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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T78354 |
Subtilisin
EC 3.4.21.14 |
Others | Others |
Subtilisin,一种细菌来源的丝氨酸蛋白酶,通常作为洗涤剂添加剂使用,特征包括热稳定性、对pH的耐受性和钙依赖性稳定性。 | |||
T4524 |
SBC-110736
SBC110736 |
Others; Serine/threonin kinase | Cell Cycle/Checkpoint; Metabolism; Others |
SBC-110736 是一种蛋白转化酶枯草杆菌蛋白酶 9 型 (PCSK9) 抑制剂。 | |||
T2626 |
SBC-115076
SBC115076 |
Others; Serine/threonin kinase | Cell Cycle/Checkpoint; Metabolism; Others |
SBC-115076 是前蛋白转化酶枯草杆菌蛋白酶/ kexin 9型(PCSK9)抑制剂。其中PCSK9 是一种前蛋白转化酶,在 LDL 受体代谢中的重要物质。 | |||
T0789 |
PMSF
Phenylmethylsulfonyl fluoride,Benzylsulfonyl fluoride,苯甲基磺酰氟 |
Serine Protease; Cysteine Protease | Proteases/Proteasome |
PMSF (Phenylmethylsulfonyl fluoride) 是一种丝氨酸/半胱氨酸蛋白酶不可逆抑制剂,常用于制备细胞裂解物。 | |||
T9920 |
Evolocumab
|
Others | Others |
Evolocumab 是人源化单克隆抗体PCSK9的抑制剂。它与循环的 PCSK9 蛋白结合,使得PCSK9与 LDLR 结合受到抑制。它可用研究于高胆固醇血症以及动脉粥样硬化性心血管疾病的研究。 | |||
TP1881L1 |
Pep 2-8 ammonium salt(1541011-97-5 free base)
|
Others | Others |
Pep 2-8 ammonium salt(1541011-97-5 free base) 是 Proprotein 转化酶枯草杆菌蛋白酶/kexin 9 型 (PCSK9) 抑制剂。 PCSK9 与 LDL 受体结合的强效抑制剂 (IC50 = 0.8 μM)。恢复用 PCSK9 处理的 HepG2 细胞中的 LDL 摄取。 | |||
T16491 |
PF-06446846 hydrochloride
|
Others | Others |
PF-06446846 hydrochloride 是一种口服活性高、高选择性PCSK9(前蛋白转化酶枯草杆菌蛋白酶/kexin 9 型)翻译抑制剂。它通过在密码子34附近诱导核糖体暂停来抑制PCSK9。 | |||
T72025 |
PCSK9-IN-10
|
Serine/threonin kinase | Cell Cycle/Checkpoint; Metabolism |
PCSK9-IN-10 是一种有效的,具有口服活性的PCSK9抑制剂,IC50值为 6.4 µM。PCSK9-IN-10 增加LDLR 蛋白的表达并降低 PCSK9 的表达。PCSK9-IN-10 可减缓动脉粥样硬化进展。PCSK9-IN-10 具有研究高脂血症的潜力。 | |||
T76489 |
Fluorescent Substrate for Subtillsin
|
||
Fluorescent Substrate for Subtilisin 是一种用于检测 Subtilisin 酶活的荧光底物。Subtilisin 是一种来自细菌的丝氨酸蛋白酶。 | |||
T72221 |
PF-06815345 hydrochloride
|
Others | Others |
PF-06815345 hydrochloride 是一款口服有效的PCSK9抑制剂,其IC50值为13.4 μM。在小鼠体内,能显著降低PCSK9水平。 | |||
T70069 |
MDK6465
|
Others | Others |
MDK6465, also known as PCSK9-IN-8b, is a novel liver-targeted inhibitor of ribosomal synthesis of proprotein convertase subtilisin/kexin type 9 (PCSK9). MDK6465 has CAS#1900686-46-5. the last 4 digits are used in its name. | |||
TP2038 |
Decanoyl-RVKR-CMK
|
||
Subtilisin/Kex2p-like proprotein convertase inhibitor; blocks activity of all seven convertases (PC1, PC2, PC4, PACE4, PC5, PC7 and furin). Abolishes proET-1 processing in endothelial cells; inhibits regulated secretion of the neuronal polypeptide VGF in | |||
TP1881 |
Pep2-8
Pep 2-8 |
||
Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor. Potent inhibitor of PCSK9 binding to LDL receptor (IC50 = 0.8 μM). Restores LDL uptake in HepG2 cells treated with PCSK9. | |||
T81711 |
N-Acetyl-DL-phenylalanine β-naphthyl ester
|
||
N-Acetyl-DL-phenylalanine β-naphthyl ester 为一芳香族氨基酸酯,用作糜蛋白酶及微生物丝氨酸蛋白酶(例如枯草杆菌蛋白酶)的显色底物。 | |||
T60541 |
PCSK9 modulator-2
|
Others | Others |
PCSK9 modulator-2 (Compound 1) 是一种有效的PCSK9调节剂(EC50 = 202 nM), 具有用于高脂血症的研究潜力。PCSK9 是降低低密度脂蛋白胆固醇 (LDL-C) 的靶点。 | |||
T36338 |
AAF-CMK (trifluoroacetate salt)
|
Others | Others |
Tripeptidyl peptidase II (TPPII) is a serine peptidase of the subtilisin-type which removes tripeptides from the free NH2 terminus of oligopeptides. AAF-CMK is an irreversible inhibitor of TPPII commonly used at 10-100 μM. It does not significantly interfere with the chymotrypsin-like activity of the proteasome. AAF-CMK also inhibits bleomycin hydrolase and puromycin-sensitive aminopeptidase when used at 50 μM. | |||
T79051 |
PCSK9-IN-15
|
Others | Others |
PCSK9-IN-15(化合物5)是一种高效PCSK9抑制剂,亲和力强(KD<200 nM)。该化合物与胆固醇代谢相关,可调控低密度脂蛋白胆固醇(LDL-C)水平,适用于研究降低胆固醇及血脂异常。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T75545 |
PCSK9-IN-9
|
Others | Others |
