Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T5361 |
T-26c
|
MMP | Proteases/Proteasome |
T-26c 是高效的、选择性的基质金属蛋白酶-13 抑制剂,IC50=6.75 pM。 | |||
T37860 |
T 26c disodium salt
|
Others | Others |
Highly potent and selective MMP13 inhibitor (IC50 = 6.9 pM). Exhibits >2600-fold selectivity for MMP13 over related MMPs. Inhibits degradation of bovine nasal septum cartilage explants in vitro . Orally bioavailable. Nara et al (2014) Thieno[2,3-d]pyrimidine-2-carboxamides bearing a carboxybenzene group at 5-position: highly potent, selective, and orally available MMP-13 inhibitors interacting with the S1 binding site. Bioorg.Med.Chem. 22 5487 PMID:25192810" | |||
T5381 |
A-893
|
Others | Others |
A-893 是一个具有细胞活性的,甲基转移酶SMYD2的抑制剂,IC50值为 2.8 nM。 |