395
58
2
431
6
Cat. No. | Product Name | ||
---|---|---|---|
L9420 | 外泌体相关化合物库 | 76 compounds | |
76 种外泌体相关的化合物,可以用于高通量和高内涵筛选; | |||
L2170 | 肿瘤免疫治疗小分子化合物库 | 449 compounds | |
449 种靶向肿瘤免疫治疗靶点的小分子,可用于高通量和高内涵筛选,是研究肿瘤免疫治疗的有力工具; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T9919 |
Alemtuzumab
|
Others | Others |
Alemtuzumab 是人源化抗 CD52单克隆抗体, CD52是一种表达于大多数淋巴细胞以及少数的髓细胞类型的糖蛋白。Alemtuzumab 与能够特异性作用于 CD52 抗原,诱导淋巴细胞深度耗竭,恢复具有调节表型的 T 细胞和 B 细胞。 | |||
T13173 |
TMPA
|
Others; AMPK | Chromatin/Epigenetic; Others; PI3K/Akt/mTOR signaling |
TMPA 是一种核受体 Nur77 和 LKB1 相互作用的拮抗剂。 | |||
T9720 |
T3Inh-1
|
Others | Others |
T3Inh-1 是一种有效的选择性 ppGalNAc-T3 抑制剂,IC50 为 7 µM。 T3Inh-1 可预防乳腺癌细胞。 T3Inh-1 降低组织细胞和小鼠中的 FGF23 激素水平,而不会引起任何毒副作用。 | |||
T16111 |
ML604086
|
CCR | Immunology/Inflammation; Microbiology/Virology |
ML604086 是选择性CCR8抑制剂,抑制循环T 细胞上 CCL1 与 CCR8 结合,还抑制 CCL1 介导的趋化性并提高细胞内 Ca2 浓度。 | |||
T10425 |
AZ084
|
CCR | Immunology/Inflammation; Microbiology/Virology |
AZ084 是可口服的选择性 CCR8变构拮抗剂,其Ki 值为 0.9 nM,可研究哮喘。 | |||
T16133 |
MRK-560
|
Gamma-secretase | Neuroscience; Proteases/Proteasome; Stem Cells |
MRK-560 是高效的、口服有效的 γ- 分泌酶抑制剂抑制剂,具有大脑屏障渗透性。 | |||
T6255 |
Bromosporine
|
Epigenetic Reader Domain; CDK | Cell Cycle/Checkpoint; Chromatin/Epigenetic |
Bromosporine 是广谱 BRD2/4/9 和 CECR2 溴结构域抑制剂,IC50为0.41、0.29、0.122和0.017 μM。 | |||
T2648 |
Pimecrolimus
SDZ-ASM 981,ASM 981,吡美莫司 |
Others | Others |
Pimecrolimus (SDZ-ASM 981) 是一种免疫亲和素配体,能与胞质受体特异性的结合。 | |||
T6540 |
Ibuprofen Lysine
布洛芬赖氨酸盐,Neoprofen |
COX | Immunology/Inflammation; Neuroscience |
Ibuprofen Lysine (Neoprofen) 是一种非甾体抗炎药。 | |||
T1394 |
Ibuprofen
Brufen,(±)-Ibuprofe,布洛芬,Motrin,Advil |
COX | Immunology/Inflammation; Neuroscience |
Ibuprofen (Advil) 是一种丙酸衍生物和非甾体抗炎药 (NSAID),具有抗炎、镇痛和解热作用。它是COX-1和COX-2的抑制剂,IC50值分别为 13 和 370 μM,导致前列腺素和血栓素前体的形成减少。 | |||
T1389 |
Dyclonine hydrochloride
盐酸达克罗宁,Dyclocaine hydrochloride,Dyclonine HCl |
Sodium Channel; Antibacterial; Antifungal | Membrane transporter/Ion channel; Microbiology/Virology |
Dyclonine hydrochloride (Dyclonine HCl) 是润喉片的有效成分,具有显著的杀菌和杀真菌作用。 | |||
T4976 |
Umbralisib
TGR-1202,RP5264,TGR 1202,TGR1202 |
PI3K | PI3K/Akt/mTOR signaling |
Umbralisib (TGR 1202) 是一种PI3Kδ抑制剂,IC50=22.2 nM,EC50=24.3 nM。它同时可抑制CK1ε,EC50=6.0 μM。 | |||
T5863 |
Indinavir sulfate
L735524 sulfate,MK-639 sulfate,硫酸茚地那韦 |
SARS-CoV; HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Indinavir sulfate (L735524 sulfate) 是一种 HIV 蛋白酶抑制剂。它抑制 HIV-1 蛋白酶,IC50 值为 0.41 nM,Ki 值为 0.24 nM。它也是SARS-CoV 3CLpro 抑制剂,IC50为 1.71 μM。 | |||
T76674 |
Cibisatamab
|
Others | Others |
Cibisatamab 是一种 T 细胞双特异性抗体,可被当作 T 细胞接合器。Cibisatamab 靶向癌细胞上的癌胚抗原 (CEA) 和 T 细胞上的 CD3,当癌细胞表面的 CEA从中等水平到高水平会触发 T 细胞杀伤。Cibisatamab 可用于研究结直肠癌类的实体癌。 | |||
T35362 |
NSC622608
|
Others | Others |
NSC622608 是 V 域 Ig 抑制 T 细胞活化 (VISTA) 的小分子配体,VISTA 是影响 T 细胞攻击肿瘤能力的免疫检查点。 | |||
T76692 |
Mosunetuzumab
BTCT-4465A |
Others | Others |
Mosunetuzumab (BTCT-4465A) 是一种基于免疫球蛋白 G1 且靶向 CD20 (B 细胞) 和 CD3 (T 细胞) 的人源化抗体。Mosunetuzumab 重定向 T 细胞以接合和消除恶性 B 细胞,可用于研究复发或难治性 (R/R) B 细胞非霍奇金淋巴瘤 (B-NHL)和难治性滤泡性淋巴瘤。 | |||
T37587 |
ML 209
|
ROR | Metabolism |
ML-209 是一种视黄酸相关的孤儿受体 RORγ 拮抗剂 (IC50= 1.1 μM)。ML-209 抑制 HEK293t 细胞中 RORγt 转录活性(IC50= 300 nM)。ML-209 不抑制细胞中 RORα。ML-209 对鼠 Th17 细胞分化具有选择性抑制,而不影响幼稚 CD4+ T 细胞分化为 Th1 和调节性 T 细胞。 | |||
T77170 |
Siplizumab
MEDI-507 |
Others | Others |
Siplizumab (MEDI-507) 是一种人源化靶向 CD2 的 IgG1 单克隆抗体。Siplizumab 在体外选择性地消耗效应记忆 T 细胞并促进同种异体反应性调节性 T 细胞的相对扩增。Siplizumab 可用于治疗斑块状银屑病。 | |||
TP1541L |
BDC2.5 mimotope 1040-31 acetate
BDC2.5 mimotope 1040-31 acetate(329696-49-3 free base) |
Others | Others |
BDC2.5 mimotope 1040-31 acetate(329696-49-3 free base) 一种用于致糖尿病 T 细胞克隆 BDC2.5 的有效激动肽 (mimotope)。它可以刺激 BDC2.5 细胞,使细胞对这种模拟表位表现出良好的反应。 1040-31 肽对 BDC2.5 TCR Tg+(转基因)T 细胞具有特异性。该肽也称为 p31。 | |||
T67892 |
BTB09089
GPR65 agonist (BTB09089) |
GPR; DNA | DNA Damage/DNA Repair; Endocrinology/Hormones; GPCR/G Protein |
BTB09089 (GPR65 agonist ) 是一种 T 细胞死亡相关基因 8 (TDAG8/GPR65) 特异性激动剂。BTB09089 诱导TDAG8 的表达,对 T 细胞和巨噬细胞细胞因子的产生进行调节。 | |||
T9104 |
TJ191
|
Apoptosis | Apoptosis |
TJ191 是一种选择性抗癌试剂,靶向低 TβRIII 表达的恶性T 细胞白血病/淋巴瘤细胞,可研究癌症。 | |||
T76924 |
Efalizumab
Hu1124,HU 1124 |
Integrin | Cytoskeletal Signaling |
Efalizumab 是一种新型针对 T 细胞的有效调节剂,是人源化 LFA-1 α 亚基(CD11a)单克隆抗体。Efalizumab 对 T 细胞激活、皮肤T细胞运输和T细胞粘附到角质形成细胞有抑制作用,可用于研究斑块银屑病和银屑病关节炎。 | |||
T25705 |
Imupedone
LF1695,LF-1695,LF 1695 |
Others | Others |
Imupedone (LF 1695) 是一种合成免疫调节剂,可调节 T 淋巴细胞和巨噬细胞,诱导骨髓前体细胞的 T 细胞分化,增加淋巴细胞对有丝分裂原、抗原和同种异体细胞的增殖反应。 | |||
T77761 |
BMS-502
|
Others | Others |
BMS-502 是一种二酰基甘油激酶 (DGK) α 和 ζ 的强效双重抑制剂, 诱导人和小鼠T细胞的免疫反应,阻断 T 细胞中细胞内检查点信号传导。BMS-502 以剂量依赖的方式刺激免疫反应,可用于研究与免疫相关的疾病。 | |||
T11782 |
KRN2 bromide
|
Others | Others |
KRN2 bromide 是有效的、选择性的 T 细胞激活核因子 (NFAT5) 的抑制剂 (IC50= 100 nM)。KRN2 bromide 可用于研究 NFAT5-介导的慢性关节炎。 | |||
T30077 |
Anisperimus
LF 150195,LF-150195,LF 15-0195,LF-15-0195,LF15-0195 |
Caspase | Apoptosis; Proteases/Proteasome |
Anisperimus (LF 15-0195) 是一种免疫抑制剂,通过促进 DISC 水平的 caspase-8 和 caspase-10 激活来增强激活诱导的 T 细胞死亡,通过促进表达 Foxp3 的调节性 CD4 T 细胞的发育来预防中枢神经系统自身免疫。 | |||
T4665 |
Temsavir
BMS626529 |
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Temsavir (BMS626529) 是一种新型附着抑制剂,靶向 HIV-1 gp120 并阻止其与 CD4+ T 细胞结合。 | |||
T8546 |
BD750
|
JAK; STAT | Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells |
BD750 是免疫抑制剂和JAK3/STAT5的抑制剂,可抑制 IL-2 诱导的、JAK3/STAT5 依赖的 T 细胞增殖,对小鼠和人 T 细胞增殖的IC50值分别为 1.5 和 1.1 μM。 | |||
T76782 |
Mogamulizumab
KW-0761 |
CXCR | Autophagy; GPCR/G Protein; Immunology/Inflammation |
Mogamulizumab (KW-0761) 是一种针对 T 细胞 CC 趋化因子受体 4 的 单克隆抗体。Mogamulizumab 具有抗癌活性,通过抗体依赖性细胞毒性 (ADCC) 消除肿瘤细胞,可用于研究癌症、成人T细胞白血病/淋巴瘤 (ATLL)、皮肤T细胞淋巴瘤(CTCL)。 | |||
T72482 |
Dazostinag disodium
|
STING | Immunology/Inflammation |
Dazostinag disodium (TAK-676) 是一种新型干扰素基因刺激剂 (STING) 激动剂,也是一种免疫系统调节剂,具有抗肿瘤活性,可激活树突状细胞、自然杀伤细胞和 T 细胞。 | |||
T76882 |
Talquetamab
JNJ-64407564,JNJ-7564 |
Dopamine Receptor | GPCR/G Protein; Neuroscience |
Talquetamab (JNJ-64407564)是一种用于多发性骨髓瘤的 T 细胞重定向 GPRC5D 双特异性抗体,具有抗肿瘤活性,通过T 细胞的募集和活化诱导 T 细胞介导的杀死表达 GPRC5 的 MM 细胞。Talquetamab 可用于治疗多发性骨髓瘤 (MM)。 | |||
TNU0430 |
N6-(p-Methoxybenzyl)adenosine
|
Nucleoside Antimetabolite/Analog | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
N6-(p-Methoxybenzyl)adenosine 是一种腺嘌呤核苷类似物,在 U87MG 神经胶质瘤细胞中显示出体外抗增殖活性,在来自受刺激外周血单核细胞 (PBMC) 的离体 γδ T 细胞中表现出免疫原性。 | |||
T29857 |
Alethine
β-Alethine |
TNF | Apoptosis |
Alethine (β-Alethine) 是一种小分子化合物,具有抗肿瘤活性,可用于治疗肿瘤和感染。 Alethine 诱导的TNFα上调增加T 细胞的细胞毒性。 | |||
T3548 |
Epacadostat
INCB 024360,艾卡哚司他,IDO Inhibitor 1 |
IDO; Indoleamine 2,3-Dioxygenase (IDO) | Metabolism |
Epacadostat (INCB 024360) 是选择性的IDO1抑制剂,IC50=71.8 nM。 | |||
T11447 |
GNF4877
|
GSK-3; DYRK | Cell Cycle/Checkpoint; PI3K/Akt/mTOR signaling; Stem Cells; Tyrosine Kinase/Adaptors |
GNF4877 是一种 DYRK1A (IC50:6 nM) 和 GSK3β (IC50:16 nM) 抑制剂。 它导致激活 T 细胞核因子核输出的阻断和 β 细胞增殖细胞增加。 | |||
TP1978L |
NFAT inhibitor, Cell Permeable aceate
|
Others | Others |
NFAT inhibitor, Cell Permeable aceate 是一种细胞可渗透的活化 T 细胞核因子 (NFAT) 抑制剂。 可用于足细胞和糖尿病肾病的研究。 | |||
T36944 |
Ara-G
|
Nucleoside Antimetabolite/Analog | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
Ara-G 是一种脱氧鸟苷 (GdR) 类似物和核苷类似物,可被 T 淋巴谱系细胞迅速转化为其相应的阿拉伯糖基鸟嘌呤核苷酸三磷酸 (araGTP),从而抑制 DNA 合成和对 T 淋巴母细胞的选择性体外毒性细胞系以及来自 T 细胞急性淋巴细胞白血病 (ALL) 患者的新鲜分离的白血病细胞。 | |||
T35569 |
CTA 056
|
Apoptosis | Apoptosis |
CTA 056 是白细胞介素-2 诱导的 T 细胞激酶(ITK)抑制剂,抑制小鼠 MOLT-4 异种移植肿瘤的生长,诱导 Jurkat 细胞凋亡,可用于研究自身免疫性疾病和T细胞恶性肿瘤。 | |||
T28903 |
T-3364366
T 3364366,T3364366 |
