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Search Results for " trpa1 "

Targets Recommended: TRP/TRPV Channel

31

抑制剂 & 化合物

10

天然产物

2

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T77511	TRPA1-IN-2	TRP/TRPV Channel	Membrane transporter/Ion channel
	TRPA1-IN-2 是一种有效且具有口服活性的 TRPA1 抑制剂，IC50 值为 0.04 µM。TRPA1-IN-2 具有抗炎活性。
T40822	TRPA1 Antagonist 3 TRPA1 Antagonist 3	Others	Others
	TRPA1 Antagonist 3 is a compound with photoswitchable properties that acts as an agonist on the TRPA1 channel, providing the ability for optical control.
T39935	TRPA1-IN-1 TRPA1-IN-1	Others	Others
	TRPA1-IN-1 is a potent, selective antagonist of the TRPA1 channel, demonstrating significant oral bioavailability as a small molecule.
T13212	TRPA1 Antagonist 1	TRP/TRPV Channel	Membrane transporter/Ion channel
	TRPA1 Antagonist 1 is an antagonist of TRPA1(IC50: 8 nM) and is a methylene phosphate prodrug which converts to its active parent drug.
T6617	Optovin	TRP/TRPV Channel	Membrane transporter/Ion channel
	Optovin 是可逆的光活化 TRPA1配体，可实现光介导的神经元兴奋。它通过与氧化还原敏感的半胱氨酸残基产生结构依赖性光化学反应激活 TRPA1。
T64337	PF-04745637 PF4745637,PF 4745637,PF 04745637,PF-4745637	TRP/TRPV Channel	Membrane transporter/Ion channel
	PF-04745637 是TRPA1的选择性拮抗剂，对人 TRPA1 的IC50为 17 nM。
T15628	JT010	TRP/TRPV Channel	Membrane transporter/Ion channel
	JT010 是一种有效的 TRPA1 激动剂 (EC50 = 0.65 nM)。
T4385	PF-4840154	TRP/TRPV Channel	Membrane transporter/Ion channel
	PF4840154 是有效的大鼠和人TrpA1通道选择性激动剂，EC50分别为 97 和 23 nM。PF-4840154 可以诱导 TrpA1 介导的小鼠伤害行为。
T7430	AM-0902	TRP/TRPV Channel	Membrane transporter/Ion channel
	AM-0902 是有效的瞬时受体电位 A1 选择性拮抗剂，作用于rTRPA1和hTRPA1的IC50分别为 71 和 131 nM。
T7205	A-967079 (1E,3E)-1-(4-氟苯基)-2-甲基-1-戊烯-3-酮肟	TRP/TRPV Channel	Membrane transporter/Ion channel
	A 967079是一种有效的TRPA1受体选择性拮抗剂，对人和大鼠 TRPA1 受体的IC50分别为 67 nM 和 289 nM。A 967079具有良好的CNS 穿透性。
T21543	AP 18	TRP/TRPV Channel	Membrane transporter/Ion channel
	AP-18 是选择性的 TRPA1 抑制剂。AP-18 可以抑制 50 μM 肉桂醛诱导的 TRPA1 激活，在小鼠和人中的 IC50 分别为 4.5 μM 和 3.1 μM。AP-18 可以逆转 CFA 诱导的小鼠机械性痛觉过敏。AP-18 可以浓度依赖的方式减弱 30 μM AITC 诱导的 Yo-Pro 摄取(IC50= 10.3 μM)。
T6530	HC-030031 2-(1,3-二甲基-2,6-二氧代-2,3-二氢-1H-嘌呤-7(6H)-基)-N-(4-异丙基苯基)乙酰胺,HC030031,TOSLAB 829227	TRP/TRPV Channel	Membrane transporter/Ion channel
	HC-030031 (TOSLAB 829227) 是一种有效的TRPA1选择性抑制剂，拮抗福尔马林和AITC 诱发的钙流入，IC50分别为5.3±0.2和6.2±0.2μM。
T8410	ASP7663	TRP/TRPV Channel	Membrane transporter/Ion channel
	ASP7663 是口服有效的TRPA1选择性激动剂。ASP7663具有抗便秘和抗腹痛的功效。
T29968	AMG-0347 UNII-CD7L9290QR	TRP/TRPV Channel	Membrane transporter/Ion channel
	AMG-0347 (UNII-CD7L9290QR)是一种靶向TRPA1(瞬时受体电位锚蛋白1)离子通道的小分子抑制剂，是一种在感觉神经元中发现的受体，参与疼痛和环境刺激物的检测。AMG-0347通过阻断TRPA1的功能起作用，具有镇痛作用。
T78082	Supercinnamaldehyde	NF-κB; Antibacterial; TRP/TRPV Channel	Membrane transporter/Ion channel; Microbiology/Virology; NF-κB
	Supercinnamaldehyde 是一种瞬时受体电位锚蛋白1(TRPA1)激活剂，具有千的抗癌和抗菌活性。Supercinnamaldehyde 抑制NF-κB信号传导，通过Nrf2诱导诱导细胞保护反应和抑制炎症反应。
T2711	Chembridge-5861528 TCS 5861528	TRP/TRPV Channel	Membrane transporter/Ion channel
	Chembridge-5861528 (TCS 5861528) 是有效的 TRPA1离子通道阻断剂。
