58
15
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16
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Cat. No. | Product Name | ||
---|---|---|---|
L8710 | 铜死亡化合物库 | 400 compounds | |
TargetMol 铜死亡化合物库集合了 400 种与铜死亡相关的化合物,可以用于铜死亡机制及相关疾病研究 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T83764 |
Sulfane Sulfur Probe 4
SSP4 |
||
Sulfane sulfur probe 4 (SSP4) 是用于检测含硫化氢衍生的多硫化物、过硫化物和硫化物的荧光探针。在含硫磺物种存在下,SSP4 经核苷酸攻击反应生成荧光素,其激发/发射峰值分别为494/515 nm,以及两分子的1,2-苯并二硫杂环-3-酮。SSP4 已应用于确定H2S3在原代小鼠神经元中的定位,并检测L. japonicus 幼苗根部的多硫化物。 | |||
T0495 |
Aminothiazole
2-Aminothiazole,2-氨基噻唑,2-Thiazolylamine,氨噻唑 |
Virus Protease; Antibacterial; Antibiotic; Antifungal | Microbiology/Virology |
Aminothiazole (2-Aminothiazole) 是一种甲状腺抑制剂,具有抗菌活性。它是一种典型的杂环胺,是合成多种生物活性分子的前体,包括染料,抗生素,硫磺药物,杀真菌剂和化学反应促进剂。 | |||
T20804 |
Bensulfuron-methyl
F-5384,DPX 84,F5384,F 5384,苄嘧磺隆 |
Others | Others |
Bensulfuron-methyl (F 5384) 是一种磺酰脲类除草剂,广泛应用于稻田阔叶杂草防治。 | |||
T21246 |
Metsulfuron-methyl
|
Others | Others |
Metsulfuron-methyl 是一种内吸传导选择性麦田高效磺酰脲类除草剂,主要防治麦田大多数阔叶杂草和禾本科杂草。 | |||
T19749 |
Azimsulfuron
A 8947,A8947,A-8947 |
Others | Others |
Azimsulfuron 是一种除草剂,可用于控制稻田杂草。 | |||
T19741 |
Mesosulfuron-methyl
Mesosulfuronmethyl Mesosulfuron methyl,Mesomaxx,甲磺胺磺隆 |
Others | Others |
Mesosulfuron-methyl (Mesosulfuronmethyl Mesosulfuron methyl) 是一种内吸性除草剂。用于谷类中禾本科杂草的出苗后防治。 | |||
T19859 |
Nicosulfuron
Milagro,Accent,Motivell,烟嘧磺隆 |
Others | Others |
Nicosulfuron (Milagro) 是一种磺酰脲类的选择性除草剂,常用作出苗后的除草剂,保护玉米作物免受杂草的侵害。它也能够降低乙酰乳酸合酶的活性。 | |||
T20623 |
Thifensulfuron-methyl
Harmony GT,Refine,Pinnacle,噻吩磺隆 |
Others | Others |
Thifensulfuron-methyl (Pinnacle) 是磺酰脲类除草剂,可用于防治玉米,小麦和大豆田中的阔叶杂草。 | |||
T124793 |
Cholinesulfuric acid.
