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Search Results for " t-lymphocyte "

Targets Recommended: Others

36

抑制剂 & 化合物

2

天然产物

1

化合物库

89

重组蛋白

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Cat. No.	Product Name
L2170	肿瘤免疫治疗小分子化合物库		449 compounds
	449 种靶向肿瘤免疫治疗靶点的小分子，可用于高通量和高内涵筛选，是研究肿瘤免疫治疗的有力工具；

化合物库

肿瘤免疫治疗小分子化合物库

Cat.No: L2170

Compounds: 449

Cat. No.	Product Name	Target	Signaling Pathways
T9919	Alemtuzumab	Others	Others
	Alemtuzumab 是人源化抗 CD52单克隆抗体， CD52是一种表达于大多数淋巴细胞以及少数的髓细胞类型的糖蛋白。Alemtuzumab 与能够特异性作用于 CD52 抗原，诱导淋巴细胞深度耗竭，恢复具有调节表型的 T 细胞和 B 细胞。
T9616	PD-1/PD-L1-IN-10	PD-1/PD-L1	Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation
	PD-1/PD-L1-IN-10 是一种口服有效的PD-1/PD-L1抑制剂 (IC50of 2.7 nM)，显示出抗肿瘤活性。
T10389L	Aspartyl-alanyl-diketopiperazine acetate DA-DKP,Aspartyl-alanyl-diketopiperazine acetate(110954-19-3 Free base)	Others	Others
	Aspartyl-alanyl-diketopiperazine acetate (DA-DKP) 可以通过与 T 淋巴细胞无反应有关的分子途径调节炎症免疫反应。
T3977L	Lifitegrast sodium SAR-1118-023,SAR1118-023,SAR 1118-023,Xiidra	Others	Others
	Lifitegrast sodium (SAR-1118) is an LFA-1 antagonist for the therapy of vascular complications of the eye. It inhibits T cell-mediated inflammation by blocking the binding of two cell surface proteins (lymphocyte function-associated antigen 1 and intercel
T77466	Tremelimumab Ticilimumab,CP-675206	Others	Others
	Tremelimumab 是一种细胞毒性T淋巴细胞相关抗原-4（CTLA-4）阻断抗体.Tremelimumab 常与 Durvalumab 联合使用来治疗肝癌、肺癌等实体癌。
T3977	Lifitegrast SHP-606,SAR 1118,立他司特,利非司特	Integrin	Cytoskeletal Signaling
	Lifitegrast (SAR 1118) 是一种整合素淋巴细胞功能相关抗原 1 拮抗剂，抑制 Jurkat T 细胞附着于ICAM-1的IC50为 2.98 nM。
TQ0007	Cintirorgon LYC-55716	ROR	Metabolism
	Cintirorgon (LYC-55716) 是一种首创的、口服有活力的的RORγ选择性激动剂。它通过调节 RORγ 表达的 T 淋巴免疫细胞的基因表达，提高效应子功能，降低免疫抑制，抑制肿瘤生长，提高生存率。
T37577	Glycogen Phosphorylase Inhibitor	Others	Others
	Glycogen phosphorylase in the liver, muscle, and brain initiate glycogenolysis by releasing glucose-1-phosphate from glycogen. Glycogen phosphorylase inhibitor is a cell-permeable acyl urea first identified as an inhibitor of human liver glycogen phosphorylase (IC50 = 53 nM). It blocks glucagon-induced hepatic glycogenolysis in vivo. Glycogen phosphorylase inhibitor has been used to study glycogen utilization in human liver HepG2 cells, retinal explants, and human T lymphocyte Kit 225 cells.
T63790	Cbl-b-IN-3	E1/E2/E3 Enzyme	Ubiquitination
	Cbl-b-IN-3是一种有效的casitas b 系淋巴瘤原癌基因-b (Cbl-b)抑制剂（ic50 < 1 nM）。Cbl-b 是一种环型E3泛素蛋白连接酶，与T 淋巴细胞激活阈值的设定有关。Cbl-b 以不依赖于蛋白水解的方式负调控p85，通过其E3泛素连接酶活性，参与了p85向CD28和T 细胞抗原受体ζ的募集，抑制PI3K 抑制了Cblb-/- t 细胞活化的增强。
T3614	Inosine pranobex Groprinosin,Isoprinosine,异丙肌苷,Immunovir,Delimmun	IL Receptor; HIV Protease	Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome
	Inosine pranobex (Delimmun) 是一种免疫增强剂，它是一种广谱抗病毒剂，用于 HIV 感染。
T26752	BC12 BC 12,BC-12	Others	Others
	BC12 exhibits unusually potent immunomodulatory actions on T lymphocyte function, including inhibition of T cell proliferation and IL-2 cytokine production.
TP1612	OVA sequence (323-336) OVA sequence 323-336
	This peptide is a cognate helper T-lymphocyte peptide that is employed to enhance CTL epitope immunogencity
TP1515	HPV16-E711-20 epitope
	HPV16-E711-20 epitope is a well-known HLA-A*0201-restricted human cytotoxic T lymphocyte (CTL) epitope of the HPV16 E7 protein that shows high-affinity binding to HLA-A2 in vitro.
T80573	Firastotug
	Firastotug为针对CTLA4的IgG1κ抗体。CTLA4作为细胞毒性T淋巴细胞相关抗原，它在自身免疫和癌症研究中扮演着重要的免疫检查点角色。
T39292	NS2 (114-121), Influenza NS2 (114-121), Influenza
	NS2 (114-121), Influenza, is a fragment derived from the nonstructural protein 2 (NS2) of the influenza virus. This compound serves as an epitope for influenza research and can be utilized to study the CD8+ cytotoxic T lymphocyte (CTL) in antiviral immune responses.
T27192	DMI-9523 DA-DKP,Ampion,DMI 9523,DM-9523	Others	Others
	DMI-9523 is nuclear factor NF-κB activation inhibitor. Antigen-stimulated human T lymphocytes produce significantly lower quantities of interferon-gamma and tumor necrosis factor-alpha after stimulation in vitro in the presence of DA-DKP. DA-DKP can modul
T77103	Nurulimab
	Nurulimab (BCD-145) 是一种抗细胞毒性 T 淋巴细胞抗原 4 (抗 CTLA-4) 人源化单克隆抗体。Nurulimab 可用于黑色素瘤的研究。
T82743	CFP10 (71–85)
	CFP10 (71–85) 是具生物活性的肽类，能激活表达不同MHC II类与I类分子的人类CD4+和CD8+ T细胞，诱导IFN-γ产生及CTL活性。(CFP10 71–85).
T82484	ELAAWCRWGFLLALLPPGIAG TFA