T22920	LE135 LE 135	Retinoid Receptor	Metabolism
	LE135 是一种有效的 RAR 拮抗剂，可选择性结合 RARα (Ki 为 1.4 μM) 和 RARβ (Ki 为 220 nM)，对 RARβ 具有更高的亲和力。LE135 对 RARγ，RXRα，RXRβ 和 RXRγ 具有高度选择性。LE135 还是一种有效的 TRPV1 和 TRPA1 受体激活剂，EC50 分别为 2.5 μM 和 20 μM。
T16532	Pico145 HC-608	TRP/TRPV Channel	Membrane transporter/Ion channel
	Pico145 (HC-608) 是有效的瞬时受体电位通道蛋白 1/4/5 (TRPC1/TRPC4/TRPC5) 抑制剂，在细胞中，抑制 (-)-englerin A 活化TRPC4/TRPC5 通道的IC50分别为 0.349 和 1.3 nM。
T2007	RQ-00203078	TRP/TRPV Channel	Membrane transporter/Ion channel
	RQ00203078是一种口服有效的TRPM8高选择性拮抗剂，对大鼠和人类TRPM8通道的IC50分别为 5.3 nM 和 8.3 nM。它对 TRPV1，TRPA1，TRPV4 或 TRPM2 通道基本没有抑制作用。
T7191	Diphenyleneiodonium chloride 二苯基氯化碘盐,DPI	NOS; Reactive Oxygen Species; NADPH; TRP/TRPV Channel	Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; NF-κB
	Diphenyleneiodonium chloride (DPI) 是 NADPH 氧化酶抑制剂，也是 TRPA1激活剂，EC50为 1 - 3 μM 。它选择性抑制胞内活性氧。
T21623	AS1269574 AS 1269574	GPR; TRP/TRPV Channel	Endocrinology/Hormones; GPCR/G Protein; Membrane transporter/Ion channel
	AS1269574 是口服有效的GPR119激动剂，在表达人 GPR119 的 HEK293 细胞中EC50为 2.5 μM。它激活 TRPA1 阳离子通道，刺激胰高血糖素样肽-1分泌。它仅在高糖条件下特异性诱导胰腺 β 细胞分泌葡萄糖依赖性胰岛素。它在 2 型糖尿病的研究中具有价值。
T25078	AMG9090 AMG 9090,AMG-9090	Others	Others
	AMG9090 is a transient receptor potential ankyrin 1 (TRPA1) antagonist.
T39408	GDC-0334	Others	Others
	GDC-0334 is a TRPA1 antagonist useful in treatment TRPA1-mediated diseases, such as pain or asthma.
T69987	AMG2504	Others	Others
	AMG2504 is a TRPA1 inhibitor.
T79875	GDC-6599	Others	Others
	GDC-6599 (Example 8)为口服活性TRPA1抑制剂，适用于研究TRPA1介导的病症，包括疼痛等。
T73432	BAY-390	Others	Others
	BAY-390 是一种选择性的，跨物种活跃的，可穿透大脑的 TRPA1抑制剂。BAY-390 抑制 hTRPA1 FLIPR，hTRPA1 Ephys，rTRPA1 FLIPR 和 rDRG Ephys，IC50值分别为 16，82，63 和 35 nM。BAY-390 可用于炎症的研究。
T80843	Wasabi Receptor Toxin WaTx
	Wasabi Receptor Toxin通过延长TRPA1通道的开放时间并降低其Ca2+渗透性，从而激活该通道。该化合物被应用于急性与持续性疼痛研究领域。
T69359	Ludartin	Others	Others
	Ludartin is a TRPA1 channel activator that has been found to produce anticancer effects by inducing DNA damage and a reduction of mitochondrial membrane potential.
T60284	4-(Phenyldiazenyl)benzoic acid	Others	Others
	4-(Phenyldiazenyl)benzoic acid 是一种光敏和可控的 TRPA1激动剂，可作为研究疼痛信号传导的药理学工具。
T38372	2-Fluoro-4-iodo benzonitrile	Others	Others
	2-Fluoro-4-iodo benzonitrile is a building block.1,2It has been used in the synthesis ofL. infantumtrypanothione reductase (Li-TryR) dimerization and oxidoreductase activity inhibitors.12-Fluoro-4-iodo benzonitrile has also been used in the synthesis of transient receptor potential ankyrin 1 (TRPA1) antagonists.2 1.Revuelto, A., Ruiz-Santaquiteria, M., de Lucio, H., et al.Pyrrolopyrimidine vs imidazole-phenyl-thiazole scaffolds in nonpeptidic dimerization inhibitors of Leishmania infantum trypan...
T31995	GRC-17536 GRC17536,GRC 17536	Others	Others
	GRC-17536 is an orally available, potent, and selective transient receptor potential anchor protein 1 (TRPA1) inhibitor that has been shown to be highly effective in the treatment of inflammation and neuropathic pain in animal models. The selectivity of G

