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Search Results for " sulfonylurea "

Targets Recommended: Others

37

抑制剂 & 化合物

5

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T8345	Carbutamide	Others	Others
	Carbutamide 是一代磺酰脲，口服具有活性，具有降血糖作用。
T21246	Metsulfuron-methyl	Others	Others
	Metsulfuron-methyl 是一种内吸传导选择性麦田高效磺酰脲类除草剂，主要防治麦田大多数阔叶杂草和禾本科杂草。
T9222	Emlenoflast MCC7840	NOD-like Receptor (NLR); NOD	Immunology/Inflammation; NF-κB
	Emlenoflast (MCC7840) 是一种 NLRP3炎症小体 (NLRP3 inflammasome) 的选择性抑制剂(IC50<100 nM)。它可用于研究炎性疾病。
T19859	Nicosulfuron Milagro,Accent,Motivell,烟嘧磺隆	Others	Others
	Nicosulfuron (Milagro) 是一种磺酰脲类的选择性除草剂，常用作出苗后的除草剂，保护玉米作物免受杂草的侵害。它也能够降低乙酰乳酸合酶的活性。
T20623	Thifensulfuron-methyl Harmony GT,Refine,Pinnacle,噻吩磺隆	Others	Others
	Thifensulfuron-methyl (Pinnacle) 是磺酰脲类除草剂，可用于防治玉米，小麦和大豆田中的阔叶杂草。
T20804	Bensulfuron-methyl F-5384,DPX 84,F5384,F 5384,苄嘧磺隆	Others	Others
	Bensulfuron-methyl (F 5384) 是一种磺酰脲类除草剂，广泛应用于稻田阔叶杂草防治。
T1603	Glipizide CP 28720,K 4024,格列吡嗪	Potassium Channel; PPAR; ABC	DNA Damage/DNA Repair; Membrane transporter/Ion channel; Metabolism
	Glipizide (CP 28720) 是一种有效的、具有口服活性的磺酰脲类抗糖尿病试剂 (anti-diabetic agent)，在 2 型糖尿病的研究中具有价值，但不适用于1 型糖尿病。Glipizide 是通过部分阻断郎格汉斯胰岛细胞中 ATP 敏感钾通道 (KATP)发挥活性。
T0816	Acetohexamide Acetohexamid,醋磺环已脲,Dymelor,醋磺己脲,Gamadiabet	Potassium Channel; NADPH	Membrane transporter/Ion channel; Metabolism
	Acetohexamide (Acetohexamid) 是磺脲类试剂，可刺激胰腺分泌胰岛素，能够用于 2 型糖尿病的相关研究。
T0127	Glimepiride Glimperide,HOE-490,格列美脲	Potassium Channel	Membrane transporter/Ion channel
	Glimepiride (HOE-490) 是一种中长效的磺酰脲类抗糖尿病化合物，其 ED50=182 μg/k。
T0490	Chlorpropamide Diabinese,氯磺丙脲	ATPase; ABC	Membrane transporter/Ion channel
	Chlorpropamide (Diabinese) 是口服降糖剂，可用于研究非胰岛素依赖型糖尿病。
T16420	P-1075	Potassium Channel	Membrane transporter/Ion channel
	P-1075 是磺酰脲受体2相关的 ATP 敏感性的钾通道(SUR2-KIR6)的激活剂，EC50为 45 nM。它在兔子中通过打开线粒体 K (ATP) 通道产生活性氧，产生保护心脏的功效。
T1634	Glibenclamide 格列本脲,Glyburide	Potassium Channel; Mitochondrial Metabolism; CFTR; P-gp; Autophagy	Autophagy; Membrane transporter/Ion channel; Metabolism; Neuroscience
	Glibenclamide (Glyburide) 是一种具有口服活性的 ATP 敏感的 K+通道抑制剂，可研究糖尿病和肥胖。它抑制 P-糖蛋白，可直接结合并阻断 KATP 的 SUR1亚基并抑制囊性纤维化跨膜传导调节蛋白。它通过诱导膜离子通透性干扰线粒体生物能，可诱导自噬。
T0371	Gliquidone AR-DF 26,格列喹酮,Glurenorm	Potassium Channel	Membrane transporter/Ion channel
	Gliquidone (AR-DF 26) 是一种磺酰脲类的抗糖尿病药物，可用于2型糖尿病的研究。
T1410	Torsemide AC-4464,JDL-464,托拉塞米,Torasemide	Na-K-Cl cotransporter	Membrane transporter/Ion channel
	Torsemide (AC-4464) 是具有口服活性的亨氏环利尿剂，也具有抗醛固酮和血管舒张活性。它可用于研究心力衰竭、肾脏疾病、肝硬化。
T1527	Gliclazide 格列齐特,S1702,SE1702	Potassium Channel	Membrane transporter/Ion channel
	Gliclazide (SE1702) 是一种有效的全细胞的 β 细胞 ATP 敏感型钾流阻断剂，IC50为 184 nM，用作降糖药。
T31966	Glycyclamide TOLCYCLAMIDE,Tolhexamide,Cyclamide,Glycyclamid,Gliciclamide	Others	Others
	Glycolamide is a sulfonylurea compound containing cyclohexyl groups.
T27883	LY 181984 LY181984,LY-181984,MPCU	Others	Others