PCSK9-IN-9 是一种天然来源的异香豆素。PCSK9-IN-9 可抑制原蛋白转化酶枯草菌素 kexin 型 9 (PCSK9)、IDOL 和 SREBP2的 mRNA 表达水平。PCSK9-IN-9 抑制 PCSK9的 IC50为 11.9 μM。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-00159 |
Subtilisin Carlsberg Protein, Bacillus licheniformis, Recombinant (His & SUMO)
subC,Subtilisin Carlsberg |
Bacillus licheniformis | E. coli |
Subtilisin is an extracellular alkaline serine protease, it catalyzes the hydrolysis of proteins and peptide amides (Ref.4, PubMed:11109488). Shows high specificity for aromatic and hydrophobic amino acids in the P1 substrate position. May play an important role in the degradation of feather keratin. Subtilisin Carlsberg Protein, Bacillus licheniformis, Recombinant (His & SUMO) is expressed in E. coli expression system with N-10xHis-SUMO tag. The predicted molecular weight is 42.0 kDa and the ac... | |||
TMPH-00172 |
Subtilisin E Protein, Bacillus subtilis, Recombinant (His & SUMO)
aprE,Subtilisin E |
Bacillus subtilis | E. coli |
Subtilisin is an extracellular alkaline serine protease, it catalyzes the hydrolysis of proteins and peptide amides. Subtilisin E Protein, Bacillus subtilis, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 43.7 kDa and the accession number is P04189. | |||
TMPY-00408 |
PCSK9 Protein, Human, Recombinant (D374Y & V474I & G670E, His)
FH3,proprotein convertase subtilisin/kexin type 9,L... |
Human | HEK293 Cells |
PCSK9 Protein, Human, Recombinant (D374Y & V474I & G670E, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 72.6 kDa and the accession number is AAV67948.1. | |||
TMPY-04966 |
PCSK9 Protein, Human, Recombinant (D374Y, His)
LDLCQ1,NARC-1,PC9,NARC1,HCHOLA3,proprotein convertase su... |
Human | HEK293 Cells |
PCSK9 Protein, Human, Recombinant (D374Y, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 72.5 kDa and the accession number is Q8NBP7-1. | |||
TMPY-05131 |
PCSK9 Protein, Human, Recombinant (His & Avi), Biotinylated
NARC-1,PC9,LDLCQ1,NARC1,FH3,proprotein convertase subtil... |
Human | HEK293 Cells |
PCSK9 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 74.3 kDa and the accession number is Q8NBP7-1. | |||
TMPJ-00443 |
PCSK9 Protein, Macaca nemestrina, Recombinant (His)
Proprotein Convertase Subtilisin/Kexin Type 9,PCSK9... |
Macaca nemestrina | HEK293 Cells |
Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) is a secretory subtilase belonging to the proteinase K subfamily. PCSK9 is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the ER , the pro domain and mature chain secrete together through noncovalent interactions. PCSK9 binds with low-density lipoprotein receptor (LDLR) and plays a major regulatory role in cholesterol homeostasis. PCSK9 also plays a role in the neural development. | |||
TMPY-01565 |
PCSK9 Protein, Rat, Recombinant (His)
proprotein convertase subtilisin/kexin type 9 |
Rat | HEK293 Cells |
PCSK9 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 72.8 kDa and the accession number is A6JYM6. | |||
TMPY-00995 |
PCSK9 Protein, Rhesus, Recombinant (His)
proprotein convertase subtilisin/kexin type 9 |
Rhesus | HEK293 Cells |
PCSK9 Protein, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 72.7 kDa and the accession number is A8T666. | |||
TMPJ-00369 |
PCSK9 Protein, Human, Recombinant (His & HA & Avi), Biotinylated
Subtilisin/Kexin-Like Protease PC9,PCSK9,NARC1,Prop... |
Human | HEK293 Cells |
PCSK9 Protein, Human, Recombinant (His & HA & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-8xHis-HA-Avi tag. The predicted molecular weight is 18 and 58-70 and 90-150 KDa and the accession number is Q8NBP7. | |||
TMPJ-00368 |
PCSK9 Protein, Human, Recombinant (Avi), Biotinylated
Subtilisin/Kexin-Like Protease PC9,PC9,NARC-1,Propr... |
Human | HEK293 Cells |
