Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T6253 |
Talazoparib
LT-673,BMN-673,他拉唑帕利 |
PARP | Chromatin/Epigenetic; DNA Damage/DNA Repair |
Talazoparib (LT-673) 是一种 PARP 抑制剂,可以抑制 PARP 1和 PARP 2 (Ki=1.2/0.87 nM),具有口服活性。Talazoparib 具有抗肿瘤活性,可以通过阻断 PARP 酶活性以及将 PARP 捕获在 DNA 损伤位点上来诱导肿瘤细胞死亡。 | |||
T16979 |
Talazoparib tosylate
BMN 673ts |
PARP | Chromatin/Epigenetic; DNA Damage/DNA Repair |
Talazoparib tosylate is a novel and potent PARP1/2 (n IC50: 0.57 nM for PARP1). | |||
T10564 |
(8R,9S)-Talazoparib
(8R,9S)-BMN-673,他拉唑帕利 (8R,9S) |
Others | Others |
(8R,9S)-Talazoparib is Talazoparib enantiomer , less active than Talazoparib on the inhibition of PARP1 (IC50: 144 nM). | |||
T79667 |
YCH1899
|
PARP | Chromatin/Epigenetic; DNA Damage/DNA Repair |
YCH1899为一种口服活性PARP抑制剂,其对PARP1/2的IC50均低于0.001 nM。该化合物对Olaparib和Talazoparib耐药的Capan-1细胞株(Capan-1/OP及Capan-1/TP细胞)表现出显著抗增殖能力,IC50分别为0.89 nM和1.13 nM。在大鼠体内,YCH1899展现优良的药代动力学属性。 |