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Search Results for " tead "

Targets Recommended: YAP

31

抑制剂 & 化合物

1

天然产物

8

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
TP2160L1	YAP-TEAD-IN-1 acetate YAP-TEAD-IN-1 acetate (1659305-78-8 Free base)	YAP	Stem Cells
	YAP-TEAD-IN-1 acetate 是一种有效的、竞争性的 YAP-TEAD 相互作用抑制剂，IC50 为 25 nM。
T77725	YAP-TEAD-IN-3 IAG933	YAP	Stem Cells
	YAP-TEAD-IN-3 是 YAP/TAZ-TEAD 相互作用的抑制剂，对于 Avi-人 TEAD4217-434 的 IC50 为 9 nM。 YAP-TEAD-IN-3 抑制 YAP 报告基因表达 (IC50 = 0.048 μM) 和 NCI-H2052 细胞增殖 (IC50 = 0.048 μM)。
TP2160	YAP-TEAD-IN-1	Others	Others
	YAP-TEAD-IN-1 is a competitive inhibitor of YAP–TEAD interaction (IC50: 25 nM). It shows a higher binding affinity to TEAD1 (Kd: 15 nM) than YAP (50-171) (Kd: 40 nM).
TP2160L	YAP-TEAD-IN-1 TFA	Others	Others
	YAP-TEAD-IN-1 TFA is a competitive inhibitor of YAP–TEAD interaction (IC50: 25 nM). It shows a higher binding affinity to TEAD1 (Kd: 15 nM) than YAP (50-171) (Kd: 40 nM).
T83951	TM2 TEAD inhibitor	Others	Others
	TM2 TEAD抑制剂是一种有效并且可逆的TEA领域转录因子抑制剂(IC50为TEAD4自动棕榈酰化和TEAD2棕榈酰化分别为38 nM和156 nM)。它抑制TEAD-YAP的结合和转录活性。TM2 TEAD抑制剂在YAP依赖型癌症细胞中，无论是单独使用还是与MEK抑制剂联合使用，都显示出强大的抗增殖效果。同时抑制体外YAP依赖的肝脏类器官生长。
T61776	TEAD-IN-2	Others	Others
	TEAD-IN-2 is an innovative, orally bioavailable inhibitor that targets the transcriptional enhancer associate domain (TEAD). It functions by regulating TEAD through ubiquitination and/or degradation by specific compounds. This compound, TEAD-IN-2, holds potential for studying various diseases, disorders, or conditions linked to TEAD [1].
T79687	TEAD-IN-6	YAP	Stem Cells
	TEAD-IN-6（Example 11-1），一种TEAD调节剂，具有阻断YAP1/TAZ与TEAD相互作用的活性，适用于癌症研究领域。
T62597	TEAD-IN-3	Others	Others
	TEAD-IN-3 (compound I-177) 是一种 TEAD 转录因子的有效抑制剂。TEAD-IN-3 能够用于增生性疾病的研究，如癌症。
