺二甲磺酸盐,TRx0237 mesylate,TRx0237 (LMTX) mesylate,Methylene blue leuco base mesylate salt,Leucomethylene Blue Dimesylate

Target: Beta Amyloid, Microtubule Associated

IFB-088 acetate

Cat.No: T111959

Target: Others

Cat.No: T30438

Target: Others

Cat.No: T39660

Target: Others

Tau Peptide (275-305) (Repeat 2 domain)

Cat.No: T40409

Cat.No: T37051

Target: Others

Cat.No: T76652

Cat.No: T80616

Cat.No: T61087

Target: Others

Cat.No: T60907

Target: Others

Cat.No: T76886

Tau-aggregation-IN-1

Cat.No: T63481

Target: Others

Aha1/Hsp90-IN-1

Cat.No: T62307

Target: Others

Cat.No: T40701

Synonym: AZP-2006

Target: Others

Aβ/tau aggregation-IN-3

Cat.No: T78173

Target: Others

Cat.No: T61579

Target: Others

Cat.No: T75361

Target: Others

Cat.No: T84747

Target: Others

Okadaic acid ammonium salt

Cat.No: T39183

Target: Others

Cat.No: T74812

Target: Others

GSK-3β inhibitor 15

Cat.No: T78874

Target: Others

Cat.No: T82242

Target: Others

Cat.No: T82243

Target: GSK-3

Methylene blue hydrate

Cat.No: T75339

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T14046	Anandamide 花生四烯酸乙醇胺,(5Z,8Z,11Z,14Z)-N-(2-Hydroxyethyl)icosa-5,8,11,14-tetraenamide	Cannabinoid Receptor; Endogenous Metabolite	GPCR/G Protein; Metabolism
	Anandamide ((5Z,8Z,11Z,14Z)-N-(2-Hydroxyethyl)icosa-5,8,11,14-tetraenamide) 是一种免疫调节剂，通过大麻素受体 CB1 和 CB2 起作用，还通过中枢神经系统中的其他靶点起作用，如 GPR18/GPR55。

