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Search Results for " txa2 "

Targets Recommended: Others

35

抑制剂 & 化合物

1

天然产物

1

重组蛋白

1

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T34862	Thromboxane A2 Rabbit aorta contracting substance,TXA-2,TXA2,TXA 2	Others	Others
	Thromboxane A2, as an unstable intermediate between the prostaglandin endoperoxides and thromboxane B2, is a potent inducer of platelet aggregation and causes vasoconstriction.
T12268	NTP42	Prostaglandin Receptor; PPAR	DNA Damage/DNA Repair; GPCR/G Protein; Immunology/Inflammation; Metabolism
	NTP42 是血栓素 A2 (TXA2) 受体的拮抗剂，IC50为 3.278 nM，可用于肺动脉高压的相关研究。
T6236	Ozagrel 奥扎格雷,OKY-046,Domenan	Thrombin; Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation; Proteases/Proteasome
	Ozagrel (Domenan) 是血栓烷 A2(TXA2) 合酶抑制剂，可抑制哮喘。它也是一种抗血小板剂，可选择性抑制人血小板聚集，IC50为 53.12 μM。
T6625	Ozagrel hydrochloride Ozagrel HCl,盐酸奥扎格雷,OKY-046 HCl	Thrombin; Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation; Proteases/Proteasome
	Ozagrel hydrochloride (OKY-046 HCl) 是一种选择性血栓素 A(2) 合成酶抑制剂，用于改善术后脑血管收缩和伴随的脑缺血。它是一种抗血小板剂，可选择性抑制人血小板聚集，IC50为 53.12 μM。
T10783	CGS 15435	PPAR	DNA Damage/DNA Repair; Metabolism
	CGS 15435是一种有效的血栓素(TxA2)合成酶抑制剂(IC50: 1 nM)。CGS 15435作用于 PGI2合成酶、环氧合酶和脂合酶比作用于血栓素合成酶选择性低得多。
T68022	Sulotroban	PPAR	DNA Damage/DNA Repair; Metabolism
	sulotroban 是一种TXA2受体拮抗剂，与伊洛前列素具有协同作用，可抑制TXA2依赖性血小板活化。
T15049	Daltroban BM-13505,SKF 96148	PPAR	DNA Damage/DNA Repair; Metabolism
	Daltroban (SKF 96148) (BM-13505) 是选择性和特异性的血栓素 A2 (TXA2) 受体拮抗剂。Daltroban 可以增加血管平滑肌细胞内钙。Daltroban 显示对再灌注损伤的保护作用。
T25741	Linotroban HN 11500,CL-871502	PPAR	DNA Damage/DNA Repair; Metabolism
	Linotroban（CL-871502）是一种有效的选择性血栓素（TXA2）受体拮抗剂，具有抗血栓活性。
T15577	Indobufen Ibustrin,吲哚布芬	COX	Immunology/Inflammation; Neuroscience
	Indobufen (Ibustrin) 是一种血小板聚集抑制剂，是下调单核细胞中的组织因子，可逆抑制血小板环氧合酶 (Cox) 的活性和血栓素 A2 (TxA2) 的合成。
T11339	Furegrelate sodium U-63557A	PPAR	DNA Damage/DNA Repair; Metabolism
	Furegrelate sodium (U-63557A) 是口服有效的、血栓素合酶选择性抑制剂，抑制人血小板微粒体血栓素 A2 (TxA2) 合酶的 IC50为 15 nM。它正在开发作为抗血小板药物。
T11339L	Furegrelate	PPAR	DNA Damage/DNA Repair; Metabolism
	FUREGRELATE 是一种血栓素 A2 (TxA2) 合酶抑制剂，可减缓新生仔猪肺动脉高压的发展。
T31213	Dazmegrel UK-38,485,UK 38485,UK 38,485,UK38,485,UK-38485	PPAR	DNA Damage/DNA Repair; Metabolism
	Dazmegrel (UK 38,485) 是一种强效特异性血栓素 A2（TXA2）合成酶抑制剂，可用于预防正常妊娠中全血小板聚集增加。
T27630	Isbogrel CV4151,CV-4151,CV 4151	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	Isbogrel (CV4151)是一种小分子血栓素A2合成酶(TXA2 synthase)抑制剂，可用来研究心律失常、短暂性脑缺血发作和血栓形成。
T68086	Imitrodast	Thrombin	Proteases/Proteasome
	Imitrodast是一种小分子血栓素A2合成酶（TXA2 synthase）抑制剂，可用于治疗免疫系统疾病、呼吸系统疾病和心血管疾病，可用于研究动脉血栓形成、哮喘和冠状血管痉挛。
