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Search Results for " traf "

Targets Recommended: NF-κB

15

抑制剂 & 化合物

1

天然产物

1

化合物库

8

重组蛋白

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Cat. No.	Product Name
L3800	NF-κB 通路分子库		729 compounds
	729 个 NF-κB 信号通路相关的小分子化合物的特有集合，用于高通量、高内涵筛选；

化合物库

NF-κB 通路分子库

Cat.No: L3800

Compounds: 729

Cat. No.	Product Name	Target	Signaling Pathways
T17157	TRAF-STOP inhibitor 6877002 CD40-TRAF6 inhibitor	NF-κB	NF-κB
	TRAF-STOP inhibitor 6877002 (CD40-TRAF6 inhibitor)是一种 CD40-TRAF6 相互作用的选择性抑制剂，可以抑制 RAW 细胞中 NF-κB 活化。TRAF-STOP 6877002 可阻止小鼠动脉粥样硬化的恶化，减少白细胞募集和巨噬细胞的活化，减少动脉粥样硬化斑块中的巨噬细胞增殖。
T24808	SMI-6860766 TRAFSTOP 6860766,TRAF-STOP 6860766,SMI 6860766,TRAFSTOP6860766,SMI6860766	Others	Others
	SMI-6860766 is a CD40-Traf6 interactions blocker that acts by ameliorating the complications of diet-induced obesity in mice.
T5821	BC-1215	Others; Ligand for E3 Ligase	Others; PROTAC
	BC-1215 是一种 F-box protein 3 抑制剂。它能够稳定 TRAF1-TRAF6 来抑制 Fbxo3-TRAF 激活途径。它与 ApaG 相互作用，阻碍来自人 PBMC 广谱 TH1 细胞因子的分泌。
T76372	TRAF6 peptide
	TRAF6 peptide 是一种特异性的TRAF6-p62相互作用抑制剂。TRAF6 peptide 能消除 NGF 依赖性TrkA 泛素化。TRAF6 peptide 在诸如阿尔茨海默症 (AD)、帕金森、ALS、头部外伤、癫痫和中风等神经系统性疾病中具有较好的研究潜力。
T78221	TRAF6 peptide TFA	E1/E2/E3 Enzyme	Ubiquitination
	TRAF6 peptide TFA是一种抑制TRAF6-p62相互作用的特异性分子，可抑制NGF依赖的TrkA泛素化，展现在阿尔茨海默症（AD）、帕金森病、ALS、创伤性脑损伤、癫痫和中风等神经系统疾病研究中的应用潜力。
T9405	1,4-Dipierazino-2,3,5,6-tetrafluorobenzene	Others	Others
	1,4-Dipierazino-2,3,5,6-tetrafluorobenzene 是一种四氟苯衍生物，它的独特结构使其能够作为药物的载体，药物可以以可控的方式释放，使其能够用于开发靶向药物递送系统。
T33127	m-(1,1,2,2-Tetrafluoroethoxy)phenyl isocyanate	Others	Others
	m-(1,1,2,2-Tetrafluoroethoxy)phenyl isocyanate is a bioactive chemical.
T64869	Ethyl 3-oxo-3-(2,3,4,5-tetrafluorophenyl)propanoate	Others	Others
	Ethyl 3-oxo-3-(2,3,4,5-tetrafluorophenyl)propanoate 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T64869，CAS号为 94695-50-8。
T27846	Lotrafiban hydrochloride SB 214857a,Lotrafiban HCl,SB-214857-A	Others	Others
	Lotrafiban hydrochloride is an platelet glycoprotein IIb/IIIa blocker with oral activity.
T35352	Titanium tetrafluoride	Others	Others
	Titanium tetrafluoride 是一种有效但不稳定的防龋剂。
T77155	Dalutrafusp alfa
	Dalutrafusp alfa (AGEN-1423; GS-1423) 为针对CD73与TGF-β的特异性双功能抗体，涉及免疫抑制路径。
T30323	Benzaldehyde, 3-(1,1,2,2-tetrafluoroethoxy)-	Others	Others
	Benzaldehyde, 3-(1,1,2,2-tetrafluoroethoxy)- is a bioactive chemical.
T80588	Bintrafusp alfa M7824,MSB0011359C
	Bintrafusp alfa (M 7824) 是高端双功能融合蛋白，融合了转化生长因子β受体II (TGF-βRII) 的细胞外域与人源IgG1单克隆抗体 (mAb) 致程序性细胞死亡配体阻断功能。该化合物主要用于癌症研究领域。
T62351	Lotrafiban	Others	Others
	Lotrafiban 是一种口服具有活力的血小板膜糖蛋白 IIb/IIIa 阻滞剂，能够用于治疗冠心病和脑血管疾病的治疗。
T63176	ALPK1-IN-1	Others	Others
	ALPK1-IN-1 (Compound A001) 是一种 α-激酶 1 (ALPK1) 的有效抑制剂。其中 ALPK1 是一种胞质内丝/苏氨酸蛋白激酶，利用与叉头相关结构域 (TIFA) 依赖的促炎 NF-κB 信号通路的 TRAF 蛋白相互作用，在激活对细菌的先天免疫反应中发挥重要作用。