|
Others | Others |
Cholinesulfuric acid. 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T124793,CAS号为 4858-96-2。 | |||
T34941 |
Triflusulfuron-methyl
Upbeet,DPX66037,DPX 66037,DPX-66037 |
Others | Others |
Triflusulfuron-methyl is a triazinylsulfonylurea herbicide. | |||
T33478 |
Monosulfuron
|
Others | Others |
Monosulfuron is an herbicide. | |||
T38615 |
Rimsulfuron
DPX-E9636,Rimsulfuron |
Others | Others |
Rimsulfuron (DPX-E9636) is a sulfonylurea herbicide specifically designed for postemergence application in maize crops. This compound effectively targets and manages grasses as well as certain types of broadleaf weeds. | |||
T80642 |
Foramsulfuron
|
Others | Others |
Foramsulfuron作为磺酰脲类除草剂,专用于玉米(Zea mays L.)中选择性地防控禾本科以及部分阔叶杂草。该化合物通过抑制关键酶乙酰乳酸合酶(acetolactate synthase, ALS)的活性,从而表现出对杂草的抑制功能,ALS主导支链氨基酸的生物合成途径。 | |||
T41081 |
Pyrazosulfuron-ethyl
|
Others | Others |
Pyrazosulfuron-ethyl, a sulphonylurea herbicide belonging to the acetolactate synthase inhibiting category, has gained extensive application in the suppression of weed proliferation within commercial cereal, soybean, and vegetable fields. | |||
T20722 |
Flucetosulfuron
LGC-42153,LGC 42153,LGC42153 |
Others | Others |
Flucetosulfuron is a sulfonylurea herbicide | |||
T0569 |
Pyrazinoic acid
Pyrazinecarboxylic acid,吡嗪甲酸 |
Others | Others |
Pyrazinoic acid (Pyrazinecarboxylic acid) 是pyrazole thiamethoxam sulfur 的中间体。 | |||
TP1869L |
Antioxidant peptide A acetate
Antioxidant peptide A acetate (159147-88-3 free base) |
Others | Others |
Antioxidant peptide A acetate (159147-88-3 free base) 是一种短肽,它含有替代的芳香族或含硫氨基酸。 | |||
T0352 |
Dibenzothiophene
二苯并噻吩,Imino semicarbazide,Diphenylene sulfide |
Others | Others |
Dibenzothiophene (Imino semicarbazide) 是有机合成过程的中间体,是由两个苯环稠合到一个中心的噻吩环。 | |||
T20290 |
Thianthrene
AI3 00638,AI300638,NSC-439,AI3-00638,噻蒽,dibenzo-1,4-dithiin,9,10-Dithiaanthracene,NSC439,Dibenzodithiodioxane,NSC 439 |
Others | Others |
Thianthrene (Dibenzodithiodioxane) 是一种含硫杂环化合物,是称为二硫因的母体杂环的衍生物,易于氧化。 | |||
T50009L |
sodium 3-amino-4,6-dimethylthieno[2,3-b]pyridine-2-carboxylate
|
Others | Others |
sodium 3-amino-4,6-dimethylthieno[2,3-b]pyridine-2-carboxylate 是一种有机硫化合物。它已被用作研究含硫化合物对酶活性和代谢途径的影响的模型化合物,也被用于研究含硫化合物对细菌生长和基因表达调控的影响。 | |||
T67766 |
HHS-0701
|
Others | Others |
HHS-0701,一种硫-三唑交换 (SuTEx) 配体,是酪氨酸反应性前列腺素还原酶 2 (PTGR2) 的有效抑制剂。HHS-0701 可以抑制脂质底物 15-Keto-PGE2 的 PTGR2 代谢。 | |||
T0682 |
Lamivudine
GR109714X,BCH-189,拉米夫定 |
HIV Protease; Reverse Transcriptase | Microbiology/Virology; Proteases/Proteasome |
Lamivudine (BCH-189) 是一种核苷逆转录酶抑制剂,可抑制HIV 逆转录酶1和2 以及乙型肝炎病毒的逆转录酶。 | |||
T9808 |
Tetradecylthioacetic acid
|
PPAR | DNA Damage/DNA Repair; Metabolism |
Tetradecylthioacetic acid 是一种合成脂肪酸,在 β 位具有硫取代。这种修饰使 TTA 无法进行完全的 β-氧化并增加其生物活性,包括激活过氧化物酶体增殖物激活受体 (PPAR),优先选择 PPARα。 | |||
T8851 |
I3MT-3
HMPSNE |
Hippo pathway | Stem Cells |
I3MT-3 (HMPSNE) 是一种有效的、具有细胞膜渗透性的、选择性的 3-巯基丙酮酸硫转移酶 (3MST)的抑制剂,IC50值为2.7 μM,对其他硫化氢/磺胺制硫酶没有活性。它靶向位于 3MST 活性位点的过硫半胱氨酸残基。 | |||
T24771 |
SCH-336
SCH336,SCH 336 |
Cannabinoid Receptor | GPCR/G Protein |
