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Search Results for " tcf "

Targets Recommended: p38 MAPK Autophagy

28

抑制剂 & 化合物

1

天然产物

7

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T4646	TA-02	p38 MAPK; Autophagy	Autophagy; MAPK
	TA02 是一种Adezmapimod 类似物，是p38 MAPK 的抑制剂，其IC50值为 20 nM。它和Adezmapimod、SB 202190 具有相似的心源活性，可抑制 TGFBR-2。
T9696	β-catenin-IN-2	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	β-catenin-IN-2 是有效的β-catenin 抑制剂。β-catenin-IN-2在结直肠癌中有研究的价值。
T3144	BML-284 Wnt agonist 1	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	BML-284 (Wnt agonist 1) 是细胞通透性 Wnt 信号激活剂，能够诱导 TCF 依赖的转录活性(EC50>700 nM)。
T23432	TC-F 2	Others	Others
	FAAH inhibitor
T8820	BML-284 hydrochloride BML-284 HCL,Wnt agonist 1 HCL	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	BML-284 hydrochloride (Wnt agonist 1 HCL) 是细胞通透性 Wnt 信号激活剂。它能够诱导 TCF 依赖的转录活性(EC50>700 nM)。
T131725	Compound TCFN92660	Others	Others
	Compound TCFN92660 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T131725，CAS号为 56070-89-4。
T131730	Compound TCFN00444	Others	Others
	Compound TCFN00444 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T131730，CAS号为 579-21-5。
T131721	Compound TCFN97859	Others	Others
	Compound TCFN97859 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T131721，CAS号为 103476-99-9。
T131726	Compound TCFN92881	Others	Others
	Compound TCFN92881 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T131726，CAS号为 90536-47-3。
T13917	tCFA15	Others	Others
	tCFA15, a trimethyl cyclohexenonic long-chain fatty alcohol with a 15-carbon atom side chain, may regulate Notch signaling and promote neuronal differentiation.
T131720	Compound TCFN95222	Others	Others
	Compound TCFN95222 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T131720，CAS号为 52387-14-1。
T131723	Compound TCFN91628	Others	Others
	Compound TCFN91628 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T131723，CAS号为 724434-08-6。
T5636	Adavivint Adavivint (SM04690)	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	Adavivint (SM04690) 是选择性的典型的Wnt 信号通路抑制剂，在 SW480 细胞中，用高通量 TCF/LEF 报告基因实验，测得EC50=19.5 nM。
T1971	WAY-262611	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	WAY262611是一种 Wnt/β- 联蛋白激动剂，也是一种Dkk1的抑制剂。它能够增加骨形成速率，在 TCF- 荧光素酶测定实验中的EC50=0.63 μM。
T21685	CCT 031374 hydrobromide	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	CCT 031374 hydrobromide 是一种 TCF/β-catenin 抑制剂，具有抗肿瘤活性。
T6113	ICG-001	Apoptosis; Epigenetic Reader Domain; Wnt/beta-catenin	Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; Stem Cells
	ICG001 是β-catenin/TCF 介导的一种转录抑制剂，选择性地阻断 β-catenin/CBP 相互作用而不干扰 β-catenin/p300 相互作用。它可特异性结合 CREB 蛋白，IC50为3 μM。
T15469	Hematein Hydroxybrasilein	Wnt/beta-catenin; Akt	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Stem Cells
	Hematein 抑制Akt/PKB Ser129磷酸化，Wnt/TCF 途径，并增加癌症细胞的凋亡。Hematein 是苏木精的氧化产物，也是变构酪蛋白激酶II 抑制剂（IC50:0.74μM）。
T2237	ICG001	Epigenetic Reader Domain; Wnt/beta-catenin	Chromatin/Epigenetic; Cytoskeletal Signaling; Stem Cells
	ICG001 拮抗 Wnt/β-catenin/TCF 介导的转录，并特异性结合元件结合蛋白(CREB) 结合蛋白 (CBP)，IC50 为 3 μM，但不是相关的转录共激活因子 p300。
T15363	FzM1.8	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	FzM1.8 是变构 FZD4 激动剂，pEC50 为 6.4。 FzM1.8 与 FZD4 结合，在没有任何 WNT 配体的情况下促进 TCF/LEF 转录活性，并激活 WNT/β-catenin 通路[1]。
T33519	MTOB α-keto-γ-Methylthiobutyric acid,4-甲硫基-2-氧丁酸钠,KMBA,MTOB salt,4-methylthio 2-oxobutyric acid	Others	Others
	MTOB (α-keto-γ-Methylthiobutyric acid) 是 c 末端结合蛋白 (CtBP) 的底物，可干扰 CtBP 在细胞培养物和小鼠中的致癌活性。它还积极调节 TCF-4 信号传导，导致癌症干细胞 (CSC) 生长和自我更新。
T10904	CWP232228	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	CWP232228 是一种高效的、选择性的Wnt/β-catenin 信号通路抑制剂，在细胞核中，拮抗 β-catenin 与 T 细胞因子结合。它能够抑制乳腺癌和肝癌干细胞的生长，抑制肿瘤的形成和转移，且没有毒性。
T39200	β-catenin-IN-37	Others	Others
	β-Catenin-IN-37 is a selective inhibitor of the protein-protein interaction between β-Catenin and T-cell factor (Tcf), known as β-catenin/Tcf PPI. It effectively inhibits canonical Wnt signaling and impedes the growth of colorectal cancer cells SW480 and HCT116, with IC50 values of 20 μM and 31 μM, respectively.
T82508	Eciskafusp alfa	PD-1/PD-L1	Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation
	Eciskafusp alfa是一种针对程序性细胞死亡1(PDCD1，亦称PD-1)的顺式靶向IL2v免疫细胞因子。它优先选择抗原特异性干细胞样PD-1+ TCF-1+ CD8+ T细胞，并促使这些细胞分化成更高效的效应器细胞。Eciskafusp alfa主要用于癌症与慢性感染的研究领域。
T71635	Murayaquinone	Others	Others
	Murayaquinone is a hepatitis C virus proteinase inhibitor and small molecule antagonist of the oncogenic Tcf/β-catenin protein complex.
T81353	Pterostilbene-isothiocyanate PTER-ITC	Others	Others
	Pterostilbene-isothiocyanate (PTER-ITC) 在体外展现出显著的抗癌活性。它通过干扰β-catenin/TCF-4的相互作用，从而针对人骨肉瘤细胞发挥作用。
T78919	β-catenin-IN-7	Others	Others
	β-catenin-IN-7（Compound 9）为一种β-catenin抑制剂，能够阻断β-catenin与Tcf-4的相互作用，进而抑制Wnt依赖性靶基因的表达，展现出抗癌活性。
T70721	UU-T01	Others	Others
	UU-T01 是 β-Catenin/T-cell factor 4 蛋白互作 (β-catenin/Tcf PPI) 的选择性抑制剂，Ki 值为 3.14 µM。UU-T01 与β-catenin 直接结合，KD 值为 0.531 µM。
T71483	Streptonigrin (racemate)	Others	Others
	Streptonigrin is an aminoquinone antitumor and antibacterial antibiotic produced by Streptomyces flocculus. Streptonigrin inhibits β-Catenin/Tcf signaling and shows cytotoxicity in β-catenin-activated cells. Streptonigrin induces delayed chromosomal instability involving interstitial telomeric sequences in Chinese hamster ovary cells. Note: Streptonigrin from natural resource is (-)-rotation, has CAS#3930-19-6 and is a R-isomer.