Others | Others |
T-3364366 是一种噻吩并嘧啶酮 delta-5 去饱和酶 (Δ5D) 抑制剂,在 HepG2 和 RLN-10 细胞中的 IC50 分别为 1.9 nM 和 2.1 nM。 | |||
TP1600L |
Iα52 acetate(137756-45-7 free base)
|
Others | Others |
Iα52 acetate(137756-45-7 free base) 是一种天然加工的肽,包含鼠 I-Eα 链的 52-68 位残基,可能有助于选择未成熟的 T 细胞。 | |||
TP1549L |
NY-BR-1 p904 A2 acetate(347142-73-8 free base)
|
Others | Others |
NY-BR-1 p904 A2 acetate(347142-73-8 free base) 对这种 NY-BR-1 表位 (p904) 特异的 T 细胞克隆可以识别表达 NY-BR-1 的乳腺肿瘤细胞。 | |||
T71703L |
Isomer-Turosteride
Isomer-Turosteride(Isomer-137099-09-3) |
Reductase | Endocrinology/Hormones; Metabolism |
Isomer-Turosteride (Isomer-Turosteride(Isomer-137099-09-3)) 是一种新型 5α- 还原酶抑制剂。Isomer-Turosteride 在成年大鼠中的抗前列腺作用与抑制T向 DHT 的转化有关。Isomer-Turosteride引起前列腺 DHT 的降低,与 T 含量的继发性增加无关。Isomer-Turosteride 具有抗癌活性,可抑制肿瘤细胞的生长。 | |||
T10165L |
5-A-RU hydrochloride
5-Amino-6-(D-ribitylamino)uracil hydrochloride |
Others | Others |
5-A-RU hydrochloride (5-Amino-6-(D-ribitylamino)uracil hydrochloride) 是细菌核黄素的中间体,可激活粘膜相关不变 T 细胞(MAIT)。5-A-RU 可用于研究乳腺癌和前列腺癌。 | |||
T77369 |
Telazorlimab
ISB-830,GBR-830 |
Immunology/Inflammation related | Immunology/Inflammation |
Telazorlimab (GBR-830) 是一种靶向活化 T 细胞上 OX40 共刺激受体的人源化单克隆抗体。Telazorlimab 可用于治疗红斑狼疮和特应性皮炎。 | |||
T24398 |
Lenaldekar
LDK |
Akt; IGF-1R; S6 Kinase | Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors |
Lenaldekar (LDK) 抑制 T 细胞扩增和自身免疫性脑脊髓炎。 Lenaldekar 导致 PI3 激酶/AKT/mTOR 通路成员的去磷酸化并延迟有丝分裂晚期的敏感细胞。 | |||
TQ0007 |
Cintirorgon
LYC-55716 |
ROR | Metabolism |
Cintirorgon (LYC-55716) 是一种首创的、口服有活力的的RORγ选择性激动剂。它通过调节 RORγ 表达的 T 淋巴免疫细胞的基因表达,提高效应子功能,降低免疫抑制,抑制肿瘤生长,提高生存率。 | |||
T77471 |
Tinurilimab
BAY 1834942 |
||
Tinurilimab (Bay 1834942) 是一种单克隆抗体,靶向并抑制 CEACAM6,CEACAM6 属于免疫检查点调节剂。 Tinurilimab 可用于效应 T 细胞对抗肿瘤的研究。 | |||
T3521 |
γ-Secretase-IN-1
Compound E |
Beta Amyloid; Gamma-secretase | Neuroscience; Proteases/Proteasome; Stem Cells |
γ-Secretase-IN-1 是一种高效的 γ-secretase 抑制剂,对T-47D 细胞显示部分抗增殖活性且抑制 β-amyloid(40),β-amyloid(42),和Notch γ-分泌酶裂解。 | |||
T35885 |
KRM-III
|
Others | Others |
KRM-III 是一种具有口服活性的 T 细胞抗原受体 (TCR) 抑制剂,具有抗炎活性,可有效抑制 TCR 和肉豆蔻酸乙酸酯/佛波霉素/离子霉素诱导的 NFAT 核因子活化和 T 细胞增殖,IC50 约为 5 μM。 | |||
T77760 |
BMS-684
|
Others | Others |
BMS-684 是一种选择性和高效性的 DGKα 抑制剂(IC50:15 nM),具有潜在的抗肿瘤活性,BMS-684 抑制 DGKα 激酶、DGKβ 和 DGKγ。BMS-684 可激活T细胞,可预防和治疗免疫相关疾病。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN1768 |
Iriflophenone
|
Estrogen Receptor/ERR; Estrogen/progestogen Receptor | Endocrinology/Hormones |
Iriflophenone 是从 Aquilaria sinensis 中分离得到,能诱导 MCF-7 和 T-47D 人乳腺癌细胞增殖。 | |||
T10183 |
6-Methoxytricin
|
Reductase | Endocrinology/Hormones; Metabolism |
6-Methoxytricin 是从积雪草中分离的黄酮类化合物,是醛糖还原酶 (AR) 和晚期糖基化终产物 (AGE) 的抑制剂,抑制生物细胞中的T细胞增殖和活化。 | |||
T6S1885 |
Benzoylmesaconine
Mesaconine 14-benzoate,苯甲酰新乌头原碱 |
Others | Others |
Benzoylmesaconine (Mesaconine 14-benzoate) 是乌头汤最丰富的组分。其中乌头汤可用于研究类风湿性关节炎。 | |||
T14854 |
Caerulomycin A
浅蓝霉素,Cerulomycin,Caerulomycin |
Antifungal | Microbiology/Virology |
Caerulomycin A (Caerulomycin) 是抗真菌和抗细菌化合物,能够诱导 T 细胞的产生。它能够抑制 IFN-γ 诱导的 STAT1 通路,从而增强 TGF-β-Smad3 信号通路。它可用于自身免疫病的研究。 | |||
TN1110 |
Shanziside
山栀苷,Shanzhiside |
IL Receptor | Immunology/Inflammation |
Shanziside (Shanzhiside) 是一种分离自福洛美属植物中的环烯醚萜苷类化合物。 | |||
T5681 |
ETHYL CAFFEATE
咖啡酸乙酯,ETHYL 3,4-DIHYDROXYCINNAMATE |
NF-κB; COX; PGE Synthase; NO Synthase | Immunology/Inflammation; Neuroscience; NF-κB |
Ethyl Caffeate (ETHYL 3,4-DIHYDROXYCINNAMATE) 是从鬼针草分离的一种酚类天然产物,在体外或在小鼠皮肤中抑制NF-κB 活化及其下游炎症介质的诱导型一氧化氮合酶、环氧合酶 2 和前列腺素 E2。 | |||
T14193 |
α-Galactosylceramide
KRN7000,α-GalCer |
Others | Others |
α-Galactosylceramide (KRN7000) 是一种具有抗肿瘤和免疫刺激作用的合成糖脂。它是一种高效的 NKT 细胞激动剂,可与 CD1d 有效结合。它与 CD1d 的复合物可与 NKT 细胞的 T 细胞抗原受体结合。 | |||
TL0013 |
Heraclenin
独活内酯 |
Anti-infection; Immunology/Inflammation related | Immunology/Inflammation; Microbiology/Virology |
Heraclenin 是一种天然呋喃香豆素。它浓度依赖性的靶向激活的 T 细胞核因子 (NFAT) ,抑制人原代 T 细胞中 T 细胞受体介导的增殖。 | |||
TN6393 |
fulvotomentoside A
|
Others | Others |
fulvotomentoside A 可降低肠道中 IL-6 和 IL-17A 的过表达,并显着增加调节性 T 细胞特异性转录因子 Foxp3 的表达。这可能是Ful 改善肠道炎症的机制之一。 | |||
TQ0131 |
Rocaglamide
Rocaglamide A,楝酰胺,Roc-A |
HSP; NF-κB; PERK | Apoptosis; Cytoskeletal Signaling; Metabolism; NF-κB |
Rocaglamide (Roc-A) 是从米仔兰中分离出来的一种天然产物,具有抗癌特性,可用于咳嗽,受伤,哮喘和炎症性皮肤病。它是一种有效的选择性热休克因子 1 活化抑制剂,IC50约为 50 nM。它是 T 细胞中 NF-κB 活化的有效抑制剂,还抑制翻译起始因子eIF4A 的功能。 | |||
TN3209 |
3′,4′,7-Trihydroxyflavone
|
ATPase; Others; p38 MAPK; NF-κB | MAPK; Membrane transporter/Ion channel; NF-κB; Others |
3',4',7-Trihydroxyflavone 是分离自蚕豆荚的黄酮苷元化合物。 | |||
TN2244 |
Sulfuretin
硫黄菊素 |
NF-κB; Autophagy | Autophagy; NF-κB |
Sulfuretin 是竞争性单酚酶和二酚酶活性抑制剂,IC50=13.64 μM。它通过抑制NF-κB 通路来抑制炎症反应。 它可用于过敏性气道炎症的研究。它减少氧化应激、血小板聚集和诱变。 | |||
T1257 |
Bestatin
Ubenimex,乌苯美司 |
Others; Aminopeptidase; Antibacterial; Antibiotic; LTR | Immunology/Inflammation; Metabolism; Microbiology/Virology; Others |
Bestatin (Ubenimex) 是 CD13 (Aminopeptidase N)/APN 和 leukotriene A4 hydrolase 抑制剂,可用于癌症研究。 | |||
T0798 |
Triamcinolone
Fluoxyprednisolone,曲安西龙,Aristocort,Rodinolone |
Glucocorticoid Receptor; COX | Endocrinology/Hormones; Immunology/Inflammation; Neuroscience |
Triamcinolone (Aristocort) 是一种皮质类固醇激素受体激动剂,也是一种合成的长效糖皮质激素,具有抗炎活性。 | |||
T2S2173 |
(E)-Naringenin chalcone
Isosalipurpol,柚皮苷查尔酮,Chalconaringenin,trans-2'4'6'4-tetrahydroxychalcone,柚皮素查耳酮 |
Others | Others |
Naringenin chalcone (Isosalipurpol) 是一种黄酮醇生物合成的中间体,在查耳酮异构酶的作用下,自发代谢成柚皮素。它具有抗炎和抗过敏活性。 | |||
T3824 |
Jaceosidin
|
Apoptosis; BCL; COX; UGT | Apoptosis; Immunology/Inflammation; Metabolism; Neuroscience |
Jaceosidin 是从毛莲蒿中得到的一种黄酮类天然产物,可激活Bax,下调 Mcl-1 和 c-FLIP 的表达,诱导癌细胞凋亡。它能够降低炎性因子水平,激活 NF-κB,抑制COX-2的表达,具有抗癌和抗炎作用。 | |||
TJS1779 |
Protosappanin A
原苏木素A,PTA |
NADPH-oxidase; IL Receptor; IκB/IKK; TNF; NF-κB; TLR; ROS; COX; HIV Protease; JAK; NO Synthase; STAT | Angiogenesis; Apoptosis; Chromatin/Epigenetic; Immunology/Inflammation; JAK/STAT signaling; Microbiology/Virology; Neuroscience; NF-κB; Proteases/Proteasome; Stem Cells |
Protosappanin A (PTA) 是从苏木中分离得到的免疫抑制成分和主要联苯化合物,通过下调 JAK2和 STAT3的磷酸化,抑制 JAK2/STAT3依赖的炎症通路。 | |||
T37280 |
PE(18:1(9Z)/0:0)
|
Endogenous Metabolite | Metabolism |
PE(18:1(9Z)/0:0) 是一种天然存在的溶血磷脂,是缩醛磷脂溶血磷脂酰乙醇胺的类似物。 PE(18:1(9Z)/0:0) 以浓度依赖性方式诱导 PC12 大鼠神经元细胞中细胞内钙的瞬时增加。 PE(18:1(9Z)/0:0) 增加 IL-4 和 IL-2 的产生,但不增加 IFN-γ 的产生。 在小鼠血清中,PE(18:1(9Z)/0:0)(1 μg/动物)诱导 T 辅助细胞 2 反应。 在寒冷暴露三天后,小鼠肩胛间棕色脂肪组织中的 PE(18:1(9Z)/0:0) 水平增加。 | |||
T2S0843 |
Negletein
黄芩素-7-甲醚,7-O-Methylbaicalein,Baicalein-7-methylether |
IL Receptor; TNF; NOS; Interleukin | Apoptosis; Immunology/Inflammation |
Negletein (7-O-Methylbaicalein) 一种神经保护剂,可增强神经生长因子的作用并诱导 PC12 细胞中的神经突生长。它通过抑制TNF-α和IL-1β表现出抗炎活性,其 IC50值分别为 16.4 和 10.8 μM。它还具有抗菌、抗缺氧和抗阿尔茨海默病活性。 | |||
T8264 |
3-Methyl-2-oxovaleric acid
|
Endogenous Metabolite | Metabolism |
3-Methyl-2-oxovaleric acid 是神经毒素,代谢毒素和酸性原,它是支链氨基酸不完整分解产生的异常代谢物。 | |||
T2S2215 |
Crebanine
|
Apoptosis; Others; Akt | Apoptosis; Cytoskeletal Signaling; Others; PI3K/Akt/mTOR signaling |
Crebanine 是来自于韦诺萨千金藤的一种生物碱,通过抑制 MAPKs 和 Akt 信号通路表现出抗炎活性,还具有抗心律失常的作用。它可诱导人类癌细胞的 G1阻滞和凋亡。 | |||
T3S2016 |
Epoxylathyrol
|
Others | Others |
Epoxylathyrol derivatives have modulation of ABCB1-mediated multidrug resistance in human colon adenocarcinoma and mouse T-Lymphoma cells. | |||
T68351 |
Homodestcardin
|
Others | Others |
Homodestcardin is a cyclic depsipeptide fungal metabolite that has been found in T. roseum and has immunosuppressant activity. It inhibits concanavalin A-induced proliferation of isolated mouse T cells. | |||
