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Search Results for " syk "

Targets Recommended: Syk Others Tyrosine Kinases Syk PKC BTK

67

抑制剂 & 化合物

5

天然产物

11

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T4391	Syk Inhibitor II dihydrochloride Syk Inhibitor II (hydrochloride)	Others; Tyrosine Kinases; Syk; PKC; BTK	Angiogenesis; Chromatin/Epigenetic; Cytoskeletal Signaling; Others; Tyrosine Kinase/Adaptors
	Syk Inhibitor II (hydrochloride) 是一种非受体酪氨酸激酶，磷酸化后，它与 FcRγ 链的基于免疫受体酪氨酸的激活基序结合，并介导与血小板功能和炎症相关的下游信号传导。 Syk inhibitor II 是一种可渗透细胞的嘧啶-甲酰胺化合物，以 ATP 竞争性方式选择性和可逆地阻断 Syk (IC50 = 41 nM)。它对 PKCε、PKCβII、ZAP-70、Btk 和 Itk 的效力要低得多（IC50s 分别为5.1、11、11.2、15.5 和 22.6 μM）。
T13045	Syk-IN-3	Syk	Angiogenesis; Tyrosine Kinase/Adaptors
	Syk-IN-3 是一种 Syk 抑制剂，具有潜在的抗炎和抗癌活性，可用于研究免疫失调。
T4348	Syk Inhibitor II	5-HT Receptor; Syk	Angiogenesis; GPCR/G Protein; Neuroscience; Tyrosine Kinase/Adaptors
	Syk Inhibitor II 是一种可渗透细胞、具有 ATP 竞争性的嘧啶-甲酰胺化合物，可选择性且可逆地抑制 Syk，IC50为 41 nM。
T9543	Syk Inhibitor II hydrochloride	Others	Others
	Syk Inhibitor II hydrochloride 信号传导的影响在狼疮中可能很突出。
T24843	Syk-IN-1 SykIN11,Syk-IN-11,Syk IN 11,Syk inhibitor-11,Syk inhibitor 11,Syk-inhibitor-11	Others	Others
	Syk-IN-11 is a selective Syk inhibitor.
T37077	Syk-IN-4	Others	Others
	Syk-IN-4 is a potent, selective, and orally bioavailable inhibitor of SYK, demonstrating an IC50 of 0.31 nM. It targets SYK, which has been identified as a potential therapeutic target for autoimmunity and hematological cancers[1].
T40976	Syk Kinase Peptide Substrate
	Syk Kinase Peptide Substrate is a Syk kinase peptide substrate.
T70931	SYK-IN-II	Others	Others
	SYK-IN-II is an inhibitor of the spleen tyrosine kinase (STK).
T4263	BAY 61-3606 2-[[7-(3,4-二甲氧基苯基)咪唑并[1,2-C]嘧啶-5-基]氨基]-3-吡啶甲酰胺,Syk inhibitor IV	Apoptosis; Syk	Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors
	BAY 61-3606 (Syk inhibitor IV) 是一种具有口服活性的，ATP 竞争性的可逆选择性Syk 抑制剂。它作用于乳腺癌细胞，通过下调 Mcl-1 促进 TRAIL 诱导的细胞凋亡。它降低神经母细胞瘤细胞中的 ERK1/2 和 Akt 磷酸化，也降低 K-rn 细胞裂解物中 Syk 磷酸化。
T79443	Syk-IN-8	Syk	Angiogenesis; Tyrosine Kinase/Adaptors
	Syk-IN-8（compound 19q）是一款Syk抑制剂，有效抗血液肿瘤细胞增殖。该化合物能够阻断PLCγ2的磷酸化过程，常用于血癌的科学研究。
T28281	OXSI-2 OXSI 2,Syk Inhibitor	Syk	Angiogenesis; Tyrosine Kinase/Adaptors
	OXSI-2 (Syk Inhibitor) 是 Syk 的抑制剂，EC50 为 313 nM，IC50 为 14 nM。 OXSI-2 完全抑制适配器蛋白 LAT Y191 磷酸化和 Syk 介导的血小板聚集。
T70930	GSK SYK inhibitor	Others	Others
	The immunoregulator spleen tyrosine kinase (SYK) is upregulated in cutaneous lupus erythematosus (CLE). This double-blind, multicentre, Phase Ib study evaluated the safety, tolerability, pharmacokinetics, pharmacodynamics and clinical efficacy of the selective SYK inhibitor GSK2646264 in active CLE lesions
T63086	SYK/JAK-IN-1	Others	Others
	SYK/JAK-IN-1 是一种 SYK/JAK 双重抑制剂，对 SYK 和 JAK2 的 IC50 值均小于 5 nM。
T78943	Syk-IN-7	Syk	Angiogenesis; Tyrosine Kinase/Adaptors
	Syk-IN-7（化合物17）是一类特定的酪氨酸激酶（SYK）抑制剂。