SCH-336是一种 CB2受体激动剂(Ki-1.8 nM, EC50-2 nM),具有有效性,选择性和口服活性。SCH-336对 CB1受体也具有生物活性,对CB2受体的选择性是CB1的100倍。SCH-336能够减少鸟苷5'-3- o -(硫)三磷酸与含hCB 的膜的结合,抑制 BaF3/CB2 细胞迁移,抑制小鼠延迟型超敏反应模型中的白细胞迁移,抑制小鼠过敏模型中抗原诱导的肺嗜酸性粒细胞增多。 | |||
T36141 |
Boscalid
|
Mitochondrial Metabolism | Metabolism |
Boscalid 是一种广谱羧酰胺类杀菌剂,通过与线粒体复合物 II/琥珀酸脱氢酶的泛醌位点结合来抑制真菌呼吸。 | |||
T31760 |
Felinine
|
Others | Others |
Felinine is a sulfur-containing amino acid. | |||
T32648 |
Leptophos oxon
Leptophos OA,Leptophos oxygen analog,Phosvel oxon,Velsicol VCS O-analog |
Others | Others |
Leptophos oxon is a phosvel analog-oxygen substituting sulfur. | |||
T19299 |
DTE
Cleland’s reagent,Dithioerythritol |
Others | Others |
Dithioerythritol (DTE), a sulfur-containing sugar derivative of the 4-carbon monosaccharide erythrose, is an epimer of dithiothreitol (DTT). | |||
T28821 |
SMR000071098
SMR-000071098,SMR 000071098 |
Others | Others |
SMR000071098 is an inhibitor of Fe-S cluster-dependent aconitase. SMR000071098 interacts with Suf proteins to inhibit iron-sulfur (Fe-S) cluster assembly. | |||
TP1869 |
Antioxidant peptide A
|
||
Antioxidant peptide A is a short peptide, which contains alternative aromatic or sulfur-containing amino acid. | |||
T32655 |
l-Ergothionine hydrochloride
l-Ergothionine HCl |
Others | Others |
l-Ergothionine hydrochloride is a sulfur-containing amino acid, which is only produced by Actinomycetales bacteria and non-yeast-like fungi belonging to the division Basidiomycota and Ascomycota. It was originally isolated from Claviceps purpurea or rye e | |||
T38437 |
NMTCA
N-Nitroso-2-methylthiazolidine4-carboxylicacid,NMTPRO,N-nitrosomethylthioproline |
Others | Others |
NMTCA (NMTPRO) is a sulfur-containing N-nitrosamino acid utilized as an endogenous nitrosation indicator in gas chromatography-thermal energy analysis. | |||
T68291 |
APSR-IN-8
|
Others | Others |
APSR-IN-8 is a first-in-class inhibitor of APS reductase (APSR), which is a critical enzyme in the assimilation of sulfate for the biosynthesis of cysteine and other essential sulfur-containing molecules. | |||
T21115 |
Timonacic, (S)-
|
Others | Others |
Timonacic, (S)- is a cyclic sulfur amino acid derivative with potential antioxidant and antineoplastic activities. Timonacic may induce malignant cells to revert back to an untransformed state by acting on cellular membranes of malignant cells through an | |||
T61102 |
HIF-1/2α-IN-2
|
Others | Others |
HIF-1/2α-IN-2 is a potent inhibitor of HIF-1/2α, which effectively reduces the levels of HIF-1/2α. This compound elicits an iron starvation response by specifically targeting ISCA2, a key protein involved in Iron Sulfur Cluster Assembly 2. [1] | |||
T10939 |
D,L-Cystathionine dihydrochloride
|
Others | Others |
D,L-Cystathionine dihydrochloride is an intermediate in the synthesis of cysteine, which acts from the isotype of cysteine-β-synthase (CBS) produced by leucine and serine. Derived from cysteine. DL-cysteine contains a cysteine (βC-S) carbon-sulfur bond. | |||
T20178 |
Metam-sodium