T0212	Seratrodast 塞曲司特,AA 2414,ABT-001	COX; Prostaglandin Receptor; PPAR	DNA Damage/DNA Repair; GPCR/G Protein; Immunology/Inflammation; Metabolism; Neuroscience
	Seratrodast (ABT-001) 是一种血栓素 A2 受体 (TP) 拮抗剂，用于治疗哮喘。
T67959	Pirodomast	Thrombin; Serine Protease	Proteases/Proteasome
	Pirodomast 是血栓素 A（TXA2）合成酶抑制剂。Pirodomast 能抑制白三烯（LT）D4、C4、E4 的形成和血栓素 B2（TXB2）的活性，但对组胺、甲氧胆碱、血清素、LTC4 或血小板活化因子诱导的豚鼠支气管痉挛的拮抗作用较弱或无效。Pirodomast 在体外对豚鼠气管只有微弱的松弛活性。Pirodomast 是一种潜在的抗过敏化合物，在体外可抑制胰蛋白酶的蛋白水解活性，在体内可阻止抗原诱发过敏绵羊的即时和晚期哮喘反应，抑制抗原诱导的过敏绵羊对组胺和卡巴胆碱的气道高反应性。
T17039	Terbogrel BIBV 308SE	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	Terbogrel 是一种可口服的、具有选择性 thromboxane A2 受体拮抗剂（IC50 约为 10 nM），是一种 thromboxane A2 synthase 抑制剂（IC50 约为 10 nM）。Terbogrel 是一种抗血小板化合物，可抑制血小板聚集，是预防血栓的潜在化合物。
T2396	Ramatroban BAY u3405,雷马曲班	GPR; Prostaglandin Receptor; PPAR	DNA Damage/DNA Repair; Endocrinology/Hormones; GPCR/G Protein; Immunology/Inflammation; Metabolism
	Ramatroban (BAY u3405) 是一种血栓素 A(2) (TxA(2)) 拮抗剂，IC50为 14 nM。它还通过抑制PGD2结合从而拮抗CRTH2，IC50为113 nM。它用于治疗过敏性鼻炎，可用于治疗哮喘的研究。
T10501	YM158 free base YM-57158	Others	Others
	YM158 free base is a potent and selective antagonist of TXA2 and LTD4 receptor (pA2s: about 8.81 and 8.87).
T15252	Etersalate Etherylate,Eterylate	Others	Others
	Etersalate inhibits platelet function. It also reduces thromboxane A2 (TXA2) levels.
T69400	Fenalcomine	Others	Others
	Fenalcomine inhibits the action of prostaglandins on smooth muscle but stimulates TXA2.
T28176	Nizofenone Y9179,Y-9179,Ekonal,Y 9179	Others	Others
	Nizofenone, a thromboxane A2 (TXA2) biosynthesis inhibitor, is used as a neuroprotective drug and used to treat stroke.
T24542	NP-313 NP 313,NSC 4264,NSC-4264,NSC4264	Others	Others
	NP-313 (NSC-4264) 是一种有效的抗血栓剂，对血栓素 A 2 合成和选择性抑制由 SOCC 介导的 Ca 2+ 内流有抑制作用，可以抑制血小板的聚集和活化。
T27588	Ifetroban 伊非曲班,BMS180291,BMS-180291,BMS 180291-02	Others	Others
	Ifetroban is a potent and selective TxA2/PGH2 receptor antagonist.
T34710	STA 2 ONO 11113,STA-2,STA2	Others	Others
	STA 2 is an analogue of TXA2, a thromboxane receptor in the colonic epithelium.
T71035	KT2-962	Others	Others
	KT2-962 is a TXA2/prostaglandin endoperoxide receptor antagonist.
T69404	Fenalcomine hydrochloride	Others	Others
	Fenalcomine hydrochloride inhibits the action of prostaglandins on smooth muscle but stimulates TXA2.
T11825	LCB-2853	PPAR	DNA Damage/DNA Repair; Metabolism
	LCB-2853 是一种有效的血栓素 A2/前列腺素 H2 （TXA2/PGH2）受体拮抗剂，具有抗血小板聚集、抗血管痉挛和抗血栓作用。
T24157	Ici D1542 D 1542,D1542,Ici-D1542,ZD 1542	Others	Others
	Ici D1542 is a drug that exhibits both potent, selective TXS inhibition and TXA2 receptor antagonism. Ici D1542 is an effective thromboxane A2 synthase inhibitor and receptor antagonist in vitro.
