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Search Results for " ttr "

Targets Recommended: Others

24

抑制剂 & 化合物

2

天然产物

5

重组蛋白

1

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T32500	L6Y TTR stabilizer L6	Others	Others
	L6Y is a transthyretin (TTR) stabilizer which binds to the T4 binding pocket of TTR and prevents the dissociation of TTR to monomer.
TMAZ-0075P	Anti-TTR Monoclonal Antibody-PE
	Anti-TTR Monoclonal Antibody-PE is a biotin-conjugated humanized rabbit antibody targeting TTR. Anti-TTR Monoclonal Antibody-PE can be used FACS.
TMAZ-0075B	Anti-TTR Monoclonal Antibody-Biotin
	Anti-TTR Monoclonal Antibody-Biotin is a biotin-conjugated humanized rabbit antibody targeting TTR. Anti-TTR Monoclonal Antibody-Biotin can be used FACS.
T75173	WT-TTR inhibitor 1	Others	Others
	WT-TTR inhibitor 1 (Compound 21)作为一种野生型转甲状腺素(WT-TTR)的抑制剂，其在100 μM浓度下的抑制率达到29.05%。
TMAZ-0075A	Anti-TTR Monoclonal Antibody-APC
	Anti-TTR Monoclonal Antibody-APC is a biotin-conjugated humanized rabbit antibody targeting TTR. Anti-TTR Monoclonal Antibody-APC can be used FACS.
TMAZ-0075A5	Anti-TTR Monoclonal Antibody-AF555
	Anti-TTR Monoclonal Antibody-AF555 is a biotin-conjugated humanized rabbit antibody targeting TTR. Anti-TTR Monoclonal Antibody-AF555 can be used FACS.
TMAZ-0075A4	Anti-TTR Monoclonal Antibody-AF488
	Anti-TTR Monoclonal Antibody-AF488 is a biotin-conjugated humanized rabbit antibody targeting TTR. Anti-TTR Monoclonal Antibody-AF488 can be used FACS.
TMAZ-0075A6	Anti-TTR Monoclonal Antibody-AF647
	Anti-TTR Monoclonal Antibody-AF647 is a biotin-conjugated humanized rabbit antibody targeting TTR. Anti-TTR Monoclonal Antibody-AF647 can be used FACS.
T36336	Burnettramic Acid A	Others	Others
	Burnettramic acid A is a fungal metabolite originally isolated fromA. burnettiithat has diverse biological activities.1It is active againstB. subtilis,S. aureus,C. albicans, andS. cerevisiae(IC50s = 2.3, 5.9, 0.5, and 0.2 μg/ml, respectively). Burnettramic acid A is cytotoxic to NS-1 murine myeloma cells but not neonatal foreskin fibroblasts (IC50s = 13.8 and >100 μg/ml, respectively). 1.Li, H., Gilchrist, C.L.M., Lacey, H.J., et al.Discovery and heterologous biosynthesis of the burnettramic aci...
T36706	Bottromycin A2	Others	Others
	Bottromycin A2is an antibiotic originally isolated fromStreptomyces.1It blocks the binding of aminoacyl-tRNA to the A site of the 50S ribosome, inhibiting protein synthesis.2Bottromycin A2is active against clinical isolates of methicillin-resistantStaphylococcus aureus(MRSA) and vancomycin-resistantEnterococciwith MIC values of 1 and 0.5 μg/ml, respectively. 1.Nakamura, S., Yajima, T., Lin, Y., et al.Isolation and characterization of bottromycins A2, B2, C2J. Antibiot. (Tokyo)20(1)1-5(1967) 2.Go...
T7582	tafamidis meglumine Fx-1006A,他发米帝司甲葡胺	Others	Others
	Tafamidis meglumine (Fx-1006A) 是transthyretin (TTR)的选择性稳定剂，对野生型 WT-TTR 和突变型同源四聚体 V30M-TTR，V122I-TTR 的活性相当，EC50值为 2.7-3.2 μM。它能够阻碍淀粉样蛋白的生成。
T4565	Tafamidis 他发米帝司甲葡胺,氯苯唑酸,Fx-1006A	Others	Others
