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Targets Recommended: Others

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Cat. No. Product Name Target Signaling Pathways
T36554 TMB 8 (hydrochloride)

Others Others
TMB 8 is a non-competitive antagonist of nicotinic acetylcholine receptors (nAChRs) with IC50 values of 390 and 350 nM, respectively, for human muscle-type and α3β4 subunit-containing ganglionic nAChRs expressed in TE671/RD or SH-SY5Y cells. It inhibits nicotine-induced dopamine release from rat brain synaptosomes (IC50 = 480 nM). TMB 8 also reduces calcium availability in smooth and skeletal muscle, blocking the contractile response in isolated rabbit aortic strip when used at a concentration o...

化合物

TMB 8 (hydrochloride)
Cat.No: T36554
Synonym:
Target: Others
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