化合物

Cat.No: T77511

Target: TRP/TRPV Channel

TRPA1 Antagonist 3

Cat.No: T40822

Synonym: TRPA1 Antagonist 3

Target: Others

Cat.No: T39935

Synonym: TRPA1-IN-1

Target: Others

TRPA1 Antagonist 1

Cat.No: T13212

Target: TRP/TRPV Channel

Cat.No: T6617

Target: TRP/TRPV Channel

Cat.No: T64337

Synonym: PF4745637,PF 4745637,PF 04745637,PF-4745637

Target: TRP/TRPV Channel

Cat.No: T15628

Target: TRP/TRPV Channel

Cat.No: T4385

Target: TRP/TRPV Channel

Cat.No: T7430

Target: TRP/TRPV Channel

Cat.No: T7205

Synonym: (1E,3E)-1-(4-氟苯基)-2-甲基-1-戊烯-3-酮肟

Target: TRP/TRPV Channel

Cat.No: T21543

Target: TRP/TRPV Channel

Cat.No: T6530

Synonym: 2-(1,3-二甲基-2,6-二氧代-2,3-二氢-1H-嘌呤-7(6H)-基)-N-(4-异丙基苯基)乙酰胺,HC030031,TOSLAB 829227

Target: TRP/TRPV Channel

Cat.No: T8410

Target: TRP/TRPV Channel

Cat.No: T29968

Synonym: UNII-CD7L9290QR

Target: TRP/TRPV Channel

Supercinnamaldehyde

Cat.No: T78082

Target: NF-κB, Antibacterial, TRP/TRPV Channel

Chembridge-5861528

Cat.No: T2711

Synonym: TCS 5861528

Target: TRP/TRPV Channel

Cat.No: T22920

Synonym: LE 135

Target: Retinoid Receptor

Cat.No: T16532

Synonym: HC-608

Target: TRP/TRPV Channel

Cat.No: T2007

Target: TRP/TRPV Channel

Diphenyleneiodonium chloride

Cat.No: T7191

Synonym: 二苯基氯化碘盐,DPI

Target: NOS, Reactive Oxygen Species, NADPH, TRP/TRPV Channel

Cat.No: T21623

Synonym: AS 1269574

Target: GPR, TRP/TRPV Channel

Cat.No: T25078

Synonym: AMG 9090,AMG-9090

Target: Others

Cat.No: T39408

Target: Others

Cat.No: T69987

Target: Others

Cat.No: T79875

Target: Others

Cat.No: T73432

Target: Others

Wasabi Receptor Toxin

Cat.No: T80843

Synonym: WaTx

Cat.No: T69359

Target: Others

4-(Phenyldiazenyl)benzoic acid

Cat.No: T60284

Target: Others

2-Fluoro-4-iodo benzonitrile

Cat.No: T38372

Target: Others

Cat.No: T31995

Synonym: GRC17536,GRC 17536

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T8307	Hydroxy-α-sanshool 羟基-α-山椒素,Hydroxy-α-sanshool	Endogenous Metabolite; TRP/TRPV Channel	Membrane transporter/Ion channel; Metabolism