	ELAAWCRWGFLLALLPPGIAG TFA (P5) 是由大鼠HER2/neu蛋白衍生的21个氨基酸长的肽段（氨基酸序号5至25）。该化合物在携带HER2阳性肿瘤的小鼠模型中，能够诱发细胞毒性T淋巴细胞(CTL)的反应。
T15337	Forodesine Immucillin-H,BCX-1777	Apoptosis	Apoptosis
	Forodesine (BCX-1777) 是一种具有口服活性和高效性的嘌呤核苷磷酸化酶 (PNP) 抑制剂，是一种新的嘌呤核苷类似物，抑制人类淋巴细胞增殖抑制剂，可通过增加 dGTP 水平而诱导白血病细胞凋亡 (apoptosis)，可用于研究皮肤T细胞淋巴瘤。
T82485	ELAAWCRWGFLLALLPPGIAG
	ELAAWCRWGFLLALLPPGIAG (P5) 是源自大鼠HER2/neu蛋白的21个氨基酸长肽（氨基酸5-25）。此肽可诱导携带HER2阳性肿瘤小鼠中的细胞毒性T淋巴细胞（CTL）反应。
T77106	Odulimomab
	Odulimomab (anti-LFA1) 是一种抗 LFA-1单克隆抗体。Odulimomab 抑制 T 淋巴细胞增殖，对缺血再灌注损伤有保护作用。Odulimomab 可用于移植排斥反应和免疫疾病的研究。
T76241	Trichomide A
	Trichomide A 是一种有效的 SHP2激活剂。Trichomide A 是一种天然的环缩肽。Trichomide A 在 Con A 激活的 T 细胞中对激活的 T 淋巴细胞介导的免疫反应具有免疫抑制活性。Trichomide A 具有研究免疫相关皮肤病的潜力。
T77104	Obrindatamab
	Obrindatamab 是一种人源化抗 B7-H3/CD3双特异性抗体。Obrindatamab 结合 B7-H3和 CD3，从而介导针对表达 B7-H3的癌细胞的重定向细胞毒性 T 淋巴细胞 (CTL) 活性。Obrindatamab 可用于癌症研究。
T16578	PRN694	Others	Others
	PRN694 shows extended target residence time on ITK and RLK, enabling durable attenuation of effector cells in vitro and in vivo. PRN694 is an irreversible, highly selective, and effective covalent interleukin-2-inducible T-cell kinase (ITK) and resting ly
T76933	Botensilimab
	Botensilimab (AGEN 1181)，一种针对细胞毒性T淋巴细胞抗原4 (CTLA-4) 的人源化单克隆抗体，既能激活先天性免疫也能激活适应性免疫，主要应用于癌症研究领域。
T78293	TSR-033
	TSR-033为针对LAG-3（淋巴细胞活化基因-3）的人源化IgG4高亲和力抗体，能增强T细胞功能及PD-1阻断效果，适用于体外及体内。作为与T细胞功能障碍相关的共抑制受体，LAG-3常与PD-1共同表达，TSR-033因此表现出抗肿瘤活性。
T77188	Tifcemalimab
	Tifcemalimab (JS004) 是一种人源化抗 BTLA(B 和 T 淋巴细胞衰减因子) 单克隆抗体。Tifcemalimab 通过与 BTLA 结合，阻断 HVEM-BTLA 的相互作用，从而阻断BTLA 介导的抑制信号通路。Tifcemalimab 可用于癌症的研究。
T64017	RORγt agonist 3	Others	Others
	RORγt agonist 3 是 RORγt 的有效激动剂。RORγt agonist 3 能够促使 Th17 细胞分化，增加促炎细胞因子水平，进而提高淋巴细胞的细胞毒性。RORγt agonist 3 能够阻碍调节性 T 细胞的产生，并免疫反应产生抑制作用。
T64140	RORγt agonist 2	Others	Others
	RORγt agonist 2 是 RORγt 的有效的激动剂。RORγt agonist 2 能够诱导 Th17 细胞分化，增加促炎细胞因子水平，进而增强淋巴细胞的细胞毒性。RORγt agonist 2 对调节性 T 细胞的产生表现出抑制作用，能够抑制免疫反应。
T85077	AKP-11	Others	Others
	AKP-11 is a sphingosine-1-phosphate receptor 1 (S1P1) agonist with an EC50 of 0.047 μM for [35S]GTPγS binding to CHO-K1 cell membranes expressing human S1P1. It reduces S1P1 surface expression and enhances Akt and ERK phosphorylation in CHO cells with S1P1-HA at a 100 nM concentration. At doses of 1.3 and 3 mg/kg, AKP-11 lowers IFN-γ and IL-17 protein levels in the spinal cord and mitigates disease severity in a rat experimental autoimmune encephalomyelitis (EAE) model. Additionally, it decrease...
T83930	SJ 11646	Others	Others
	SJ11646是一种高效的LCK（淋巴细胞特异性蛋白酪氨酸激酶）降解剂（PROTAC；DC50= 0.00838 pM）。该化合物由Dasatinib作为LCK配体，以及基于苯基谷氨酰亚胺的cereblon结合体组成。它在体外对LCK激活的T细胞急性淋巴细胞白血病（T-ALL）细胞株和初级白血病样本展现出细胞毒性。在体内，SJ11646在源自患者的T-ALL异种移植模型中显示出抗白血病效果。
T83910	S1PL-IN-31 Sphingosine-1-Phosphate Lyase Inhibitor 31,S1PL Inhibitor 31,S1P Lyase Inhibitor 31	Others	Others
	S1PL-IN-31是一种鞘氨醇-1-磷酸(S1P)裂解酶的抑制剂(IC50 = 210 nM)，同时也是Smoothened(Smo)受体的对抗剂(IC50 = 440 nM)。在体内，S1PL-IN-31 (每天2 mg/kg)能够防止实验性自身免疫性脑炎(EAE)模型大鼠中，由髓鞘少突胶质细胞糖蛋白(MOG)肽段MOG29-152诱发的颈部及胸部淋巴细胞渗透和神经肌肉虚弱。该化合物降低了大鼠的淋巴细胞总数及CD4+ T细胞、CD8+ T细胞和B细胞的水平。S1PL-IN-31 (每天3及10 mg/kg剂量)在雄性和雌性大鼠心脏和淋巴结中增加了S1P水平，并且在雌性大鼠中降低了心率。
T80066	ShK toxin	Potassium Channel	Membrane transporter/Ion channel
	ShK toxin 是从加勒比海葵（Stichodactylu helianthus）的全身提取物中分离出的一种蛋白，能够阻断电压依赖性钾通道(Kv1.3 通道)。在竞争实验中，ShK toxin 与树突毒素 I 及α-树突毒素相互竞争，以与大鼠脑突触体膜结合，从而促进乙酰胆碱的释放。此外，ShK toxin 抑制培养的大鼠背根神经节神经元中的K+ 电流，并且能够抑制T淋巴细胞的增殖。
T37548	azido-FTY720 azido-FTY720	Others	Others
	FTY720 is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analog of sphingosine. It is a novel immune modulator that prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs. FTY720 is phosphorylated by sphingosine kinase, which then acts as a potent agonist at four of the sphingosine-1-phosphate (S1P) receptors (S1P1, S1P3, S1P4, and S1P5). Down-regulation of S1P1 recept...
T37052	Tetranactin	Others	Others
	Tetranactin is a macrotetrolide and a monovalent cation ionophore that has been found in S. aureus and has antibacterial, insecticidal, and mitogenic activities. It exhibits an equilibrium permeability ratio 1,000-fold greater for lithium than sodium or cesium ions accross bilayer membranes at low voltages. Tetranactin inhibits the growth of Gram-positive bacteria and C. miyabeanus and R. solani fungi when used at concentrations less than 0.9 μg/ml. Tetranactin (0.5-1.5 μg per insect) dose-depen...