TN1670 |
Ganodermanondiol
灵芝酮二醇 |
HIV Protease; Nrf2; AMPK | Chromatin/Epigenetic; Immunology/Inflammation; Microbiology/Virology; PI3K/Akt/mTOR signaling; Proteases/Proteasome |
Ganodermanondiol exhibits potent cytoprotective effects on t-BHP-induced hepatotoxicity in human liver-derived HepG2 cells, presumably through Nrf2-mediated antioxidant enzymes and AMPK. | |||
T11365 |
Ganodermanontriol
|
Others | Others |
Ganodermanontriol, a sterol derived from Ganoderma lucidum, showcases hepatoprotective activity and possesses anti-inflammatory properties in tert-butyl hydroperoxide (t-BHP)-damaged hepatic cells through the upregulation of HO-1 expression. | |||
T38243 |
Hygrolidin
|
Others; ADC Cytotoxin | Antibody-drug Conjugate/ADC Related; Others |
Hygrolidin is a macrocyclic lactone originally isolated from S. hygroscopicus. It inhibits proliferation of a variety of cancer cell lines, including DLD-1 colon cancer, LNCaP prostate cancer, and K562 leukemia cells (IC50s = 2.9, 5.2, and 33 ng/ml, respectively). Hygrolidin induces the expression and levels of p21 in DLD-1 cells, but not WI-38 fibroblasts, and leads to cell accumulation in the G1 and S phases without inducing apoptosis. It has antiparasitic activity against T. cruzi, L. donovan... | |||
T14003 |
15-Acetoxyscirpenol
|
Caspase | Apoptosis; Proteases/Proteasome |
15-Acetoxyscirpenol, a member of the acetoxyscirpenol moiety mycotoxins (ASMs), potently induces apoptosis and inhibits the growth of Jurkat T cells in a dose-dependent manner. This effect is mediated through the activation of caspases independent of caspase-3[1]. | |||
T38838 |
QS-21
Stimulon,QS-21 |
Others | Others |
QS-21, an immunostimulatory saponin, is a powerful vaccine adjuvant that stimulates both Th2 humoral and Th1 cell-mediated immune responses by interacting with antigen presenting cells (APCs) and T cells. Additionally, QS-21 activates the NLRP3 inflammasome, leading to the release of cytokines IL-1β and IL-18, which are dependent on caspase-1. | |||
TN4778 |
Physalin H
|
gp120/CD4; Antifection; Autophagy | Autophagy; Immunology/Inflammation; Microbiology/Virology |
Physalin H is an Hh signaling inhibitor blocks GLI1-DNA-complex formation, it also strong quinone reductase induction activity with IR (Induction ratio, QR induction activity) value of 3.74±0.02. Physalin H shows immunosuppressive effects on T cells both | |||
TN4457 | Lucidal | Others | Others |
Lucialdehyde C (Lucidal) exhibits potent cytotoxicity against LLC, T-47D, Sarcoma 180, and Meth-A tumor cells with ED(50) values of 10.7, 4.7, 7.1, and 3.8 microg/ml, respectively. | |||
T35910 |
Petromurin C
|
Others | Others |
Petromurin C is a bis-indolyl benzenoid fungal metabolite originally isolated from the ascostromata of P. muricatus. It is cytotoxic to NS-1 mouse myeloma cells (IC50 = 33 μg/ml) and has activity against T. foetus in vitro (IC50 = 100 μg/ml). | |||
T14063 |
7α,25-Dihydroxycholesterol
7α,25-OHC |
EBI2/GPR183; Endogenous Metabolite | GPCR/G Protein; Metabolism |
7α,25-Dihydroxycholesterol 是一种孤儿 GPCR 受体EBI2 (GPR183)的内源性配体和有效选择性激动剂。它对激活 EBI2 有很强的作用 (EC50=140 pM;Kd=450 pM)。它能够作为一种趋化因子,指导 B 细胞、T 细胞和树突状细胞的迁移。 | |||
T14995 |
Concanamycin A
Folimycin,Concanamycin,X 4357B,Antibiotic X 4357B |
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Concanamycin A (Folimycin) 是一种多聚环内酯类抗生素,是选择性空泡状 H+-ATP 酶 (V-ATPase) 和溶酶体酸化抑制剂,可用于研究炎症。Concanamycin A 可增强细胞毒性 T 淋巴细胞对受感染原代细胞的免疫清除,抑制来自 HIV 和猿猴免疫缺陷病毒不同分支的 Nef 等位基因,可用于研究HIV 感染。 | |||
T75661 |
Thymopentin acetate
|
Others | Others |
Thymopentin acetate为胸腺皮质及髓质上皮细胞主要分泌的生物活性肽,是一有效免疫调节剂,具有极短的血浆半衰期(30秒),能促进自人类胚胎干细胞生成T细胞群。 | |||
TN3721 |
Cryptofolione
|
Antifection | Microbiology/Virology |
Z-Cryptofolione and Cryptomoscatone D2 as highly efficacious inhibitors of the G(2) checkpoint, G(2) checkpoint inhibitors can force cells arrested in G(2) phase by DNA damage to enter mitosis. Cryptofolione shows moderate cytotoxicity in both macrophages and T. cruzi amastigotes, it also displays a mild inhibitory effect on the promastigote form of Leishmania spp. | |||
TN3723 |
Cryptomeridiol
|
PAFR; Antifection | GPCR/G Protein; Microbiology/Virology |
Cryptomeridiol is a potential skin-whitening agent, exhibits melanogenesis inhibitory activity on α-MSH-stimulated B16 melanoma cells. Cryptomeridiol has low activity against A. niger, T. mentagrophytes, and C. albicans. (-)-Cryptomeridiol also exhibits a significant and concentration-dependent inhibitory effect on PAF receptor binding, with inhibitory concentration (IC)(50) values of 17.5 uM. | |||
TN7505 |
Thujopsene
NSC 44707 |
Others | Others |
Thujopsene, a sesquiterpene found in T. dolabrata, exhibits a wide range of biological activities. It inhibits Na+/K+-ATPase and cytochrome P450 (CYP) isoform CYP2B6 with IC50 values of 25.9 µg/ml and Ki of 0.8 µM, respectively. Additionally, thujopsene demonstrates antimicrobial efficacy against both Gram-positive and Gram-negative bacteria, such as S. aureus, M. luteus, and S. typhimurium, with MICs ranging from 25-50 µg/ml. It also suppresses antigen-induced β-hexosaminidase release in IgE-se... | |||
TN1663 |
Ganoderic acid DM
灵芝酸DM,灵芝酸 DM |
PARP; Androgen Receptor; CDK | Cell Cycle/Checkpoint; Chromatin/Epigenetic; DNA Damage/DNA Repair; Endocrinology/Hormones |
Ganoderic acid DM is an antiandrogenic osteoclastogenesis inhibitor, it especially suppresses the expression of c-Fos and nuclear factor of activated T cells c1 (NFATc1), this suppression leads to the inhibition of dendritic cell-specific transmembrane pr | |||
TN5498 |
6,7,4'-Trihydroxyflavanone
|
Others | Others |
6,7,4'-Trihydroxyflavanone 具有多种药理活性,包括抗风湿、抗缺血、抗炎、抗破骨细胞和对 METH 诱导的 T 细胞失活的保护作用。 6,7,4'-三羟基黄烷酮可用于研究治疗患有神经退行性疾病的 METH 成瘾者。 | |||
T21441 |
Prostratin
12-Deoxyphorbol-13-acetate |
Others | Others |
Prostratin, a protein kinase C activator, has been shown to exhibit promising therapeutic potential against other diseases such as cancer and Alzheimer's disease. Prostratin has the potential to be useful in the treatment of HIV as it could flush viral re | |||
TMA1008 |
Ganoderic acid S
|
Others | Others |
A novel combination of triterpenoids includes at least ganoderic acid S (GAS), ganoderic acid T (GAT), ganoderic acid Me (GAMe), ganoderic acid R (GAR), and ganodermic acid S (GMAS), the composition is suitable for the treatment or prophylaxis of colon ca | |||
T36961 |
Malformin C
|
Others | Others |
Malformin C is a natural fungus-derived bicyclic pentapeptide that has antibacterial properties, particularly against species of Bacillus. Malformin C potently blocks the ability of bleomycin to induce G2 arrest in human T-cell leukemia-derived Jurkat cells (IC50 = 0.9 nM). It less potently abrogates colchicine-induced M phase arrest in Jurkat cells (IC50 = 24 nM). Malformin C inhibits cell growth dose-dependently in Colon 38 and HCT 115 cancer cells (IC50s = 0.27 and 0.18 μM, respectively) but ... | |||
TN5880 |
Mesuol
|
||
Mesuol has antioxidant activity, it shows very high scavenging activity against DPPH radical; it also has immunomodulatory activity, can potentiate percentage neutrophil adhesion in neutrophil adhesion test in rats and phagocytosis in carbon clearance assay. Mesuol can suppress HIV-1 replication in Jurkat T cells, it inhibits TNFα-induced HIV-1-LTR transcriptional activity by targeting the nuclear factor-κB (NF-κB) pathway. | |||