	Hydroxy-α-sanshool 是分离自胡椒的烷基酰胺，作为 TRPA1的共价激动剂和 TRPV1的非共价激动剂，EC50分别为69和 1.1 µM。
T12514	Podocarpic acid	Others; TRP/TRPV Channel	Membrane transporter/Ion channel; Others
	Podocarpic acid 是一种天然产物，是一种新型 TRPA1 激活剂。
TQ0001	1,4-Cineole Isocineole,1,4-桉叶素	Endogenous Metabolite; TRP/TRPV Channel	Membrane transporter/Ion channel; Metabolism
	1,4-Cineole (Isocineole) 是天然广泛分布的含氧单萜烯，存在于桉树油中，可激活人TRPM8和TRPA1。
TN3575	(±)-Cannabichromene Cannabichromene,大麻色原烯,Cannabichrome	Cannabinoid Receptor	GPCR/G Protein
	(±)-Cannabichromene 是一种发现于大麻的 2,2-dimethyl-2H-chromene 衍生物。
TN1927	Methyl Kakuol 1-(6-methoxy-1,3-benzodioxol-5-yl)propan-1-one	TRP/TRPV Channel	Membrane transporter/Ion channel
	Methyl Kakuol 是 TRPA1 的激动剂，EC50 为 0.27 µM，可用于作为 MBST 成分 Asiasari Radix 的活性成分的研究。
T3727	Methyl syringate Syringic Acid Methyl Ester,丁香酸甲酯	TRP/TRPV Channel	Membrane transporter/Ion channel
	Methyl syringate (Syringic Acid Methyl Ester) 是水仙花蜜的化学标记物，是有效的细菌和真菌漆酶酚介质。它也是TRPA1激动剂。
TCS0102	Pulegone 胡薄荷酮,(+)-Pulegone,蒲勒酮，胡薄荷酮，长叶薄荷酮	Calcium Channel; Endogenous Metabolite; TRP/TRPV Channel	Membrane transporter/Ion channel; Metabolism
	Pulegone ((+)-Pulegone) 是 Calamintha nepeta (L.) Savi 的精油的主要化学成分，也是禽类驱虫剂之一。它在禽类物种中驱避作用的分子靶点是伤害感受性 TRP 锚蛋 1。它刺激鸡感觉神经元中的 TRPM8 和 TRPA1 通道，并在高浓度下抑制前者但不抑制后者。
T2994	(E)-Cardamonin Alpinetin chalcone,Cardamomin,小豆蔻明,Cardamonin,(E)-Cardamoni,豆蔻明	Apoptosis; TRP/TRPV Channel	Apoptosis; Membrane transporter/Ion channel
	(E)-Cardamonin (Alpinetin chalcone) 是一种新型hTRPA1阳离子通道拮抗剂，IC50值为454 nM。
T7177	Capsazepine	Apoptosis; TRP/TRPV Channel	Apoptosis; Membrane transporter/Ion channel
	Capsazepine 是一种 TRPV1 受体的拮抗剂， IC50值为 562 nM。它可阻断由激活 TRPV1 离子通道的辣椒素引起的热痛感，是辣椒素拮抗剂。
T13953	Umbellulone	Others	Others
	Umbellulone is a natural product isolated from Umbellularia californica, and stimulates the TRPA1 channel in a subset of peptidergic, nociceptive neurons, activating the trigeminovascular system via this mechanism.