化合物

Cat.No: T9919

Target: Others

PD-1/PD-L1-IN-10

Cat.No: T9616

Target: PD-1/PD-L1

Aspartyl-alanyl-diketopiperazine acetate

Cat.No: T10389L

Synonym: DA-DKP,Aspartyl-alanyl-diketopiperazine acetate(110954-19-3 Free base)

Target: Others

Lifitegrast sodium

Cat.No: T3977L

Synonym: SAR-1118-023,SAR1118-023,SAR 1118-023,Xiidra

Target: Others

Cat.No: T77466

Synonym: Ticilimumab,CP-675206

Target: Others

Cat.No: T3977

Synonym: SHP-606,SAR 1118,立他司特,利非司特

Target: Integrin

Cat.No: TQ0007

Synonym: LYC-55716

Target: ROR

Glycogen Phosphorylase Inhibitor

Cat.No: T37577

Target: Others

Cat.No: T63790

Target: E1/E2/E3 Enzyme

Inosine pranobex

Cat.No: T3614

Synonym: Groprinosin,Isoprinosine,异丙肌苷,Immunovir,Delimmun

Target: IL Receptor, HIV Protease

Cat.No: T26752

Synonym: BC 12,BC-12

Target: Others

OVA sequence (323-336)

Cat.No: TP1612

Synonym: OVA sequence 323-336

HPV16-E711-20 epitope

Cat.No: TP1515

Cat.No: T80573

NS2 (114-121), Influenza

Cat.No: T39292

Synonym: NS2 (114-121), Influenza

Cat.No: T27192

Synonym: DA-DKP,Ampion,DMI 9523,DM-9523

Target: Others

Cat.No: T77103

CFP10 (71–85)