化合物

Cat.No: T4646

Target: p38 MAPK, Autophagy

β-catenin-IN-2

Cat.No: T9696

Target: Wnt/beta-catenin

Cat.No: T3144

Synonym: Wnt agonist 1

Target: Wnt/beta-catenin

Cat.No: T23432

Target: Others

BML-284 hydrochloride

Cat.No: T8820

Synonym: BML-284 HCL,Wnt agonist 1 HCL

Target: Wnt/beta-catenin

Compound TCFN92660

Cat.No: T131725

Target: Others

Compound TCFN00444

Cat.No: T131730

Target: Others

Compound TCFN97859

Cat.No: T131721

Target: Others

Compound TCFN92881

Cat.No: T131726

Target: Others

Cat.No: T13917

Target: Others

Compound TCFN95222

Cat.No: T131720

Target: Others

Compound TCFN91628

Cat.No: T131723

Target: Others

Cat.No: T5636

Synonym: Adavivint (SM04690)

Target: Wnt/beta-catenin

Cat.No: T1971

Target: Wnt/beta-catenin

CCT 031374 hydrobromide

Cat.No: T21685

Target: Wnt/beta-catenin

Cat.No: T6113

Target: Apoptosis, Epigenetic Reader Domain, Wnt/beta-catenin

Cat.No: T15469

Synonym: Hydroxybrasilein

Target: Wnt/beta-catenin, Akt

Cat.No: T2237

Target: Epigenetic Reader Domain, Wnt/beta-catenin

Cat.No: T15363

Target: Wnt/beta-catenin

Cat.No: T33519

Synonym: α-keto-γ-Methylthiobutyric acid,4-甲硫基-2-氧丁酸钠,KMBA,MTOB salt,4-methylthio 2-oxobutyric acid

Target: Others

Cat.No: T10904

Target: Wnt/beta-catenin

β-catenin-IN-37

Cat.No: T39200

Target: Others

Eciskafusp alfa

Cat.No: T82508

Target: PD-1/PD-L1

Cat.No: T71635

Target: Others

Pterostilbene-isothiocyanate

Cat.No: T81353

Synonym: PTER-ITC

Target: Others

β-catenin-IN-7

Cat.No: T78919

Target: Others

Cat.No: T70721

Target: Others

Streptonigrin (racemate)