T62691	Syk Inhibitor II dihydrochloride dihydrate	Others	Others
	Syk Inhibitor II dihydrochloride dihydrate 是一种高度选择性的、有效的、ATP 竞争性 Syk 抑制剂 (IC50: 41 nM)。Syk Inhibitor II dihydrochloride dihydrate 抑制 RBL 细胞释放 5-HT (IC50: 460 nM)，对其他激酶的作用较弱。Syk Inhibitor II dihydrochloride dihydrate 表现出抗过敏作用。
T76083	Syk Kinase Peptide Substrate, Biotin labeled
	SykKinase Peptide Substrate, Biotin labeled 是生物素标记的、Syk 激酶多肽底物。
T16776	RO9021	Syk	Angiogenesis; Tyrosine Kinase/Adaptors
	RO9021 是口服具有活力的，ATP 竞争性的 SYK 抑制剂，其 IC50=5.6 nM。
T39437	Cevidoplenib dimesylate	Syk	Angiogenesis; Tyrosine Kinase/Adaptors
	Cevidoplenib dimesylate 是一种脾酪氨酸激酶 (Syk) 抑制剂，具有抗炎和免疫调节特性。
T11824LL	Lanraplenib GS-9876	Syk	Angiogenesis; Tyrosine Kinase/Adaptors
	Lanraplenib (GS-9876) 是高效的、选择性的、口服具有活力的 SYK 抑制剂 (IC50=9.5 nM) ，能够用于炎症性疾病的研究。它通过糖蛋白 VI (GPVI) 受体抑制血小板中的 SYK 活性，而不会延长猴子或人类的出血时间 (BT)。
T6101	Entospletinib GS-9973	Syk	Angiogenesis; Tyrosine Kinase/Adaptors
	Entospletinib (GS-9973) 是选择性的Syk 抑制剂，其IC50=7.7 nM。
T6594	MNS	Syk; Src; p97	Angiogenesis; Tyrosine Kinase/Adaptors; Ubiquitination
	MNS 是一种酪氨酸激酶抑制剂和广谱抗血小板药物，是一种 β-硝基苯乙烯衍生物。它完全抑制 U46619 (IC50:2.1 μM)、ADP (IC50:4.1 μM)、花生四烯酸 (IC50:5.8 μM)、胶原 (IC50:7.0 μM)和凝血酶 (IC50:12.7 μM)诱导的血小板聚集，并抑制 Src (IC50:27.3 μM)、Syk (IC50:2.8 μM) 和 FAK (IC50:97.6 μM)。
T14331	Gusacitinib ASN-002	JAK; Syk	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors
	Gusacitinib (ASN-002) 是一种有效的 SYK 激酶和JAK 激酶的双抑制剂，IC50值为 5 到 46 nM 之间，具有抗癌活性。
T3185	R112	Syk	Angiogenesis; Tyrosine Kinase/Adaptors
	R112 是 ATP 竞争性的 Syk 激酶抑制剂，它能够抑制 Syk 激酶活性，Ki=6 nM，IC50=226 nM。
T6115	Fostamatinib R788,福他替尼	FLT; Syk; Monoamine Transporter; Adenosine Receptor	Angiogenesis; GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience; Tyrosine Kinase/Adaptors
	Fostamatinib (R788) 是一种口服具有活力的 R406 前药。其中R406 是具有口服活性的，有效的，ATP 竞争性的Syk/FLT3抑制剂(Ki:30 nM，IC50:41 nM)，也能够抑制 Lyn (IC50:63 nM) 和 Lck (IC50:37 nM)。
T2487	Cerdulatinib PRT2070,赛度替尼,PRT062070	Tyrosine Kinases; JAK; Syk	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors
	Cerdulatinib (PRT2070) 是一种选择性 Tyk2抑制剂，IC50为 0.5 nM。它是 JAK 和 SYK 的双抑制剂，抑制JAK1、2、3 和SYK 的IC50分别为12、6、8 和 32。
T6174	R406 R-406 besylate	Apoptosis; FLT; Syk	Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors
	R406 (R-406 besylate) 是一种具有口服活性的 ATP 竞争性 Syk/FLT3抑制剂，Ki 为 30 nM。它有效抑制 Syk 激酶活性，IC50为 41 nM。它还抑制 Lyn 和 Lck，IC50值分别为 63 nM 和 37 nM。它可减轻免疫复合物介导的炎症。
T6957	PRT-060318 P142-76,PRT318,PRT-060318 2HCl	Syk	Angiogenesis; Tyrosine Kinase/Adaptors
	PRT-060318 (P142-76) 是一种新颖的、选择性的酪氨酸激酶 (Syk) 抑制剂，其IC50=4 nM。
T2467	R406 free base R406 (free base)	Apoptosis; FLT; Syk	Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors
	R406 free base (R406(free base)) 是一种具有口服活性的，ATP 竞争性的Syk/FLT3抑制剂，Ki 为 30 nM。它有效抑制 Syk 激酶活性，IC50为 41 nM，可减轻免疫复合物介导的炎症。它还抑制 Lyn 和 Lck，IC50分别为 63 nM 和 37 nM。
T70929	Naldemedine tosylate S-297995 tosylate	Others	Others
