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Cat. No. | Product Name | ||
---|---|---|---|
L9700 | 内质网应激化合物库 | 193 compounds | |
193 个内质网应激相关的化合物集合,可用于高通量和高内涵筛选; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T5491 |
GSK3179106
|
c-RET | Apoptosis; Tyrosine Kinase/Adaptors |
GSK3179106 是选择性的、具有口服活性的RET 激酶抑制剂,对人和大鼠 RET 的 IC50 分别为 0.4 nM 和 0.2 nM。它能够减轻炎症后和应激引起的内脏超敏反应,对肠易激综合征具有潜在的应用价值。 | |||
TP1889 |
MCL0020
MCL 0020 |
Melanocortin Receptor | GPCR/G Protein; Neuroscience |
MCL0020 是一种有效的选择性黑素皮质素MC4受体拮抗剂,IC50为 11.63 nM。它剂量依赖性减轻束缚应激诱发的厌食症,在体内表现出抗焦虑样活性。 | |||
T1997 |
JNJ-31020028
JNJ 31020028 |
Neuropeptide Y Receptor | GPCR/G Protein; Neuroscience |
JNJ-31020028是神经肽Y2受体选择性可脑渗透抑制剂,对人Y2和鼠源Y2受体pIC50值分别为8.07和8.22,其神经肽 Y2 受体的选择性比人 Y1/Y4/Y5 受体高 100 倍。 | |||
T16481 |
PF-04995274
|
5-HT Receptor | GPCR/G Protein; Neuroscience |
PF-04995274 是强效,高亲和力,口服活性血清素 4 受体的部分激动剂。它是可脑渗透的,可用于与阿尔茨海默症相关的认知障碍的研究。 | |||
T5913 |
Sulbutiamine
舒布硫胺,Bisibuthiamine |
Antioxidant | oxidation-reduction |
Sulbutiamine (Bisibuthiamine) 是合成的维生素 B1 类似物,可用于研究无力症。 | |||
T12779 |
Ru-32514
|
GABA Receptor | Membrane transporter/Ion channel; Neuroscience |
Ru-32514 是一种苯二氮受体激动剂,可部分逆转小鼠应激诱导的觉醒,可用于研究神经系统疾病。 | |||
T13867 |
RH01386
|
Others | Others |
RH01386是可以预防 ER 应激诱导的β细胞功能障碍和死亡、抑制促凋亡基因表达的小分子。它恢复内质网应激受损的葡萄糖刺激的胰岛素分泌反应。对2型糖尿病具有潜在的研究价值。 | |||
T5500 |
DORA-22
|
OX Receptor | GPCR/G Protein; Neuroscience |
DORA-22 是一种双食欲素受体拮抗剂,可改善轻度压力引起的失眠,对记忆的影响很小。 | |||
T4125 |
HSF1A
|
HSP | Cytoskeletal Signaling; Metabolism |
HSF1A 是一种可渗透细胞的 HSF1 激活剂,可保护哺乳动物细胞免受应激诱导的细胞凋亡。它还是 TRiC/CCT 的特异性抑制剂。 | |||
T20797 |
NE-100 hydrochloride
NE100 Hydrochloride,NE 100 HCl,NE 100 Hydrochloride,NE-100 Hydrochloride,NE-100 HCl |
Sigma receptor | GPCR/G Protein |
NE-100 hydrochloride (NE-100 HCl) 是选择性sigma-1 受体拮抗剂,IC50为 4.16 nM。它在体内具有抗精神病活性。它也能抑制内质网应激诱导的海马细胞死亡。 | |||
T14491 |
B022
|
NF-κB | NF-κB |
B022 是一种具有选择性和高效性的 NF-κB 诱导激酶(NIK)抑制剂(Ki:4.2 nM),是治疗肝脏炎症和损伤的化学探针。B022 可避免肝脏免受氧化应激和毒素引起的炎症和损伤。 | |||
T21824 |
Sephin1
NSC 65390,IFB-088 |
Phosphatase | Metabolism |
Sephin1 (IFB-088) 是 GADD34 (PPP1R15A) 的选择性抑制剂,这是一种应激诱导的蛋白磷酸酶 1 复合物调节亚基,可将 eIF2α 去磷酸化。 | |||
T22577 |
Antalarmin hydrochloride
|
CRFR; Immunology/Inflammation related | GPCR/G Protein; Immunology/Inflammation |
Antalarmin hydrochloride 是促肾上腺皮质激素释放因子 1 (CRF1) 的拮抗剂。 Antalarmin hydrochloride 具有抗炎作用并抑制与肠易激综合征相关的应激性胃溃疡。 | |||
T8869 |
B355252
|
Others | Others |
B355252 是苯氧基噻吩磺酰胺小分子,NGF 受体激动剂。它能增强 NGF 诱导的神经突生长。它可减轻 DNA 损伤、抑制 ROS 生成、降低 LDH 水平以及预防神经元凋亡,保护缺血性神经元免受神经元损失。它具有抗细胞凋亡作用。 | |||
T4400 |
DIM-C-pPhOH
CDIM8 |
Apoptosis; Others | Apoptosis; Others |
DIM-C-pPhOH (CDIM8) 是一种核受体 4A1(NR4A1) 拮抗剂,可降低细胞增殖,对 ACHN 细胞和 786-O 细胞的IC50值分别为 13.6 μM 和 13.0 μM。它抑制癌细胞的生长和 mTOR 信号传导,诱导细胞凋亡和细胞应激。 | |||
T9564 |
IRE1α kinase-IN-1
|
IRE1 | Cell Cycle/Checkpoint |
IRE1α kinase-IN-1 是IRE1α 的选择性抑制剂(IC50为 77 nM),对 IRE1α 的选择性高于 IRE1β 亚型 100 倍。它抑制内质网诱导的 IRE1α 寡聚和自磷酸化,并抑制 IRE1α RNase 活性 (IC50=80 nM)。 | |||
T34081 |
Piromelatine
NEU-P-11,NEU-P 11,NEU-P11 |
P2X Receptor; 5-HT Receptor; MT Receptor; Sodium Channel; TRP/TRPV Channel | GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience |
