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Search Results for " tead4?yap1 "
Targets Recommended: YAP

1

抑制剂 & 化合物

1

重组蛋白

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Cat. No. Product Name Target Signaling Pathways
T8421 TED-347

YAP Stem Cells
TED-347 是不可逆的、共价的 YAP-TEAD 蛋白质-蛋白质相互作用变构抑制剂,对 TEAD4Yap1 蛋白质-蛋白质相互作用的 EC50为 5.9 μM。它与 TEAD4 中央口袋内的 Cys-367 特异性共价结合(Ki:10.3 μM)。它可以抑制 TEAD 的转录活性,并且具有抗肿瘤作用。

化合物

TED-347
Cat.No: T8421
Synonym:
Target: YAP
Cat. No. Product Name Species Expression System
TMPH-03764 YAP1 Protein, Human, Recombinant (His)

YAP1-2gamma,YAP2L,YAP65

Human P. pastoris (Yeast)
Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1,...

重组蛋白

YAP1 Protein, Human, Recombinant (His)
Cat.No: TMPH-03764
Species: Human
Expression System: P. pastoris (Yeast)
TargetMol Loading
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