T75632 |
Ganoderic acid T1
|
Others | Others |
Ganoderic acid T1是Ganoderic acid T的去乙酰化衍生物,具有促进癌细胞凋亡(apoptosis)的功能。它通过降低线粒体膜电位以及激活caspase-9和caspase-3来引发细胞凋亡,并增加细胞内ROS的产生,从而表现出促氧化活性和细胞性毒作用,同时减弱抗氧化防御系统。 | |||
T36845 |
Isogarcinol
|
Others | Others |
Isogarcinol is a natural polyisoprenylated benzophenone first isolated from plant species in the genus Garcinia. It has immunosuppressant actions, inhibiting the protein phosphatase calcineurin (IC50 = 36 μM) and suppressing the proliferation of T cells. Oral administration of isogarcinol in mice decreases delayed type hypersensitivity, prolongs graft survival in allogeneic skin transplants, suppresses inflammation in collagen-induced arthritis, and reduces clinical symptoms in experimental auto... | |||
T73402 |
Flavipin
|
Others | Others |
Flavipin 是一种芳香烃受体(Ahr)激动剂,可诱导小鼠 CD4+T 细胞和 CD11b+巨噬细胞表达 Ahr 下游基因。Flavipin 抑制 Arid5a 在 Il23a3'UTR 上的稳定功能,这是一种新发现的靶 mRNA。Flavipin 具有清除 DPPH 自由基的能力,IC50值为7.2 μM,对α-葡萄糖苷酶具有较强的抑制作用,IC50值为 33.8 μM。 | |||
TN5033 |
Skullcapflavone I
|
IL Receptor; Caspase; Prostaglandin Receptor | Apoptosis; GPCR/G Protein; Immunology/Inflammation; Proteases/Proteasome |
Skullcapflavone I has anti-inflammatory and anti-allergic potential, it can significantly inhibit LPS stimulated NO and PGE(2) release in J774A.1 macrophages and inhibit LPS induced IL-6 production in a concentration dependent manner. Skullcapflavone I se | |||
TN2190 |
Scoulerine
|
Apoptosis; Beta-Secretase; BACE; Parasite | Apoptosis; Microbiology/Virology; Neuroscience |
Scoulerine 是抗有丝分裂化合物。它抑制细胞增殖,阻止细胞周期,并诱导癌细胞凋亡。它也是BACE1(淀粉样前体蛋白裂解酶 1) 的抑制剂。 | |||
T35741 |
Gliovirin
|
Others | Others |
Gliovirin is a fungal metabolite that has been found inT. harzianumand has fungicidal, antimicrobial and anti-inflammatory activities.1It is active against the plant pathogenic fungusP. ultimum(MIC = 60 ng/ml) and the parasiteT. brucei brucei(IC50= 90 ng/ml), but has no effect on the plant pathogenic fungiR. solani,P. omnivorum,T. basicola,R. arrhizus, andV. dahliaeor the bacteriaB. thuringiensis,P. fluorescens, andX. malvacearumwhen used at concentrations up to 1,000 ng/ml.2,3Gliovirin decrease... | |||
T36886 |
Pestalotin
|
Others | Others |
Pestalotin is a fungal metabolite originally isolated from P. cryptomeriaecola with diverse biological activities. It induces reducing sugar release in embryoless rice endosperms when used at concentrations ranging from 3 to 100 mg/L and enhances growth of rice seedlings (O. sativa) when used in combination with gibberellin A3 at concentrations ranging from 30 to 500 mg/L. Pestalotin has antifungal activity, reducing the growth of C. albicans, C. neoformans, T. rubrum, and A. fumigatus (MICs = 1... | |||
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Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPJ-01323 |
NTAL Protein, Human, Recombinant (His)
Williams-Beuren Syndrome Chromosomal Region 5 P,Membrane-Ass... |
Human | HEK293 Cells |
Linker for Activation of T-Cells Family Member 2 (LAT2) is a single-pass type III membrane protein. LAT2 is highly expressed in the spleen, peripheral blood lymphocytes, and germinal centers of lymph nodes. LAT2 is involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. It may also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. ... | |||
TMPH-01557 |
ILF2 Protein, Human, Recombinant (GST)
Interleukin enhancer-binding factor 2,ILF2... |
Human | E. coli |
Appears to function predominantly as a heterodimeric complex with ILF3. This complex may regulate transcription of the IL2 gene during T-cell activation. It can also promote the formation of stable DNA-dependent protein kinase holoenzyme complexes on DNA. Essential for the efficient reshuttling of ILF3 (isoform 1 and isoform 2) into the nucleus. ILF2 Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 70.1 kDa and the acce... | |||
TMPH-01653 |
MLANA Protein, Human, Recombinant (His)
Protein Melan-A,Melanoma antigen recognize... |
Human | P. pastoris (Yeast) |
Involved in melanosome biogenesis by ensuring the stability of GPR143. Plays a vital role in the expression, stability, trafficking, and processing of melanocyte protein PMEL, which is critical to the formation of stage II melanosomes. MLANA Protein, Human, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 15.2 kDa and the accession number is Q16655. | |||
TMPH-01652 |
MLANA Protein, Human, Recombinant (B2M & His)
Antigen LB39-AA,Protein Melan-A,MLANA,Mela... |
Human | E. coli |
Involved in melanosome biogenesis by ensuring the stability of GPR143. Plays a vital role in the expression, stability, trafficking, and processing of melanocyte protein PMEL, which is critical to the formation of stage II melanosomes. MLANA Protein, Human, Recombinant (B2M & His) is expressed in E. coli expression system with N-6xHis-B2M tag. The predicted molecular weight is 27.2 kDa and the accession number is Q16655. | |||
TMPY-01648 |
TREML2 Protein, Human, Recombinant (His)
TLT2,dJ238O23.1,triggering recep<... |
Human | HEK293 Cells |
Trem-like transcript 2 protein, also known as Triggering receptor expressed on myeloid cells-like protein 2, TREML2 and TLT2, is a single-pass type I membrane protein that contains one Ig-like V-type (immunoglobulin-like) domain. TREML2 is detected in cultured B cells, T cell leukemia and monocyte leukemia. TREML2 is expressed constitutively on CD8 T-cells and induced on CD4 T-cells after activation. TREML2 is a cell surface receptor that may play a role in the innate and adaptive immune respons... | |||
TMPY-03956 |
Fas Ligand Protein, Human, Recombinant (His)
TNLG1A,FASL,FASLG,CD178,CD95-L,APT1LG1,AP<... |
Human | P. pastoris (Yeast) |
Fas Ligand, also known as FASLG and CD95L, is the ligand for FAS. It is a transmembrane protein which binds to TNFRSF6/FAS. Interaction of FAS with fas Ligand is critical in triggering apoptosis of some types of cells such as lymphocytes. Fas Ligand may be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Fas Ligand Protei... | |||
TMPJ-01464 |
IL-2 Superkine Protein, Human, Recombinant (L100F, R101D, L105V, I106V, I112F)
TCGF,Aldesleukin,T-Cell Growth Fa... |
Human | HEK293 Cells |
Interleukin-2(IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system,belongs to the IL-2 family. It is a powerful immunoregulatory lymphokine produced by T-cells in response to antigenic or mitogenic stimulation. IL-2/IL-2R signaling is required for T-cell proliferation and other fundamental functions that are essential for the immune response. IL-2 stimulates growth and differentiation of B-cells, NK cells, lymphokine-activated killer cells, monocytes, macrophages... | |||
TMPY-01964 |
CD16a Protein, Human, Recombinant (F176V, His)
FCGRIII,Fc gamma RIIIa,FCR-10,FCRIII,FCRIIIA,FCGR3,CD16A,Fc... |
Human | HEK293 Cells |
The Fc receptor with low affinity for IgG (FCGR3, or CD16) is encoded by 2 nearly identical genes, FCGR3A and FCGR3B, resulting in tissue-specific expression of alternative membrane-anchored isoforms. FCGR3A, it is also known as CD16a, encodes a transmembrane protein expressed on activated monocytes/macrophages, natural killer (NK) cells, and a subset of T cells. CD16a / FCGR3A is a receptor expressed on NK cells that facilitates antibody dependent cellular cytotoxicity (ADCC) by binding to the... | |||
TMPJ-00038 |
IL-7 Protein, Mouse, Recombinant (His)