Cat.No: T82743

ELAAWCRWGFLLALLPPGIAG TFA

Cat.No: T82484

Cat.No: T15337

Synonym: Immucillin-H,BCX-1777

Target: Apoptosis

ELAAWCRWGFLLALLPPGIAG

Cat.No: T82485

Cat.No: T77106

Cat.No: T76241

Cat.No: T77104

Cat.No: T16578

Target: Others

Cat.No: T76933

Cat.No: T78293

Cat.No: T77188

RORγt agonist 3

Cat.No: T64017

Target: Others

RORγt agonist 2

Cat.No: T64140

Target: Others

Cat.No: T85077

Target: Others

Cat.No: T83930

Target: Others

Cat.No: T83910

Synonym: Sphingosine-1-Phosphate Lyase Inhibitor 31,S1PL Inhibitor 31,S1P Lyase Inhibitor 31

Target: Others

Cat.No: T80066

Target: Potassium Channel

Cat.No: T37548

Synonym: azido-FTY720

Target: Others

Cat.No: T37052

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T20879	Tacrolimus monohydrate FK-506,FR 900506,Prograf,FR900506,Tacrolimus hydrate,LCP-Tacro,他克莫司一水合物,FK 506	Phosphatase; Others; Antibacterial; Antibiotic; Autophagy	Autophagy; Metabolism; Microbiology/Virology; Others
	Tacrolimus monohydrate (LCP-Tacro) 是大环内酯类化合物，它与 FK506 结合蛋白 (FKBP) 结合形成复合物并抑制钙调神经磷酸酶，从而抑制 T 淋巴细胞信号转导和 IL-2 转录。具有强免疫抑制特性。
T1257	Bestatin Ubenimex,乌苯美司	Others; Aminopeptidase; Antibacterial; Antibiotic; LTR	Immunology/Inflammation; Metabolism; Microbiology/Virology; Others
	Bestatin (Ubenimex) 是 CD13 (Aminopeptidase N)/APN 和 leukotriene A4 hydrolase 抑制剂，可用于癌症研究。

天然产物

Tacrolimus monohydrate

Cat.No: T20879

Synonym: FK-506,FR 900506,Prograf,FR900506,Tacrolimus hydrate,LCP-Tacro,他克莫司一水合物,FK 506