	Tafamidis (Fx-1006A) 是选择性的transthyretin (TTR)稳定剂，对野生型 WT-TTR 、突变型同源四聚体 V30M-TTR、V122I-TTR 的活性相当，它们的EC50值为2.7-3.2 μM。它对淀粉样蛋白的生成具有抑制作用。
T9447	AG-10 Acoramidis	Others	Others
	AG-10 (Acoramidis) 是选择性的、口服有效的甲状腺素转运蛋白 (TTR (transthyretin)) 的稳定剂，显示出对野生型和 V1221 突变型均有效。
T39740	Acoramidis hydrochloride AG10 hydrochloride,Alxn2060 hydrochloride	Others	Others
	Acoramidis hydrochloride (Alxn2060 hydrochloride) 是具有口服活性的、选择性的甲状腺素转运蛋白 (TTR (transthyretin)) 的稳定剂，对野生型和 V1221 突变型均有效。Acoramidis hydrochloride 可用于转体甲状腺素淀粉样变性的研究。
T15116	Dichlorophenyl-ABA	Others	Others
	Dichlorophenyl-ABA is a transthyretin (TTR) amyloid fibril formation inhibitor. It inhibits aggregate formation in more than 80% in TTR L55P-expressing cells.
T38918	Revusiran ALN-TTRSC	Others	Others
	Revusiran (ALN-TTRSC) is a first-generation short interfering RNA (siRNA) that specifically targets transthyretin (TTR) mRNA. It is utilized in TTR-mediated amyloidosis research.
T74645	Eplontersen	Others	Others
	Eplontersen 是一种三触角的、N-乙酰半乳糖胺 (GalNAc3)-缀合的反义寡核苷酸，能够靶向甲状腺素运载蛋白 TTR 的 mRNA，抑制变体和野生型 TTR 产生。错误折叠的 TTR 诱导心脏和周围神经的淀粉样原纤维形成，并介导淀粉样 TTR (ATTR) 蛋白变性疾病。
T39304	Vutrisiran ALN-TTRsc02	Others	Others
	Vutrisiran (ALN-TTRsc02) is an investigational, liver-directed small interfering ribonucleic acid (siRNA) compound designed for research on transthyretin (TTR)-mediated amyloidosis.
T38909	Inotersen sodium ISIS-420915 sodium	Others	Others
	Inotersen sodium, also known as ISIS-420915 sodium, is a 2′-O-methoxyethyl-modified antisense oligonucleotide compound. It effectively inhibits transthyretin (TTR) protein production by targeting the TTR RNA transcript, thereby reducing TTR transcript levels. Inotersen sodium holds potential for research on hereditary TTR amyloidosis polyneuropathy.
T38804	Patisiran sodium	Others	Others
	Patisiran sodium is a double-stranded small interfering RNA (siRNA) that selectively targets a specific sequence within the transthyretin (TTR) messenger RNA (mRNA). By doing so, it effectively blocks the hepatic synthesis of both mutant and wild-type TTR. Patisiran sodium has significant applications in the field of hereditary TTR amyloidosis research.
T79417	PITB	Others	Others
	PITB是一种选择性且具口服活性的TTR聚集抑制剂，主要用于研究ATTR疾病。
T61423	Transthyretin-IN-1	Others	Others
	Transthyretin-IN-1 (Compound 1d) is a potent inhibitor of transthyretin (TTR) fibril formation, making it a valuable tool for investigating Alzheimer’s disease [1].
T71785	GUN35758	Others	Others
	GUN35758, also known as 4'-Carboxybenzo-18C6, is a novel transthyretin (ttr) amyloidogenesis inhibitor, stabilizing the ttr tetramer by binding to the allosteric sites on the molecular surface of the ttr tetramer. This product has no formal name at the moment. For the convenience of communication, a temporary code name was therefore proposed according to MedKoo Chemical Nomenclature (see web page: https://www.medkoo.com/page/naming).
T62141	RBP4 ligand-1	Others	Others
	RBP4 ligand-1 是一种视黄醇结合蛋白 4 (RBP4) 的非视黄醇配体。RBP4 ligand-1 在放射配体结合检测和 FRET 检测中对 hRBP4SPAIC50 和 RBP4–TTR FRET IC50值分别为 0.23±0.11 和 0.13±0.12 μM。

