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Search Results for " tmprss2 "

Targets Recommended: ACK

18

抑制剂 & 化合物

4

重组蛋白

1

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T5092	AIM-100 AIM100	ACK	Tyrosine Kinase/Adaptors
	AIM-100 是选择性的 Ack1 抑制剂 (IC50:21.58 nM)。它还抑制 Tyr267磷酸化，但不抑制其他激酶，包括 PI3K 和 AKT 亚家族成员。它具有抗癌活性。
T0828	Bromhexine hydrochloride Bromhexine HCl,Auxit,盐酸溴己新,Bisolvon	SARS-CoV; HIV Protease; Autophagy	Autophagy; Microbiology/Virology; Proteases/Proteasome
	Bromhexine hydrochloride (Bisolvon) 是TMPRSS2蛋白酶的一种特异性有效抑制剂，IC50为 0.75 μM。它可预防和控制SARS-CoV-2感染。它是一种粘液溶解剂，用于治疗与粘稠或过多粘液相关的呼吸系统疾病。
T2391	Camostat mesylate FOY-S980,甲磺酸卡莫司他,FOY305,Camostat mesilate	Serine/threonin kinase; SARS-CoV; Sodium Channel	Cell Cycle/Checkpoint; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology
	Camostat mesylate (FOY-S980) 是口服活性合成的丝氨酸蛋白酶抑制剂，用于慢性胰腺炎。它是TMPRSS2的抑制剂，对SARS-CoV-2具有抗病毒活性。它抑制前列腺素、胰蛋白酶和苦参多糖的活性。
T0860L	Mefloquine Ro215998,WR 142490,Ro-215998,氟甲喹羟哌啶,Lariam,Ro 215998	Others	Others
	Mefloquine (Ro 215998) 是一种喹啉抗疟药，是一种抗 SARS-CoV-2 进入抑制剂。 Mefloquine 也是一种 K+ 通道 (KvQT1/minK) 拮抗剂，IC50 为 ~1 μM。它可用于疟疾、系统性红斑狼疮和癌症研究。
T60085	MM3122 GTPL11533,MM-3122,Ac-GQFR-kbt	SARS-CoV	Microbiology/Virology
	MM3122 (MM-3122) 是一种选择性的 II 型跨膜丝氨酸蛋白酶 (TMPRSS2) 抑制剂，IC50为 0.34 nM。MM3122 可以有效阻断 TMPRSS2，从而抑制 SARS-CoV-2 和 MERS-CoV 进入人类细胞。
T74040	Boc-Gln-Ala-Arg-AMC hydrochloride
	Boc-Gln-Ala-Arg-AMC hydrochloride 是一种荧光化合物，可作为胰蛋白酶 (trypsin)的底物，也可用于测定 TMPRSS2 的蛋白水解活性。
T22600	BC 11 hydrobromide	Apoptosis; Serine Protease; ROS	Apoptosis; Immunology/Inflammation; Proteases/Proteasome
	BC 11 hydrobromide是一种选择性 TMPRSS2 和尿激酶 (uPA) 抑制剂。BC-11 诱导线粒体活性减弱，促进活性氧的产生，促进细胞凋亡，可用于研究乳腺癌。
T29110	VPC-13163 2,3-dihydro-2,3'-Bi-1H-indole,VPC13163,NSC52361,NSC 52361,VPC 13163	Others	Others
	VPC-13163 (NSC-52361) 对 LNCaP 和耐恩杂鲁胺的前列腺癌细胞系 (MR49F) 具有很强的抗增殖活性，而它不影响 AR 独立 PC3 细胞系的生长。它还抑制 LNCaP 和 MR49F 中的前列腺特异性抗原 (PSA) 并降低 AR 靶基因 PSA 和 TMPRSS2 的表达。这些发现表明 VPC-13566 表现出 AR BF3 特定的作用机制。