化合物

TRAF-STOP inhibitor 6877002

Cat.No: T17157

Synonym: CD40-TRAF6 inhibitor

Target: NF-κB

Cat.No: T24808

Synonym: TRAFSTOP 6860766,TRAF-STOP 6860766,SMI 6860766,TRAFSTOP6860766,SMI6860766

Target: Others

Cat.No: T5821

Target: Others, Ligand for E3 Ligase

TRAF6 peptide

Cat.No: T76372

TRAF6 peptide TFA

Cat.No: T78221

Target: E1/E2/E3 Enzyme

1,4-Dipierazino-2,3,5,6-tetrafluorobenzene

Cat.No: T9405

Target: Others

m-(1,1,2,2-Tetrafluoroethoxy)phenyl isocyanate

Cat.No: T33127

Target: Others

Ethyl 3-oxo-3-(2,3,4,5-tetrafluorophenyl)propanoate

Cat.No: T64869

Target: Others

Lotrafiban hydrochloride

Cat.No: T27846

Synonym: SB 214857a,Lotrafiban HCl,SB-214857-A

Target: Others

Titanium tetrafluoride

Cat.No: T35352

Target: Others

Dalutrafusp alfa

Cat.No: T77155

Benzaldehyde, 3-(1,1,2,2-tetrafluoroethoxy)-

Cat.No: T30323

Target: Others

Bintrafusp alfa

Cat.No: T80588

Synonym: M7824,MSB0011359C

Cat.No: T62351

Target: Others

Cat.No: T63176

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
TN4865	Putraflavone	Beta Amyloid; BACE	Neuroscience
	Putraflavone possesses a good antioxidant activity via its DPPH free radical scavenging.