天然产物

Cat.No: T14046

Synonym: 花生四烯酸乙醇胺,(5Z,8Z,11Z,14Z)-N-(2-Hydroxyethyl)icosa-5,8,11,14-tetraenamide

Target: Cannabinoid Receptor, Endogenous Metabolite

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-03425	Tau Protein, Human, Recombinant (His) PPND,FTDP-17,MTBT1,DDPAC,MAPTL,MTBT2,microtubule-associated ...	Human	E. coli
	MAPT (microtubule-associated protein tau) can produce tau proteins. Tau proteins are proteins that stabilize microtubules. They are abundant in neurons of the central nervous system and are less common elsewhere, but are also expressed at very low levels in CNS astrocytes and oligodendrocytes. When tau proteins are defective, and no longer stabilize microtubules properly, they can result in dementias such as Alzheimer's disease. Tau protein is a highly soluble microtubule-associated protein (MAP...
TMPH-02785	Tau Protein, Mouse, Recombinant (His) Microtubule-associated protein tau,Mapt,Pa...	Mouse	HEK293 Cells
	Tau Protein, Mouse, Recombinant (His) is expressed in HEK293.
TMPJ-00828	Tau-F Protein, Human, Recombinant Neurofibrillary tangle protein,Paired helical filam...	Human	E. coli
	Tau proteins are proteins which contain four Tau/MAP repeats. They promote microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. They are abundant in neurons of the central nervous system and are less common elsewhere, but are also expressed at very low levels in CNS astrocytes and oligodendrocytes. The tau proteins are the product of alternative splicing from a single gene that in humans is designated MAPT. When tau proteins are def...
TMPJ-00827	Tau-D Protein, Human, Recombinant (His) PHF-Tau,MAPTL,MAPT,Paired Helical Filament-Tau<...	Human	E. coli
	Microtubule-Associated Protein TAU is abundantly expressed in neurons of the central nervous system and less commonly expressed elsewhere, but is also expressed at very low levels in CNS astrocytes and oligodendrocytes. Tau interacts with tubulin to stabilize microtubules and promotes tubulin assembly into microtubules. The C-terminus of TAU binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau acts as a linker protein. When tau is defective,...
TMPH-03336	Tau Protein, Rat, Recombinant (His) Neurofibrillary tangle protein,Mapt,Paired helical ...	Rat	HEK293 Cells
	Tau Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with N-10xHis tag. The predicted molecular weight is 81.2 kDa and the accession number is P19332.
TMPH-02444	Tau Protein, Rhesus macaque, Recombinant (His) Microtubule-associated protein tau,MAPT,Pa...	Rhesus	HEK293 Cells
	Tau Protein, Rhesus macaque, Recombinant (His) is expressed in HEK293 mammalian cells with N-10xHis tag. The predicted molecular weight is 50.6 kDa and the accession number is P57786.
TMPH-02443	Tau Protein, Rhesus macaque, Recombinant (His & SUMO) Neurofibrillary tangle protein,MAPT,Microtubule-ass...	Rhesus	E. coli
	Tau Protein, Rhesus macaque, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 63.8 kDa and the accession number is P57786.
TMPH-03335	Tau Protein, Rat, Recombinant (E. coli, His) Mapt,Neurofibrillary tangle protein,Microtubule-ass...	Rat	E. coli
	Tau Protein, Rat, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 82.4 kDa and the accession number is P19332.
TMPH-01683	Tau-F Protein, Human, Recombinant (HEK293, His) Microtubule-associated protein tau,Paired ...	Human	HEK293 Cells
	Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the ...
TMPH-00279	Interferon tau-1/IFNT1 Protein, Bovine, Recombinant (His) Trophoblastin,Trophoblast protein 1,Interferon ...	Bovine	P. pastoris (Yeast)
	Interferon tau-1/IFNT1 Protein, Bovine, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 21.8 kDa and the accession number is P15696.
TMPH-00278	Interferon tau-1/IFNT1 Protein, Bovine, Recombinant (E. coli, His) Trophoblast antiluteolytic protein,IFNT1,Trophoblas...	Bovine	E. coli
	Interferon tau-1/IFNT1 Protein, Bovine, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 23.8 kDa and the accession number is P15696.
TMPH-02478	PRKAA1 Protein, Mouse, Recombinant (His) Prkaa1,Tau-protein kinase PRKAA1,Hydroxyme...	Mouse	Baculovirus Insect Cells
	PRKAA1 Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with N-6xHis tag. The predicted molecular weight is 65 kDa and the accession number is Q5EG47.
TMPH-02479	PRKAA1 Protein, Mouse, Recombinant (E. coli, His) 5'-AMP-activated protein kinase catalytic subunit a...	Mouse	E. coli
	PRKAA1 Protein, Mouse, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 39.8 kDa and the accession number is Q5EG47.
TMPH-01171	CDK5 Protein, Human, Recombinant Serine/threonine-protein kinase PSSALRE,Cyclin-depe...	Human	E. coli
	CDK5 Protein, Human, Recombinant is expressed in E. coli.
TMPY-01085	VLDLR Protein, Human, Recombinant (His) VLDLRCH,CAMRQ1,CHRMQ1,very low density lipoprotein ...	Human	HEK293 Cells
	The very low density lipoprotein receptor, known as VLDLR, is a single-pass type 1 integral membrance protein and a member of the LDL receptor family. This receptor family includes LDL receptor, LRP, megalin, VLDLR and ApoER2, and is characterized by a cluster of cysteine-rich class A repeats, epidermal growth factor (EGF)-like repeats, YWTD repeats and an O-linked sugar sdomain. VLDLR contains 3 EGF-like domains, 8 LDL-receptor class A domains, as well as 6 LDL-receptor class B repeats, and is ...
TMPY-04396	C-ABL/ABL1 Protein, Human, Recombinant (GST) v-abl,ABL,JTK7,ABL proto-oncogene 1, non-receptor tyrosine k...	Human	Baculovirus Insect Cells
	c-Abl belongs to the class of tyrosine kinases and is the prototype of a subfamily which includes two members, c-Abl and Arg (Abl-related gene). Both proteins are localized at the cell membrane, actin cytoskeleton and cytosol, and c-Abl is present in the nucleus as well. c-Abl is a non-receptor tyrosine kinase that participates in multiple signaling pathways linking the cell surface, cytoskeleton, and the nucleus. Recent in vitro studies have also linked c-Abl to amyloid-beta-induced toxicity an...
TMPK-01146	LGMN Protein, Human, Recombinant (His) AI746452,Legumain,LGMN1,Prsc1,AEP,LGMN,AU022324	Human	HEK293 Cells
	Recently, functional studies have demonstrated that legumain (LGMN) cleaves both amyloid β-protein precursor and tau, promoting senile plaques and formation of neurofibrillary tangles, which may play a crucial role in the pathogenesis of Alzheimer's disease (AD). In single-variant association analysis, none of the common variants in LGMN were statistically significant. In gene-based analysis, the LGMN gene also showed no association with AD.
TMPH-02228	TRA2B Protein, Human, Recombinant (His & Myc) TRA2B,Transformer-2 protein homolog B,Splicing fact...	Human	Baculovirus Insect Cells
	Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the effects of splicing regulators, like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to pre-mRNA.
TMPY-04556	CDK5 Protein, Human, Recombinant (GST) PSSALRE,cyclin-dependent kinase 5	Human	Baculovirus Insect Cells
	Cell division protein kinase 5, also known as Cyclin-dependent kinase 5, Serine/threonine-protein kinase PSSALRE, Tau protein kinase II catalytic subunit, TPKII catalytic subunit and CDK5, is a cytoplasm protein which belongs to theprotein kinase superfamily, CMGC Ser/Thr protein kinase family and CDC2 / CDKX subfamily. Cyclin-dependent kinases (Cdks) are a family of proline-directed Ser/Thr kinases known for their role in the control of cell cycle progression. In 1992, this family was jo...
TMPH-02229	TRA2B Protein, Human, Recombinant (His & SUMO) TRA2B,Transformer-2 protein homolog B,Splicing fact...	Human	E. coli
	Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the effects of splicing regulators, like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to pre-mRNA. TRA2B Protein, Human, Recombinant (His & SUMO) is expr...
TMPY-02340	HNMT Protein, Human, Recombinant (GST) HMT,HNMT-S1,HNMT-S2,histamine N-methyltransferase	Human	E. coli
	HNMT (Histamine N-methyltransferase) is a Protein Coding gene. This gene encodes the first enzyme which is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. HNMT, the major enzyme for the metabolism of histamine in the rat brain, is potently inhibited by 9-amino-1,2,3,4-tetrahydroacridine (tacrine). Methylation is an important pathway in the biotransformation of many drugs, neurotransmitters, and xenobiotic compounds. Histamine N-methyltransferase (HNMT) catalyzes the N ...