T17189	U-46619 9,11-Methanoepoxy PGH2	Progesterone Receptor; PPAR	DNA Damage/DNA Repair; Metabolism; Others
	U-46619是一种有效的TXA2激动剂，是一种血栓素A2类似物（内过氧化物），有诱导肌球蛋白轻链9 (Myl9)基因缺失小鼠主动脉平滑肌(SM)收缩的功能。
T62924	Ifetroban sodium	Others	Others
	Ifetroban (BMS-180291) sodium 是一种口服具有活力的血栓素 A2 (TXA2) 或前列腺素 H2 (PGH2) 受体拮抗剂。Ifetroban sodium 表现出抗血小板活性，能够抑制肿瘤细胞迁移，且对细胞增殖无影响。Ifetroban sodium 能够用于研究心肌缺血、中风、高血压、血栓、心肌病。
T84627	11-dehydro-2,3-dinor Thromboxane B2 11-dehydro-2,3-dinor TXB2	Others	Others
	11-Dehydro-2,3-dinor Thromboxane B2 (11-dehydro-2,3-dinor TXB2) is a metabolite derived from the inactive TXA2 metabolite, TXB2. Its formation involves the action of cytosolic aldehyde dehydrogenase (ALDH) and β-oxidation processes. Remarkably, levels of 11-dehydro-2,3-dinor TXB2 have been observed to increase by 5.2-fold in a surgery-induced rat model of tendon overuse, highlighting its potential role in physiological stress responses.
T84626	2,3-dinor Thromboxane B2 2,3-dinor TXB2	Others	Others
	Thromboxane B2 (TXB2) is a compound significantly released from aggregating platelets and undergoes metabolic transformation during circulation into 11-dehydro TXB2 and 2,3-dinor TXB2. The latter, 2,3-dinor TXB2, serves as a prevalent urinary metabolite of TXB2 and acts as an indicator for in vivo TXA2 synthesis. Studies have shown that in healthy male volunteers, the median excretion rate of 2,3-dinor TXB2 is measured at 10.3 ng/hour, equivalent to 138 pg/mg of creatinine.
T84575	U-51605	Others	Others
	U-51605, a stable analog of the endoperoxide prostaglandin H2 (PGH2), functions as an inhibitor with greater selectivity towards prostacyclin (PGI) synthase over thromboxane (TX) synthase. It also acts as a partial agonist at TP receptors. Studies show that at a concentration of 2.8 µM, U-51605 effectively inhibits PGI synthase in human foreskin fibroblasts, while a concentration of 5.6 µM is required to inhibit human platelet TX synthase. Furthermore, U-51605, at up to 1 µM, decreases the relea...
T36550	CAY10535	Others	Others
	TPα and TPβ are two isoforms of the human TP receptor, the G protein-coupled receptor (GPCR) that mediates the actions of thromboxane A2 (TXA2). Although their distinct physiological functions have not been fully elucidated, TPβ is believed to be responsible for vascular endothelial growth factor-induced endothelial cell differentiation and migration whereas TPα appears to be the predominant isoform expressed in platelets. CAY10535 is a TP receptor antagonist that shows ~20-fold selectivity for ...