Sodium methyldithiocarbamate,Carbation,Metham sodium,Carbathione,Carbothion |
Others | Others |
Metam-sodium 是一种有机钠盐和有机硫杀虫剂,呈黄色至浅黄绿色溶液,具有不同强度的胺和硫气味。它可以用作除草剂、杀虫剂、杀真菌剂和杀虫剂。 | |||
T37000 |
7-Azido-4-methylcoumarin
|
Others | Others |
7-Azido-4-methylcoumarin (AzMC) is a coumarin fluorescent probe for hydrogen sulfide (H2S).1 AzMC selectively fluoresces in the presence of H2S over a panel of reactive nitrogen, oxygen, and sulfur species. AzMC displays excitation/emission maxima of 340/445 nm, respectively. |1. Chen, B., Li, W., Lv, C., et al. Fluorescent probe for highly selective and sensitive detection of hydrogen sulfide in living cells and cardiac tissues. Analyst 138(3), 946-951 (2013). | |||
T77774 |
tetrathiomolybdate
|
Others | Others |
Tetrathiomolybdate (TM) 通过其特征性硫桥Mo2S6O2簇促进细胞铜外排蛋白ATP7B的金属结合域(WLN4)二聚化,应用于威尔逊病(Wilson’s disease)的临床治疗。 | |||
T75025 |
ChoKα inhibitor-5
|
Others | Others |
ChoKα inhibitor-5,一种含硫胆碱激酶(Choline Kinase)抑制剂,对HChoK α1表现出显著抑制效果,IC50值为0.64 μM。此外,该化合物还可诱导细胞凋亡,常用于癌症相关研究领域。 | |||
T75024 |
ChoKα inhibitor-3
|
Others | Others |
ChoKα inhibitor-3 是一种含硫的胆碱激酶抑制剂。ChoKα inhibitor-3 可抑制 HChoK α1,IC50值为 0.66 μM。ChoKα inhibitor-3 也可诱导凋亡。ChoKα inhibitor-3 可用于癌症的研究。 | |||
T37786 |
1-thio-β-D-Glucose (sodium salt)
|
Others | Others |
1-thio-β-D-Glucose is an analog of β-D-glucose in which sulfur replaces the hydroxyl group at the one position. The thiol group allows diverse chemical reactions, including click chemistry and polymerization. 1-thio-β-D-Glucose can be labeled with technetium-99m for analytical and diagnostic procedures. It can also be used as a substrate for glucose oxidase, which leads to the production of 1-thio-β-D-gluconic acid. | |||
T83831 |
Sp-2'-Deoxyguanosine-5'-O-(1-thiotriphosphate) sodium
Sp-dGTP-α-S |
Others | Others |
Sp-2'-Deoxyguanosine-5'-O-(1-thiotriphosphate) 是一种含硫异构体,属于核苷酸三磷酸2'-脱氧鸟苷-5'-O-三磷酸(dGTP)。它通过抑制脱氧核苷酸三磷酸三磷酸水解酶SAMHD1 (Ki = 820 nM)发挥作用。 | |||
T83837 |
Rp-Thymidine-5'-O-(1-thiotriphosphate) sodium
Rp-dTTP-α-S |
Others | Others |
Rp-Thymidine-5'-O-(1-thiotriphosphate) (Rp-TTP-α-S) 是含硫核苷酸衍生物 TTP-α-S 的一个异构体。它能与HIV-1逆转录酶结合(在镁、锰酸盐和钴存在下的Kds分别为45.7、27.32和39.44 µM)。 | |||
T83828 |
Sp-2'-Deoxycytidine-5'-O-(1-thiotriphosphate) sodium
Sp-dCTP-α-S |
Others | Others |
Sp-2'-Deoxycytidine-5'-O-(1-thiotriphosphate) (Sp-dCTP-α-S) 是含硫核苷酸衍生物 dCTP-α-S 的异构体。它抑制解氧核苷酸三磷酸三磷酸水解酶 SAMHD1(Ki = 6.3 µM)。 | |||
T85035 |
Chloramine-T hydrate
|
Others | Others |
Chloramine-T serves as a versatile reagent in numerous synthetic procedures, including aminohydroxylation, allylic amination, as a nitrogen source in aziridination reactions of alkenes and olefins, and for the deprotection of thio groups in sulfur-containing molecules. Additionally, it plays a role in the synthesis of Factor Xa inhibitors. At a concentration of 0.2% w/v, Chloramine-T acts as an effective antiseptic agent with bactericidal properties against S. epidermidis, S. aureus, E. faecalis... | |||
T83834 |
Sp-Guanosine-5'-O-(1-thiotriphosphate) sodium
Sp-GTP-α-S,GTPαS(Sp),GTPαS(A) |
Others | Others |