重组蛋白

Tau Protein, Human, Recombinant (His)

Cat.No: TMPY-03425

Species: Human

Expression System: E. coli

Tau Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02785

Species: Mouse

Expression System: HEK293 Cells

Tau-F Protein, Human, Recombinant

Cat.No: TMPJ-00828

Species: Human

Expression System: E. coli

Tau-D Protein, Human, Recombinant (His)

Cat.No: TMPJ-00827

Species: Human

Expression System: E. coli

Tau Protein, Rat, Recombinant (His)

Cat.No: TMPH-03336

Species: Rat

Expression System: HEK293 Cells

Tau Protein, Rhesus macaque, Recombinant (His)

Cat.No: TMPH-02444

Species: Rhesus

Expression System: HEK293 Cells

Tau Protein, Rhesus macaque, Recombinant (His & SUMO)

Cat.No: TMPH-02443

Species: Rhesus

Expression System: E. coli

Tau Protein, Rat, Recombinant (E. coli, His)

Cat.No: TMPH-03335

Species: Rat

Expression System: E. coli

Tau-F Protein, Human, Recombinant (HEK293, His)

Cat.No: TMPH-01683

Species: Human

Expression System: HEK293 Cells

Interferon tau-1/IFNT1 Protein, Bovine, Recombinant (His)

Cat.No: TMPH-00279

Species: Bovine

Expression System: P. pastoris (Yeast)

Interferon tau-1/IFNT1 Protein, Bovine, Recombinant (E. coli, His)

Cat.No: TMPH-00278

Species: Bovine

Expression System: E. coli

PRKAA1 Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02478

Species: Mouse

Expression System: Baculovirus Insect Cells

PRKAA1 Protein, Mouse, Recombinant (E. coli, His)

Cat.No: TMPH-02479

Species: Mouse

Expression System: E. coli

CDK5 Protein, Human, Recombinant

Cat.No: TMPH-01171

Species: Human

Expression System: E. coli

VLDLR Protein, Human, Recombinant (His)

Cat.No: TMPY-01085

Species: Human

Expression System: HEK293 Cells

C-ABL/ABL1 Protein, Human, Recombinant (GST)

Cat.No: TMPY-04396

Species: Human

Expression System: Baculovirus Insect Cells

LGMN Protein, Human, Recombinant (His)

Cat.No: TMPK-01146

Species: Human

Expression System: HEK293 Cells

TRA2B Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-02228

Species: Human

Expression System: Baculovirus Insect Cells

CDK5 Protein, Human, Recombinant (GST)

Cat.No: TMPY-04556

Species: Human

Expression System: Baculovirus Insect Cells

TRA2B Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-02229

Species: Human

Expression System: E. coli

HNMT Protein, Human, Recombinant (GST)

Cat.No: TMPY-02340

Species: Human

Expression System: E. coli

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