Target: Phosphatase, Others, Antibacterial, Antibiotic, Autophagy

Cat.No: T1257

Synonym: Ubenimex,乌苯美司

Target: Others, Aminopeptidase, Antibacterial, Antibiotic, LTR

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-01604	CTLA-4 Protein, Mouse, Recombinant (His) Ly-56,Cd152,cytotoxic T-lymphocy<...	Mouse	HEK293 Cells
	CTLA-4 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15.46 kDa and the accession number is Q6GTR6.
TMPH-03319	IL-17A Protein, Rat, Recombinant (His) Cytotoxic T-lymphocyte-a...	Rat	E. coli
	IL-17A Protein, Rat, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 21.0 kDa and the accession number is Q61453.
TMPY-05159	Granzyme A/GZMA Protein, Human, Recombinant (His) CTLA3,granzyme A (granzyme 1, cytot	Human	HEK293 Cells
	Granzyme A/GZMA Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 27.5 kDa and the accession number is P12544-1.
TMPJ-01172	IL-17 Protein, Mouse, Recombinant (His) CTLA8,IL-17,IL-17A,Interleukin-17A,CT<...	Mouse	HEK293 Cells
	Interleukin-17 is a potent pro-inflammatory cytokine produced by activated memory T cells. There are at least six members of the IL-17 family in humans and in mice. Mature mouse IL-17A shares 61% and 89% amino acid sequence identity with human and rat IL-17A, respectively. As IL-17 shares properties with IL-1 and TNF-alpha, it may induce joint inflammation and bone and cartilage destruction. This cytokine is found in synovial fluids of patients with rheumatoid arthritis, and produced by rheumato...
TMPY-04824	CTLA-4 Protein, Human, Recombinant CTLA-4,GSE,IDDM12,CELIAC3,ALPS5,CD,GRD4,cyt	Human	HEK293 Cells
	CTLA-4 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 13.5 kDa and the accession number is P16410-1.
TMPY-04348	CTLA-4 Protein, Human, Recombinant (His) ALPS5,CD152,GRD4,cytotoxic T-lymp...	Human	HEK293 Cells
	CTLA-4 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15 kDa and the accession number is P16410-1.
TMPY-04047	BTLA Protein, Rhesus, Recombinant (hFc) B and T lymphocyte associated	Rhesus	HEK293 Cells
	BTLA Protein, Rhesus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 41.4 kDa and the accession number is A0A8J8XCU2.
TMPY-05101	BTLA Protein, Rhesus, Recombinant (His) B and T lymphocyte associated	Rhesus	HEK293 Cells
	BTLA Protein, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 19.3 kDa and the accession number is A0A8J8XCU2.
TMPY-00461	BTLA Protein, Rat, Recombinant (mFc) B and T lymphocyte associated	Rat	HEK293 Cells
	BTLA Protein, Rat, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 43.4 kDa and the accession number is Q6PNM1-1.
TMPY-02557	CTLA-4 Protein, Rat, Recombinant (His) cytotoxic T-lymphocyte-a...	Rat	HEK293 Cells
	CTLA-4 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15.2 kDa and the accession number is Q62859.
TMPY-06923	BTLA Protein, Mouse, Recombinant (His) B and T lymphocyte associated,A63...	Mouse	HEK293 Cells
	BTLA Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 21.54 kDa and the accession number is AAI08964.1.
TMPY-00620	CTLA-4 Protein, Canine, Recombinant (hFc) cytotoxic T-lymphocyte-a...	Canine	HEK293 Cells
	CTLA-4 Protein, Canine, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 40.1 kDa and the accession number is A0A8C0TW59.
TMPY-03186	BTLA Protein, Mouse, Recombinant (hFc) B and T lymphocyte associated,A63...	Mouse	HEK293 Cells
	BTLA Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 43.75 kDa and the accession number is AAI08964.1.
TMPY-02411	CTLA-4 Protein, Canine, Recombinant (His) cytotoxic T-lymphocyte-a...	Canine	HEK293 Cells
	CTLA-4 Protein, Canine, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 14.8 kDa and the accession number is A0A8C0TW59.
TMPY-00817	Granzyme B/GZMB Protein, Human, Recombinant (His) CGL1,CTLA1,CSP-B,CTSGL1,HLP,SECT,...	Human	HEK293 Cells
	Granzyme B, also known as GZMB, is the most prominent member of the granzyme family of cell death-inducing serine proteases expressed in the granules of cytotoxic T lymphocytes (CTLs) and NK cells. Granzyme B enters the target cells depending on another membrane-binding granule protein, perforin, results in the activation of effector caspases and mitochondrial depolarization through caspase-dependent and -independent pathways, and consequently induces rapid cell apoptosis. Over 3 substrates of G...
TMPJ-00129	BTLA Protein, Human, Recombinant (His) B- and T-Lymphocyte-Associated Pr...	Human	HEK293 Cells
	B- and T-Lymphocyte Attenuator (BTLA) is a single-pass type I membrane protein containing 1 Ig-like V-type (immunoglobulin-like) domain. BTLA expression is induced during activation of T cells, and BTLA remains expressed on Th1 cells but not Th2 cells. Like PD1 and CTLA4, BTLA interacts with a B7 homolog, B7H4. However, unlike PD-1 and CTLA-4, BTLA displays T-Cell inhibition via interaction with tumor necrosis family receptors (TNF-R), not just the B7 family of cell surface receptors. BTLA is a ...
TMPJ-00635	CTLA-4 Protein, Cynomolgus, Recombinant (hFc) Cytotoxic T-lymphocyte-a...	Cynomolgus	HEK293 Cells
	CTLA-4 Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 45-60 KDa and the accession number is G7PL88.
TMPY-02492	CTLA-4 Protein, Rat, Recombinant (hFc) cytotoxic T-lymphocyte-a...	Rat	HEK293 Cells
	CTLA-4 Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 40.5 kDa and the accession number is Q62859.
TMPY-03589	CTLA4 Protein, Cynomolgus/Rhesus, Recombinant (His) cytotoxic T-lymphocyte-a...	Cynomolgus,Rhesus	HEK293 Cells
	CTLA4 Protein, Cynomolgus/Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 14.9 kDa and the accession number is Q9BDC4.
TMPY-03359	CTLA-4 Protein, Cynomolgus, Rhesus, Recombinant (hFc) cytotoxic T-lymphocyte-a...	Cynomolgus,Rhesus	HEK293 Cells
	CTLA-4 Protein, Cynomolgus, Rhesus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 40.4 kDa and the accession number is Q9BDC4.
TMPJ-00636	CTLA-4 Protein, Cynomolgus, Recombinant (His) Cytotoxic T-lymphocyte p...	Cynomolgus	HEK293 Cells
	CTLA-4 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 17-25 KDa and the accession number is G7PL88.
TMPJ-00640	CTLA-4 Protein, Cavia porcellus, Recombinant (His) Cytotoxic T-lymphocyte p...	Cavia porcellus	P. pastoris (Yeast)
	CTLA-4 Protein, Cavia porcellus, Recombinant (His) is expressed in P. pastoris yeast expression system with C-6xHis tag. The predicted molecular weight is 18-40 KDa and the accession number is H0VUB1.
TMPJ-00420	CTLA-4 Protein, Mouse, Recombinant (Flag) Cytotoxic T-lymphocyte p...	Mouse	HEK293 Cells
	Mouse Cytotoxic Tlymphocyte 4(CTLA-4,CD152), is a type I transmembrane T cell inhibitory molecule. Within the ECD, Mouse CTLA-4 shares 68% aa sequence identity with human. CTLA4 is similar to the T cell costimulatory protein CD28 since both of the molecules bind to CD80 and CD86 on antigen-presenting cells. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found inregulatory T cells and may play an important role in their fu...
TMPJ-00108	CTLA-4 Protein, Human, Recombinant (GST) Cytotoxic T-lymphocyte p...	Human	HEK293 Cells
	CTLA-4 Protein, Human, Recombinant (GST) is expressed in HEK293 mammalian cells with C-GST tag. The predicted molecular weight is 40-55 KDa and the accession number is P16410.
TMPJ-00107	CTLA-4 Protein, Human, Recombinant (Flag) Cytotoxic T-lymphocyte p...	Human	HEK293 Cells
	CTLA-4 Protein, Human, Recombinant (Flag) is expressed in HEK293 mammalian cells with C-Flag tag. The predicted molecular weight is 20 KDa and the accession number is P16410.
TMPY-06913	BTLA Protein, Human, Recombinant (His & Avi), Biotinylated BTLA1,B and T lymphocyte associa<...	Human	HEK293 Cells
	BTLA Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 17 kDa.
TMPY-06829	BTLA Protein, Human, Recombinant (isoform 1,mFc) BTLA1,CD272,B and T lymphocyte as...	Human	HEK293 Cells
	BTLA Protein, Human, Recombinant (isoform 1,mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 40.56 kDa and the accession number is NP_861445.4.
