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Targets Recommended: Necroptosis

抑制剂 & 化合物

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T80286	TP4 (Nile tilapia piscidin)	Necroptosis	Apoptosis
	TP4（Nile tilapia piscidin）是一种piscidin样的抗菌肽，其口服活性被证实。此化合物对多种革兰氏阳性及阴性菌株均有效（MIC: 0.03-10 μg/mL），并展现了溶血性。TP4还能增强免疫响应、提升抗氧化能力和改善肠道健康，助于防御细菌感染。除此之外，TP4显示抗肿瘤效果，并可通过激发癌细胞线粒体功能障碍导致坏死（necrosis）。
T34866	Thymocartin Thymocartinum,TP 4,Thymopoietin II (32-35),RGH 0206
	Thymocartin (RGH 0206) 是天然存在胸腺因子 (胸腺生成素) 的 32-35 片段。Thymocartin 可用于研究免疫缺陷病。
T12268	NTP42	Prostaglandin Receptor; PPAR	DNA Damage/DNA Repair; GPCR/G Protein; Immunology/Inflammation; Metabolism
	NTP42 是血栓素 A2 (TXA2) 受体的拮抗剂，IC50为 3.278 nM，可用于肺动脉高压的相关研究。
T14445	Azido-PEG4-C2-acid	Others; ADC Linker	Antibody-drug Conjugate/ADC Related; Others
	Azido-PEG4-C2-acid, a PEG-based PROTAC linker, is utilized in the synthesis of vRucaparib-TP4. It serves as a non-cleavable 4 unit PEG ADC linker for antibody-drug conjugate (ADC) synthesis.
T18662	(S,R,S)-AHPC-C2-PEG4-N3 VH032-C2-PEG4-N3	Others	Others
	(S,R,S)-AHPC-C2-PEG4-N3 (VH032-C2-PEG4-N3) is a synthesized E3 ligase ligand-linker conjugate combining the (S,R,S)-AHPC-based VHL ligand with a 4-unit polyethylene glycol (PEG) linker, employed in PROteolysis TAgeting Chimera (PROTAC) technology. This compound facilitates the creation of vRucaparib-TP4, a potent PARP1 degrader demonstrating a half-maximal degrading concentration (DC50) of 82 nM[1].

化合物

TP4 (Nile tilapia piscidin)

Cat.No: T80286

Synonym:

Target: Necroptosis

Thymocartin

Cat.No: T34866

Synonym: Thymocartinum,TP 4,Thymopoietin II (32-35),RGH 0206

Target: Prostaglandin Receptor, PPAR

Azido-PEG4-C2-acid

Cat.No: T14445

Synonym:

Target: Others, ADC Linker

(S,R,S)-AHPC-C2-PEG4-N3

Cat.No: T18662

Synonym: VH032-C2-PEG4-N3

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPK-01132	PRL-1/PTP4A1 Protein, Human, Recombinant (His) PTPCAAX1,PRL1,PRL-1,PTP(CAAXI),PTP	Human	E. coli
	Phosphatases of regenerating liver (PRL-1, PRL-2, and PRL-3, also known as PTP4A1, PTP4A2, and PTP4A3) control magnesium homeostasis through an association with the CNNM magnesium transport regulators. PRL-1 (PTP4A1) is a key molecule that activates tyrosine phosphorylation, which is important for cancer progression and metastasis.
TMPK-00742	PRL-3/PTP4A3 Protein, Human, Recombinant (His) PRL-R,PRLR,PRL3,PTP4A3,PRL-3	Human	E. coli
	Phosphatases of regenerating liver (PRL-1, PRL-2, and PRL-3, also known as PTP4A1, PTP4A2, and PTP4A3) control magnesium homeostasis through an association with the CNNM magnesium transport regulators. PTP4A3 (PRL-3) plays an important role in the tumorigenesis and metastasis of multiple tumors.
TMPH-01892	ATP4A Protein, Human, Recombinant (His & Myc) ATP4A,Gastric H(+)/K(+) ATPase su...	Human	E. coli
	ATP4A Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 54.6 kDa and the accession number is P20648.
TMPY-01118	SLC27A4/FATP4 Protein, Human, Recombinant (His) FATP4,IPS,solute carrier family 27 (fatty ...	Human	HEK293 Cells
	SLC27A4/ATG4B complex might act as a new potential therapeutic target of lung tumor chemotherapy. The solute carrier 27A (SLC27A) gene family encodes fatty acid transport proteins (FATPs) and includes 6 members. Autism spectrum disorders (ASD) are now recognized as disorders caused by impaired early brain development, it is possible that functional abnormalities of SLC27A genes may contribute to the pathogenesis of ASD. The expression of SLC27A3 and SLC27A4 in human neural stem cells derived fro...
TMPH-01894	ATP4B Protein, Human, Recombinant Proton pump beta chain,Potassium-transporting ATPas...	Human	E. coli
	ATP4B Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 26.6 kDa and the accession number is P51164.
TMPY-02386	PTP4A2 Protein, Human, Recombinant (GST) HNMT-S2,PRL-2,HNMT-S1,protein tyrosine phosphatase type IVA,...	Human	E. coli
	PRL-2 (Protein-tyrosine phosphatase of regenerating liver 2), also known as PTP4A2 (Protein tyrosine phosphatase type IVA, member 2), is a member of PTP family and has an important function in controlling cell growth. PRL-2 phosphatases may be multifunctional enzymes with diverse roles in a variety of tissue and cell types. The phosphatase of regenerating liver (PRL) family, comprising PRL-1, PRL-2 and PRL-3, is a group of prenylated phosphatases that are candidate cancer biomarkers and therapeu...
TMPH-01893	ATP4B Protein, Human, Recombinant (GST) Proton pump beta chain,Gastric H(+)/K(+) ATPase sub...	Human	E. coli
	ATP4B Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 53.6 kDa and the accession number is P51164.