T72888	YAP-TEAD-IN-2	YAP	Stem Cells
	YAP-TEAD-IN-2 (化合物6)作为一种YAP-TEAD PPI抑制剂，表现出高效性，其半抑制浓度(IC50)仅为2.7 nM。
T8421	TED-347	YAP	Stem Cells
	TED-347 是不可逆的、共价的 YAP-TEAD 蛋白质-蛋白质相互作用变构抑制剂，对 TEAD4•Yap1 蛋白质-蛋白质相互作用的 EC50为 5.9 μM。它与 TEAD4 中央口袋内的 Cys-367 特异性共价结合(Ki:10.3 μM)。它可以抑制 TEAD 的转录活性，并且具有抗肿瘤作用。
T9032	MGH-CP1	Others	Others
	MGH-CP1 是 TEAD2 (IC50:710 nM) 及 TEAD4 (IC50:672 nM) 自棕榈酰化抑制剂，口服有活性，可降低细胞内源性或异位表达的 TEAD 蛋白棕榈酰化水平。MGH-CP1 与 Lats1/2 缺失，是 Myc 的表达受到抑制，阻碍上皮细胞过度增殖，诱导细胞凋亡。
T9954	K-975	Others	Others
	K-975是一种高选择性的具有口服活性的TEAD 抑制剂，可有效抑制TEAD 和YAP1/TAZ 之间的蛋白质-蛋白质相互作用。
T22372	MYF-01-37 1-[3-Methyl-3-[3-(trifluoromethyl)anilino]pyrrolidin-1-yl]prop-2-en-1-one	Others; YAP	Others; Stem Cells
	MYF-01-37 (1-[3-Methyl-3-[3-(trifluoromethyl)anilino]pyrrolidin-1-yl]prop-2-en-1-one) 是共价TEAD 抑制剂，靶向 Cys380，能够可逆地抑制 YAP/TEAD 相互作用。
T64342	DC-TEADin02	YAP	Stem Cells
	DC-TEADin02 是 TEAD 自棕榈酰化抑制剂 (IC50 = 197 nM)。 DC-TEADin02 可用于有关发育、再生和组织稳态的研究。
T77580	IK-930 compound I-32	YAP	Stem Cells
	IK-930 是一种具有口服活性 TEAD 抑制剂（EC50 < 0.1 µM）具有强效性。
T35545	VT107	YAP	Stem Cells
	VT107 是一种强效的泛 TEAD 自身棕榈酰化抑制剂。VT-107 可用于癌症研究。
T62077	VT103 VT-103,VT 103	YAP	Stem Cells
	VT103 是一种具有口服活性和选择性的 TEAD1 蛋白棕榈酰化抑制剂，是 VT101 的类似物。 VT103 有潜在的抗肿瘤活性，可抑制 YAP/TAZ-TEAD 促进的基因转录，阻断 TEAD auto-palmitoylation，阻断 YAP/TAZ和TEAD 之间的相互作用。VT103 可用于研究HER2阳性乳腺癌、前列腺癌和三阴性乳腺癌。
T69760	TT-10 TAZ-K	YAP	Stem Cells
	TT-10 (TAZ-K) 作为YES相关蛋白(YAP)-转录增强因子结构域(TEAD)活性的激活剂，适用于心肌细胞丢失伴随心脏病研究。
T69638	VT-105 VT 105	Others	Others
	VT-105 是一种强效的选择性 TEAD 自棕榈酰化抑制剂，可抑制 NF2 缺陷间皮瘤的增殖和肿瘤生长。
T78558	GNE-7883 GNE 7883,GNE7883	YAP	Stem Cells
	GNE-7883是一种靶向 TEAD 转录因子的抑制剂，抑制细胞增殖，抑制YAP/TAZ的激活，可用于研究YAP/TAZ依赖型肿瘤。
T3112	Verteporfin 维替泊芬,BPD-MA,CL 318952	Apoptosis; YAP; VDA; Autophagy	Angiogenesis; Apoptosis; Autophagy; Stem Cells