TMPY-06930	BTLA Protein, Human, Recombinant (isoform1,hFc) B and T lymphocyte associated,B	Human	HEK293 Cells
	BTLA Protein, Human, Recombinant (isoform1,hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 40.47 kDa and the accession number is NP_861445.4.
TMPY-06922	BTLA Protein, Human, Recombinant (isoform1, His) B and T lymphocyte associated,B	Human	HEK293 Cells
	BTLA Protein, Human, Recombinant (isoform1, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15.19 kDa and the accession number is NM_181780.4.
TMPY-00175	BTLA Protein, Human, Recombinant (hFc) BTLA1,B and T lymphocyte associa<...	Human	HEK293 Cells
	BTLA Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 38.8 kDa and the accession number is Q7Z6A9-2.
TMPY-05416	BTLA Protein, Human, Recombinant (hFc & Avi), Biotinylated BTLA1,CD272,B and T lymphocyte as...	Human	HEK293 Cells
	BTLA Protein, Human, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with hFc and Avi tag. The predicted molecular weight is 40.6 kDa and the accession number is Q7Z6A9-2.
TMPY-05828	BTLA Protein, Human, Recombinant (mFc) BTLA1,B and T lymphocyte associa<...	Human	HEK293 Cells
	BTLA Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 40.09 kDa and the accession number is AAP44003.1.
TMPY-04968	CTLA-4 Protein, Mouse, Recombinant (His), Biotinylated cytotoxic T-lymphocyte-a...	Mouse	HEK293 Cells
	CTLA-4 Protein, Mouse, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15.3 kDa and the accession number is Q6GTR6.
TMPJ-00959	B7-2 Protein, Rabbit, Recombinant (His) CD86,T-lymphocyte activat	Rabbit	HEK293 Cells
	B7-2 Protein, Rabbit, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 38-70 KDa and the accession number is P42071.
TMPY-01721	CTLA-4 Protein, Mouse, Recombinant (hFc) Ly-56,Ctla-4,Cd152,cytotoxic ...	Mouse	HEK293 Cells
	CTLA-4 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 41 kDa and the accession number is Q6GTR6.
TMPY-06326	CTLA-4 Protein, Mouse, Recombinant (His & Avi), Biotinylated cytotoxic T-lymphocyte-a...	Mouse	HEK293 Cells
	CTLA-4 Protein, Mouse, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 17.27 kDa and the accession number is NP_033973.2.
TMPJ-00329	CD19 Protein, Rhesus macaque, Recombinant (hFc) B-Lymphocyte Antigen CD19,CD19,Differen	Rhesus	HEK293 Cells
	CD19 is a single-pass type I membrane protein containing 2 Ig-like C2-type (immunoglobulin-like) domains. CD19 is expressed on follicular dendritic cells and B cells. In fact, it is present on B cells from earliest recognizable B-lineage cells during development to B-cell blasts but is lost on maturation to plasma cells. CD19 primarily acts as a B cell co-receptor in conjunction with CD21 and CD81. Upon activation, the cytoplasmic tail of CD19 becomes phosphorylated, which leads to binding by Sr...
TMPJ-00630	B7-1 Protein, Cynomolgus, Recombinant (hFc) B7,CD80,T-lymphocyte activat<...	Cynomolgus	HEK293 Cells
	Cynomologous Cluster of Differentiation 80, also called B7-1, is a member of cell surface immunoglobulin superfamily.It is expressed on the surface of antigen-presenting cells including activated B cells, macrophages and dendritic cells.CD80 plays key, yet distinct roles in the activation of T cells. B7-1/CD80 and B7-2/CD86, together with their receptors CD28 and CTLA4, constitute one of the dominant co-stimulatory pathways that regulate T- and B- cell responses. CD80 is mostly expressed on the ...
TMPJ-00641	B7-2 Protein, Rhesus macaque, Recombinant (His) Activation B7-2 antigen,T	Rhesus	HEK293 Cells
	B7-2 Protein, Rhesus macaque, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 40-90 KDa and the accession number is H9ZFI8.
TMPJ-00632	B7-2 Protein, Cynomolgus, Recombinant (hFc) T-lymphocyte activation ...	Cynomolgus	HEK293 Cells
	B7-2 Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 70-100 KDa and the accession number is G7NXR4.
TMPJ-00958	B7-1 Protein, Rabbit, Recombinant (His) Activation B7-1 antigen,T	Rabbit	HEK293 Cells
	Cluster of Differentiation 80, also called B7-1, is a member of cell surface immunoglobulin superfamily which plays key, yet distinct roles in the activation of T cells. B7-1/CD80 and B7-2/CD86, together with their receptors CD28 and CTLA4, constitute one of the dominant co-stimulatory pathways that regulate T- and B- cell responses. CD80 is mostly expressed on the surface of antigen-presenting cells including activated B cells, macrophages and dendritic cells. Although both CTLA-4 and CD28 can ...
TMPH-01412	Granzyme B Protein, Human, Recombinant (E. coli, His) Cytotoxic T-lymphocyte p...	Human	E. coli
	Granzyme B Protein, Human, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 31.0 kDa and the accession number is P10144.
TMPJ-01444	IL-17A Protein, Cynomolgus, Recombinant (His) CTLA-8,CTLA8,IL17A,IL-17,IL-17A,Cyt	Cynomolgus	HEK293 Cells
	Interleukin-17 is a potent pro-inflammatory cytokine produced by activated memory T cells. There are at least six members of the IL-17 family in humans and in mice. As IL-17 shares properties with IL-1 and TNF-alpha, it may induce joint inflammation and bone and cartilage destruction. This cytokine is found in synovial fluids of patients with rheumatoid arthritis, and produced by rheumatoid arthritis synovium. It increases IL-6 production, induces collagen degradation and decreases collagen synt...
TMPJ-00359	SLAMF3 Protein, Human, Recombinant (His) Signaling lymphocytic activation ...	Human	HEK293 Cells
	SLAMF3 (CD229) is a type I transmembrane glycoprotein in the SLAM subgroup of the CD2 family. Mature human SLAMF3 consists of a 407 amino acid (aa) extracellular domain (ECD) with two Ig-like V-set and two Ig-like truncated C2-set domains. The ECD of human SLAMF3 shares 57% - 59% aa sequence identity with mouse and rat SLAMF3. Within the first two Ig-like domains that are common to all SLAM proteins, human SLAMF3 shares 24% - 39% aa sequence identity with human 2B4, BLAME, CD2F-10, CD84, CRACC, ...
TMPY-01804	CD229 Protein, Mouse, Recombinant (His) T100,SLAMF3,CD229,AI893573,Lgp100,lymphocyt	Mouse	HEK293 Cells
	CD229 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 46.5 kDa and the accession number is Q01965.
TMPJ-01154	SLAMF3 Protein, Mouse, Recombinant (His) SLAM family member 3,T-lymphocyte surface ...	Mouse	HEK293 Cells
	CD229(SLAMF3) is a type I transmembrane glycoprotein in the SLAM subgroup of the CD2 family. Mature mouse CD229 consists of a 406 aa extracellular domain (ECD) with two Ig-like V-set and two Ig-like truncated C2-set domains, a 21 aa transmembrane segment, and a 180 aa cytoplasmic domain with two immunoreceptor tyrosinebased switch motifs ITSMs. Within the first two Ig-like domains that are common to all SLAM proteins, mouse CD229 shares 22%-36% aa sequence identity with mouse 2B4, BLAME, CD2F10,...
TMPY-06824	CTLA-4 Protein, Human, Recombinant (hFc & Avi), Biotinylated CD152,cytotoxic T-lymphocyt	Human	HEK293 Cells
	CTLA-4 Protein, Human, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with hFc and Avi tag. The predicted molecular weight is 42.89 kDa and the accession number is NP_005205.2.
TMPY-04948	CTLA-4 Protein, Human, Recombinant (His), Biotinylated GSE,ALPS5,GRD4,IDDM12,cytotoxic T...	Human	HEK293 Cells
	CTLA-4 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15 kDa and the accession number is P16410-1.
TMPY-04998	CTLA-4 Protein, Human, Recombinant (rFc) GRD4,CELIAC3,ALPS5,CD,CTLA-4,CD152,cyto	Human	HEK293 Cells
	CTLA-4 Protein, Human, Recombinant (rFc) is expressed in HEK293 mammalian cells with rFc tag. The predicted molecular weight is 39.7 kDa and the accession number is P16410-1.
TMPY-05002	CTLA-4 Protein, Human, Recombinant (hFc) CD,cytotoxic T-lymphocyt...	Human	HEK293 Cells
	CTLA-4 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 40.7 kDa and the accession number is P16410-1.
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重组蛋白