Sp-Guanosine-5'-O-(1-thiotriphosphate) (Sp-GTP-α-S) 是一种含硫核苷酸衍生物GTP-α-S的异构体。它能结合到微管蛋白上,在20 mM的浓度下用于无细胞实验时可诱导微管组装。 | |||
T36677 |
Rp-8-bromo-Cyclic AMPS (sodium salt)
|
Others | Others |
Rp-8-bromo-Cyclic AMPS (Rp-8-bromo-cAMPS) is a cell-permeable cAMP analog that combines an exocyclic sulfur substitution in the equatorial position of the cyclophosphate ring with a bromine substitution in the adenine base of cAMP. It acts as an antagonist of cAMP-dependent protein kinases (PKAs) and is resistant to hydrolysis by cyclic nucleotide phosphodiesterases. Rp-8-bromo-cAMPS more effectively antagonizes cAMP-dependent activation of purified PKA type I from rabbit muscle than PKA type II... | |||
T78043 |
S-(2-Carboxyethyl)-L-cysteine
S-Carboxyethylcysteine |
||
S-(2-Carboxyethyl)-L-cysteine(S-羧乙基半胱氨酸)为一非蛋白质(改性)硫氨基酸,在Acacia种子中被发现。该化合物能够影响大鼠对种子蛋白质的利用效率,并可能抑制由蛋氨酸诱发的大鼠生长速度,同时对大鼠血浆氨基酸水平产生不利影响。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T39668 |
Methyl propyl disulfide
|
Others | Others |
Methyl propyl disulfide 是在大蒜和洋葱中产生的挥发性含硫化合物,具有抗癌活性。 | |||
T1285 |
Anethole trithione
茴三硫,Anetholtrithion |
Others; AChR | Neuroscience; Others |
Anethole trithione (Anetholtrithion) 是硫杂环胆碱,是一种胆汁分泌刺激剂,可增强唾液分泌并增加 mAChR 受体,用于口干症的研究。 | |||
T19081 |
1,3-Dithiane
1,3-Dithian,M-DITHIANE,1,3-Dithiacyclohexane,1,3-二噻烷 |
Anti-infection; Endogenous Metabolite; Antibacterial | Metabolism; Microbiology/Virology |
1,3-Dithiane (1,3-Dithian) 是一种受保护的甲醛阴离子等价物,可用作有用的标记合成子。它是在煮熟的牛肉提取物中发现的含硫美拉德反应产物 。 | |||
TJO2742 |
DL-Methionine
蛋氨酸,methionine,DL-蛋氨酸,Acimetion,Racemethionine |
Parasite | Microbiology/Virology |
DL-Methionine (Acimetion) 存在于肉类、鱼类和奶制品中,是可用于动物的天然饲料,还可杀死马铃薯上的金线虫。它是一种含有硫的必需氨基酸,具有氧化应激防御作用。 | |||
T2203 |
D-Carnitine hydrochloride
(S)-Carnitine Hydrochloride,L-Carnitine hydrochloride |
Others; Endogenous Metabolite | Metabolism; Others |
D-Carnitine hydrochloride ((S)-Carnitine Hydrochloride) 已被用于研究麦角硫因素转运蛋白 SLC22A4 和肉毒碱转运蛋白 SLC22A5,也被用于使棕榈酸进入线粒体。 | |||
TN2244 |
Sulfuretin
硫黄菊素 |
NF-κB; Autophagy | Autophagy; NF-κB |
Sulfuretin 是竞争性单酚酶和二酚酶活性抑制剂,IC50=13.64 μM。它通过抑制NF-κB 通路来抑制炎症反应。 它可用于过敏性气道炎症的研究。它减少氧化应激、血小板聚集和诱变。 | |||
T7878 |
Halosulfuron-methyl
A841101,Sempra,A 841101,氯吡嘧磺隆,A-841101 |
Others | Others |
Halosulfuron-methyl (A841101) 是一种常见的除草剂。 | |||
T10939L |
L-Cystathionine
L-胱硫醚,Cystathionine,ZINC1532680,L-(+)-Cystathionine,Cystathionine, L- |
Apoptosis; Endogenous Metabolite | Apoptosis; Metabolism |
L-Cystathionine (Cystathionine, L-) 是一种与含硫氨基酸的代谢条件有关的关键非蛋白质氨基酸。L-Cystathionine 可用于有关心血管保护的研究。 | |||
T1658 |
Selenomethionine
DL-Selenomethionine,DL-硒代蛋氨酸,Seleno-DL-methionine,硒代蛋氨酸 |
Amino Acids and Derivatives; Endogenous Metabolite; Autophagy | Autophagy; Metabolism |
Selenomethionine (Seleno-DL-methionine) 是一种硒代氨基酸,是蛋氨酸的硒类似物。 它具有作为植物代谢物的作用。 它是硒代蛋氨酸和硒代氨基酸的成员。 | |||
T22311 |
Djenkolic Acid
jengkolic acid,Djenkolate,3,3'-(亞甲二硫)雙丙胺酸,S,S'-Methylenebiscysteine |
Others | Others |
Djenkolic Acid (S,S'-Methylenebiscysteine) 是天然存在于东南亚植物 Archidendron jiringa 的 Djenkol 豆中的含硫非蛋白质氨基酸。它是人类急性肾损伤的一个不常见但重要的原因。 | |||
T2O2733 |
L-Cystine