	Verteporfin (BPD-MA) 是一种 YAP 抑制剂，抑制 YAP-TEAD 相互作用。Verteporfin 也是一种光敏剂，用于光动力疗法。Verteporfin 还可以诱导细胞凋亡，抑制自噬。
T60148	MSC-4106	YAP	Stem Cells
	MSC-4106 是一种有效的、具有口服活性的 YAP/TAZ-TEAD 抑制剂。 MSC-4106 阻断 TEAD1 和 TEAD3 的自棕榈酰化，并且对 NCI-H226 异种移植瘤模型显示抑制作用。
T60218	YAP/TAZ inhibitor-2	YAP	Stem Cells
	YAP/TAZ inhibitor-2 是一种有效的具有口服活性的TEAD-YAP/TAZ 抑制剂，EC50值为 3 nM。YAP/TAZ inhibitor-2 具有抗增殖和抗肿瘤活性。
T81056	SWTX-143	YAP	Stem Cells
	SWTX-143，一新型共价YAP/TAZ-TEAD 抑制剂，能结合四种TEAD亚型的棕榈酰化口袋。SWTX-143特异性、不可逆地抑制YAP/TAZ-TEAD转录活性，表现出抗肿瘤活性。
T79427	LM-41	YAP	Stem Cells
	LM-41是一种衍生自Flufenamic acid的TEAD抑制剂，能有效下调CTGF、Cyr61、Axl和NF2的表达水平。此外，LM-41抑制了人类MDA-MB-231乳腺癌细胞的迁移。
T79428	AF-2112	YAP	Stem Cells
	AF-2112为Flufenamic acid衍生物，作为TEAD抑制剂，能显著抑制CTGF、Cyr61、Axl及NF2基因表达。
T68934	VT101 free base	Others	Others
	VT101 is a TEAD Auto-palmitoylation inhibitor that Selectively Inhibit Proliferation and Tumor Growth of NF2-deficient Mesothelioma. VT101 inhibited the firefly luciferase reporter dose-dependently and had no 204 effect on the Renilla luciferase reporter.
T76005	Super-TDU (1-31)
	Super-TDU (1-31) 是 Super-TDU 的肽片段。Super-TDU (1-31) 是 YAP-TEAD 复合物的抑制剂。Super-TDU 在胃癌小鼠模型中显示出有效的抗肿瘤活性并抑制肿瘤生长。
T71424	VT-102 free base	Others	Others
	VT-102 is a TEAD Auto-palmitoylation inhibitor that Selectively Inhibit Proliferation and Tumor Growth of NF2-deficient Mesothelioma. VT102 inhibited the firefly luciferase reporter dose-dependently and had no 204 effect on the Renilla luciferase reporter.
T76005L	Super-TDU (1-31) (TFA)
	Super-TDU (1-31) TFA 是 Super-TDU 的肽片段。Super-TDU (1-31) TFA 是YAP-TEAD 复合物的抑制剂。Super-TDU TFA 在胃癌小鼠模型中显示出有效的抗肿瘤活性并抑制肿瘤生长。
T76004	Super-TDU TFA
	Super-TDU TFA 是一种特异性的 YAP 拮抗剂，可以靶向 YAP-TEAD 相互作用。Super-TDU TFA 可以抑制胃癌小鼠模型的肿瘤生长。