	Naldemedine tosylate (S-297995)为具口服活性的μ-阿片受体拮抗剂(PAMORA)。其对重组人源μ-、δ-及κ-阿片受体展现出高亲和力(Ki分别为0.34，0.43，0.94 nM)及强拮抗效果(IC50分别为25.57，7.09，16.1 nM)。适用于研究由阿片类物质引起的便秘(OIC)。Naldemedine tosylate也被预测可能与SARS-CoV2 3CLpro结合。
T6776	BAY 61-3606 dihydrochloride BAY 61-3606,BAY-61-3606 dihydrochloride	Apoptosis; Syk	Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors
	BAY 61-3606 dihydrochloride (BAY 61-3606) 是一种口服有效的，ATP 竞争性的，可逆的选择性Syk 抑制剂。它降低神经母细胞瘤细胞中的 ERK1/2 和 Akt 磷酸化，也降低 K-rn 细胞裂解物中 Syk 磷酸化。它作用于乳腺癌细胞，通过下调 Mcl-1 促进 TRAIL 诱导的细胞凋亡。
T4209	TAK-659 hydrochloride TAK-659	VEGFR; FLT; Tyrosine Kinases; JAK; Syk	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors
	TAK-659 hydrochloride (TAK-659) 是可逆的、高效的、选择性的、口服有效的 SYK/FLT3 双抑制剂，对 SYK 和 FLT3 作用的IC50值分别为 3.2 nM、4.6 nM。它能诱导肿瘤细胞死亡，却不作用于非肿瘤细胞，对慢性淋巴细胞白血病具有潜在的研究价值。
T0948	Adrenalone hydrochloride Adrenalone HCl,肾上腺酮盐酸盐,盐酸肾上腺酮	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Adrenalone hydrochloride (Adrenalone HCl) 是一种多巴胺β氧化酶 (dopamine β oxidase) 抑制剂，结构与去甲肾上腺素转运蛋白 (NET) 配体相似，IC50=36.9 μM。它是一种肾上腺素能 (adrenergic) 激动剂，用作局部血管收缩剂和止血剂。
T2696	PRT062607 hydrochloride PRT062607 (P505-15, BIIB057) HCl,P505-15 Hydrochloride	MLK; Syk; Src	Angiogenesis; MAPK; Tyrosine Kinase/Adaptors
	PRT062607 hydrochloride (P505-15 Hydrochloride) 是纯化的 Syk 抑制剂，IC50=1-2 nM。
T6104	Cerdulatinib hydrochloride Cerdulatinib,PRT2070,PRT062070 hydrochloride,PRT062070,PRT2070 hydrochloride	MLK; c-Fms; Tyrosine Kinases; Hippo pathway; JAK; Syk	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; MAPK; Stem Cells; Tyrosine Kinase/Adaptors
	Cerdulatinib hydrochloride (PRT2070 hydrochloride) 是一种选择性可逆，具有口服活性、 ATP 竞争性的 SYK 和 JAK 的双重抑制剂，抑制 JAK1、2、3、SYK 和 Tyk2的 IC50值分别为12、6、8、32 和 0.5 nM。它可用于研究自身免疫性疾病和B 细胞恶性肿瘤。
T2605	Fostamatinib Disodium Tamatinib Fosdium,福他替尼二钠盐,R788(Disodium),R788 Disodium,R788 (Fostamatinib) Disodium	FLT; Syk	Angiogenesis; Tyrosine Kinase/Adaptors
	Fostamatinib Disodium (R788 Disodium) 是一种口服具有活力的 R406 前药。其中R406 是具有口服活性的，有效的，ATP 竞争性的Syk/FLT3抑制剂(Ki:30 nM，IC50:41 nM)，也能够抑制 Lyn (IC50:63 nM) 和 Lck (IC50:37 nM)。
T22430	SRX3207	Others; PI3K; Syk	Angiogenesis; Others; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
	SRX3207 是 Syk 和 PI3K 的抑制剂，可缓解肿瘤免疫抑制。
T32088	Sovleplenib HMPL 523,HMPL523,HMPL-523	Syk	Angiogenesis; Tyrosine Kinase/Adaptors
	Sovleplenib (HMPL523) 是一种可口服且具有选择性和高效性的脾酪氨酸激酶 SYK 抑制剂，IC50 为 25 nM。Sovleplenib 具有抗肿瘤活性，可用于免疫性血小板减少症(ITP)的研究。
T9789	Cevidoplenib dimesylate hydrochloride	Syk	Angiogenesis; Tyrosine Kinase/Adaptors
	Cevidoplenib dimesylate hydrochloride 是一种脾酪氨酸激酶 (Syk) 抑制剂，具有潜在的免疫调节和抗炎特性。
T2600	AG490 Zinc02557947,Tyrphostin AG 490,AG 490,AG-490,Tyrphostin B42	EGFR; JAK; STAT; Autophagy	Angiogenesis; Autophagy; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors
	AG490 (Tyrphostin B42) 是一种 EGFR 抑制剂，IC50为 0.1 μM。它对 EGFR 的选择性比 ErbB2 高 135 倍，还抑制 JAK2。