Cystine Acid,cystine,胱氨酸,L-胱氨酸 |
Antioxidant; Ferroptosis; Endogenous Metabolite | Apoptosis; Metabolism; oxidation-reduction |
L-Cystine (Cystine Acid) 是一种从半胱氨酸氨基酸硫醇侧链氧化获得的含硫衍生物。它起到抗氧化剂的作用,保护组织免受辐射和污染,减缓衰老过程。它还有助于蛋白质合成。 | |||
T2O2721 |
L-Cysteine
Thioserine,L-半胱氨酸,cysteine,半胱氨酸,L-(+)-Cysteine |
Endogenous Metabolite | Metabolism |
L-Cysteine (L-(+)-Cysteine) 是人体非必需的含硫氨基酸。L-Cysteine 对蛋白质合成、解毒和多种代谢功能很重要。L-Cysteine 存在于指甲、皮肤和头发的主要蛋白质-角蛋白中,对胶原蛋白的生成、皮肤弹性和质地都很重要。L-Cysteine 是抗氧化剂谷胱甘肽的一种成分,在辅酶A、肝素和生物素等基本生化物质的代谢中起着重要作用,也是氨基酸牛磺酸的制造所必需的。 | |||
T38524 |
Paeoniflorin sulfite
|
Others | Others |
During the sulfur-fumigation process of Paeoniae Radix Alba, Paeoniflorin, which serves as a principal constituent, can be converted into Paeoniflorin sulfite. | |||
T17173 |
Tropodithietic acid
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Others | Others |
Tropodithietic acid, a sulfur-containing antibiotic produced by the marine bacterium Phaeobacter inhibens, exhibits potent antibiotic efficacy across a diverse array of bacteria, encompassing alpha- and gammaproteobacteria, flavobacteria, and actinobacteria. | |||
T35624 |
Ajoene
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Others | Others |
Ajoene is a disulfide that has been found inA. sativumand has diverse biological activities, including antibacterial, anticancer, antiplatelet, and antioxidant properties.1,2,3,4It is active against Gram-positive (MICs = 5-160 µg/ml) and Gram-negative bacteria (MICs = 136-200 µg/ml), as well as yeasts (MICs = 10-20 µg/ml).1Ajoene is cytotoxic to mouse melanoma cells (IC50= 18 µM), as well as human colon, lung, mammary, and pancreatic cancer cells (IC50s = 7-41 µM).2It reduces... |
Cat. No. | Product Name | Species | Expression System |
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TMPH-03178 |
TusA Protein, Pseudomonas aeruginosa, Recombinant (His & SUMO)
tusA,Sulfur carrier protein TusA |
Pseudomonas aeruginosa | E. coli |
Sulfur carrier protein which probably makes part of a sulfur-relay system. TusA Protein, Pseudomonas aeruginosa, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 21.8 kDa and the accession number is Q9I3F3. | |||
TMPY-03227 |
CISD1 Protein, Human, Recombinant (His)
ZCD1,CDGSH iron sulfur domain 1,C10orf70,mitoNEET,M... |
Human | E. coli |
Mitochondrial dysfunction is thought to play a significant role in neurodegeneration observed in Parkinson's disease (PD), the loss of mitoNEET (CISD1), an iron-sulfur containing protein that regulates mitochondrial bioenergetics, results in mitochondrial dysfunction and loss of striatal dopamine and tyrosine hydroxylase. CDGSH iron sulfur domain 1 (CISD1, also termed mitoNEET), an iron-containing outer mitochondrial membrane protein, negatively regulates ferroptotic cancer cell death. At the ce... | |||
TMPH-00641 |
YTFE Protein, E. coli, Recombinant (GST)
Regulator of cell morphogenesis and NO signaling,Iron-su... |
E. coli | E. coli |
Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions. YTFE Protein, E. coli, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 51.9 kDa and the accession number is P69506. | |||
