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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T21439 |
Tacrine
他克林,CS 12602,Tacrinum,Tetrahydroaminocrine |
AChR | Neuroscience |
Tacrine (CS 12602) 一种间接胆碱能激动剂和中枢作用的抗胆碱酯酶。它被批准用于治疗阿尔茨海默病。 | |||
T2191 |
Tacrine hydrochloride (hydrate)
Tacrine,他克林盐酸盐水合物,Tacrine hydrochloride hydrate,Tetrahydroaminacrine,Tetrahydroaminoacridine |
AChR; AChE | Neuroscience |
Tacrine hydrochloride hydrate (Tetrahydroaminacrine) 是一种乙酰胆碱酯酶 (AChE) 和丁酰胆碱酯酶 (BChE) 的抑制剂,它们的IC50值分别为 31 nM 和 25.6 nM。 | |||
T22435 |
Tacrine hydrochloride
四氢氨基吖啶,盐酸他克林,Tacrine HCl |
Others | Others |
Tacrine is a indirect cholinergic agonist and centrally acting anticholinesterase. Tacrine hydrochloride hydrate is an inhibitor of acetyl (AChE) and butyryl-cholinestrase (BChE) with IC50s of 31 nM and 25.6 nM, respectively. | |||
T22048 |
bis(7)-Tacrine
|
Others | Others |
Bis(7)-tacrine dihydrochloride 衍生自 tacrine ,是一种二聚体乙酰胆碱酯酶 (AChE) 抑制剂,具有治疗阿尔茨海默病的潜力。Bis(7)-tacrine dihydrochloride 通过阻断 NMDA 受体防止谷氨酸诱导的神经元凋亡。Bis(7)-tacrine dihydrochloride 是一种有效的 GABAA 受体拮抗剂。 | |||
T21556 |
Hydroxytacrine maleate
Velnacrine maleate,HP 029 maleate |
AChE | Neuroscience |
Hydroxytacrine maleate (Velnacrine maleate) 是一种胆碱酯酶(cholinesterase) 抑制剂,可增强啮齿动物的记忆力,可用于研究阿尔茨海默型老年性痴呆(SDAT)。 | |||
T15132 |
Dimetacrine
Dimethacrine,二甲他林 |
Others | Others |
Dimetacrine is a useful antidepressant. | |||
T29481 |
7-Bromotacrine
|
Others | Others |
7-Bromotacrine is a biochemical. | |||
T15132L |
Dimetacrine tartrate
Linostil,Istonil,Istonyl,Miroistonil,MO 709 |
Others | Others |
Dimetacrine tartrate is a tricyclic antidepressant (TCA) used for the therapy of depression in Europe and formerly in Japan. | |||
T35975 |
6,9-Dichloro-1,2,3,4-tetrahydroacridine
|
Others | Others |
6,9-Dichloro-1,2,3,4-tetrahydroacridine is a synthetic intermediate in the synthesis of tacrine-based acetylcholinesterase (AChE) inhibitors.1It is also an intermediate in the synthesis of multifunctional tacrine hybrids that possess radical scavenging, amyloid-β aggregation inhibitory, and/or β-secretase 1 (BACE1) inhibitory activities in addition to their activity as AChE inhibitors.2,3 1.Recanatini, M., Cavalli, A., Belluti, F., et al.SAR of 9-amino-1,2,3,4-tetrahydroacridine-based acetylchol... | |||
T73245 |
AChE-IN-9
|
Others | Others |
AChE-IN-9 是一种Tacrine 连接乙酰化 β-葡萄糖的糖缀合物。AChE-IN-9 也是一种AChE 抑制剂,IC50为 0.4 μM,对健康细胞的肝毒性低。Tacrine 可用于阿兹海默症的研究。 | |||
T63144 |
ZLMT-12
|
Others | Others |
ZLMT-12 (compound 35) 是他克宁衍生物,是一种有效的 CDK2 (IC50: 0.011 μM) 和 CDK9 (IC50: 0.002 μM) 抑制剂。ZLMT-12 能够较弱的抑制 AChE (IC50: 19.023 μM) 和 BuChE (IC50: 2.768 μM)。ZLMT-12 具抗增殖活性,且细胞毒性较低。ZLMT-12 能够将细胞周期阻滞在 S 期和 G2/M 期,并诱导细胞凋亡。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T5S1025 |
Picfeltarraenin IA
苦玄参苷IA,Picfeltarraenin A,苦玄参苷 IA |
AChE | Neuroscience |
Picfeltarraenin IA (Picfeltarraenin A) 是一种Picriafel-terraeLour (P.fel-terrae) 中提取的三萜类化合物,是一种乙酰胆碱酯酶抑制剂。它可用于感染,癌症和炎症的研究。 | |||
TN2067 |
Picfeltarraegenin X
苦玄参苷X,Picfeltarraenin X |
AChR | Neuroscience |
Picfeltarraenin X shows stronger AChE inhibition than the known AChE inhibitor Tacrine. | |||
TN4711 |
Onitin
|
Others | Others |
Onitin shows super-oxide and DPPH free radical scavenging effects.It also exhibits hepatoprotective activity on tacrine-induced cytotoxicity in human liver-derived Hep G2 cells. | |||
TN2487 |
1,3,5,6-Tetrahydroxyxanthone
|
Others | Others |
1,3,5,6-Tetrahydroxyxanthone shows moderate hepatoprotective activity with EC(50) values of 160.2 +/- 0.6 microM against tacrine-induced cytotoxicity in HepG2 cells. It can inhibit angiotensin-I-converting-enzyme activity in a dose-dependent manner. | |||
TN5154 |
Torilolone
|
Others | Others |
Torilin and torilolone show hepatoprotective effects on tacrine-induced cytotoxicity in human liver-derived Hep G2 cells,the EC50 values are 20.6 +/- 1.86 and 3.6 +/- 0.1 microM, respectively; and silybin as a positive control shows an EC50 value of 69.0 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-02340 |
HNMT Protein, Human, Recombinant (GST)
HMT,HNMT-S1,HNMT-S2,histamine N-methyltransferase |
Human | E. coli |
HNMT (Histamine N-methyltransferase) is a Protein Coding gene. This gene encodes the first enzyme which is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. HNMT, the major enzyme for the metabolism of histamine in the rat brain, is potently inhibited by 9-amino-1,2,3,4-tetrahydroacridine (tacrine). Methylation is an important pathway in the biotransformation of many drugs, neurotransmitters, and xenobiotic compounds. Histamine N-methyltransferase (HNMT) catalyzes the N ... |