interleukin-7,白介素,IL-7,IL-7 interleukin-7,... |
Mouse | HEK293 Cells |
Mouse interleukin-7(IL-7) is the member of hemopoietin family which is important to the differentiation, proliferation, and survival of lymphocyte. Mouse IL-7 shares approximately 88% aa sequence identity with rat IL-7 and 58-60% with human, equine, bovine, ovine, porcine, feline and canine IL-7. It is widely expressed in primary and secondary lymphoid tissues cell and stromal epithelial cells of the thymus, bone marrow, and intestines. IL-7 activation of IL-7 R alpha is critical for both T cell... | |||
TMPY-04779 |
BTN3A2 Protein, Human, Recombinant (His)
BTF3,BT3.2,BTF4,BTN3.2,C... |
Human | HEK293 Cells |
The three butyrophilin BTN3A molecules, BTN3A1, BTN3A2, and BTN3A3, are members of the B7/butyrophilin-like group of Ig superfamily receptors, which modulate the function of T cells. BTN3A2 is overexpressed in gastric tumors, and deletion of BTN3A2 inhibited proliferation, migration, and invasion of gastric cancer cells. The butyrophilin 3 (BTN3) receptors are implicated in the T lymphocytes regulation and present a wide plasticity in mammals. A thorough phylogenetic analysis reveals a concerted... | |||
TMPJ-00051 |
IL-3 Protein, Mouse, Recombinant (His)
Mast cell growth factor,Il3,Mul |
Mouse | HEK293 Cells |
Interleukin 3 is a pleiotropic factor produced primarily by activated T cells that can stimulate the proliferation and differentiation of pluripotent hematopoietic stem cells as well as various lineage committed progenitors. In addition, IL-3 also affects the functional activity of mature mast cells, basophils, eosinophils and macrophages.Because of its multiple functions and targets, it was originally studied under different names, including mast cell growth factor P-cell stimulating factor, bu... | |||
TMPJ-01461 |
IL-15RA & IL-15 Protein, Human, Recombinant (hFc)
IL-15 Receptor α & IL-15 Fusion Protein,In... |
Human | HEK293 Cells |
IL15RA is a high-affinity receptor for interleukin-15. Il15ra associates as a heterotrimer with the IL-2 receptor beta and gamma subunits to initiate signal transduction. It can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Il15ra is expressed in special cells including a wide variety of Tand B cells and non-lymphoid cells.IL-15 is a cytokine that regulates T cell and natural killer cell activation and proliferation. IL-15 ... | |||
TMPJ-01465 |
GM-CSF/CSF2 Protein, Human, Recombinant (E. coli)
Colony-Stimulating Factor,CSF2,CS... |
Human | E. coli |
Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) was initially characterized as a growth factor that can support the in vitro colony formation of granulocyte-macrophage progenitors. It is produced by a number of different cell types (including activated T cells, B cells, macrophages, mast cells, endothelial cells and fibroblasts) in response to cytokine of immune and inflammatory stimuli. Besides granulocyte-macrophage progenitors, GM-CSF is also a growth factor for erythroid, megakaryo... | |||
TMPJ-00042 |
TSLP Protein, Human, Recombinant
TSLP,Thymic stromal lymphopoie |
Human | E. coli |
Thymic stromal lymphopoietin (TSLP) is a novel member of the hemopoietic cytokine family that promotes the development of B cells and shares overlapping activity with IL-7. The human TSLP protein comprises a 28 amino acids (aa) signal sequence and 131 aa mature region. Human TSLP has two isoforms lfTSLP and sfTSLP produced by alternative splicing . lfTSLP is expressed in a number of tissues including heart, liver and prostate, and sfTSLP (63aa) is predominantly expressed in keratinocytes of oral... | |||
TMPY-00817 |
Granzyme B/GZMB Protein, Human, Recombinant (His)
CGL1,CTLA1,CSP-B,CTSGL1,HLP,SECT,... |
Human | HEK293 Cells |
Granzyme B, also known as GZMB, is the most prominent member of the granzyme family of cell death-inducing serine proteases expressed in the granules of cytotoxic T lymphocytes (CTLs) and NK cells. Granzyme B enters the target cells depending on another membrane-binding granule protein, perforin, results in the activation of effector caspases and mitochondrial depolarization through caspase-dependent and -independent pathways, and consequently induces rapid cell apoptosis. Over 3 substrates of G... | |||
TMPY-04826 |
LILRB5/CD85c Protein, Human, Recombinant (His)
leukocyte immunoglobulin like receptor B5,... |
Human | HEK293 Cells |
A genetic variant in LILRB5 (leukocyte immunoglobulin-like receptor subfamily-B) (rs12975366: T > C: Asp247Gly) has been reported to be associated with lower creatine phosphokinase (CK) and lactate dehydrogenase (LDH) levels. Both biomarkers are released from injured muscle tissue, making this variant a potential candidate for susceptibility to muscle-related symptoms. LILRB5/CD85c Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weig... | |||
TMPY-00369 |
LY6D Protein, Human, Recombinant (mFc)
E48,lymphocyte antigen 6 complex, locus D,... |
Human | HEK293 Cells |
LY6D (Lymphocyte Antigen 6 Family Member D) is a Protein Coding gene. It may act as a specification marker at the earliest stage specification of lymphocytes between B- and T-cell development. Marks the earliest stage of B-cell specification. The expression of LY6D is induced in MCF10A cells by X-ray irradiation. The induction of LY6D expression is triggered through a pathway regulated by ATM, CHK2, and p53. This method is a new Ab-directed proteomic strategy for the analysis of membrane protein... | |||
TMPY-03274 |
CXCL11 Protein, Human, Recombinant
SCYB9B,I-TAC,chemokine (C-X-C motif) ligan... |
Human | E. coli |
I-TAC, also known as CXCL11, is a small cytokine belonging to the CXC chemokine family. It is highly expressed in peripheral blood leukocytes, pancreas and liver, with moderate levels in thymus, spleen and lung and low expression levels were in small intestine, placenta and prostate. The I-TAC chemokine elicits its effects on its target cells by interacting with the cell surface chemokine receptor CXCR3, with a higher affinity than do the other ligands for this receptor, CXCL9 and CXCL10. I-TAC ... | |||
TMPY-02279 |
Nucleoside phosphorylase/PNP Protein, Human, Recombinant (His)
PUNP,PRO1837,purine nucleoside phosphorylase,NP |
Human | E. coli |
Purine nucleoside phosphorylase (PNP) is a purine-metabolizing enzyme that catalyzes the reversible phosphorolysis of 6-oxypurine (deoxy)nucleosides to their respective bases and (deoxy)ribose-1-phosphate. It is a key enzyme in the purine salvage pathway of mammalian cells. Purine nucleoside phosphorylase is a transferase that catalyzes the addition of phosphate and removal of a purine base from guanosine and similar nucleosides.PNP defects result in metabolic abnormalities and fatal T cell immu... | |||
TMPJ-01462 |
IL-15RA & IL-15 Protein, Human, Recombinant - PBS Lyophilized (hFc)
IL15,IL15RA&IL15,IL-15,Interleukin-15,IL-15 Recep |
Human | HEK293 Cells |
IL15RA is a high-affinity receptor for interleukin-15. Il15ra associates as a heterotrimer with the IL-2 receptor beta and gamma subunits to initiate signal transduction. It can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Il15ra is expressed in special cells including a wide variety of Tand B cells and non-lymphoid cells.IL-15 is a cytokine that regulates T cell and natural killer cell activation and proliferation. IL-15 ... | |||
TMPJ-01210 |
IL-33 Protein, Mouse, Recombinant
