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Search Results for " tmp "

Targets Recommended: ROR

32

抑制剂 & 化合物

6

天然产物

13

重组蛋白

1

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T13172L1	TMP-778	ROR	Metabolism
	TMP-778是一种RORγt 的选择性逆向激动剂。
T36126	TMP-153	Acyltransferase	Metabolism
	TMP-153 是一种新型高效的 ACAT 抑制剂，对动物肠道和肝脏 ACAT 的 IC50 值为 5-10 nM。TMP-153 具有降胆固醇作用，可抑制大鼠和仓鼠的胆固醇吸收并降低血浆胆固醇。
T13174	TMPyP4 tosylate TMP 1363	DNA/RNA Synthesis; Telomerase	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	TMPyP4 tosylate (TMP 1363) 是四链体 (G-quadruplex) 的特异性配体，抑制四链体和 IGF-1 之间的相互作用。它也是端粒酶抑制剂，在骨肉瘤细胞系中显示抗肿瘤作用。
T3983	TMP195 TFMO 2,TMP 195	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	TMP195 (TFMO 2) 是一种选择性 IIa 类组蛋白脱乙酰酶 (HDAC) 抑制剂。对 HDAC4、HDAC5、HDAC7，HDAC9的 Ki 值分别为59、60、26，5 nM。
T1857	TMP269	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	TMP269 是一种有效的特异性 IIa 类 HDAC 抑制剂，分别抑制 HDAC 4/HDAC 5/HDAC 7/HDAC 9，IC50值分别为 157 nM，97 nM，43 nM 和 23 nM。
T31017	Coumarin-TMP-Halo Coumarin TMP Halo,CTH	Others	Others
	Coumarin-TMP-Halo is a specific fluorescent protein labeling agent.
T34893	TMP-NVOC-Halo TNH	Others	Others
	TMP-NVOC-Halo is a caged protein labeling agent.
T80972	TNH TMP-NVOC linker-Halo	Others	Others
	TNH为一种二聚体，能够渗透活细胞并招募蛋白质至细胞结构。
T78534	NVOC cage-TMP-Halo	Others	Others
	NVOC cage-TMP-Halo是一种具有细胞渗透能力和光激活特性的蛋白质二聚化诱导剂。该化合物可对活细胞内蛋白质定位进行快速且可逆的控制，适用于研究动态细胞过程。
T24899	Trimosulfa Trimethoprim-sulfamethoxazole,Sulfamethoxazole-trimethoprim,TMP-SMX,Trimforte,Trimethoprimsulfa	Others	Others
	Trimosulfa is a fixed antibiotic combination that widely used for mild-to-moderate bacterial infections and as prophylaxis against opportunistic infections.
T13172L	TMP778	Others	Others
	TMP778 is an effective and selective RORγt inverse agonist (IC50: 7 nM in FRET assay).
T17108	TMP920	ROR	Metabolism
	TMP920 inhibits RORγt binding to the SRC1 peptide (IC50: 0.03 μM). TMP920 is a highly potent and selective RORγt antagonist.
T13172	TMP780	ROR	Metabolism
	TMP780 is an inverse RORγt agonist (IC50: 13 nM). RORγt is a tractable drug target for the treatment of cutaneous inflammatory disorders.
T83821	Thymidine-5'-O-(α,β-methylene)diphosphate sodium α,β-Methylenethymidine diphosphate,Thymidine-5'-O-methylenediphosphate,TMP-CP,α,β-MTDP	Others	Others
	TMP-CP（Thymidine-5’-O-(α,β-methylene)diphosphate）是TDP的一种水解稳定衍生物，同时也是一种thymidine kinase抑制剂（Ki = 23 µM）。它已被用作α,β-methylene-2’-deoxythymidine 5’-triphosphate合成的前体，该合成物是DNA polymerase的一种不可切割底物。
T40732	TMPD dihydrochloride	Others	Others
	TMPD dihydrochloride 是酶促转化氧化还原的活性底物和用于还原血红素过氧化物酶的电子供体。
T13173	TMPA	Others; AMPK	Chromatin/Epigenetic; Others; PI3K/Akt/mTOR signaling
	TMPA 是一种核受体 Nur77 和 LKB1 相互作用的拮抗剂。
T60080	TMPH 2,2,6,6-Tetramethylpiperidin-4-yl heptanoate	AChR	Neuroscience
	TMPH 是一种 nAChR 抑制剂，可抑制缺乏 α5、α6 或 β3 亚基的 nAChR。 TMPH 可用于关于 nAChR 功能障碍或神经系统疾病的研究。
T64440	Fmoc-Cys(STmp)-OH	Others	Others
	Fmoc-Cys(STmp)-OH是一种半胱氨酸衍生物，可用与合成双环肽和线性肽。
T61780	MtTMPK-IN-4	Others	Others
	MtTMPK-IN-4 (compound 2), a para-piperidine, is a highly potent inhibitor of thymidylate kinase (MtTMPK) in Mycobacterium tuberculosis, exhibiting an IC50 value of 6.1 μM. Additionally, it possesses remarkable inhibitory activity against tyrosinase. Furthermore, MtTMPK-IN-4 exhibits potent antibacterial properties [1] [2].