TMPH-01561 |
ISCU Protein, Human, Recombinant (His & Myc)
NifU-like protein,ISCU,Iron-sulfur cluster assembly... |
Human | Baculovirus Insect Cells |
Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic Functions as a cytoplasmic scaffold protein for the de novo synthesis of iron-sulfur clusters in the cytoplasm. | |||
TMPH-00016 |
Ferredoxin Protein, Acetoanaerobium sticklandii, Recombinant (His & Myc)
Ferredoxin |
Acetoanaerobium sticklandii | E. coli |
Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. | |||
TMPH-03505 |
Glutaredoxin 4/GrxD Protein, Shigella flexneri, Recombinant (His & SUMO)
grxD,Monothiol glutaredoxin,Glutaredoxin 4 |
Shigella flexneri | E. coli |
Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters. | |||
TMPH-03706 |
LEB6 Protein, Vicia faba, Recombinant (His)
LEB6,Legumin type B |
Vicia faba | P. pastoris (Yeast) |
This protein found in the seeds of many leguminous and non-leguminous plants is the source of sulfur-containing amino acids in seed meals. LEB6 Protein, Vicia faba, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 19.0 kDa and the accession number is P16079. | |||
TMPH-03705 |
NfuA Protein, Vibrio vulnificus, Recombinant
nfuA,Fe/S biogenesis protein NfuA |
Vibrio vulnificus | E. coli |
Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins. NfuA Protein, Vibrio vulnificus, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 21.0 kDa and the accession number is Q8DDU2. | |||
TMPH-03746 |
NfuA Protein, E. coli, Recombinant (Avi & His & MBP), Biotinylated
Fe/S biogenesis protein NfuA,nfuA |
ENT-Escherichia coli | E. coli |
Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins. NfuA Protein, E. coli, Recombinant (Avi & His & MBP), Biotinylated is expressed in E. coli expression system with N-MBP and C-6xHis-Avi tag. The predicted molecular weight is 68.8 kDa and the accession number is B1X760. | |||
TMPH-00621 |
NfuA Protein, E. coli, Recombinant (His)
Fe/S biogenesis protein NfuA,nfuA |
E. coli | E. coli |
Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins. NfuA Protein, E. coli, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 25.1 kDa and the accession number is B1X760. | |||
TMPH-00188 |
BioAB Protein, Bacteroides fragilis, Recombinant (His & Myc)
Adenosylmethionine-8-amino-7-oxononanoate aminotransferase B... |
Bacteroides fragilis | E. coli |
Catalyzes two activities which are involved in the biotine biosynthesis: the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism, and the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). BioAB Protein, Bacteroides fragilis, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The p... | |||
TMPH-02661 |
Frataxin/FXN Protein, Mouse, Recombinant (E. coli, His)
Fxn,Frataxin, mitochondrial |
Mouse | E. coli |
Promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+); the oligomeric form but not the monomeric form has in vitro ferroxidase activity. May be able to store large amounts of iron in the form of a ferrihydrite mineral by oligomerization. Modulates the RNA-binding activit... | |||