Cat.No: T71483

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T5S1982	Periplocin Periplocoside,杠柳毒苷	Apoptosis; Others	Apoptosis; Others
	Periplocin (Periplocoside) 是从黑龙骨中分离出的一种强心类固醇。它可促进肿瘤细胞凋亡并抑制肿瘤生长。它通过激活 Na/K-ATPase 介导的 Src/ERK 和 PI3K/Akt 途径，具有促进伤口愈合的潜力。

天然产物

Cat.No: T5S1982

Synonym: Periplocoside,杠柳毒苷

Target: Apoptosis, Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPK-00369	HGF Protein, Human, Recombinant (hFc) HGF,F-TCF,HGFB,SF,F-TCFB,肝细胞生长因子,DFNB39,He...	Human	HEK293 Cells
	Hepatocyte growth factor (HGF) is an important component of the pathophysiology of IR, with increased levels in most common IR conditions, including obesity. HGF has a role in the metabolic flux of glucose in different insulin sensitive cell types; plays a key role in β-cell homeostasis; and is capable of modulating the inflammatory response.HGF plays a central role in these metabolic disorders,HGF levels could be employed as a biomarker for disease status/progression, and HGF/c-Met signaling pa...
TMPY-02327	HGF Protein, Human, Recombinant SF,hepatocyte growth factor (hepapoietin A,HGFB,F-TCF	Human	CHO Cells
	HGF Protein, Human, Recombinant is expressed in CHO mammalian cells. The predicted molecular weight is 79.7 kDa and the accession number is P14210-1.
TMPJ-00986	CTCF Protein, Human, Recombinant Transcriptional Repressor CTCF,CCCTC-Binding Factor...	Human	E. coli
	Transcriptional Repressor CTCF (CTCF) belongs to the CTCF Zinc-Finger Protein family. CTCF contains twelve C2H2-type zinc fingers and interacts with CHD8. CTCF is widely expressed in many tissues, and it is absent in primary spermatocytes. CTCF is involved in transcriptional regulation by binding to chromatin insulators and preventing interaction between promoter and nearby enhancers and silencers. CTCF plays an essential role in oocyte and preimplantation embryo development by activating or rep...
TMPH-01961	Wnt3a Protein, Human, Recombinant (His) WNT3A,Protein Wnt-3a	Human	E. coli
	Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. Required for normal embryonic mesoderm development and formation of caudal somites. Required for normal morphogenesis of the developing neural tube. Mediates self-renewal of the stem cells at the bottom on intestinal crypts (in vitro). Wnt3a Protein, Human, Recombinant (His) is expressed in E. coli ...
TMPH-02865	Wnt3 Protein, Mouse, Recombinant (His & SUMO) Proto-oncogene Int-4,Proto-oncogene Wnt-3,Wnt3	Mouse	E. coli
	Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. Required for normal gastrulation, formation of the primitive streak, and for the formation of the mesoderm during early embryogenesis. Required for normal formation of the apical ectodermal ridge and for normal embryonic limb development.
TMPH-02859	Wnt3a Protein, Mouse, Recombinant (His) Wnt3a,Protein Wnt-3a	Mouse	E. coli
	Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. Required for normal embryonic mesoderm development and formation of caudal somites. Required for normal morphogenesis of the developing neural tube. Mediates self-renewal of the stem cells at the bottom on intestinal crypts (in vitro). Wnt3a Protein, Mouse, Recombinant (His) is expressed in E. coli ...
TMPJ-00163	R-Spondin 3/RSPO3 Protein, Human, Recombinant (hFc & His) Protein with TSP type-1 repeat,RSPO3,R-spondin-3,Roof plate-...	Human	HEK293 Cells
	R-spondin-3 (RSPO3), also known as Protein with TSP type-1 repeat, Roof plate-specific spondin-3, Thrombospondin type-1 domain-containing protein 2, PWTSR, THSD2 and CRISTIN1, is a member of the thrombospondin type 1 repeat supergene family. RSPO3 is a secreted protein and widely expressed in many tissues. RSPO3 contains two Furin-like repeats which have been found in a variety of eukaryotic proteins involved in the mechanism of signal transduction by receptor tyrosine kinases, and one TSP type-...

重组蛋白

HGF Protein, Human, Recombinant (hFc)

Cat.No: TMPK-00369

Species: Human

Expression System: HEK293 Cells

HGF Protein, Human, Recombinant

Cat.No: TMPY-02327

Species: Human

Expression System: CHO Cells

CTCF Protein, Human, Recombinant

Cat.No: TMPJ-00986

Species: Human

Expression System: E. coli

Wnt3a Protein, Human, Recombinant (His)

Cat.No: TMPH-01961

Species: Human

Expression System: E. coli

Wnt3 Protein, Mouse, Recombinant (His & SUMO)

Cat.No: TMPH-02865

Species: Mouse

Expression System: E. coli

Wnt3a Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02859

Species: Mouse

Expression System: E. coli

R-Spondin 3/RSPO3 Protein, Human, Recombinant (hFc & His)

Cat.No: TMPJ-00163

Species: Human

Expression System: HEK293 Cells

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