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Targets Recommended: TOPK TOPK

抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T15481	HI-TOPK-032	TOPK	MAPK
	HI-TOPK-032 是一种特异性 TOPK 有效抑制剂。
T61440	TOPK-p38/JNK-IN-1	Others	Others
	TOPK-p38/JNK-IN-1 (Compound B12) is an orally active inhibitor of the TOPK-p38/JNK signaling pathway, with an IC50 value of 2.14 μM for the inhibition of NO production. It demonstrates anti-inflammatory properties by inhibiting downstream phosphorylation of related proteins and preventing the degradation of TOPK [1].
T4135	OTS964 hydrochloride OTS964	Apoptosis; TOPK; CDK	Apoptosis; Cell Cycle/Checkpoint; MAPK
	OTS964 hydrochloride (OTS964) 是一种口服有效的，高亲和力和选择性的 TOPK 抑制剂，IC50为 28 nM。它也是一种细胞周期蛋白依赖激酶 CDK11抑制剂，结合 CDK11B 的 Kd 值为 40 nM。
T1756L	Ilaprazole IY81149,艾普拉唑,IY 81149,IY-81149	Proton pump; TOPK	MAPK; Membrane transporter/Ion channel
	Ilaprazole (IY-81149) 是一种具有口服活性质子泵抑制剂，以剂量依赖性方式不可逆地抑制H+/K+-ATPase，在兔壁细胞制剂中的IC50为 6 μM。它也是一种有效的T 细胞起源蛋白激酶(TOPK)抑制剂，用于胃溃疡的研究。
T1756	Ilaprazole sodium IY-81149 sodium,艾普拉唑钠	Proton pump; TOPK	MAPK; Membrane transporter/Ion channel
	Ilaprazole sodium (IY-81149 sodium) 是一种具有口服活性质子泵抑制剂，以剂量依赖性方式不可逆地抑制 H+/K+-ATPase，在兔壁细胞制剂中的 IC50为 6 μM。它也是一种有效的 T 细胞起源蛋白激酶(TOPK)抑制剂，用于胃溃疡的研究。
T0199	Cephradine Anspor,Cephradin,Velosef,SQ-11436,Sefril,头孢拉定	TOPK; Antibacterial; Antibiotic	MAPK; Microbiology/Virology
	Cephradine (Anspor) 是广谱口服活性头孢菌素。它对革兰氏阳性和革兰氏阴性病原体都有活性。它已用于泌尿生殖系统、胃肠道和呼吸道感染以及皮肤和软组织感染的研究。它通过直接抑制TOPK 抑制太阳紫外线诱导的皮肤炎症。
T4134	OTS514 hydrochloride OTS-514 hydrochloride,OTS514 hydrochloride(1338540-63-8(free base))	Apoptosis; TOPK	Apoptosis; MAPK
	OTS514 hydrochloride 是一种高效的TOPK 抑制剂，IC50为 2.6 nM。它可强效抑制 TOPK 阳性的肿瘤细胞生长，诱导细胞周期停滞和凋亡。
T4134L	OTS514 OTS514 HCl,OTS514 Hydrochloride,OTS-514,OTS 514	Apoptosis; TOPK	Apoptosis; MAPK
	OTS514 (OTS514 Hydrochloride) 是一种高效的 TOPK 抑制剂，IC50为 2.6 nM。它强效抑制 TOPK 阳性的肿瘤细胞生长，还可诱导细胞周期停滞和凋亡。
T69727	ADA-07	Others	Others
	ADA-07 is a TOPK inhibitor which interacts with TOPK at the ATP-binding pocket and inhibits its kinase activity, thereby suppressing SUV-induced phosphorylation of ERK1/2, p38, and JNKs, and subsequently inhibiting AP-1 activity.
T61800	OTS964	Others	Others
	OTS964 is a potent, orally active compound that operates as a highly selective inhibitor of TOPK with an IC 50 of 28 nM [1]. Additionally, it demonstrates significant inhibitory action against cyclin-dependent kinase CDK11, specifically binding to CDK11B with a K d of 40 nM [2].
T78218	Ilaprazole sodium hydrate IY-81149 sodium hydrate	Proton pump	Membrane transporter/Ion channel
	Ilaprazole (IY-81149) sodium hydrate是一种具有口服活性的质子泵抑制剂，可以量依赖性地不可逆抑制H+/K+-ATPase，并在兔壁细胞制剂中展示出IC50为6μM的效力。该化合物主要用于胃溃疡的研究，并已证实是一种有效的T细胞起源蛋白激酶(TOPK)抑制剂。

化合物

Target: Apoptosis, TOPK, CDK

Ilaprazole

Cat.No: T1756L

Synonym: IY81149,艾普拉唑,IY 81149,IY-81149

Target: Proton pump, TOPK

Ilaprazole sodium

Cat.No: T1756

Synonym: IY-81149 sodium,艾普拉唑钠

Target: Proton pump, TOPK

Cephradine

Cat.No: T0199

Synonym: Anspor,Cephradin,Velosef,SQ-11436,Sefril,头孢拉定

Target: TOPK, Antibacterial, Antibiotic

OTS514 hydrochloride

Cat.No: T4134

Synonym: OTS-514 hydrochloride,OTS514 hydrochloride(1338540-63-8(free base))

Target: Apoptosis, TOPK

OTS514

Cat.No: T4134L

Synonym: OTS514 HCl,OTS514 Hydrochloride,OTS-514,OTS 514

Target: Apoptosis, TOPK

Ilaprazole sodium hydrate

Cat.No: T78218

Synonym: IY-81149 sodium hydrate

Target: Proton pump

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-04547	PBK/TOPK Protein, Human, Recombinant (His) HEL164,Nori-3,CT84,TOPK,PDZ binding kinase,SPK	Human	Baculovirus Insect Cells
	PDZ binding kinase (PBK), also known as TOPK (T-LAK cell-originated protein kinase), is a serine/threonine kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family, and has all the characteristic protein kinase subdomains and a C-terminal PDZ-binding T/SXV motif. PBK is expressed in the testis restrictedly expressed in outer cell layer of seminiferous tubules, as well as placenta. PBK may be enrolled in the activation of lymphoid cells and support testicular fun...

重组蛋白

PBK/TOPK Protein, Human, Recombinant (His)

Cat.No: TMPY-04547

Species: Human

Expression System: Baculovirus Insect Cells

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