天然产物

Hydroxy-α-sanshool

Cat.No: T8307

Synonym: 羟基-α-山椒素,Hydroxy-α-sanshool

Target: Endogenous Metabolite, TRP/TRPV Channel

Podocarpic acid

Cat.No: T12514

Target: Others, TRP/TRPV Channel

Cat.No: TQ0001

Synonym: Isocineole,1,4-桉叶素

Target: Endogenous Metabolite, TRP/TRPV Channel

(±)-Cannabichromene

Cat.No: TN3575

Synonym: Cannabichromene,大麻色原烯,Cannabichrome

Target: Cannabinoid Receptor

Cat.No: TN1927

Synonym: 1-(6-methoxy-1,3-benzodioxol-5-yl)propan-1-one

Target: TRP/TRPV Channel

Methyl syringate

Cat.No: T3727

Synonym: Syringic Acid Methyl Ester,丁香酸甲酯

Target: TRP/TRPV Channel

Cat.No: TCS0102

Synonym: 胡薄荷酮,(+)-Pulegone,蒲勒酮，胡薄荷酮，长叶薄荷酮

Target: Calcium Channel, Endogenous Metabolite, TRP/TRPV Channel

Cat.No: T2994

Synonym: Alpinetin chalcone,Cardamomin,小豆蔻明,Cardamonin,(E)-Cardamoni,豆蔻明

Target: Apoptosis, TRP/TRPV Channel

Cat.No: T7177

Target: Apoptosis, TRP/TRPV Channel

Cat.No: T13953

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-03389	TRPA1 Protein, Rat, Recombinant (His & Myc) Wasabi receptor,Trpa1,Transient receptor p...	Rat	E. coli
	TRPA1 Protein, Rat, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 27.3 kDa and the accession number is Q6RI86.
TMPH-02740	IL-31R alpha Protein, Mouse, Recombinant (His) ZcytoR17,Interleukin-31 receptor subunit a...	Mouse	E. coli
	Associates with OSMR to form the interleukin-31 receptor which activates STAT3 and to a lower extent STAT1 and STAT5. May function in skin immunity. Mediates IL31-induced itch, probably in a manner dependent on cation channels TRPA1 and TRPV1. Positively regulates numbers and cycling status of immature subsets of myeloid progenitor cells in bone marrow in vivo and enhances myeloid progenitor cell survival in vitro. IL-31R alpha Protein, Mouse, Recombinant (His) is expressed in E. coli expression...

重组蛋白

TRPA1 Protein, Rat, Recombinant (His & Myc)

Cat.No: TMPH-03389

Species: Rat

Expression System: E. coli

IL-31R alpha Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02740

Species: Mouse

Expression System: E. coli

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