	LY 181984 is an sulfonylurea with antitumor properties.
T13712	Glyparamide	Others	Others
	Glyparamide is a chlorophenyl-containing sulfonylurea with hypoglycemic activity.
TP2383	Glipentide Staticum,UR661,UR-661,UR 661,Glisentide
	Glieptide, a second-generation sulfonylurea, promotes the accumulation of fructose 2, 6-diphosphate in liver cells.
T20722	Flucetosulfuron LGC-42153,LGC 42153,LGC42153	Others	Others
	Flucetosulfuron is a sulfonylurea herbicide
T35640	trans-carboxy Glimepiride	Others	Others
	trans-carboxy Glimepiride is a metabolite of the sulfonylurea glimepiride .1It is formed from glimepiride in a two-step process mediated by the cytochrome P450 (CYP) isoform CYP2C9 and cytosolic enzymes. 1.Noh, K., Kim, E., Jeong, T.C., et al.Simultaneous determination of glimepiride and its metabolites in human plasma by liquid chromatography coupled to a tandem mass spectrometryArch. Pharm. Res.34(12)2073-2078(2011)
T35641	trans-hydroxy Glimepiride	Others	Others
	trans-hydroxy Glimepiride is an active metabolite of the sulfonylurea glimepiride .1It is formed from glimepiride primarily in the liver by the cytochrome P450 (CYP) isoform CYP2C9. 1.Langtry, H.D., and Balfour, J.A.Glimepiride. A review of its use in the management of type 2 diabetes mellitusDrugs55(4)563-584(1998)
T38456	Tribenuron	Others	Others
	Tribenuron, a slow acting sulfonylurea herbicide, controls broadleaf weed.
T0371L	Gliquidone sodium	Others	Others
	Gliquidone sodium is a hypoglycemic sulfonylurea which may protect the liver from injury from diabetes.
T84960	Nicorandil N-oxide	Others	Others
	Nicorandil N-oxide, a metabolite of nicorandil, functions as an activator of the ATP-sensitive potassium channel Kir6.2 (SUR2B/Kir6.2) and is associated with the sulfonylurea receptor 2B (SUR2B), while also serving as a nitric oxide donor.
T9222L	Emlenoflast sodium MCC7840 sodium	NOD	Immunology/Inflammation; NF-κB
	Emlenoflast sodium (MCC7840 sodium)是磺酰脲类化合物，是一种选择性NLRP3炎症小体 (NLRP3 inflammasome) 的抑制剂，对NLRP3炎症小体的IC50值小于 100 nM，可用于炎性疾病的研究。
T38615	Rimsulfuron DPX-E9636,Rimsulfuron	Others	Others
	Rimsulfuron (DPX-E9636) is a sulfonylurea herbicide specifically designed for postemergence application in maize crops. This compound effectively targets and manages grasses as well as certain types of broadleaf weeds.
T61461	Anticancer agent 37	Others	Others
	Anticancer agent 37 (compound 18) is a sulfonylurea derivative known for its potent anticancer activity. It efficiently inhibits the growth of HePG2 cells, displaying an IC 50 value of 17.2 μg/mL [1].
T61602	Anticancer agent 35	Others	Others
	Anticancer agent 35 (compound 10) 是一种磺酰脲类衍生物，一种有效的抗癌剂。Anticancer agent 35 抑制 A549、A431、PACA2 细胞生长，IC50分别为 18.1 μg/mL、4.0 μg/mL、18.9 μg/mL。
T36740	Guanosine 5’-diphosphate (sodium salt hydrate)	Others	Others