TMPH-02660 |
Frataxin/FXN Protein, Mouse, Recombinant (His)
Fxn,Frataxin, mitochondrial |
Mouse | P. pastoris (Yeast) |
Promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+); the oligomeric form but not the monomeric form has in vitro ferroxidase activity. May be able to store large amounts of iron in the form of a ferrihydrite mineral by oligomerization. Modulates the RNA-binding activit... | |||
TMPY-03658 |
ETHE1 Protein, Human, Recombinant (His)
YF13H12,HSCO,ethylmalonic encephalopathy 1 |
Human | E. coli |
ETHE1, also known as HSCO, is a sulfur dioxygenase that localizes within the mitochondrial matrix. ETHE1 probably plays an important role in metabolic homeostasis in mitochondria. It may also function as a nuclear-cytoplasmic shuttling protein that binds transcription factor RELA/NFKB3 in the nucleus and exports it to the cytoplasm. ETHE1 can suppresses p53-induced apoptosis by preventing nuclear localization of RELA. Mutations in ETHE1 gene result in ethylmalonic encephalopathy. Ethylmalonic en... | |||
TMPY-02482 |
Aconitase 1 Protein, Human, Recombinant (His)
HEL60,IRP1,ACONS,aconitase 1, soluble,IREBP,IREBP1,IREB1 |
Human | Baculovirus Insect Cells |
Aconitase 1(ACO1) or IRP1 is one member of the aconitase family that contains a diverse group of iron-sulphur(Fe-S) isomerases and two types of iron regulatory protein. Aconitase exits in two forms: one is soluble and the other is mitochondrial. ACO1 is the soluble existing form, and the mitochondrial form is ACO2. Residues from all three N-terminal domains and the larger C-terminal domain contribute to the active site region. When the enzyme is activated, it gains an additional iron atom. ACO1 ... | |||
TMPY-02375 |
acnB Protein, E. coli, Recombinant
yacI,yacJ |
E. coli | E. coli |
Escherichia coli contains two major aconitases (Acns), AcnA and AcnB. They are distantly related monomeric Fe-S proteins that contain different arrangements of four structural domains. acnA is specifically subject to SoxRS-mediated activation, whereas acnB encodes the major aconitase that is synthesized earlier in the growth cycle than AcnA. It is concluded that AcnB is the major citric acid cycle enzyme. Aconitate hydratase 2 (acnB) catalyzes the isomerization of citrate to isocitrate via cis-a... |
Cat. No. | Product Name | Target | Signaling Pathways |
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TMID-0285 |
Lamivudine-13C-d2
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Lamivudine-13C-d2 是 Lamivudine 的 13C 和氘代化合物。Lamivudine 的 CAS 号为 134678-17-4。Lamivudine 是一种核苷逆转录酶抑制剂,可抑制HIV逆转录酶1和2 以及乙型肝炎病毒的逆转录酶。 | |||
TMIJ-0384 |
L-Cysteine-d3
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L-Cysteine-d3 是 L-Cysteine 的氘代化合物。L-Cysteine 的 CAS 号为 52-90-4。L-Cysteine 是人体非必需的含硫氨基酸。L-Cysteine 对蛋白质合成、解毒和多种代谢功能很重要。L-Cysteine 存在于指甲、皮肤和头发的主要蛋白质-角蛋白中,对胶原蛋白的生成、皮肤弹性和质地都很重要。L-Cysteine 是抗氧化剂谷胱甘肽的一种成分,在辅酶A、肝素和生物素等基本生化物质的代谢中起着重要作用,也是氨基酸牛磺酸的制造所必需的。 |