天然产物

Cat.No: TN4865

Target: Beta Amyloid, BACE

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-01270	TRAIP Protein, Human, Recombinant (His) E3 ubiquitin-protein ligase TRAIP,TRAF-interacting ...	Human	E. coli
	E3 ubiquitin ligase required to protect genome stability in response to replication stress. Acts as a key regulator of interstrand cross-link repair, which takes place when both strands of duplex DNA are covalently tethered together, thereby blocking replication and transcription. Controls the choice between the two pathways of replication-coupled interstrand-cross-link repair by mediating ubiquitination of MCM7 subunit of the CMG helicase complex. Short ubiquitin chains on MCM7 promote recruitm...
TMPH-02287	ZRANB1 Protein, Human, Recombinant (His & Myc) TRAF-binding domain-containing protein,Zinc finger ...	Human	E. coli
	Specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'-linked diubiquitin. Also cleaves 'Lys-63'-linked chains, but with 40-fold less efficiency compared to 'Lys-29'-linked ones. Positive regulator of the Wnt signaling pathway that deubiquitinates APC protein, a negative regulator of Wnt-mediated transcription. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration. May also modulate TNF-alpha signaling. ZRANB1 Prot...
TMPJ-00168	HVEM Protein, Mouse, Recombinant (hFc) Tnfrsf14,Herpesvirus entry mediator,ATAR,Tumor necrosis fact...	Mouse	HEK293 Cells
	Mouse Protein Tnfrsf14, is a type I transmembrane protein belonging to the TNF receptor superfamily. It is tumor necrosis factor receptor superfamily member 14 and expressed on the surface of T cells during the resting state. Interaction of HVEM with TNF family member LIGHT co-stimulates T cells and promotes inflammation. HVEM also triggers inhibitory signaling cascade in effector T (Teff) cells and regulatory T cells (Tregs) as a ligand of B and T lymphocyte attenuator. Tnfrsf14 is detected in ...
TMPH-02208	TRAF3 Protein, Human, Recombinant LMP1-associated protein 1,TNF receptor-associated factor 3,R...	Human	E. coli
	Regulates pathways leading to the activation of NF-kappa-B and MAP kinases, and plays a central role in the regulation of B-cell survival. Part of signaling pathways leading to the production of cytokines and interferon. Required for normal antibody isotype switching from IgM to IgG. Plays a role T-cell dependent immune responses. Plays a role in the regulation of antiviral responses. Is an essential constituent of several E3 ubiquitin-protein ligase complexes. May have E3 ubiquitin-protein liga...
TMPH-02207	TRAF3 Protein, Human, Recombinant (His) TRAF3,RING-type E3 ubiquitin transferase TRAF	Human	E. coli
	TRAF3 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 68.6 kDa and the accession number is Q13114.
TMPH-02209	TRAF5 Protein, Human, Recombinant (His & SUMO) TRAF5,RING finger protein 84,TNF receptor-associate...	Human	E. coli
	Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Mediates activation of NF-kappa-B and probably JNK. Seems to be involved in apoptosis. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR.
TMPH-02210	TRAF6 Protein, Human, Recombinant (His & SUMO) RING finger protein 85,E3 ubiquitin-protein ligase TRAF<...	Human	E. coli
	TRAF6 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 75.6 kDa and the accession number is Q9Y4K3.
TMPJ-00674	RANK/TNFRSF11A Protein, Mouse, Recombinant (His) Receptor activator of NF-KB,TNFRSF11A,Osteoclast differentia...	Mouse	HEK293 Cells
	Receptor activator of NF-κB(RANK,TNFRSF11A) belongs to one member of tumor necrosis factor receptor family.It is a receptor for TNFSF11/RANKL/TRANCE/OPGL. This gene encodes a type 1 membrane protein with a 30 amino acids (aa) signal peptide, 184 aa extracellular region , a 20 aa transmembrane domain and a 391 aa cytoplasmic region. Human and murine RANK share 81% aa identity in their extracellular domains. RANK is ubiquitous highly expressed in trabecular bone, thymus, small intestine, lung, br...

重组蛋白

TRAIP Protein, Human, Recombinant (His)

Cat.No: TMPH-01270

Species: Human

Expression System: E. coli

ZRANB1 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-02287

Species: Human

Expression System: E. coli

HVEM Protein, Mouse, Recombinant (hFc)

Cat.No: TMPJ-00168

Species: Mouse

Expression System: HEK293 Cells

TRAF3 Protein, Human, Recombinant

Cat.No: TMPH-02208

Species: Human

Expression System: E. coli

TRAF3 Protein, Human, Recombinant (His)

Cat.No: TMPH-02207

Species: Human

Expression System: E. coli

TRAF5 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-02209

Species: Human

Expression System: E. coli

TRAF6 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-02210

Species: Human

Expression System: E. coli

RANK/TNFRSF11A Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-00674

Species: Mouse

Expression System: HEK293 Cells

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