Interleukin-1 family member 11,白细胞介素,NF-HEV and IL-... |
Mouse | E. coli |
Mouse Interleukin 33 (IL-33) is a 30 kDa proinflammatory cytokine which may also regulates gene transcription in producer cells. IL-33 is constitutively expressed in smooth muscle and airway epithelia. IL-33 was identified based on sequence and structural homology with IL-1 family cytokines. It is up‑regulated in arterial smooth muscle, dermal fibroblasts, and keratinocytes following IL-1 alpha or IL‑1 beta stimulation. IL-33 is structurally related to IL-1, which induces helper T cells to produ... | |||
TMPJ-00662 |
RANKL/TNFSF11/CD254 Protein, Human, Recombinant (E. coli)
Receptor activator of nuclear fac... |
Human | E. coli |
CD254, also known as RANKL, TNFSF11, TRANCE, OPGL and ODF, is a type II membrane protein of the tumor necrosis factor (TNF) superfamily, and affects the immune system and control bone regeneration and remodeling. RANKL is the ligand of nuclear factor (NF)-κB (RANK). When RANKL binds to RANK, it will undergo trimerization and then bind to an adaptor molecule TNF receptor-associated factor 6 (TRAF6). This results in the activation of several downstream signaling cascades, including the NFκB, mitog... | |||
TMPY-06981 |
IL-1 alpha/IL-1A Protein, Human, Recombinant (E. coli)
interleukin 1 α,IL1,白介素,IL-1F1,IL1-α,IL-1A,IL1F1,白细... |
Human | E. coli |
IL-1 alpha is a member of the interleukin 1 cytokine family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation, and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophage... | |||
TMPJ-00994 |
LTBR Protein, Mouse, Recombinant (hFc)
Tnfcr,Lymphotoxin-beta recept... |
Mouse | HEK293 Cells |
It is a single-pass type I membrane protein and contains 4 TNFR-Cys repeats. The protein is a member of the tumor necrosis factor (TNF) family of receptors. It is expressed on the surface of most cell types, including cells of epithelial and myeloid lineages, but not on T and B lymphocytes. The protein is the receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. It promotes apoptosis via TRAF3 and TRAF5 and may play a role in the development of lymphoid organs... | |||
TMPJ-01172 |
IL-17 Protein, Mouse, Recombinant (His)
CTLA8,IL-17,IL-17A,Interleukin-17A,CT<... |
Mouse | HEK293 Cells |
Interleukin-17 is a potent pro-inflammatory cytokine produced by activated memory T cells. There are at least six members of the IL-17 family in humans and in mice. Mature mouse IL-17A shares 61% and 89% amino acid sequence identity with human and rat IL-17A, respectively. As IL-17 shares properties with IL-1 and TNF-alpha, it may induce joint inflammation and bone and cartilage destruction. This cytokine is found in synovial fluids of patients with rheumatoid arthritis, and produced by rheumato... | |||
TMPJ-00137 |
APRIL/TNFSF13 Protein, Human, Recombinant (Flag & His)
TRDL-1,TNF- and APOL-related leuk... |
Human | HEK293 Cells |
APRIL (a proliferation-inducing ligand), also known as TNFSF13, TALL2, TRDL1, and CD256, is a member of the TNF ligand superfamily. It is synthesized as a 32 kDa proprotein which is cleaved by furin in the Golgi to release the active 17 kDa soluble molecule. Secreted human APRIL, which consists almost entirely of a single TNF homology domain, shares 85% amino acid sequence identity with mouse and rat APRIL. Both APRIL and its close relative BAFF bind and signal through the TNF superfamily recept... | |||
TMPY-04483 |
IRAK4 Protein, Human, Recombinant (His)
IPD1,NY-REN-64,REN64,interleukin-1 recepto... |
Human | Baculovirus Insect Cells |
Interleukin-1 receptor-associated kinase 4, also known as Renal carcinoma antigen NY-REN-64, IRAK-4, and IRAK4, is a member of the protein kinase superfamily, TKL Ser/Thr protein kinase family, and Pelle subfamily. IRAK4 contains one death domain and one protein kinase domain. IRAK4 is required for the efficient recruitment of IRAK1 to the IL-1 receptor complex following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. ... | |||
TMPJ-01441 |
OX40L/TNFSF4 Protein, Cynomolgus, Recombinant (His)
OX-40L,TNFSF4,Tumor necrosis fact... |
Cynomolgus | HEK293 Cells |
Tumor necrosis factor ligand superfamily member 4(TNFSF4/OX40L) is a single-pass type II membrane protein. OX40L is expressed by DCs, macrophages and B cells and signals via its cognate receptor OX40 which is mainly expressed on APCs. OX40L/OX40 interactions are important in T-cell activation and survival and for the generation of memory T cells from activated effector T cells. It is a cytokine that binds to TNFRSF4, Co-stimulates T-cell proliferation and cytokine production. OX40L/OX40 interact... | |||
TMPH-01020 |
BTN3A1 Protein, Human, Recombinant (Yeast, His)
Butyrophilin subfamily 3 member A1,BTN3A1,... |
Human | P. pastoris (Yeast) |
Plays a role in T-cell activation and in the adaptive immune response. Regulates the proliferation of activated T-cells. Regulates the release of cytokines and IFNG by activated T-cells. Mediates the response of T-cells toward infected and transformed cells that are characterized by high levels of phosphorylated metabolites, such as isopentenyl pyrophosphate. BTN3A1 Protein, Human, Recombinant (Yeast, His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 26.2 kDa and the... | |||
TMPK-01135 |
CD3 epsilon/CD3e Protein, Cynomolgus, Recombinant (His)
T3E,CD3-ε,FLJ18683,CD3e,IMD18,CD3-epsilon,T |
Cynomolgus | HEK293 Cells |
CD3E, is a single-pass type I membrane protein.CD3 (cluster of differentiation 3) T cell co-receptor helps to activate both the cytotoxic T cell (CD8 naive T cells) and also T helper cells (CD4 naive T cells). It consists of a protein complex and is composed of four distinct chains. In mammals, the complex contains a CD3γ chain, a CD3δ chain, and two CD3ε chains. CD3 epsilon/CD3e Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular... | |||
TMPK-00095 |
CD3 epsilon/CD3e 1-27 peptide Protein, Human, Recombinant (hFc & Avi)
CD3-epsilon,IMD18,T3E,CD3-ε,CD3E/CD3 ε 1-27 pep... |
Human | HEK293 Cells |
CD3E, is a single-pass type I membrane protein.CD3 (cluster of differentiation 3) T cell co-receptor helps to activate both the cytotoxic T cell (CD8 naive T cells) and also T helper cells (CD4 naive T cells). It consists of a protein complex and is composed of four distinct chains. In mammals, the complex contains a CD3γ chain, a CD3δ chain, and two CD3ε chains. CD3 epsilon/CD3e 1-27 peptide Protein, Human, Recombinant (hFc & Avi) is expressed in HEK293 mammalian cells with C-hFc-Avi tag. The p... | |||
TMPK-01351 |
CD3 epsilon/CD3e epsilon 1-27 peptide Protein, Cynomolgus, Recombinant (hFc & Avi), Biotinylated
TCRE,FLJ18683,T3E,CD3E,CD3-epsilon,CD3E/CD... |
Cynomolgus | HEK293 Cells |
CD3E, is a single-pass type I membrane protein.CD3 (cluster of differentiation 3) T cell co-receptor helps to activate both the cytotoxic T cell (CD8 naive T cells) and also T helper cells (CD4 naive T cells). It consists of a protein complex and is composed of four distinct chains. In mammals, the complex contains a CD3γ chain, a CD3δ chain, and two CD3ε chains. CD3 epsilon/CD3e epsilon 1-27 peptide Protein, Cynomolgus, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cell... | |||
TMPJ-00168 |
HVEM Protein, Mouse, Recombinant (hFc)
Tnfrsf14,Herpesvirus entry mediat... |
Mouse | HEK293 Cells |