化合物

Cat.No: T32500

Synonym: TTR stabilizer L6

Target: Others

Anti-TTR Monoclonal Antibody-PE

Cat.No: TMAZ-0075P

Anti-TTR Monoclonal Antibody-Biotin

Cat.No: TMAZ-0075B

WT-TTR inhibitor 1

Cat.No: T75173

Target: Others

Anti-TTR Monoclonal Antibody-APC

Cat.No: TMAZ-0075A

Anti-TTR Monoclonal Antibody-AF555

Cat.No: TMAZ-0075A5

Anti-TTR Monoclonal Antibody-AF488

Cat.No: TMAZ-0075A4

Anti-TTR Monoclonal Antibody-AF647

Cat.No: TMAZ-0075A6

Burnettramic Acid A

Cat.No: T36336

Target: Others

Cat.No: T36706

Target: Others

tafamidis meglumine

Cat.No: T7582

Synonym: Fx-1006A,他发米帝司甲葡胺

Target: Others

Cat.No: T4565

Synonym: 他发米帝司甲葡胺,氯苯唑酸,Fx-1006A

Target: Others

Cat.No: T9447

Synonym: Acoramidis

Target: Others

Acoramidis hydrochloride

Cat.No: T39740

Synonym: AG10 hydrochloride,Alxn2060 hydrochloride

Target: Others

Dichlorophenyl-ABA

Cat.No: T15116

Target: Others

Cat.No: T38918

Synonym: ALN-TTRSC

Target: Others

Cat.No: T74645

Target: Others

Cat.No: T39304

Synonym: ALN-TTRsc02

Target: Others

Inotersen sodium

Cat.No: T38909

Synonym: ISIS-420915 sodium

Target: Others

Patisiran sodium

Cat.No: T38804

Target: Others

Cat.No: T79417

Target: Others

Transthyretin-IN-1

Cat.No: T61423

Target: Others

Cat.No: T71785

Target: Others

Cat.No: T62141

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T36337	Burnettramic Acid A aglycone	Others	Others
	Burnettramic acid A aglycone is a fungal metabolite and an aglycone form of burnettramic acid A originally isolated fromA. burnettiithat has anticancer activity.1It is cytotoxic to NS-1 murine myeloma cells but not neonatal foreskin fibroblasts (IC50s = 8.4 and >100 μg/ml, respectively). 1.Li, H., Gilchrist, C.L.M., Lacey, H.J., et al.Discovery and heterologous biosynthesis of the burnettramic acids: Rare PKS-NRPS-derived bolaamphiphilic pyrrolizidinediones from an Australian fungus, Aspergillus...
T4S1637	gamma-Mangostin Normangostin,γ-倒捻子素	Others; 5-HT Receptor	GPCR/G Protein; Neuroscience; Others
	gamma-Mangostin (Normangostin) 是从药用植物山竹的果壳中提纯的一种天然产物，是一种竞争性5-HT2A 受体拮抗剂。它是运甲状腺素蛋白原纤维化抑制剂，与甲状腺素结合位点结合并稳定了 TTR 四聚体，具有抗高血压、预防结肠癌等作用。

天然产物

Burnettramic Acid A aglycone

Cat.No: T36337

Target: Others

gamma-Mangostin

Cat.No: T4S1637

Synonym: Normangostin,γ-倒捻子素

Target: Others, 5-HT Receptor

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-02947	Transthyretin Protein, Mouse, Recombinant Prealbumin,Transthyretin,Ttr	Mouse	E. coli
	Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. Transthyretin Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 13.5 kDa and the accession number is P07309.
TMPH-02946	Transthyretin Protein, Mouse, Recombinant (His & SUMO) Transthyretin,Prealbumin,Ttr	Mouse	E. coli
	Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. Transthyretin Protein, Mouse, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 29.6 kDa and the accession number is P07309.
TMPH-02242	Transthyretin Protein, Human, Recombinant (hFc & Myc) TTR,ATTR,Transthyretin,Prealbumin,TBPA	Human	HEK293 Cells
	Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.
TMPK-01090	Transthyretin/Prealbumin Protein, Cynomolgus, Recombinant (His) Prealbumin,TBPA,CTS,HEL111,Transthyretin,TTR,AT...	Cynomolgus	HEK293 Cells
	Transthyretin is a highly conserved homotetrameric protein, mainly synthetized by the liver and the choroid plexus of brain. The carrier role of TTR is well-known; however, many other functions have emerged, namely in the nervous system. TTR aggregates are responsible for many amyloidosis such as familial amyloidotic polyneuropathy and cardiomyopathy. Normal TTR can also aggregate and deposit in the heart of old people and in preeclampsia placental tissue.
TMPY-00261	Meprin beta Protein, Human, Recombinant (His) meprin A, β,Meprin β,meprin A, beta	Human	HEK293 Cells
	MEP1B (Meprin A Subunit Beta) is a Protein Coding gene. This gene encodes the beta subunit. Targeted disruption of this gene in mice affects embryonic viability, renal gene expression profiles, and distribution of the membrane-associated alpha subunit in the kidney and intestine. Meprins are cell membrane, oligomeric metalloendopeptidases composed of two distinct but evolutionarily related subunits, alpha, and beta. MEP1A is mapped to the short arm of chromosome 6 by the use of radiation and som...

重组蛋白

Transthyretin Protein, Mouse, Recombinant

Cat.No: TMPH-02947

Species: Mouse

Expression System: E. coli

Transthyretin Protein, Mouse, Recombinant (His & SUMO)

Cat.No: TMPH-02946

Species: Mouse

Expression System: E. coli

Transthyretin Protein, Human, Recombinant (hFc & Myc)

Cat.No: TMPH-02242

Species: Human

Expression System: HEK293 Cells

Transthyretin/Prealbumin Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-01090

Species: Cynomolgus

Expression System: HEK293 Cells

Meprin beta Protein, Human, Recombinant (His)

Cat.No: TMPY-00261

Species: Human

Expression System: HEK293 Cells

Cat. No.	Product Name	Target	Signaling Pathways
TMIH-0549	Tafamidis-d3
	Tafamidis-d3 是 Tafamidis 的氘代化合物。Tafamidis 的 CAS 号为 594839-88-0。Tafamidis 是选择性的transthyretin (TTR)稳定剂，对野生型 WT-TTR 、突变型同源四聚体 V30M-TTR、V122I-TTR 的活性相当，它们的EC50值为2.7-3.2 μM。它对淀粉样蛋白的生成具有抑制作用。

同位素标记化合物

Cat.No: TMIH-0549

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