CTLA-4 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-01604

Species: Mouse

Expression System: HEK293 Cells

IL-17A Protein, Rat, Recombinant (His)

Cat.No: TMPH-03319

Species: Rat

Expression System: E. coli

Granzyme A/GZMA Protein, Human, Recombinant (His)

Cat.No: TMPY-05159

Species: Human

Expression System: HEK293 Cells

IL-17 Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-01172

Species: Mouse

Expression System: HEK293 Cells

CTLA-4 Protein, Human, Recombinant

Cat.No: TMPY-04824

Species: Human

Expression System: HEK293 Cells

CTLA-4 Protein, Human, Recombinant (His)

Cat.No: TMPY-04348

Species: Human

Expression System: HEK293 Cells

BTLA Protein, Rhesus, Recombinant (hFc)

Cat.No: TMPY-04047

Species: Rhesus

Expression System: HEK293 Cells

BTLA Protein, Rhesus, Recombinant (His)

Cat.No: TMPY-05101

Species: Rhesus

Expression System: HEK293 Cells

BTLA Protein, Rat, Recombinant (mFc)

Cat.No: TMPY-00461

Species: Rat

Expression System: HEK293 Cells

CTLA-4 Protein, Rat, Recombinant (His)

Cat.No: TMPY-02557

Species: Rat

Expression System: HEK293 Cells

BTLA Protein, Mouse, Recombinant (His)

Cat.No: TMPY-06923

Species: Mouse

Expression System: HEK293 Cells

CTLA-4 Protein, Canine, Recombinant (hFc)

Cat.No: TMPY-00620

Species: Canine

Expression System: HEK293 Cells

BTLA Protein, Mouse, Recombinant (hFc)