T78238	4′-DTMP 4-Demethyltrimethoprim	DHFR; Antifungal	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology
	4′-DTMP (4-Demethyltrimethoprim) 是一种有效的 DHFR 抑制剂，具有抗菌活性，诱导与酶的额外局部相互作用，对大肠杆菌具有抑制作用。
T63657	MtTMPK-IN-9	Others	Others
	MtTMPK-IN-9 是中等效力的分支杆菌胸苷酸激酶 (MtbTMPK)抑制剂 (IC50: 48 μM)。MtTMPK-IN-9 对抗分枝杆菌具有亚微摩尔活性，但没有显著的细胞毒性。MtTMPK-IN-9 能够用于研究结核病。
T63491	MtTMPK-IN-8	Others	Others
	MtTMPK-IN-8 是具有中等效力的分支杆菌胸苷酸激酶 (MtbTMPK)抑制剂，没有显著的细胞毒性，对抗分枝杆菌表现出亚微摩尔活性 (MICs = 0.78~9.4 μM)，能够用于研究结核病。
T27314	Fe-TMPyP	Others	Others
	Fe-TMPyP binds to the prion protein PrP and inhibits misfolding. Fe-TMPyP is also a peroxynitrite decomposition catalyst.
T61781	MtTMPK-IN-6	Others	Others
	MtTMPK-IN-6 (compound 1) is a highly effective inhibitor (IC 50 = 29 μM) of M. tuberculosis thymidylate kinase (Mtb TMPK). It is a valuable compound for tuberculosis research [1].
T62305	MtTMPK-IN-2	Others	Others
	MtTMPK-IN-2 (compound 15)为一高效MtbTMPK抑制剂，IC50值达1.1 μM。该化合物对MtbH37Rv表现出抑制活性（MIC = 12.5 μM），同时对人成纤维细胞MRC-5显示出一定细胞毒性（EC50= 6.1 μM）。MtTMPK-IN-2适用于结核病研究。
T23462	TMPH hydrochloride	Others	Others
	neuronal nicotinic ACh receptors (nAChRs) antagonist
T61573	MtTMPK-IN-5	Others	Others
	MtTMPK-IN-5 (compound 17) is a highly effective inhibitor of M. tuberculosis thymidylate kinase (Mtb TMPK), demonstrating remarkable enzyme inhibitory activity with an IC50 value of 34 μM. Additionally, MtTMPK-IN-5 exhibits notable activity against M. tuberculosis, as evidenced by a minimum inhibitory concentration (MIC) of 12.5 μM. Given its potent properties, MtTMPK-IN-5 serves as a valuable tool for tuberculosis research [1].
T28986	TMPPAA	Others	Others
	TMPPAA is an allosteric agonist of 5-HT3 receptor.
T61796	MtTMPK-IN-1	Others	Others
	MtTMPK-IN-1 (compound 3) is a highly effective inhibitor of Mycobacterium tuberculosis thymidylate kinase (Mt TMPK), exhibiting an IC50 value of 2.5 μM. It displays moderate to weak activity against Mtb H37Rv while demonstrating low cytotoxicity in human fibroblast cells MRC-5. MtTMPK-IN-1 is a valuable tool for tuberculosis research [1].
T62897	MtTMPK-IN-3	Others	Others
	MtTMPK-IN-3（compound 25）是一种针对结核分枝杆菌胸苷酸激酶（MtbTMPK）的有效抑制剂，具有0.12 μM的IC50值。该化合物对MtbH37Rv展示出了抑制效果（MIC=12.5 μM），同时对人成纤维细胞MRC-5显示出一定的细胞毒性（EC50=12.5 μM）。MtTMPK-IN-3适用于结核病研究领域。
T35966	Mn(III)TMPyP	Others	Others
	Mn(III)TMPyP is a manganese-porphyrin which acts as a superoxide dismutase (SOD) mimetic and peroxynitrite decomposition catalyst. SOD mimetics described to date are unstable and are capable of catalyzing undesired side-reactions in addition to the dismutation of the superoxide radical (O2-). Mn(III)TMPyP is an SOD mimetic with increased stability to pH and hydrogen peroxide. The rate constant for superoxide dismutation and peroxynitrite decomposition are 3.9 x 107 M-1s-1 and ~2 x 106 M-1s-1, re...
T63639	MtTMPK-IN-7	Others	Others
	MtTMPK-IN-7 是中等效力的分支杆菌胸苷酸激酶 (MtbTMPK) 抑制剂 (IC50: 47 μM)。MtTMPK-IN-7 对抗分枝杆菌表现出亚微摩尔活性，其 MICs 值为 2.3~4.7 μM。MtTMPK-IN-7 能够用于研究结核病。