	Guanosine 5’-diphosphate (GDP) is a purine nucleotide and biosynthetic precursor of guanosine 5’-triphosphate .1It has been used to study the conformations of GTPases.2GDP (100 μM) activates sulfonylurea receptor 2B (SUR2B) linked to the inward-rectifier potassium channel 6.1 (Kir6.1) in HEK293T cells in a patch-clamp assay.3 1.Berg, J.M., Tymoczko, J.L., and Stryer, L.Biochemistry(2002) 2.Vetter, I.R., and Wittinghofer, A.The guanine nucleotide-binding switch in three dimensionsScience294(5545)...
T14040	4-Hydroxytolbutamide Hydroxytolbutamide	Potassium Channel	Membrane transporter/Ion channel
	4-Hydroxytolbutamide(Hydroxytolbutamide), a metabolite of Tolbutamide, which is metabolized by CYP2C8 and CYP2C9. Tolbutamide is a first generation potassium channel blocker and a sulfonylurea oral antidiabetic[1][2].
T35635	rac-trans-4-hydroxy Glyburide	Others	Others
	rac-trans-4-hydroxy Glyburide is an active metabolite of the SUR1/Kir6.2 sulfonylurea inhibitor glyburide .1,2It is formed from glyburide by the cytochrome P450 (CYP) isoforms CYP2C8 and CYP2C9.1rac-trans-4-hydroxy Glyburide inhibits glyburide binding to rat brain synaptosomes at the high and low affinity sites of SUR1/Kir6.2 with IC50values of 0.95 and 100 nM, respectively.2 1.Zharikova, O.L., Fokina, V.M., Nanovskaya, T.N., et al.Identification of the major human hepatic and placental enzymes ...
T62278	Anticancer agent 36	Others	Others
	Anticancer agent 36 (compound 11) 是一种有效的抗微生物剂和抗癌剂，是一种磺酰脲类衍生物。Anticancer agent 36 对蕈状芽孢杆菌、大肠杆菌和白色念珠菌的微生物生长有抑制作用 (MIC: 0.156 - 0.039 mg/mL)。Anticancer agent 36 能够抑制 A549 细胞 (IC50: 19.7 μg/mL)、PC3 细胞 (IC50: 11.9 μg/mL) 生长。
T62754	Anticancer agent 34	Others	Others
	Anticancer agent 34 (compound 9) 是一种磺酰脲类衍生物，也是一种有效的抗微生物剂和抗癌剂。Anticancer agent 34 对蕈状芽孢杆菌、大肠杆菌和白色念珠菌的微生物生长表现出抑制作用 (MIC: 0.039-0.156 mg/ml)。Anticancer agent 34 能够抑制 A549 细胞 (IC50: 8.4 μg/ml)、PC3 细胞 (IC50: 7.8 μg/ml) 的生长。
T71284	Glimepiride urethane	Others	Others
	Glimepiride urethane is a third generation sulfonylurea compound, which increases the release of insulin from pancreatic beta cells. In addition, glimepiride increases the activity of intracellular insulin receptors. Glimepiride increases osteoblast proliferation and differentiation, which is thought to be related to its ability to activate the PI3K and Akt pathway. Furthermore, Glimepiride enhances intrinsic peroxisome proliferator-activated receptor γ activity. Glimepiride also increases prote...
T80642	Foramsulfuron	Others	Others
	Foramsulfuron作为磺酰脲类除草剂，专用于玉米(Zea mays L.)中选择性地防控禾本科以及部分阔叶杂草。该化合物通过抑制关键酶乙酰乳酸合酶(acetolactate synthase, ALS)的活性，从而表现出对杂草的抑制功能，ALS主导支链氨基酸的生物合成途径。
T79446	INF200	NOD-like Receptor (NLR)	Immunology/Inflammation
	INF200（compound 5）是一种磺酰脲衍生的抑制剂，既能抑制NLRP3也能抑制NLRP3介导的焦亡(pyroptosis)。在HFD诱导的大鼠模型上，INF200对心脏代谢表现出有益效果，并且在(10 μM)浓度下减少了人巨噬细胞中IL-1β的释放，表现出抗炎特性。它还能改善血糖控制和脂质水平，降低全身炎症和心功能障碍的标志物（尤其是BNP水平）。此外，INF200在血流动力学评估中还可提升心肌损伤后的缺血/再灌注损伤(IRI)恢复。