化合物

Cat.No: T34862

Synonym: Rabbit aorta contracting substance,TXA-2,TXA2,TXA 2

Target: Others

Cat.No: T12268

Target: Prostaglandin Receptor, PPAR

Cat.No: T6236

Synonym: 奥扎格雷,OKY-046,Domenan

Target: Thrombin, Prostaglandin Receptor

Ozagrel hydrochloride

Cat.No: T6625

Synonym: Ozagrel HCl,盐酸奥扎格雷,OKY-046 HCl

Target: Thrombin, Prostaglandin Receptor

Cat.No: T10783

Target: PPAR

Cat.No: T68022

Target: PPAR

Cat.No: T15049

Synonym: BM-13505,SKF 96148

Target: PPAR

Cat.No: T25741

Synonym: HN 11500,CL-871502

Target: PPAR

Cat.No: T15577

Synonym: Ibustrin,吲哚布芬

Target: COX

Furegrelate sodium

Cat.No: T11339

Synonym: U-63557A

Target: PPAR

Cat.No: T11339L

Target: PPAR

Cat.No: T31213

Synonym: UK-38,485,UK 38485,UK 38,485,UK38,485,UK-38485

Target: PPAR

Cat.No: T27630

Synonym: CV4151,CV-4151,CV 4151

Target: Prostaglandin Receptor

Cat.No: T68086

Target: Thrombin

Cat.No: T0212

Synonym: 塞曲司特,AA 2414,ABT-001

Target: COX, Prostaglandin Receptor, PPAR

Cat.No: T67959

Target: Thrombin, Serine Protease

Cat.No: T17039

Synonym: BIBV 308SE

Target: Prostaglandin Receptor

Cat.No: T2396

Synonym: BAY u3405,雷马曲班

Target: GPR, Prostaglandin Receptor, PPAR

YM158 free base

Cat.No: T10501

Synonym: YM-57158

Target: Others

Cat.No: T15252

Synonym: Etherylate,Eterylate

Target: Others

Cat.No: T69400

Target: Others

Cat.No: T28176

Synonym: Y9179,Y-9179,Ekonal,Y 9179

Target: Others

Cat.No: T24542

Synonym: NP 313,NSC 4264,NSC-4264,NSC4264

Target: Others

Cat.No: T27588

Synonym: 伊非曲班,BMS180291,BMS-180291,BMS 180291-02

Target: Others

Cat.No: T34710

Synonym: ONO 11113,STA-2,STA2

Target: Others

Cat.No: T71035

Target: Others

Fenalcomine hydrochloride

Cat.No: T69404

Target: Others

Cat.No: T11825

Target: PPAR

Cat.No: T24157

Synonym: D 1542,D1542,Ici-D1542,ZD 1542

Target: Others

Cat.No: T17189

Synonym: 9,11-Methanoepoxy PGH2

Target: Progesterone Receptor, PPAR

Ifetroban sodium

Cat.No: T62924

Target: Others

11-dehydro-2,3-dinor Thromboxane B2

Cat.No: T84627

Synonym: 11-dehydro-2,3-dinor TXB2

Target: Others

2,3-dinor Thromboxane B2

Cat.No: T84626

Synonym: 2,3-dinor TXB2

Target: Others

Cat.No: T84575

Target: Others

Cat.No: T36550

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T3915	Ginsenoside Ro 人参皂苷Ro,Chikusetsusaponin 5,Polysciasaponin P3,人参皂苷 Ro,Chikusetsusaponin V	Calcium Channel; Reductase; Prostaglandin Receptor	Endocrinology/Hormones; GPCR/G Protein; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism
	Ginsenoside Ro (Chikusetsusaponin V) 能降低 TXA2产量，较弱降低 COX-1 和 TXAS 活性，具有 Ca2+拮抗剂的抗血小板作用，IC50为 155 μM。

天然产物

Cat.No: T3915

Synonym: 人参皂苷Ro,Chikusetsusaponin 5,Polysciasaponin P3,人参皂苷 Ro,Chikusetsusaponin V

Target: Calcium Channel, Reductase, Prostaglandin Receptor

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-00516	StxA2 Protein, Enterobacteria phage 933W, Recombinant (E189K, His & Myc) Verotoxin 2 subunit A,Verocytotoxin 2 subu...	Enterobacteria phage 933W	E. coli
	The A subunit is responsible for inhibiting protein synthesis through the catalytic inactivation of 60S ribosomal subunits. After endocytosis, the A subunit is cleaved by furin in two fragments, A1 and A2: A1 is the catalytically active fragment, and A2 is essential for holotoxin assembly with the B subunits.

重组蛋白

StxA2 Protein, Enterobacteria phage 933W, Recombinant (E189K, His & Myc)

Cat.No: TMPH-00516

Species: Enterobacteria phage 933W

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
TMIH-0281	Indobufen-d5
	Indobufen-d5 是 Indobufen 的氘代化合物。Indobufen 的 CAS 号为 63610-08-2。Indobufen 是一种血小板聚集抑制剂，是下调单核细胞中的组织因子，可逆抑制血小板环氧合酶 (Cox) 的活性和血栓素 A2 (TxA2) 的合成。

同位素标记化合物

Cat.No: TMIH-0281

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