化合物

Cat.No: T13172L1

Target: ROR

Cat.No: T36126

Target: Acyltransferase

TMPyP4 tosylate

Cat.No: T13174

Synonym: TMP 1363

Target: DNA/RNA Synthesis, Telomerase

Cat.No: T3983

Synonym: TFMO 2,TMP 195

Target: HDAC

Cat.No: T1857

Target: HDAC

Coumarin-TMP-Halo

Cat.No: T31017

Synonym: Coumarin TMP Halo,CTH

Target: Others

TMP-NVOC-Halo

Cat.No: T34893

Synonym: TNH

Target: Others

Cat.No: T80972

Synonym: TMP-NVOC linker-Halo

Target: Others

NVOC cage-TMP-Halo

Cat.No: T78534

Target: Others

Cat.No: T24899

Synonym: Trimethoprim-sulfamethoxazole,Sulfamethoxazole-trimethoprim,TMP-SMX,Trimforte,Trimethoprimsulfa

Target: Others

Cat.No: T13172L

Target: Others

Cat.No: T17108

Target: ROR

Cat.No: T13172

Target: ROR

Thymidine-5'-O-(α,β-methylene)diphosphate sodium

Cat.No: T83821

Synonym: α,β-Methylenethymidine diphosphate,Thymidine-5'-O-methylenediphosphate,TMP-CP,α,β-MTDP