化合物

Cat.No: T8345

Target: Others

Metsulfuron-methyl

Cat.No: T21246

Target: Others

Cat.No: T9222

Synonym: MCC7840

Target: NOD-like Receptor (NLR), NOD

Cat.No: T19859

Synonym: Milagro,Accent,Motivell,烟嘧磺隆

Target: Others

Thifensulfuron-methyl

Cat.No: T20623

Synonym: Harmony GT,Refine,Pinnacle,噻吩磺隆

Target: Others

Bensulfuron-methyl

Cat.No: T20804

Synonym: F-5384,DPX 84,F5384,F 5384,苄嘧磺隆

Target: Others

Cat.No: T1603

Synonym: CP 28720,K 4024,格列吡嗪

Target: Potassium Channel, PPAR, ABC

Cat.No: T0816

Synonym: Acetohexamid,醋磺环已脲,Dymelor,醋磺己脲,Gamadiabet

Target: Potassium Channel, NADPH

Cat.No: T0127

Synonym: Glimperide,HOE-490,格列美脲

Target: Potassium Channel

Cat.No: T0490

Synonym: Diabinese,氯磺丙脲

Target: ATPase, ABC

Cat.No: T16420

Target: Potassium Channel

Cat.No: T1634

Synonym: 格列本脲,Glyburide

Target: Potassium Channel, Mitochondrial Metabolism, CFTR, P-gp, Autophagy

Cat.No: T0371

Synonym: AR-DF 26,格列喹酮,Glurenorm

Target: Potassium Channel

Cat.No: T1410

Synonym: AC-4464,JDL-464,托拉塞米,Torasemide

Target: Na-K-Cl cotransporter

Cat.No: T1527

Synonym: 格列齐特,S1702,SE1702

Target: Potassium Channel

Cat.No: T31966

Synonym: TOLCYCLAMIDE,Tolhexamide,Cyclamide,Glycyclamid,Gliciclamide

Target: Others

Cat.No: T27883

Synonym: LY181984,LY-181984,MPCU

Target: Others

Cat.No: T13712

Target: Others

Cat.No: TP2383

Synonym: Staticum,UR661,UR-661,UR 661,Glisentide

Flucetosulfuron

Cat.No: T20722

Synonym: LGC-42153,LGC 42153,LGC42153

Target: Others

trans-carboxy Glimepiride

Cat.No: T35640

Target: Others

trans-hydroxy Glimepiride

Cat.No: T35641

Target: Others

Cat.No: T38456

Target: Others

Gliquidone sodium

Cat.No: T0371L

Target: Others

Nicorandil N-oxide

Cat.No: T84960

Target: Others

Emlenoflast sodium

Cat.No: T9222L

Synonym: MCC7840 sodium

Target: NOD

Cat.No: T38615

Synonym: DPX-E9636,Rimsulfuron

Target: Others

Anticancer agent 37

Cat.No: T61461

Target: Others

Anticancer agent 35

Cat.No: T61602

Target: Others

Guanosine 5’-diphosphate (sodium salt hydrate)

Cat.No: T36740

Target: Others

4-Hydroxytolbutamide

Cat.No: T14040

