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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T74271 |
TRIM24/BRPF1-IN-2
|
Others | Others |
TRIM24/BRPF1-IN-2 (compound 20l) 是一种有效的 TRIM24/BRPF1双重抑制剂,IC50值分别为 0.98 和 1.16 μM。 TRIM24/BRPF1-IN-2 显示出 TRIM24/BRPF1 溴结构域结合亲和力。 TRIM24/BRPF1-IN-2 可用于前列腺癌研究。 | |||
T15178 |
dTRIM24
|
Others; PROTACs | Others; PROTAC |
dTRIM24 是一种基于 PROTAC 技术的选择性双功能 TRIM24 降解剂,由von Hippel-Lindau 和TRIM24 两者配体构成。 | |||
T2127 |
OF-1
|
Epigenetic Reader Domain | Chromatin/Epigenetic |
OF-1 是溴结构域的一种抑制剂,其对TRIM24 和BRPF1B 的IC50值分别为270 mM 和1.2 μM。 | |||
T11597 |
IACS-9571
ASIS-P040 |
Epigenetic Reader Domain | Chromatin/Epigenetic |
IACS-9571 is a selective and potent inhibitor of TRIM24 and BRPF1, (IC50: 8 nM for TRIM24; Kds: 31 nM and 14 nM for TRIM24 and BRPF1). | |||
T11597L |
IACS-9571 Hydrochloride (1800477-30-8 free base)
IACS-9571 Hydrochloride,ASIS-P040 Hydrochloride |
Epigenetic Reader Domain | Chromatin/Epigenetic |
IACS-9571 Hydrochloride is a selective and potent inhibitor of TRIM24 and BRPF1, (IC50: 8 nM for TRIM24; Kds: 31 nM and 14 nM for TRIM24 and BRPF1). | |||
T72274 |
IACS-9571 hydrochloride
ASIS-P040 hydrochloride |
Others | Others |
IACS-9571 (ASIS-P040) hydrochloride 是溴结构域蛋白 TRIM24和 BRPF1的抑制剂,对 TRIM24 的 IC50和 Kd 值分别为 8 nM 和 31 nM,对 BRPF1的 Kd 值为 14 nM。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-02221 |
TRIM24 Protein, Human, Recombinant (His & SUMO)
Transcription intermediary factor 1-alpha,E3 ubiquitin-prote... |
Human | E. coli |
Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. Promotes ubiquitination and proteasomal degradation of p53/TP53. Plays a role in the regulation of cell proliferation and apopt... |