T3712	Mivebresib ABBV-075,米维布塞	Apoptosis; Epigenetic Reader Domain	Apoptosis; Chromatin/Epigenetic
	Mivebresib (ABBV-075) 是一种有效的，口服活性的溴结构域和末端结构域 (BET) 抑制剂，结合BRD4的Ki 值是 1.5 nM。
T81205	SARS-CoV-2-IN-66	SARS-CoV	Microbiology/Virology
	SARS-CoV-2-IN-66 (1)，一种维生素K衍生物，作为SARS-CoV-2抑制剂，其在VeroE6/TMPRSS2细胞模型中的EC50值达到70.8 μM。
T71079	I 432	Others	Others
	I 432 is a TMPRSS2 (transmembrane serine proteinase 2) inhibitor (Ki =0.9 nM).
T78610	Propamidine	Parasite	Microbiology/Virology
	Propamidine为TMPRSS2共价抑制剂，亦展现抗菌活性。
T79920	Debrisoquin Debrisoquine,Ro 5-3307/1,Isocaramidine	SARS-CoV	Microbiology/Virology
	Debrisoquin (Isocaramidine) 是一种抑制剂，针对TMPRSS2，能够在依赖TMPRSS2的机制中抑制SARS-CoV-2进入人肺细胞系，IC50 值为22 μM。该化合物适用于抗病毒研究领域。
T78402	Boc-Gln-Ala-Arg-AMC acetate
	Boc-Gln-Ala-Arg-AMC醋酸盐是trypsin的一种荧光底物，主要用于检测TMPRSS2的蛋白水解活性。
T69035	Camostat free base	Others	Others
	Camostat, also known as FOY 305, is a serine protease inhibitor. Camostat is used in the treatment of some forms of cancer and is also effective against some viral infections, as well as inhibiting fibrosis in liver or kidney disease or pancreatitis. It is an inhibitor of the enzyme transmembrane protease, serine 2 (TMPRSS2). Inhibition of TMPRSS2 partially blocked infection by SARS-CoV and Human coronavirus NL63 in HeLa cell cultures. In vitro study showed that camostat significantly reduces...
T81204	SARS-CoV-2-IN-67	SARS-CoV	Microbiology/Virology
	SARS-CoV-2-IN-67 (Compound 16) 是抗SARS-CoV-2的维生素K衍生物，其在VeroE6/TMPRSS2细胞中EC50值为64.8 μM。该化合物能够抑制SARS-CoV-2 RdRp活性。
T81206	SARS-CoV-2-IN-65	SARS-CoV	Microbiology/Virology
	SARS-CoV-2-IN-65（compound 2f（81））是一种具有口服活性的有效可逆SARS-CoV-2进入抑制剂。它通过抑制Calu-3细胞中RBD:ACE2的相互作用和TMPRSS2的活性，阻断了假病毒通过ACE2依赖性途径的进入。
T81849	MAT-POS-e194df51-1	SARS-CoV	Microbiology/Virology
	MAT-POS-e194df51-1 是一种非共价、非肽类、口服活性的SARS-CoV-2主蛋白酶 (Mpro) 抑制剂，IC50 值达 37nM。该化合物展现细胞毒性，其在 A549-ACE2-TMPRSS2 和 HeLa-ACE2 细胞线上的 EC50 值分别为 64 nM 和 126 nM。

