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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T8485 |
THIQ
|
Melanocortin Receptor | GPCR/G Protein; Neuroscience |
THIQ 是一种选择性黑皮质素 4 受体 (MC4R) 激动剂,对 hMC4R 和 rMC4R 的 IC50 分别为 1.2 和 0.6 nM。 | |||
T34858 |
THIQ-20c
THIQ 20c |
Others | Others |
THIQ-20c is a steroidomimetic and chimeric microtubule disruptor. | |||
T70179 |
THIQ-40
|
Others | Others |
THIQ-40 is a novel potent erα antagonist and selective estrogen receptor degrader (serd), exhibiting good oral bioavailability, antitumor efficacy, and serd activity in vivo | |||
T70178 |
Sonidegib metabolite M25
|
Others | Others |
Sonidegib metabolite M25 is a smoothened (SMO) antagonist. |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-01640 |
MRGPRX2 Protein, Human, Recombinant (His)
Mas-related G-protein coupled receptor member X2,MRGPRX2 |
Human | E. coli |
Mast cell-specific receptor for basic secretagogues, i.e. cationic amphiphilic drugs, as well as endo- or exogenous peptides, consisting of a basic head group and a hydrophobic core. Recognizes and binds small molecules containing a cyclized tetrahydroisoquinoline (THIQ), such as non-steroidal neuromuscular blocking drugs (NMBDs), including tubocurarine and atracurium. In response to these compounds, mediates pseudo-allergic reactions characterized by histamine release, inflammation and airway c... |