T2045	JANEX-1 Jak3 inhibitor I,WHI-P131	JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	JANEX-1 (Jak3 inhibitor I) 是一种特异性JAK3抑制剂，Ki 和IC50分别为 2.3 和 78 μM。
T6277	Doramapimod BIRB 796,达马莫德,度马莫德	Raf; p38 MAPK; Autophagy	Autophagy; MAPK
	Doramapimod (BIRB 796) 是一种具有口服活性的p38 MAPK 抑制剂，Kd 值为0.1nM。它也抑制B-Raf 和 Abl，IC50分别为 83 nM 和 14.6 μM。
T32613	LCB 03-0110 dihydrochloride	Src	Angiogenesis; Tyrosine Kinase/Adaptors
	LCB 03-0110 Dihydrochloride 是BTK 和SYK 家族以及DDR2家族中c-Src 激酶（IC50=1.3 nM）和酪氨酸激酶的有效抑制剂。在体外抑制LPS 诱导的巨噬细胞活化和TGF-β1诱导的成纤维细胞活化，抑制巨噬细胞和成纤维细胞的活化，并抑制伤口愈合模型中的瘢痕形成。
T5524	Aurora kinase inhibitor-3 Aurora Kinase Inhibitor III	Aurora Kinase	Cell Cycle/Checkpoint; Chromatin/Epigenetic
	Aurora kinase inhibitor-3 (Aurora Kinase Inhibitor III) 是一种有效的，选择性 Aurora A 激酶抑制剂，IC50为 42 nM。
T9428	HM43239	FLT	Angiogenesis; Tyrosine Kinase/Adaptors
	HM43239 是一种具有口服活性和选择性 FLT3抑制剂，IC50值为 1.1 nM (FLT3 野生型)、1.8 nM (FLT3 ITD 突变型) 和 1.0 nM (FLT3 D835Y 突变型)。HM43239 作为可逆的 I 型抑制剂直接抑制 FLT3 的激酶活性，并调节 p-STAT5, p-ERK SYK, JAK1/2 和 TAK1。HM43239 抑制白血病细胞的增殖并诱导其凋亡 (apoptosis)。
T3211	Midostaurin 米哚妥林,N-Benzoylstaurosporine,PKC412,CGP41231,CGP 41251,苯甲酰基十字孢碱	Others; PKC	Chromatin/Epigenetic; Cytoskeletal Signaling; Others
	Midostaurin (PKC412) 是一种多靶点蛋白激酶抑制剂，有抗肿瘤活性，对 PKCα/β/γ、Syk、Flk-1、Akt、PKA、c-Kit、c-Fgr、c-Src、FLT3、PDFRβ和VEGFR1/2的IC50值范围为 22 到500 nM 之间。
T24584	P505-15 Acetate PRT 062607 Acetate,P505 15 Acetate,PRT-062607 Acetate,PRT062607 Acetate,P50515 Acetate	Tyrosinase	Proteases/Proteasome
	P505-15 Acetate 是脾脏酪氨酸激酶的选择性抑制剂，通过抑制白细胞免疫功能和炎症起作用，导致关节炎评分降低和组织学损伤减轻。
T11824L	Lanraplenib monosuccinate GS-9876 monosuccinate	Syk	Angiogenesis; Tyrosine Kinase/Adaptors
	Lanraplenib monosuccinate inhibits SYK activity in platelets via the glycoprotein VI (GPVI) receptor without prolonging bleeding time (BT) in monkeys or humans. Lanraplenib monosuccinate is a highly selective and orally active SYK inhibitor (IC50=9.5 nM) in development for the treatment of inflammatory diseases.
T11824	Lanraplenib succinate GS-9876 succinate	Syk	Angiogenesis; Tyrosine Kinase/Adaptors
	Lanraplenib succinate inhibits SYK activity in platelets via the glycoprotein VI (GPVI) receptor without prolonging bleeding time (BT) in monkeys or humans. Lanraplenib succinate is a highly selective and orally active SYK inhibitor (IC50=9.5 nM) in development for the treatment of inflammatory diseases.
T16995	TAS05567	FLT; c-RET; JAK; Syk	Angiogenesis; Apoptosis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors
	TAS05567 is a potent, highly selective, and ATP-competitive Syk inhibitor (IC50: 0.37 nM). TAS05567 only shows >70% inhibition of Syk and 4 other kinases (FLT3, JAK2, KDR, and RET with IC50s of 10 nM, 4.8 nM, 600 nM, and 29 nM, respectively) in a panel of 192 kinases.
T21062	TAK-659 TAK 659,TAK659	Others	Others
	TAK-659 is a spleen tyrosine kinase (SYK) inhibitor.