Synonym: Hydroxytolbutamide

Target: Potassium Channel

rac-trans-4-hydroxy Glyburide

Cat.No: T35635

Target: Others

Anticancer agent 36

Cat.No: T62278

Target: Others

Anticancer agent 34

Cat.No: T62754

Target: Others

Glimepiride urethane

Cat.No: T71284

Target: Others

Cat.No: T80642

Target: Others

Cat.No: T79446

Target: NOD-like Receptor (NLR)

Cat. No.	Product Name	Target	Signaling Pathways
TMIH-0253	Gliclazide-d7
	Gliclazide-d7 是 Gliclazide 的氘代化合物。Gliclazide 的 CAS 号为 21187-98-4。Gliclazide 是一种有效的全细胞的 β 细胞 ATP 敏感型钾流阻断剂，IC50为 184 nM，用作降糖药。
TMID-0267	Glipizide-d11
	Glipizide-d11 是 Glipizide 的氘代化合物。Glipizide 的 CAS 号为 29094-61-9。Glipizide 是一种有效的、具有口服活性的磺酰脲类抗糖尿病试剂 (anti-diabetic agent)，在 2 型糖尿病的研究中具有价值，但不适用于1 型糖尿病。Glipizide 是通过部分阻断郎格汉斯胰岛细胞中 ATP 敏感钾通道 (KATP)发挥活性。
TMIJ-0523	Gliquidone-d6
	Gliquidone-d6 是 Gliquidone 的氘代化合物。Gliquidone 的 CAS 号为 33342-05-1。Gliquidone 是一种磺酰脲类的抗糖尿病药物，可用于2型糖尿病的研究。
T71402	Nicorandil-d4
	Nicorandil-d4 is intended for use as an internal standard for the quantification of nicorandil by GC- or LC-MS. Nicorandil is an activator of sulfonylurea receptor 2B (SUR2B) linked to ATP-sensitive potassium channel Kir6.2 (EC50 = ~10 µM) and a nitric oxide (NO) donor. It is selective for SUR2B/Kir6.2 over the SUR2A/Kir6.2 channel (EC50 = >500 µM). Nicorandil activates soluble guanylate cyclase in a cell-free assay and relaxes partially depolarized isolated bovine coronary artery strips (EC50 =...
T71981	Gliclazide-d4
	Gliclazide-d4 is intended for use as an internal standard for the quantification of gliclazide by GC- or LC-MS. Gliclazide is a sulfonylurea and an inhibitor of pancreatic β-cell ATP-sensitive potassium (KATP) channels. It is selective for pancreatic β-cell over cardiac and arterial smooth muscle cell KATP channels. Gliclazide (5 μM) increases insulin-induced glucose uptake and glucose transporter 4 (GLUT4) translocation to the plasma membrane in a differentiated 3T3L1 adipocyte model of insulin...

同位素标记化合物

Cat.No: TMIH-0253

Cat.No: TMID-0267

Cat.No: TMIJ-0523

Cat.No: T71402

Cat.No: T71981

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