Mouse Protein Tnfrsf14, is a type I transmembrane protein belonging to the TNF receptor superfamily. It is tumor necrosis factor receptor superfamily member 14 and expressed on the surface of T cells during the resting state. Interaction of HVEM with TNF family member LIGHT co-stimulates T cells and promotes inflammation. HVEM also triggers inhibitory signaling cascade in effector T (Teff) cells and regulatory T cells (Tregs) as a ligand of B and T lymphocyte attenuator. Tnfrsf14 is detected in ... | |||
TMPJ-00064 |
OX40L/TNFSF4 Protein, Human, Recombinant (His)
TNFSF4,Glycoprotein Gp34,TAX ... |
Human | HEK293 Cells |
Tumor necrosis factor ligand superfamily member 4(TNFSF4/OX40L) is a single-pass type II membrane protein.OX40L is expressed on the surface of activated B cells, T cells, dendritic cells and endothelial cells. OX40L binds to OX40 (CD134), a member of the TNF receptor superfamily that is expressed predominantly on activated CD4+ T cells. OX40-OX40L co-stimulates signal to promote the survival and proliferation of activated CD4+ T cells and prolong the immune response. It involved in T-cell proli... | |||
TMPH-01021 |
BTN3A1 Protein, Human, Recombinant (E. coli, His)
CD277,Butyrophilin subfamily 3 member A1,BT |
Human | E. coli |
Plays a role in T-cell activation and in the adaptive immune response. Regulates the proliferation of activated T-cells. Regulates the release of cytokines and IFNG by activated T-cells. Mediates the response of T-cells toward infected and transformed cells that are characterized by high levels of phosphorylated metabolites, such as isopentenyl pyrophosphate. BTN3A1 Protein, Human, Recombinant (E. coli, His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular wei... | |||
TMPJ-00877 |
IL-2 Protein, Rat, Recombinant (His)
白介素,白细胞介素,IL2,Interleukin-2,TCGF,IL-2,... |
Rat | HEK293 Cells |
Interleukin-2(IL-2)is a O-glycosylated four α-helix bundle cytokine that has potent stimulatory activity for antigenactivated T cells. It is expressed by CD4+ and CD8+ T cells, γδ T cells, B cells, dendritic cells, and eosinophils. Mature rat IL-2 shares 66% and 73% amino acid sequence identity with human and mouse IL-2,respectively. The receptor for IL-2 consists of three subunits that are present on the cell surface in varying preformed complexes. IL-2 is a powerful immunoregulatory lymphokine... | |||
TMPK-01350 |
CD3 epsilon/CD3e 1-27 peptide Protein, Cynomolgus, Recombinant (hFc & Avi)
CD3E,T3E,FLJ18683,CD3-ε,CD3E/CD3 ε 1-27 pept |
Cynomolgus | HEK293 Cells |
CD3E, is a single-pass type I membrane protein.CD3 (cluster of differentiation 3) T cell co-receptor helps to activate both the cytotoxic T cell (CD8 naive T cells) and also T helper cells (CD4 naive T cells). It consists of a protein complex and is composed of four distinct chains. In mammals, the complex contains a CD3γ chain, a CD3δ chain, and two CD3ε chains. CD3 epsilon/CD3e 1-27 peptide Protein, Cynomolgus, Recombinant (hFc & Avi) is expressed in HEK293 mammalian cells with C-hFc-Avi tag. ... | |||
TMPJ-00145 |
4-1BB/CD137/TNFRSF9 Protein, Mouse, Recombinant (hFc)
Tumor necrosis factor receptor su... |
Mouse | HEK293 Cells |
Tumor necrosis factor receptor superfamily member 9(TNFRSF9) is a member of the tumor necrosis factor (TNF) receptor family. It can be induced by lymphocyte activation (ILA) and is expressed by activated T cells, but to a larger extent on CD8 than on CD4 T cells. In addition, TNFRSF9 expression is found on dendritic cells, follicular dendritic cells, natural killer cells, granulocytes and cells of blood vessel walls at sites of inflammation. As receptor for TNFSF9/4-1BBL, it can activate T cells... | |||
TMPJ-00099 |
CD28 Protein, Mouse, Recombinant (hFc & His)
T-cell-specific surface glycoprotein CD28,... |
Mouse | HEK293 Cells |
T-cell-specific surface glycoprotein CD28, contains an Ig-like V-type domain. CD28 is one of the proteins expressed on T cells that provide co-stimulatory signals, which are required for their activation. It is the receptor for CD80 and CD86. When activated by Toll-like receptor ligands, the CD80 expression is upregulated in antigen presenting cells (APCs). The CD86 expression on antigen presenting cells is constitutive. CD28 is the only B7 receptor constitutively expressed on naive T cells. It ... | |||
TMPK-01136 |
CD3 epsilon/CD3e Protein (Primary Amine Labeling), Cynomolgus, Recombinant (His), Biotinylated
TCRE,CD3e,CD3-epsilon,FLJ18683,CD3-ε,CD3E/CD3 ε,IMD... |
Cynomolgus | HEK293 Cells |
CD3E, is a single-pass type I membrane protein.CD3 (cluster of differentiation 3) T cell co-receptor helps to activate both the cytotoxic T cell (CD8 naive T cells) and also T helper cells (CD4 naive T cells). It consists of a protein complex and is composed of four distinct chains. In mammals, the complex contains a CD3γ chain, a CD3δ chain, and two CD3ε chains. CD3 epsilon/CD3e Protein (Primary Amine Labeling), Cynomolgus, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells ... | |||
TMPJ-01316 |
IL-21 Protein, Mouse, Recombinant (His)
白细胞介素,IL-21,Interleukin-21,白介素,IL21 |
Mouse | E. coli |
Interleukin-21(IL-21) is an approximately 14 kDa cytokine which belongs to the IL-15/IL-21 family. Mature mouse IL-21 shares 66%,59%, 58%, and 88% aa sequence identity with mature canine, human, rabbit, and rat IL-21, respectively. IL-21 is produced by activated T follicular helper cells (Tfh), Th17 cells, and NKT cells. It exerts its biological effects through a heterodimeric receptor complex (IL-21 specific IL-21 R). IL-21 is a cytokine that has potent regulatory effects on cells of the immun... | |||
TMPK-01018 |
B7-H3 Protein, Human, Recombinant (aa 29-245, His)
PRO352,B7H3, UNQ309,PSEC0249,CD276,B7-H3,B7 homolog 3 |
Human | HEK293 Cells |
B7-H3, a member of the B7 family of immunomodulatory molecules, is overexpressed in a wide range of solid cancers.B7-H3 binds to activated T cells via an as yet unidentified receptor. In assays using sub-optimal amount so anti-CD3 stimulation, 2Ig‑B7‑H3 enhances T cell proliferation, T cell interferon-gamma (IFN-gamma) production, and cytotoxic T cells induction. B7-H3 Protein, Human, Recombinant (aa 29-245, His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weig... | |||
TMPK-00315 |
B7-H3 (4Ig) /B7-H3b Protein, Human, Recombinant (His & Avi), Biotinylated
4Ig-B7-H3,CD276,UNQ309,B7-H3,PRO352,PSEC0249,B7 homolog 3 |
Human | HEK293 Cells |
B7-H3, a member of the B7 family of immunomodulatory molecules, is overexpressed in a wide range of solid cancers.B7-H3 binds to activated T cells via an as yet unidentified receptor. In assays using sub-optimal amount so anti-CD3 stimulation, 2Ig‑B7‑H3 enhances T cell proliferation, T cell interferon-gamma (IFN-gamma) production, and cytotoxic T cells induction. B7-H3 (4Ig) /B7-H3b Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. T... | |||
TMPK-00314 |
B7-H3 (4Ig) /B7-H3b Protein, Human, Recombinant (His & Avi)
B7-H3,PSEC0249,PRO352, 4Ig-B7-H3,B7 homolog 3,UNQ309,CD276 |
Human | HEK293 Cells |
B7-H3, a member of the B7 family of immunomodulatory molecules, is overexpressed in a wide range of solid cancers.B7-H3 binds to activated T cells via an as yet unidentified receptor. In assays using sub-optimal amount so anti-CD3 stimulation, 2Ig‑B7‑H3 enhances T cell proliferation, T cell interferon-gamma (IFN-gamma) production, and cytotoxic T cells induction. B7-H3 (4Ig) /B7-H3b Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted m... | |||