化合物

Syk Inhibitor II dihydrochloride

Cat.No: T4391

Synonym: Syk Inhibitor II (hydrochloride)

Target: Others, Tyrosine Kinases, Syk, PKC, BTK

Cat.No: T13045

Target: Syk

Syk Inhibitor II

Cat.No: T4348

Target: 5-HT Receptor, Syk

Syk Inhibitor II hydrochloride

Cat.No: T9543

Target: Others

Cat.No: T24843

Synonym: SykIN11,Syk-IN-11,Syk IN 11,Syk inhibitor-11,Syk inhibitor 11,Syk-inhibitor-11

Target: Others

Cat.No: T37077

Target: Others

Syk Kinase Peptide Substrate

Cat.No: T40976

Cat.No: T70931

Target: Others

Cat.No: T4263

Synonym: 2-[[7-(3,4-二甲氧基苯基)咪唑并[1,2-C]嘧啶-5-基]氨基]-3-吡啶甲酰胺,Syk inhibitor IV

Target: Apoptosis, Syk

Cat.No: T79443

Target: Syk

Cat.No: T28281

Synonym: OXSI 2,Syk Inhibitor

Target: Syk

GSK SYK inhibitor

Cat.No: T70930

Target: Others

Cat.No: T63086

Target: Others

Cat.No: T78943

Target: Syk

Syk Inhibitor II dihydrochloride dihydrate

Cat.No: T62691

Target: Others

Syk Kinase Peptide Substrate, Biotin labeled

Cat.No: T76083

Cat.No: T16776

Target: Syk

Cevidoplenib dimesylate

Cat.No: T39437

Target: Syk

Cat.No: T11824LL

Synonym: GS-9876

Target: Syk

Cat.No: T6101

Synonym: GS-9973

Target: Syk

Cat.No: T6594

Target: Syk, Src, p97

Cat.No: T14331

Synonym: ASN-002

Target: JAK, Syk

Cat.No: T3185

Target: Syk

Cat.No: T6115

Synonym: R788,福他替尼

Target: FLT, Syk, Monoamine Transporter, Adenosine Receptor

Cat.No: T2487

Synonym: PRT2070,赛度替尼,PRT062070

Target: Tyrosine Kinases, JAK, Syk

Cat.No: T6174

Synonym: R-406 besylate

Target: Apoptosis, FLT, Syk

Cat.No: T6957

Synonym: P142-76,PRT318,PRT-060318 2HCl

Target: Syk

Cat.No: T2467

Synonym: R406 (free base)

Target: Apoptosis, FLT, Syk

Naldemedine tosylate

Cat.No: T70929

Synonym: S-297995 tosylate

Target: Others

BAY 61-3606 dihydrochloride

Cat.No: T6776

Synonym: BAY 61-3606,BAY-61-3606 dihydrochloride

Target: Apoptosis, Syk

TAK-659 hydrochloride

Cat.No: T4209

Synonym: TAK-659

Target: VEGFR, FLT, Tyrosine Kinases, JAK, Syk

Adrenalone hydrochloride

Cat.No: T0948

Synonym: Adrenalone HCl,肾上腺酮盐酸盐,盐酸肾上腺酮

Target: Adrenergic Receptor

PRT062607 hydrochloride

Cat.No: T2696

Synonym: PRT062607 (P505-15, BIIB057) HCl,P505-15 Hydrochloride

Target: MLK, Syk, Src

Cerdulatinib hydrochloride

Cat.No: T6104

Synonym: Cerdulatinib,PRT2070,PRT062070 hydrochloride,PRT062070,PRT2070 hydrochloride

