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Search Results for " t. gondii "

Targets Recommended: Dopamine Receptor

11

抑制剂 & 化合物

1

天然产物

1

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T7943	Fluphenazine decanoate	Dopamine Receptor	GPCR/G Protein; Neuroscience
	Fluphenazine decanoate 是一种高度连续的多巴胺 D2受体阻滞剂，是一种长效吩噻嗪抗精神病药，用于精神分裂症的研究。
T72081	CpCDPK1/TgCDPK1-IN-2	Parasite	Microbiology/Virology
	CpCDPK1/TgCDPK1-IN-2 是 CpCDPK1 和 TgCDPK1 双重抑制剂，对 CpCDPK1 和 TgCDPK1 有抑制这样，IC50 值分别为 12 和 5 nM。CpCDPK1/TgCDPK1-IN-2 可用于研究弓形虫 (T. gondii)、细小隐孢子虫 (C. parvum) 和隐孢子虫 (C. hominus) 等顶复门原生动物感染相关疾病。
T36692	Fanotaprim	DHFR	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism
	Fanotaprim 是二氢叶酸还原酶的有效抑制剂，抑制 tgDHFR (Toxoplasma gondiiDHFR) 和 hDHFR (human DHFR)的 IC50分别为 1.57 和 308 nM。Fanotaprim 在研究弓形虫病方面具有价值。
T21687	Conoidin A	Parasite	Microbiology/Virology
	Conoidin A 是刚地弓形虫过氧化物酶 II 的细胞通透性抑制剂，有杀线虫特性。它共价结合 TgPrxII 的过氧化物催化位点 Cys47，不可逆地抑制其过氧化物活性，IC50为 23 µM。它也抑制哺乳动物 PrxI 和 PrxII 的氧化。它具有抗氧化、神经保护作用，可研究缺血性心脏病。
T61671	MMV687807	Others	Others
	MMV687807 is a potent anthelmintic compound exhibiting strong efficacy against Toxoplasma gondii (T. gondii). It demonstrates an IC50 value of 0.15 μM and a CC50 value of 1.69 μM [1].
T11846	LHVS	Cysteine Protease	Proteases/Proteasome
	LHVS effectively blocks T. gondii microneme protein secretion (IC50=10 μM), gliding motility, and cell invasion. LHVS is a potent, non-selective cysteine protease inhibitor.
T40191	17-GMB-APA-GA	Others; ADC Cytotoxin	Antibody-drug Conjugate/ADC Related; Others
	17-GMB-APA-GA, a potent HSP90 inhibitor, is an ADC cytotoxin commonly employed for studying latent T. gondii infection.
T61114	Anti-Trypanosoma cruzi agent-2	Others	Others
	Anti-Trypanosoma cruzi agent-1 (Compd 3b) 对NINOA trypomastigote (IC50= 0.51 μM) 和 INC-5 epimastigote (IC50= 3.06 μM) 锥虫具有选择性，具有有效的抗弓形虫活性。
T83881	4-(3,4-Difluorobenzo)curcumin CDF	Others	Others
	4-(3,4-Difluorobenzo)curcumin（CDF）是一种具有抗寄生虫和抗癌活性的半合成香豆素。它能减少被T. gondii持鞭毛体和无鞭毛体感染的Vero细胞的数量（EC50s分别为0.8和0.37 µM）。CDF（4和8 µM）通过增强5-氟尿嘧啶和奥沙利铂对化药抵抗性HCT116细胞主要和次要结肠球形成的抑制作用。
T17257	WR99210	DHFR; Antifolate; Antibacterial	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology
	WR99210 是一种有效的、可口服的且毒性较低的二氢叶酸还原酶 (DHFR) 抑制剂 (IC50<0.075 nM)。WR99210 具有较好的抗寄生虫活性，对间日疟原虫和恶性疟原虫株 (包括耐 Pyrimethamine 的恶性疟原虫株) 以及弓形虫有良好的抑制作用。
T84403	4-Thiouracil 2-hydroxy-4-Mercaptopyrimidine,4-Thiopyrimidin-2-one,NSC 43288,4-TU	Others	Others
	4-Thiouracil is a photoactivatable probe designated for site-specific applications in detecting RNA structures and nucleic acid-nucleic acid contacts. Upon illumination with ultraviolet light exceeding 300 nm and in the presence of oxygen, it serves as an energy donor, facilitating the generation of singlet oxygen through triplet-triplet energy transfer. This process enables the highly reactive oxygen species to interact with 4-thiouracil, leading to the formation of uracil and uracil-6-sulfonat...

化合物

Fluphenazine decanoate

Cat.No: T7943

Target: Dopamine Receptor

CpCDPK1/TgCDPK1-IN-2

Cat.No: T72081

Target: Parasite

Cat.No: T36692

Target: DHFR

Cat.No: T21687

Target: Parasite

Cat.No: T61671

Target: Others

Cat.No: T11846

Target: Cysteine Protease

Cat.No: T40191

Target: Others, ADC Cytotoxin

Anti-Trypanosoma cruzi agent-2

Cat.No: T61114

Target: Others

4-(3,4-Difluorobenzo)curcumin

Cat.No: T83881

Synonym: CDF

Target: Others

Cat.No: T17257

Target: DHFR, Antifolate, Antibacterial

Cat.No: T84403

Synonym: 2-hydroxy-4-Mercaptopyrimidine,4-Thiopyrimidin-2-one,NSC 43288,4-TU

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T35750	Trypacidin	Others	Others
	Trypacidin is a fungal metabolite originally isolated fromA. fumigatus.1It is active againstB. subtilisandM. bovis(MICs = 12.5 and 1.25 μg/ml, respectively), as well asT. cruziandT. gondii(MICs = 5-10 and 10-20 μg/ml, respectively).1,2It reduces viability and induces lysis of A549 human lung cancer cells (IC50s = 7.4 μM for both).3Trypacidin increases survival in a mouse model ofT. gondiiinfection when administered in six doses of 12.5 mg/kg each.1 1.Balan, J., Ebringer, L., Nemec, P., et al.Ant...

天然产物

Cat.No: T35750

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-02929	ENTPD2 Protein, Human, Recombinant (aa 29-460, His) ectonucleoside triphosphate dipho...	Human	Baculovirus Insect Cells
	NTPDase 2, also known as ENTPD2, belongs to the ecto-nucleoside triphosphate diphosphohydrolase family (E-NTPDase). Members of E-NTPDase family are nucleotidases able to hydrolyze 5′-nucleoside tri- and/or diphosphates; the main role of these enzymes is the termination of purinergic signaling. NTPDases are ubiquitous and were previously shown in other parasites including the trypanosomatides of genus Leishmania and in T. brucei. NTPase activity would act as a timer and is crucial to T. gondii in...

重组蛋白

ENTPD2 Protein, Human, Recombinant (aa 29-460, His)

Cat.No: TMPY-02929

Species: Human

Expression System: Baculovirus Insect Cells

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