TMPK-01017 |
B7-H3 Protein, Human, Recombinant (aa 29-245, hFc)
B7H3,B7-H3,B7 homolog 3,PSEC0249,CD276,PRO352, UNQ309 |
Human | HEK293 Cells |
B7-H3, a member of the B7 family of immunomodulatory molecules, is overexpressed in a wide range of solid cancers.B7-H3 binds to activated T cells via an as yet unidentified receptor. In assays using sub-optimal amount so anti-CD3 stimulation, 2Ig‑B7‑H3 enhances T cell proliferation, T cell interferon-gamma (IFN-gamma) production, and cytotoxic T cells induction. B7-H3 Protein, Human, Recombinant (aa 29-245, hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weig... | |||
TMPK-01398 |
CD40 Ligand Trimer Protein, Human, Recombinant (hFc)
CD40 Ligand,CD40LIGM,IGM,gp39,TNFSF5,TRAP,... |
Human | HEK293 Cells |
CD40 ligand or CD40L, also called CD154, is a protein that is primarily expressed on activated T cells and is a member of the TNF superfamily of molecules. It binds to CD40 (protein) on antigen-presenting cells (APC), which leads to many effects depending on the target cell type. In total CD40L has three binding partners: CD40, α5β1 integrin and αIIbβ3. CD154 acts as a costimulatory molecule and is particularly important on a subset of T cells called T follicular helper cells. | |||
TMPK-00078 |
CD27 Ligand/CD70 Trimer Protein, Human, Recombinant (His), FITC-Labeled
TNFSF7, Ki-24 antigen,CD70,TNFSF7... |
Human | HEK293 Cells |
CD70, also named CD27 ligand (CD27L), is a type II transmembrane glycoprotein belonging to the TNF superfamily (TNFSF) and has been designated TNFSF7. CD70 is a cytokine that binds to CD27. Plays a role in T-cell activation. Induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells. CD27 Ligand/CD70 Trimer Protein, Human, Recombinant (His), FITC-Labeled is expressed in HEK293 mammalian cells with N-His tag. The predicted molecular weight is 51.8 kDa and ... | |||
TMPJ-00420 |
CTLA-4 Protein, Mouse, Recombinant (Flag)
Cytotoxic T-lymphocyte p... |
Mouse | HEK293 Cells |
Mouse Cytotoxic Tlymphocyte 4(CTLA-4,CD152), is a type I transmembrane T cell inhibitory molecule. Within the ECD, Mouse CTLA-4 shares 68% aa sequence identity with human. CTLA4 is similar to the T cell costimulatory protein CD28 since both of the molecules bind to CD80 and CD86 on antigen-presenting cells. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found inregulatory T cells and may play an important role in their fu... | |||
TMPK-01016 |
B7-H3 Protein, Human, Recombinant (hFc), FITC-Labeled
B7H3, UNQ309,PRO352,PSEC0249,B7 homolog 3,B7-H3,CD276 |
Human | HEK293 Cells |
B7-H3, a member of the B7 family of immunomodulatory molecules, is overexpressed in a wide range of solid cancers.B7-H3 binds to activated T cells via an as yet unidentified receptor. In assays using sub-optimal amount so anti-CD3 stimulation, 2Ig‑B7‑H3 enhances T cell proliferation, T cell interferon-gamma (IFN-gamma) production, and cytotoxic T cells induction. B7-H3 Protein, Human, Recombinant (hFc), FITC-Labeled is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular w... | |||
TMPK-00955 |
CD161 Protein, Human, Recombinant (His & Avi), Biotinylated
NKRP1,HNKR-P1a,NKRP1A,CD161,NKR-P1A,Ly59,NKRP1ANKR,NKR,NKR-P... |
Human | HEK293 Cells |
CD161 (NKRP1) is a lectin-like receptor present on NK cells and rare T-cell subsets. We have observed CD161 expression in some cases of T-cell prolymphocytic leukemia (T-PLL) and found it to be useful in follow-up and detection of disease after treatment. CD161 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 21.4 kDa and the accession number is Q12918-1. | |||
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Cat. No. | Product Name | Target | Signaling Pathways |
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T35775 |
HT-2 Toxin-13C22
HT-2 Toxin-13C22 |
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HT-2 toxin-13C22is intended for use as an internal standard for the quantification of HT-2 toxin by GC- or LC-MS. HT-2 toxin is a type A trichothecene mycotoxin and an active, deacetylated metabolite of the trichothecene mycotoxin T-2 toxin .1,2Like T-2 toxin, HT-2 toxin inhibits protein synthesis and cell proliferation in plants.2HT-2 toxin also reduces viability of HepG2, A549, HEp-2, Caco-2, A-204, U937, Jurkat, and RPMI-8226 cancer cells with IC50values ranging from 3.1 to 23 ng/ml and human... | |||
T71055 |
Albendazole-d7
|
||
Albendazole-d7 is intended for use as an internal standard for the quantification of albendazole by GC- or LC-MS. Albendazole is an orally bioavailable benzimidazole anthelmintic that is active against a variety of helminths, including liver flukes, tapeworms, and roundworms. It eliminates Trichostrongylus in the fourth stomach of cattle and sheep when orally administered at doses ranging from 2.5 to 10 mg/kg as well as other species in the fourth stomach and the small and large intestine. Alben... | |||
T36383 |
L-Thyroxine-13C9,15N
L-Thyroxine-13C9,15N |
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L-Thyroxine-13C9,15N is intended for use as an internal standard for the quantification of L-thyroxine by GC- or LC-MS. L-Thyroxine is a synthetic form of the thyroid hormone thyroxine. In vivo, L-thyroxine (0.9 and 2.7 μg) inhibits synthesis and release of thyrotropin induced by thyrotropin-releasing hormone from the anterior pituitary in mice. It also reverses decreases in levels of circulating thymic serum factor (FTS) and the number of T rosette-forming cells in an old age-induced mouse mode... | |||
T35513 |
13C15-Nivalenol
13C15-Nivalenol |
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13C15-Nivalenol is intended for use as an internal standard for the quantification of nivalenol by GC- or LC-MS. Nivalenol is a trichothecene mycotoxin that has been found inFusarium.1It is lethal to mice (LD50= 6.9 mg/kg).2Nivalenol (5, 10, and 15 mg/kg) also induces thymic, splenic, and Peyer's patch cell apoptosis in mice.3 1.Yang, Z., Concannon, J., Ng, K.S., et al.Tetrandrine identified in a small molecule screen to activate mesenchymal stem cells for enhanced immunomodulationSci. Rep.63026... | |||
T35789 |
Palmitic acid-1-13C
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Palmitic acid-13C is intended for use as an internal standard for the quantification of palmitic acid by GC- or LC-MS. Palmitic acid is a 16-carbon saturated fatty acid. It comprises approximately 25% of human total plasma lipids.1 It increases protein levels of COX-2 in RAW 264.7 cells when used at a concentration of 75 μM.2 Palmitic acid is involved in the acylation of proteins to anchor membrane-bound proteins to the lipid bilayer.2,3,4,5,6 |1. Santos, M.J., López-Jurado, M., Llopis, J., et a... | |||
T35791 |
Palmitic acid-13C
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Palmitic acid-13C is intended for use as an internal standard for the quantification of palmitic acid by GC- or LC-MS. Palmitic acid-13C contains 13C at the C2 position and has been used in the study of free fatty acid incorporation into phospholipid fatty acids in soil microbes.1 Palmitic acid is a 16-carbon saturated fatty acid. It comprises approximately 25% of human total plasma lipids.2 It increases protein levels of COX-2 in RAW 264.7 cells when used at a concentration of 75 μM.3 Palmitic ... |