Target: MLK, c-Fms, Tyrosine Kinases, Hippo pathway, JAK, Syk

Fostamatinib Disodium

Cat.No: T2605

Synonym: Tamatinib Fosdium,福他替尼二钠盐,R788(Disodium),R788 Disodium,R788 (Fostamatinib) Disodium

Target: FLT, Syk

Cat.No: T22430

Target: Others, PI3K, Syk

Cat.No: T32088

Synonym: HMPL 523,HMPL523,HMPL-523

Target: Syk

Cevidoplenib dimesylate hydrochloride

Cat.No: T9789

Target: Syk

Cat.No: T2600

Synonym: Zinc02557947,Tyrphostin AG 490,AG 490,AG-490,Tyrphostin B42

Target: EGFR, JAK, STAT, Autophagy

Cat.No: T2045

Synonym: Jak3 inhibitor I,WHI-P131

Target: JAK

Cat.No: T6277

Synonym: BIRB 796,达马莫德,度马莫德

Target: Raf, p38 MAPK, Autophagy

LCB 03-0110 dihydrochloride

Cat.No: T32613

Target: Src

Aurora kinase inhibitor-3

Cat.No: T5524

Synonym: Aurora Kinase Inhibitor III

Target: Aurora Kinase

Cat.No: T9428

Target: FLT

Cat.No: T3211

Synonym: 米哚妥林,N-Benzoylstaurosporine,PKC412,CGP41231,CGP 41251,苯甲酰基十字孢碱

Target: Others, PKC

P505-15 Acetate

Cat.No: T24584

Synonym: PRT 062607 Acetate,P505 15 Acetate,PRT-062607 Acetate,PRT062607 Acetate,P50515 Acetate

Target: Tyrosinase

Lanraplenib monosuccinate

Cat.No: T11824L

Synonym: GS-9876 monosuccinate

Target: Syk

Lanraplenib succinate

Cat.No: T11824

Synonym: GS-9876 succinate

Target: Syk

Cat.No: T16995

Target: FLT, c-RET, JAK, Syk

Cat.No: T21062

Synonym: TAK 659,TAK659

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
TN1644	Flavanomarein	Others	Others
	Flavanomarein 是Coreopsis tinctoria Nutt 的主要黄酮类化合物，对糖尿病性肾病具有保护作用。它具有很好的抗氧化，降糖，降压和降血脂作用。
T0610	Piceatannol 白皮杉醇,trans-Piceatannol,Astringenin	Apoptosis; Serine/threonin kinase; PKA; Syk; PKC; Autophagy	Angiogenesis; Apoptosis; Autophagy; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; Metabolism; Tyrosine Kinase/Adaptors
	Piceatannol (Astringenin) 是一种Syk 抑制剂，可降低由 TNF 诱导的 iNOS 表达，可研究急性肺损伤。它是存在于各种水果和蔬菜中天然存在的多酚二苯乙烯，可诱导细胞自噬和凋亡，具有抗癌和抗炎特性。
TN7075	Linocinnamarin 3-[4-(beta-D-Glucopyranosyloxy)phenyl]acrylic acid methyl ester	Phospholipase; Syk	Angiogenesis; Metabolism; Tyrosine Kinase/Adaptors
	Linocinnamarin (3-[4-(beta-D-Glucopyranosyloxy)phenyl]acrylic acid methyl ester) 是从 Fragaria ananassa Duch 中分离出来的。它对抗原刺激脱粒的抑制主要是由于 Syk/磷脂酶 Cgamma (PLCgamma) 途径的失活。
T4S0498	Glaucocalyxin A 蓝萼甲素,Wangzaozin B,Leukamenin F	Apoptosis; Akt; Caspase; PI3K	Apoptosis; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	Glaucocalyxin A (Leukamenin F) 是来自日本黑纹病菌的一种对映型月桂基二萜，具有抗肿瘤作用。它通过调节PI3K/Akt 信号通路抑制 GLI1 的核易位，诱导骨肉瘤凋亡。
TN6667	Spinacetin
	Spinacetin has anti-inflammatory effects, it weakly inhibited nitric oxide production and reduced prostaglandin E2 levels to different extents. It shows the activities in preventing inflammatory processes, which might be at least partially attributed to t