Target: Others

TMPD dihydrochloride

Cat.No: T40732

Target: Others

Cat.No: T13173

Target: Others, AMPK

Cat.No: T60080

Synonym: 2,2,6,6-Tetramethylpiperidin-4-yl heptanoate

Target: AChR

Fmoc-Cys(STmp)-OH

Cat.No: T64440

Target: Others

Cat.No: T61780

Target: Others

Cat.No: T78238

Synonym: 4-Demethyltrimethoprim

Target: DHFR, Antifungal

Cat.No: T63657

Target: Others

Cat.No: T63491

Target: Others

Cat.No: T27314

Target: Others

Cat.No: T61781

Target: Others

Cat.No: T62305

Target: Others

TMPH hydrochloride

Cat.No: T23462

Target: Others

Cat.No: T61573

Target: Others

Cat.No: T28986

Target: Others

Cat.No: T61796

Target: Others

Cat.No: T62897

Target: Others

Cat.No: T35966

Target: Others

Cat.No: T63639

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T4730	Thymidine-5'-monophosphate disodium salt 胸苷酸二钠,Thymidine 5'-monophosphate disodium salt,TMP DISODIUM SALT	Others; Endogenous Metabolite	Metabolism; Others
	Thymidine-5'-monophosphate disodium salt (TMP DISODIUM SALT) 是内源性代谢产物的一种。
T4558	Trioxsalen 三甲沙林,Trimethylpsoralen,Trioxysalen,Trisoralen	DNA Alkylator/Crosslinker; DHFR	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism
	Trioxsalen (Trioxysalen) 是一种呋喃香豆素和补骨脂素衍生物，与 UV-A 一起用于光疗治疗白癜风和手部湿疹。它是一种光化学 DNA 交联剂，可用于激光激活定位的基因组链间交联可视化。
T7892	ATMP	Others	Others
	ATMP 是一种具有螯合特性的膦酸。它是一种阻垢剂。
T0572	Methyl 3,4,5-trimethoxybenzoate Methyl gallate trimethyl ether,Methyl EudesMate,3,4,5-Trimethoxybenzoic acid methyl ester,Methyl tri-O-methylgallate,甲氧苄啶杂质H,Trimethylgallic acid methyl ester	Others; Antioxidant	Others; oxidation-reduction
	Methyl EudesMate 是由 Gallic acid 为原料合成得到，具有抗氧化活性，常用于生产磺胺增效剂中间体、甲氧苄氨嘧啶 (TMP)以及许多其它药物。
T83320	4'-Demethylpodophyllotoxone
	4'-Demethylpodophyllotoxone为链格孢（Alternaria alternata）S-f6的生物转化中间产物，经4-(2,3,5,6-tetramethylpyrazine-1) (4-TMP)修饰后形成的新化合物，可有效抑制人胃癌细胞系（BGC-823）的生长。
T75540	Ipomoeassin F	Others	Others
	Ipomoeassin F 是一种高效且具有选择性的内质网(ER)蛋白转位抑制剂，它通过作用于ER膜上的Sec61复合物（Sec61α）的成孔亚基来实现其功能。此化合物能特异性抑制SARS-CoV-2蛋白在ER膜上的转位，同时阻碍分泌蛋白和I型跨膜蛋白（TMP）的ER转运，但对III型TMP的转运不产生影响。

天然产物

Thymidine-5'-monophosphate disodium salt

Cat.No: T4730

Synonym: 胸苷酸二钠,Thymidine 5'-monophosphate disodium salt,TMP DISODIUM SALT

Target: Others, Endogenous Metabolite

Cat.No: T4558

Synonym: 三甲沙林,Trimethylpsoralen,Trioxysalen,Trisoralen

Target: DNA Alkylator/Crosslinker, DHFR

Cat.No: T7892

Target: Others

Methyl 3,4,5-trimethoxybenzoate

Cat.No: T0572

Synonym: Methyl gallate trimethyl ether,Methyl EudesMate,3,4,5-Trimethoxybenzoic acid methyl ester,Methyl tri-O-methylgallate,甲氧苄啶杂质H,Trimethylgallic acid methyl ester