化合物

Cat.No: T5092

Synonym: AIM100

Target: ACK

Bromhexine hydrochloride

Cat.No: T0828

Synonym: Bromhexine HCl,Auxit,盐酸溴己新,Bisolvon

Target: SARS-CoV, HIV Protease, Autophagy

Camostat mesylate

Cat.No: T2391

Synonym: FOY-S980,甲磺酸卡莫司他,FOY305,Camostat mesilate

Target: Serine/threonin kinase, SARS-CoV, Sodium Channel

Cat.No: T0860L

Synonym: Ro215998,WR 142490,Ro-215998,氟甲喹羟哌啶,Lariam,Ro 215998

Target: Others

Cat.No: T60085

Synonym: GTPL11533,MM-3122,Ac-GQFR-kbt

Target: SARS-CoV

Boc-Gln-Ala-Arg-AMC hydrochloride

Cat.No: T74040

BC 11 hydrobromide

Cat.No: T22600

Target: Apoptosis, Serine Protease, ROS

Cat.No: T29110

Synonym: 2,3-dihydro-2,3'-Bi-1H-indole,VPC13163,NSC52361,NSC 52361,VPC 13163

Target: Others

Cat.No: T3712

Synonym: ABBV-075,米维布塞

Target: Apoptosis, Epigenetic Reader Domain

SARS-CoV-2-IN-66

Cat.No: T81205

Target: SARS-CoV

Cat.No: T71079

Target: Others

Cat.No: T78610

Target: Parasite

Cat.No: T79920

Synonym: Debrisoquine,Ro 5-3307/1,Isocaramidine

Target: SARS-CoV

Boc-Gln-Ala-Arg-AMC acetate

Cat.No: T78402

Camostat free base

Cat.No: T69035

Target: Others

SARS-CoV-2-IN-67

Cat.No: T81204

Target: SARS-CoV

SARS-CoV-2-IN-65

Cat.No: T81206

Target: SARS-CoV

MAT-POS-e194df51-1

Cat.No: T81849

Target: SARS-CoV

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-02237	TMPRSS2 Protein, Human, Recombinant (His & Myc) Serine protease 10,Transmembrane protease serine 2,...	Human	HEK293 Cells
	Plasma membrane-anchored serine protease that participates in proteolytic cascades of relevance for the normal physiologic function of the prostate. Androgen-induced TMPRSS2 activates several substrates that include pro-hepatocyte growth factor/HGF, the protease activated receptor-2/F2RL1 or matriptase/ST14 leading to extracellular matrix disruption and metastasis of prostate cancer cells. In addition, activates trigeminal neurons and contribute to both spontaneous pain and mechanical allodynia....
TMPH-02235	TMPRSS2 Protein, Human, Recombinant (Cell-Free, His) Transmembrane protease serine 2,Serine protease 10,...	Human	E. coli
	TMPRSS2 Protein, Human, Recombinant (Cell-Free, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 46.9 kDa and the accession number is O15393.
TMPH-02236	TMPRSS2 Protein, Human, Recombinant (E. coli, His) Transmembrane protease serine 2,TMPRSS...	Human	E. coli
	Plasma membrane-anchored serine protease that participates in proteolytic cascades of relevance for the normal physiologic function of the prostate. Androgen-induced TMPRSS2 activates several substrates that include pro-hepatocyte growth factor/HGF, the protease activated receptor-2/F2RL1 or matriptase/ST14 leading to extracellular matrix disruption and metastasis of prostate cancer cells. In addition, activates trigeminal neurons and contribute to both spontaneous pain and mechanical allodynia....
TMPH-02238	TMPRSS2 Protein, Human, Recombinant (Avi & His & MBP), Biotinylated TMPRSS2,Transmembrane protease serine ...	Human	E. coli
	TMPRSS2 Protein, Human, Recombinant (Avi & His & MBP), Biotinylated is expressed in E. coli expression system with N-MBP and C-6xHis-Avi tag. The predicted molecular weight is 90.6 kDa and the accession number is O15393.

重组蛋白

TMPRSS2 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-02237

Species: Human

Expression System: HEK293 Cells

TMPRSS2 Protein, Human, Recombinant (Cell-Free, His)

Cat.No: TMPH-02235

Species: Human

Expression System: E. coli

TMPRSS2 Protein, Human, Recombinant (E. coli, His)

Cat.No: TMPH-02236

Species: Human

Expression System: E. coli

TMPRSS2 Protein, Human, Recombinant (Avi & His & MBP), Biotinylated

Cat.No: TMPH-02238

Species: Human

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
TMIJ-0339	Bromhexine-d3 HCl
	Bromhexine-d3 HCl 是 Bromhexine HCl 的氘代化合物。Bromhexine HCl 的 CAS 号为 611-75-6。Bromhexine hydrochloride 是TMPRSS2蛋白酶的一种特异性有效抑制剂，IC50为 0.75 μM。它可预防和控制SARS-CoV-2感染。它是一种粘液溶解剂，用于治疗与粘稠或过多粘液相关的呼吸系统疾病。

同位素标记化合物

Bromhexine-d3 HCl

Cat.No: TMIJ-0339

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