天然产物

Cat.No: TN1644

Target: Others

Cat.No: T0610

Synonym: 白皮杉醇,trans-Piceatannol,Astringenin

Target: Apoptosis, Serine/threonin kinase, PKA, Syk, PKC, Autophagy

Cat.No: TN7075

Synonym: 3-[4-(beta-D-Glucopyranosyloxy)phenyl]acrylic acid methyl ester

Target: Phospholipase, Syk

Glaucocalyxin A

Cat.No: T4S0498

Synonym: 蓝萼甲素,Wangzaozin B,Leukamenin F

Target: Apoptosis, Akt, Caspase, PI3K

Cat.No: TN6667

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-03623	NKp80/KLRF1 Protein, Cynomolgus, Recombinant (hFc) killer cell lectin like receptor F1,KLRF1	Cynomolgus	HEK293 Cells
	NKp80, also known as KLRF1, is an activating homodimeric C-type lectin-like receptor that is expressed on nearly all-natural killer cells and stimulates their cytotoxicity and cytokine release. NKp80 stimulates cytotoxicity upon engagement of its genetically linked ligand: myeloid-specific CTLR activation-induced C-type lectin (AICL). NKp80, but not NKp80 mutated at tyrosine 7 (NKp80/Y7F), is tyrosine phosphorylated. Accordingly, NKp80/Y7F, but not NKp80/Y3F or NKp80/Y37F, failed to induce cytot...
TMPH-02441	IL-15 Protein, Rhesus macaque, Recombinant (His) IL15,Interleukin-15	Rhesus	P. pastoris (Yeast)
	Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL15 requires interaction of IL15 with components of the IL2 receptor, including IL2RB and probably IL2RG but not IL2RA. In neutrophils, stimulates phagocytosis probably by signaling through the IL15 receptor, composed of the subunits IL15RA, IL2RB and IL2RG, which results in kinase SYK activation. IL-15 Protein, Rhesus macaque, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 1...
TMPJ-00252	SIRP beta 1 Protein, Human, Recombinant (His) CD172b,CD172 antigen-like family member B,Signal-regulatory ...	Human	HEK293 Cells
	Signal-regulatory protein beta-1 (SIRPB1, CD172b) is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein was found to interact with TYROBP/DAP12, a protein bearing immunoreceptor tyrosine-based activation motifs. This protein was also reported to participate...
TMPY-02131	Acid Phosphatase/ACP1 Protein, Human, Recombinant (GST) acid phosphatase 1, soluble,HAAP	Human	E. coli
	The low molecular weight phosphotyrosine phosphatase (LMW-PTP), also known as Acid phosphatase 1 (ACP1), belongs to the low molecular weight phosphotyrosine protein phosphatase family are involved in the regulation of important physiological functions, including stress resistance and synthesis of the polysaccharide capsule. ACP1/LMW-PTP is an enzyme involved in platelet-derived growth factor-induced mitogenesis and cytoskeleton rearrangement. LMW-PTP is able to specifically bind and dephosphoryl...
TMPH-00320	Snaclec rhodocytin subunit alpha Protein, Calloselasma rhodostoma, Recombinant (His) Rhodoaggretin subunit alpha,Aggretin alpha chain,Snaclec rho...	Calloselasma rhodostoma	P. pastoris (Yeast)
	Elicits platelet aggregation by the binding to the C-type lectin domain family 1 member B (CLEC1B/CLEC2). Binding leads to tyrosine phosphorylation in the cytoplasmic tail of CLEC1B, which promotes the binding of spleen tyrosine kinase (Syk), subsequent activation of PLC-gamma-2, and platelet activation and aggregation. Binding to GPIbalpha (GP1BA) and alpha-2/beta-1 (ITGA2/ITGB1) may also induce aggregation, but this is controversial. Snaclec rhodocytin subunit alpha Protein, Calloselasma rhodo...
TMPY-03440	Sts1 Protein, Human, Recombinant (His) STS-1,ubiquitin associated and SH3 domain containing B,p70,S...	Human	E. coli
	UBASH3B contains a ubiquitin associated domain at the N-terminus, an SH3 domain, and a C-terminal domain with similarities to the catalytic motif of phosphoglycerate mutase. UBASH3B was found to inhibit endocytosis of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor. UBASH3B interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. It promotes accumulation of activated target receptors, such as T-cell receptors and EGFR, on...
TMPH-00323	Snaclec rhodocytin subunit beta Protein, Calloselasma rhodostoma, Recombinant (His & Myc) Aggretin beta chain,Rhodoaggretin subunit beta,Snaclec rhodo...	Calloselasma rhodostoma	E. coli
	Elicits platelet aggregation by the binding to the C-type lectin domain family 1 member B (CLEC1B/CLEC2). Binding leads to tyrosine phosphorylation in the cytoplasmic tail of CLEC1B, which promotes the binding of spleen tyrosine kinase (Syk), subsequent activation of PLCgamma2, and platelet activation and aggregation. Binding to GPIbalpha (GP1BA) and alpha2/beta-1 (ITGA2/ITGB1) may also induce aggregation, but this is controversial. Snaclec rhodocytin subunit beta Protein, Calloselasma rhodostom...
TMPH-00322	Snaclec rhodocytin subunit beta Protein, Calloselasma rhodostoma, Recombinant (His) Snaclec rhodocytin subunit beta,Aggretin beta chain,Rhodoagg...	Calloselasma rhodostoma	P. pastoris (Yeast)
	Elicits platelet aggregation by the binding to the C-type lectin domain family 1 member B (CLEC1B/CLEC2). Binding leads to tyrosine phosphorylation in the cytoplasmic tail of CLEC1B, which promotes the binding of spleen tyrosine kinase (Syk), subsequent activation of PLCgamma2, and platelet activation and aggregation. Binding to GPIbalpha (GP1BA) and alpha2/beta-1 (ITGA2/ITGB1) may also induce aggregation, but this is controversial. Snaclec rhodocytin subunit beta Protein, Calloselasma rhodostom...
TMPH-00321	Snaclec rhodocytin subunit alpha Protein, Calloselasma rhodostoma, Recombinant (His & SUMO) Rhodoaggretin subunit alpha,Aggretin alpha chain,Snaclec rho...	Calloselasma rhodostoma	E. coli
	Elicits platelet aggregation by the binding to the C-type lectin domain family 1 member B (CLEC1B/CLEC2). Binding leads to tyrosine phosphorylation in the cytoplasmic tail of CLEC1B, which promotes the binding of spleen tyrosine kinase (Syk), subsequent activation of PLC-gamma-2, and platelet activation and aggregation. Binding to GPIbalpha (GP1BA) and alpha-2/beta-1 (ITGA2/ITGB1) may also induce aggregation, but this is controversial. Snaclec rhodocytin subunit alpha Protein, Calloselasma rhodo...
TMPJ-00534	hFcgR4 Protein, Mouse, Recombinant (His) Low Affinity Immunoglobulin γ Fc Region Receptor IV,FcgR4,Lo...	Mouse	HEK293 Cells
	Fcgr4, also known as CD16-2, is one of the receptors for Fc region of IgG which involve in immune responses. Fcgr4 mainly functions in cellular response to lipopolysaccharide, NK T cell proliferation, regulation of sensory perception of pain, wound healing etc. Three groups are included for Fc γ receptors (FcR), and they are Fc γ RI (CD64), Fc γ RII (CD32), and Fc γ RIII (CD16). Among these, CD64 possess high affinity even for monomeric IgG, while CD32 and CD16 display a relative lower affinity ...
TMPH-01692	MAPK3 Protein, Human, Recombinant (His) MAP kinase isoform p44,p44-ERK1,MAPK3,Extracellular signal-r...	Human	E. coli
	Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, c...