化合物

YAP-TEAD-IN-1 acetate

Cat.No: TP2160L1

Synonym: YAP-TEAD-IN-1 acetate (1659305-78-8 Free base)

Target: YAP

YAP-TEAD-IN-3

Cat.No: T77725

Synonym: IAG933

Target: YAP

YAP-TEAD-IN-1

Cat.No: TP2160

Target: Others

YAP-TEAD-IN-1 TFA

Cat.No: TP2160L

Target: Others

TM2 TEAD inhibitor

Cat.No: T83951

Target: Others

Cat.No: T61776

Target: Others

Cat.No: T79687

Target: YAP

Cat.No: T62597

Target: Others

YAP-TEAD-IN-2

Cat.No: T72888

Target: YAP

Cat.No: T8421

Target: YAP

Cat.No: T9032

Target: Others

Cat.No: T9954

Target: Others

Cat.No: T22372

Synonym: 1-[3-Methyl-3-[3-(trifluoromethyl)anilino]pyrrolidin-1-yl]prop-2-en-1-one

Target: Others, YAP

Cat.No: T64342

Target: YAP

Cat.No: T77580

Synonym: compound I-32

Target: YAP

Cat.No: T35545

Target: YAP

Cat.No: T62077

Synonym: VT-103,VT 103

Target: YAP

Cat.No: T69760

Synonym: TAZ-K

Target: YAP

Cat.No: T69638

Synonym: VT 105

Target: Others

Cat.No: T78558

Synonym: GNE 7883,GNE7883

Target: YAP

Cat.No: T3112

Synonym: 维替泊芬,BPD-MA,CL 318952

Target: Apoptosis, YAP, VDA, Autophagy

Cat.No: T60148

Target: YAP

YAP/TAZ inhibitor-2

Cat.No: T60218

Target: YAP

Cat.No: T81056

Target: YAP

Cat.No: T79427

Target: YAP

Cat.No: T79428

Target: YAP

VT101 free base

Cat.No: T68934

Target: Others

Super-TDU (1-31)

Cat.No: T76005

VT-102 free base

Cat.No: T71424

Target: Others

Super-TDU (1-31) (TFA)

Cat.No: T76005L

Cat.No: T76004

Cat. No.	Product Name	Target	Signaling Pathways
T1679	Thiostrepton Thiactin,Bryamycin,Alaninamide,硫链丝菌素	DNA/RNA Synthesis; Antibacterial; Antibiotic	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	Thiostrepton (Alaninamide) 是一种选择性抑制FOXM1的抗生素。FOXM1会与 YAP/TEAD 复合物结合，形成YAP/TEAD/FOXM1 复合物。

天然产物

Cat.No: T1679

Synonym: Thiactin,Bryamycin,Alaninamide,硫链丝菌素

Target: DNA/RNA Synthesis, Antibacterial, Antibiotic

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-02943	TEAD4 Protein, Mouse, Recombinant TEA domain family member 4,TEF-1-related factor 1,Tead	Mouse	E. coli
	TEAD4 Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 25.7 kDa and the accession number is Q62296.
TMPH-02223	TEAD4 Protein, Human, Recombinant (His) Transcription factor 13-like 1,Transcription factor RTEF-1,T...	Human	E. coli
	TEAD4 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 44.7 kDa and the accession number is Q15561.
TMPH-02222	TEAD1 Protein, Human, Recombinant (His) TEAD1,Transcriptional enhancer factor TEF-1,Transcr...	Human	E. coli
	Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expr...
TMPH-02225	TEAD2 Protein, Human, Recombinant (His & Myc) TEA domain family member 2,Transcriptional enhancer factor T...	Human	E. coli
	Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expr...
TMPH-02942	TEAD4 Protein, Mouse, Recombinant (His & Myc) TEF-1-related factor FR-19,TEF-1-related factor 1,TEA domain...	Mouse	E. coli
	TEAD4 Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 33.0 kDa and the accession number is Q62296.
TMPH-02224	TEAD4 Protein, Human, Recombinant (His & Myc) Transcription factor 13-like 1,TEA domain family member 4,Tr...	Human	Baculovirus Insect Cells
	TEAD4 Protein, Human, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 44.5 kDa and the accession number is Q15561.
TMPH-02226	TEAD3 Protein, Human, Recombinant (His & SUMO) DTEF-1,TEA domain family member 3,Transcriptional enhancer f...	Human	E. coli
	Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expr...
TMPH-03764	YAP1 Protein, Human, Recombinant (His) YAP1-2gamma,YAP2L,YAP65	Human	P. pastoris (Yeast)
	Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1,...

重组蛋白

TEAD4 Protein, Mouse, Recombinant

Cat.No: TMPH-02943

Species: Mouse

Expression System: E. coli

TEAD4 Protein, Human, Recombinant (His)

Cat.No: TMPH-02223

Species: Human

Expression System: E. coli

TEAD1 Protein, Human, Recombinant (His)

Cat.No: TMPH-02222

Species: Human

Expression System: E. coli

TEAD2 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-02225

Species: Human

Expression System: E. coli

TEAD4 Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02942

Species: Mouse

Expression System: E. coli

TEAD4 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-02224

Species: Human

Expression System: Baculovirus Insect Cells

TEAD3 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-02226

Species: Human

Expression System: E. coli

YAP1 Protein, Human, Recombinant (His)

Cat.No: TMPH-03764

Species: Human

Expression System: P. pastoris (Yeast)

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