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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T71048 |
Tacrolimus anhydrous 8-epimer
|
Others | Others |
Tacrolimus anhydrous 8-epimer is a new l-pipecolic acid macrolide lactone, an important immunosuppressive drug that blocks T cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2. | |||
T71046 |
FK-1052
|
Others | Others |
FK-1052 is a serotonin 3 & 4 dual receptor antagonist. | |||
T14298 |
Rimiducid
|
Apoptosis; Others; Fatty Acid Synthase | Apoptosis; Metabolism; Others |
Rimiducid 是一种可渗透脂质的他克莫司类似物,是一种二聚剂,通过交联 FKBP 结构域起作用。它将 Caspase 9 自杀开关二聚化并迅速诱导细胞凋亡。 | |||
T3097 |
Mycophenolic Acid Impurity
马替麦考酚酸杂质,5,7-dihydroxy-4-methylphthalide |
Others | Others |
Mycophenolic Acid Impurity (5,7-dihydroxy-4-methylphthalide) 是一种免疫抑制药物和有效的抗增殖剂,可用于代替旧的抗增殖剂 azathioprine。它通常用作三联疗法的一部分,包括钙调神经磷酸酶抑制剂(ciclosporin 或 tacrolimus)和prednisolone。它还可用于研究选择表达编码 XGPRT(黄嘌呤鸟嘌呤磷酸核糖基转移酶)的大肠杆菌基因的动物细胞。 | |||
T32504 |
L-732531
L732531,L 732531 |
Others | Others |
L-732531 is a tacrolimus-related immunosuppressant with lower toxicity. | |||
T32462 |
L 683519
L683519,13-Desmethyl FK 506,L-683519 |
Others | Others |
L 683519 is one of the Tacrolimus impurities with immunosuppressant and could restrain the activity of FK-506 binding protein. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T2144 |
Tacrolimus
他克莫司,Fujimycin,FK506,FR900506 |
Phosphatase; Others; Antibacterial; Antibiotic; mTOR; Autophagy | Autophagy; Metabolism; Microbiology/Virology; Others; PI3K/Akt/mTOR signaling |
Tacrolimus (Fujimycin) 属于大环内酯类抗生素,可以与 FKBP12 结合形成高亲和力复合物 (Ki=0.2 nM),抑制钙/钙调蛋白依赖性蛋白磷酸酶的活性。Tacrolimus 是一种免疫抑制剂,通过抑制 IL-2 的释放,全面抑制 T 淋巴细胞的作用。 | |||
T20879 |
Tacrolimus monohydrate
FK-506,FR 900506,Prograf,FR900506,Tacrolimus hydrate,LCP-Tacro,他克莫司一水合物,FK 506 |
Phosphatase; Others; Antibacterial; Antibiotic; Autophagy | Autophagy; Metabolism; Microbiology/Virology; Others |
Tacrolimus monohydrate (LCP-Tacro) 是大环内酯类化合物,它与 FK506 结合蛋白 (FKBP) 结合形成复合物并抑制钙调神经磷酸酶,从而抑制 T 淋巴细胞信号转导和 IL-2 转录。具有强免疫抑制特性。 | |||
T2481 |
Ascomycin
FK520,Immunomycin,子囊霉素,FR-900520 |
Phosphatase; Others; Antibiotic; Parasite; Antifungal | Metabolism; Microbiology/Virology; Others |
Ascomycin (Immunomycin) 是 Tacrolimus 的乙基类似物,具有免疫抑制特性。它也是一种大环聚酮类抗生素,具有抗疟疾、抗真菌和抗痉挛等多种生物活性。它可防止移植排斥,并具有用于各种皮肤病研究的潜力。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TMIH-0548 |
Tacrolimus-13C-d2
|
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Tacrolimus-13C-d2 是 Tacrolimus 的 13C 和氘代化合物。 |