PCSK9 Protein, Human, Recombinant (Avi), Biotinylated is expressed in HEK293 mammalian cells with C-Avi tag. The predicted molecular weight is 19&65 KDa and the accession number is Q8NBP7. | |||
TMPY-05218 |
PCSK9 Protein, Human, Recombinant (mFc)
HCHOLA3,PC9,proprotein convertase subtilisin/kexin ... |
Human | HEK293 Cells |
PCSK9 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 97.4 kDa and the accession number is Q8NBP7-1. | |||
TMPY-05199 |
PCSK9 Protein, Human, Recombinant (D374Y, mFc)
PC9,proprotein convertase subtilisin/kexin type 9,F... |
Human | HEK293 Cells |
PCSK9 Protein, Human, Recombinant (D374Y, mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 97.5 kDa and the accession number is Q8NBP7-1. | |||
TMPY-01635 |
PCSK1 Protein, Human, Recombinant (His)
proprotein convertase subtilisin/kexin type 1,SPC3,... |
Human | HEK293 Cells |
Neuroendocrine convertase 1, also known as Prohormone convertase 1, Proprotein convertase 1, PCSK1 and NEC1, is an enzyme which belongs to the peptidase S8 family and Furin subfamily. PCSK1 is an enzyme that performs the proteolytic cleavage of prohormones to their intermediate (or sometimes completely cleaved) forms. It is present only in neuroendocrine cells such as brain, pituitary and adrenal, and most often cleaves after a pair of basic residues within prohormones but can occasionally cleav... | |||
TMPY-05114 |
PCSK9 Protein, Human, Recombinant (D374Y & V474I & G670E, His), Biotinylated
LDLCQ1,NARC-1,PC9,FH3,NARC1,HCHOLA3,proprotein convertase |
Human | HEK293 Cells |
PCSK9 Protein, Human, Recombinant (D374Y & V474I & G670E, His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 72.6 kDa and the accession number is Q8NBP7-1. | |||
TMPY-05270 |
PCSK9 Protein, Human, Recombinant (D374Y, mFc), Biotinylated
FH3,NARC-1,PC9,LDLCQ1,proprotein convertase subtilisin |
Human | HEK293 Cells |
PCSK9 Protein, Human, Recombinant (D374Y, mFc), Biotinylated is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 97.5 kDa and the accession number is Q8NBP7-1. | |||
TMPH-01661 |
MBTPS1 Protein, Human, Recombinant (His & SUMO)
MBTPS1,Membrane-bound transcription factor site-1 protease,<... |
Human | E. coli |
MBTPS1 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 37.5 kDa and the accession number is Q14703. | |||
TMPY-05217 |
PCSK9 Protein, Mouse, Recombinant (mFc)
HCHOLA3,Narc1,AI415265,AI747682,FH3,proprotein convertase |
Mouse | HEK293 Cells |
PCSK9 Protein, Mouse, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 97.6 kDa and the accession number is Q80W65. | |||
TMPY-01245 |
PCSK9 Protein, Mouse, Recombinant (His)
proprotein convertase subtilisin/kexin type 9,AI747... |
Mouse | HEK293 Cells |
PCSK9 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 72.6 kDa and the accession number is Q80W65. | |||
TMPH-02408 |
SPI Protein, Lentinula edodes, Recombinant (His)
Serine protease inhibitor |
Lentinula edodes | E. coli |
Serine protease inhibitor. Active against beta-trypsin and alpha-chymotrypsin with dissociation constants of 0.35 nM and 40 nM respectively. Inhibits factor XIa, but not other enzymes involved in coagulation and fibrinolysis. Does not inhibit subtilisin, lysyl endopeptidase, arginyl endopeptidase or papain. | |||
TMPK-00483 |
PCSK9 Protein, Cynomolgus, Recombinant (His)
PCSK9 |
Cynomolgus | HEK293 Cells |
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is an enzyme encoded by the PCSK9 gene in humans on chromosome 1.The first two PCSK9 inhibitors, alirocumab and evolocumab, were approved as once every two week injections, by the U.S. Food and Drug Administration in 2015 for lowering LDL-particle concentrations when statins and other drugs were not sufficiently effective or poorly tolerated. |