Target: Others, Antioxidant

4'-Demethylpodophyllotoxone

Cat.No: T83320

Cat.No: T75540

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-00499	TMP21 Protein, Human, Recombinant (mFc) Tmp-21-I,p23,S31III125,TMP21,P24(DELTA),tr...	Human	HEK293 Cells
	TMED10 disrupts the complex formation between TGF-beta type I (also termed ALK5) and type II receptors (TbetaRII). Misexpression studies revealed that TMED10 attenuated TGF-beta-mediated signaling. A 20-amino acid-long region from Thr(91) to Glu(110) within the extracellular region of TMED10 was found to be crucial for TMED10 interaction with both ALK5 and TbetaRII. Synthetic peptides corresponding to this region inhibit both TGF-beta-induced Smad2 phosphorylation and Smad-dependent transcriptio...
TMPH-03643	TmpB Protein, Treponema phagedenis, Recombinant (His & Myc) Treponemal membrane protein B,tmpB,Antigen Tmp<...	Treponema phagedenis	E. coli
	Tmp may serve as a porin or transport protein for large molecules. TmpB Protein, Treponema phagedenis, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 47.4 kDa and the accession number is P29720.
TMPH-02945	TMPRSS4 Protein, Mouse, Recombinant (His & SUMO) Channel-activating protease 4,Transmembrane protease serine ...	Mouse	E. coli
	Plasma membrane-anchored serine protease that directly induces processing of pro-uPA/PLAU into the active form through proteolytic activity. Seems to be capable of activating ENaC. TMPRSS4 Protein, Mouse, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 57.8 kDa and the accession number is Q8VCA5.
TMPH-02238	TMPRSS2 Protein, Human, Recombinant (Avi & His & MBP), Biotinylated TMPRSS2,Transmembrane protease serine 2,Serine prot...	Human	E. coli
	TMPRSS2 Protein, Human, Recombinant (Avi & His & MBP), Biotinylated is expressed in E. coli expression system with N-MBP and C-6xHis-Avi tag. The predicted molecular weight is 90.6 kDa and the accession number is O15393.
TMPH-02234	TMPRSS11A Protein, Human, Recombinant (His) Epidermal type-II transmembrane serine protease,Transmembran...	Human	E. coli
	Probable serine protease which may play a role in cellular senescence. Overexpression inhibits cell growth and induce G1 cell cycle arrest.
TMPH-02239	TMPRSS4 Protein, Human, Recombinant (His & Myc) Channel-activating protease 2,TMPRSS4,Transmembrane...	Human	E. coli
	Plasma membrane-anchored serine protease that directly induces processing of pro-uPA/PLAU into the active form through proteolytic activity. Seems to be capable of activating ENaC.; (Microbial infection) In gut epithelial cells, facilitates human coronavirus SARS-CoV-2 infection through, at least, the cleavage of coronavirus spike glycoproteins which activates the glycoprotein for host cell entry. TMPRSS4 Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10...
TMPH-02235	TMPRSS2 Protein, Human, Recombinant (Cell-Free, His) Transmembrane protease serine 2,Serine protease 10,TMP	Human	E. coli
	TMPRSS2 Protein, Human, Recombinant (Cell-Free, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 46.9 kDa and the accession number is O15393.
TMPJ-00960	TMPO Protein, Human, Recombinant (His) Thymopoietin-Related Peptide Isoforms β/γ,Splenin,TMP	Human	E. coli
	Thymopentin is a member of the LEM family. Thymopentin is expressed in many tissues, highly in the adult thymus and fetal liver. The N-terminal contains two structurally independent domains, LEM domain and LEM-like domain. The C-terminal domain forms a four-stranded coiled coil. Thymopentin may be involved in the structural organization of the nucleus and in the post-mitotic nuclear assembly. It is associated with T-cell development and function. Meantime, Thymopentin plays an important role, to...
TMPH-02236	TMPRSS2 Protein, Human, Recombinant (E. coli, His) Transmembrane protease serine 2,TMPRSS2,Serine prot...	Human	E. coli
	Plasma membrane-anchored serine protease that participates in proteolytic cascades of relevance for the normal physiologic function of the prostate. Androgen-induced TMPRSS2 activates several substrates that include pro-hepatocyte growth factor/HGF, the protease activated receptor-2/F2RL1 or matriptase/ST14 leading to extracellular matrix disruption and metastasis of prostate cancer cells. In addition, activates trigeminal neurons and contribute to both spontaneous pain and mechanical allodynia....
TMPH-02237	TMPRSS2 Protein, Human, Recombinant (His & Myc) Serine protease 10,Transmembrane protease serine 2,TMP	Human	HEK293 Cells
	Plasma membrane-anchored serine protease that participates in proteolytic cascades of relevance for the normal physiologic function of the prostate. Androgen-induced TMPRSS2 activates several substrates that include pro-hepatocyte growth factor/HGF, the protease activated receptor-2/F2RL1 or matriptase/ST14 leading to extracellular matrix disruption and metastasis of prostate cancer cells. In addition, activates trigeminal neurons and contribute to both spontaneous pain and mechanical allodynia....
TMPY-04928	TMPRSS11B Protein, Human, Recombinant (His) transmembrane protease, serine 11B	Human	HEK293 Cells
	TMPRSS11B Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 44.3 kDa and the accession number is CAD91168.1.
TMPY-04985	TMPRSS11D Protein, Human, Recombinant (His) transmembrane protease, serine 11D,HAT	Human	HEK293 Cells
	TMPRSS11D (HAT) belongs to the large type II transmembrane serine protease (TTSP) family, participating in various biological and physiological processes. TMPRSS11D protein expression in tumorous tissues were correlated with NSCLC patients' clinical characteristics and overall survival. Both TMPRSS11D mRNA and protein expression levels were significantly higher in NSCLC tumorous tissues than in adjacent normal tissues. High TMPRSS11D protein expression was associated with high TNM stages, and hi...
TMPY-01041	Compound TMPY-01041