重组蛋白

NKp80/KLRF1 Protein, Cynomolgus, Recombinant (hFc)

Cat.No: TMPY-03623

Species: Cynomolgus

Expression System: HEK293 Cells

IL-15 Protein, Rhesus macaque, Recombinant (His)

Cat.No: TMPH-02441

Species: Rhesus

Expression System: P. pastoris (Yeast)

SIRP beta 1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00252

Species: Human

Expression System: HEK293 Cells

Acid Phosphatase/ACP1 Protein, Human, Recombinant (GST)

Cat.No: TMPY-02131

Species: Human

Expression System: E. coli

Snaclec rhodocytin subunit alpha Protein, Calloselasma rhodostoma, Recombinant (His)

Cat.No: TMPH-00320

Species: Calloselasma rhodostoma

Expression System: P. pastoris (Yeast)

Sts1 Protein, Human, Recombinant (His)

Cat.No: TMPY-03440

Species: Human

Expression System: E. coli

Snaclec rhodocytin subunit beta Protein, Calloselasma rhodostoma, Recombinant (His & Myc)

Cat.No: TMPH-00323

Species: Calloselasma rhodostoma

Expression System: E. coli

Snaclec rhodocytin subunit beta Protein, Calloselasma rhodostoma, Recombinant (His)

Cat.No: TMPH-00322

Species: Calloselasma rhodostoma

Expression System: P. pastoris (Yeast)

Snaclec rhodocytin subunit alpha Protein, Calloselasma rhodostoma, Recombinant (His & SUMO)

Cat.No: TMPH-00321

Species: Calloselasma rhodostoma

Expression System: E. coli

hFcgR4 Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-00534

Species: Mouse

Expression System: HEK293 Cells

MAPK3 Protein, Human, Recombinant (His)

Cat.No: TMPH-01692

Species: Human

Expression System: E. coli

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