Cat.No: TMPY-03186

Species: Mouse

Expression System: HEK293 Cells

CTLA-4 Protein, Canine, Recombinant (His)

Cat.No: TMPY-02411

Species: Canine

Expression System: HEK293 Cells

Granzyme B/GZMB Protein, Human, Recombinant (His)

Cat.No: TMPY-00817

Species: Human

Expression System: HEK293 Cells

BTLA Protein, Human, Recombinant (His)

Cat.No: TMPJ-00129

Species: Human

Expression System: HEK293 Cells

CTLA-4 Protein, Cynomolgus, Recombinant (hFc)

Cat.No: TMPJ-00635

Species: Cynomolgus

Expression System: HEK293 Cells

CTLA-4 Protein, Rat, Recombinant (hFc)

Cat.No: TMPY-02492

Species: Rat

Expression System: HEK293 Cells

CTLA4 Protein, Cynomolgus/Rhesus, Recombinant (His)

Cat.No: TMPY-03589

Species: Cynomolgus,Rhesus

Expression System: HEK293 Cells

CTLA-4 Protein, Cynomolgus, Rhesus, Recombinant (hFc)

Cat.No: TMPY-03359

Species: Cynomolgus,Rhesus

Expression System: HEK293 Cells

CTLA-4 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPJ-00636

Species: Cynomolgus

Expression System: HEK293 Cells

CTLA-4 Protein, Cavia porcellus, Recombinant (His)

Cat.No: TMPJ-00640

Species: Cavia porcellus

Expression System: P. pastoris (Yeast)

CTLA-4 Protein, Mouse, Recombinant (Flag)

Cat.No: TMPJ-00420

Species: Mouse

Expression System: HEK293 Cells

CTLA-4 Protein, Human, Recombinant (GST)

Cat.No: TMPJ-00108

Species: Human

Expression System: HEK293 Cells

CTLA-4 Protein, Human, Recombinant (Flag)

Cat.No: TMPJ-00107

Species: Human

Expression System: HEK293 Cells

BTLA Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPY-06913

Species: Human

Expression System: HEK293 Cells

BTLA Protein, Human, Recombinant (isoform 1,mFc)

Cat.No: TMPY-06829

Species: Human

Expression System: HEK293 Cells

BTLA Protein, Human, Recombinant (isoform1,hFc)

Cat.No: TMPY-06930

Species: Human

Expression System: HEK293 Cells

BTLA Protein, Human, Recombinant (isoform1, His)

Cat.No: TMPY-06922

Species: Human

Expression System: HEK293 Cells

BTLA Protein, Human, Recombinant (hFc)

Cat.No: TMPY-00175

Species: Human

Expression System: HEK293 Cells

BTLA Protein, Human, Recombinant (hFc & Avi), Biotinylated

Cat.No: TMPY-05416

Species: Human

Expression System: HEK293 Cells

BTLA Protein, Human, Recombinant (mFc)

Cat.No: TMPY-05828

Species: Human

Expression System: HEK293 Cells

CTLA-4 Protein, Mouse, Recombinant (His), Biotinylated

Cat.No: TMPY-04968

Species: Mouse

Expression System: HEK293 Cells

B7-2 Protein, Rabbit, Recombinant (His)

Cat.No: TMPJ-00959

Species: Rabbit

Expression System: HEK293 Cells

CTLA-4 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPY-01721

Species: Mouse

Expression System: HEK293 Cells

CTLA-4 Protein, Mouse, Recombinant (His & Avi), Biotinylated

Cat.No: TMPY-06326

Species: Mouse

Expression System: HEK293 Cells

CD19 Protein, Rhesus macaque, Recombinant (hFc)

Cat.No: TMPJ-00329

Species: Rhesus

Expression System: HEK293 Cells

B7-1 Protein, Cynomolgus, Recombinant (hFc)

Cat.No: TMPJ-00630

Species: Cynomolgus

Expression System: HEK293 Cells

B7-2 Protein, Rhesus macaque, Recombinant (His)

Cat.No: TMPJ-00641

Species: Rhesus

Expression System: HEK293 Cells

B7-2 Protein, Cynomolgus, Recombinant (hFc)

Cat.No: TMPJ-00632

Species: Cynomolgus

Expression System: HEK293 Cells

B7-1 Protein, Rabbit, Recombinant (His)

Cat.No: TMPJ-00958

Species: Rabbit

Expression System: HEK293 Cells

Granzyme B Protein, Human, Recombinant (E. coli, His)

Cat.No: TMPH-01412

Species: Human

Expression System: E. coli

IL-17A Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPJ-01444

Species: Cynomolgus

Expression System: HEK293 Cells

SLAMF3 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00359

Species: Human

Expression System: HEK293 Cells

CD229 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-01804

Species: Mouse

Expression System: HEK293 Cells

SLAMF3 Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-01154

Species: Mouse

Expression System: HEK293 Cells

CTLA-4 Protein, Human, Recombinant (hFc & Avi), Biotinylated

Cat.No: TMPY-06824

Species: Human

Expression System: HEK293 Cells

CTLA-4 Protein, Human, Recombinant (His), Biotinylated

Cat.No: TMPY-04948

Species: Human

Expression System: HEK293 Cells

CTLA-4 Protein, Human, Recombinant (rFc)

Cat.No: TMPY-04998

Species: Human

Expression System: HEK293 Cells

CTLA-4 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-05002

Species: Human

Expression System: HEK293 Cells

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