重组蛋白

TMP21 Protein, Human, Recombinant (mFc)

Cat.No: TMPY-00499

Species: Human

Expression System: HEK293 Cells

TmpB Protein, Treponema phagedenis, Recombinant (His & Myc)

Cat.No: TMPH-03643

Species: Treponema phagedenis

Expression System: E. coli

TMPRSS4 Protein, Mouse, Recombinant (His & SUMO)

Cat.No: TMPH-02945

Species: Mouse

Expression System: E. coli

TMPRSS2 Protein, Human, Recombinant (Avi & His & MBP), Biotinylated

Cat.No: TMPH-02238

Species: Human

Expression System: E. coli

TMPRSS11A Protein, Human, Recombinant (His)

Cat.No: TMPH-02234

Species: Human

Expression System: E. coli

TMPRSS4 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-02239

Species: Human

Expression System: E. coli

TMPRSS2 Protein, Human, Recombinant (Cell-Free, His)

Cat.No: TMPH-02235

Species: Human

Expression System: E. coli

TMPO Protein, Human, Recombinant (His)

Cat.No: TMPJ-00960

Species: Human

Expression System: E. coli

TMPRSS2 Protein, Human, Recombinant (E. coli, His)

Cat.No: TMPH-02236

Species: Human

Expression System: E. coli

TMPRSS2 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-02237

Species: Human

Expression System: HEK293 Cells

TMPRSS11B Protein, Human, Recombinant (His)

Cat.No: TMPY-04928

Species: Human

Expression System: HEK293 Cells

TMPRSS11D Protein, Human, Recombinant (His)

Cat.No: TMPY-04985

Species: Human

Expression System: HEK293 Cells

Compound TMPY-01041

Cat.No: TMPY-01041

Expression System:

Cat. No.	Product Name	Target	Signaling Pathways
TMIJ-0194	Tetramethylpyrazine-d12
	Tetramethylpyrazine-d12 是 Tetramethylpyrazine 的氘代化合物。Tetramethylpyrazine 的 CAS 号为 1124-11-4。Tetramethylpyrazine 是从Ligusticum wallichii中提取的一种烷基吡嗪，常在薯条、面包、茶、乳制品、豆制品等食物中作为香精。它对大鼠具有潜在的抗神经和抗炎活性。

同位素标记化合物

Tetramethylpyrazine-d12

Cat.No: TMIJ-0194

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