Piromelatine 是褪黑激素 MT1/MT2 受体、5-HT1A 和 5-HT1D 的激动剂,也是 5-HT2B 的拮抗剂。Piromelatine 具有抗痛觉活性,对 P2X3、TRPV1 和 Nav1.7 通道有抑制作用,可用于促进睡眠、缓解疼痛、抗神经退行性疾病和抗抑郁疾病的研究。 | |||
T16550 |
PKR-IN-C16
|
Others | Others |
PKR-IN-C16 是一种特异性蛋白激酶抑制剂。它能够抑制 PKR 的自磷酸化,解除 PKR 在原代神经元细胞培养中诱导的翻译阻断。 | |||
T26684 |
Auten-99 HBr
Auten-99,Auten-99 hydrochloride. Auten-99 HBr,Auten99,Auten 99 |
Phosphatase | Metabolism |
Auten-99 HBr (Auten-99) 是新型肌管蛋白磷酸酶 Jumpy( MTMR14) 的抑制剂,可通过血脑屏障,具有强大的神经保护作用。 | |||
T50032 |
5-(2-furyl)-N-propylisoxazole-3-carboxamide
|
Others | Others |
5-(2-furyl)-N-propylisoxazole-3-carboxamide 是一种用作分子结构单元的化合物,被认为是 NMDA 受体的调节剂,已被证明对神经元细胞中谷氨酸诱导的兴奋性毒性和氧化应激具有保护作用。它也被发现具有抗炎活性,使其成为阿尔茨海默病和帕金森病等疾病的潜在治疗剂。 | |||
T7042 |
1,5-Isoquinolinediol
|
PARP | Chromatin/Epigenetic; DNA Damage/DNA Repair |
1,5-Isoquinolinediol 是一种多聚(ADP-核糖)合成酶抑制剂,对PARP1的IC50值为 0.39 µM。它用于研究 PARP1 在 DNA 修复和氧化应激诱导的细胞死亡中的作用。 | |||
T35449 |
α-(difluoromethyl)-DL-Arginine
DFMA,RMI 71897,α-(difluoromethyl)-DL-Arginine |
Others | Others |
α-(difluoromethyl)-DL-Arginine (RMI 71897) 是一种酶激活的、不可逆的大肠杆菌(Ki = 800 μM)、铜绿假单胞菌和肺炎克雷伯菌精氨酸脱羧酶抑制剂。在0.01 mM 时,它已被证明可以防止渗透胁迫诱导的燕麦叶片细胞精氨酸脱羧酶活性和腐胺合成的增加。当α-(difluoromethyl)-DL-Arginine 与多种多胺类似物联用时,能在10 mM 的最低浓度下抑制克氏锥虫在哺乳动物宿主细胞中的生长,并在T 细胞受体α缺陷小鼠模型中阻止小锥虫的生长。 | |||
T13488 |
2-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide
2-_E-2-decenoylamino_ethyl_2-_cyclohexylethyl__sulfide |
Prostaglandin Receptor | GPCR/G Protein; Immunology/Inflammation |
2-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide is a compound known to inhibit stress-induced ulcers, effectively maintaining the levels of phospholipase A2 and prostaglandin E2 in rats subjected to water immersion-restrained stress-induced ulceration. | |||
T26002 |
Pyclen
|
Others | Others |
Pyclen is an inhibitor of cell death induced by oxidative stress and an inhibitor of AB1-40 aggregation induced by Cu2+ ion. It can both prevent and disrupt Cu(2+) induced AB(1-40) aggregation. | |||
T31263 |
Deanol aceglumate
Otrun,Deanolo aceglumato,Risatarun,Deanoli aceglumas |
Others | Others |
Deanol aceglumate is combination of deanol and N-acetyl-L-glutamic acid. deanol aceglumate can effect Hepatoprotective on stress-induced gastropathy and diabetes mellitus. | |||
T25807 |
MHY884
MHY 884,MHY-884 |
Others | Others |
MHY884 is an inhibitor of tyrosinase that acts by inhibiting UVB-induced activation of the NF-κB signaling pathway through the downregulation of oxidative stress. | |||
T10809 |
CHPG
|
Others | Others |
CHPG is a selective agonist of mGluR5. In BV2 microglial cells, it attenuates SO2-induced oxidative stress and inflammation through the TSG-6/NF-κB pathway. | |||
T26596 |
Allylpyrocatechol
|
Others | Others |
Allylpyrocatechol is an antioxidant. Allylpyrocatechol attenuates collagen-induced arthritis via attenuation of oxidative stress secondary to modulation of the MAPK, JAK/STAT, and Nrf2/HO-1 pathways. | |||
T26172 |
S3QEL-2
S3QEL2,S3QEL 2 |
Others | Others |
S3QEL-2 is a retrograde signaling modulator. It acts by strongly mitigating the oxidative stress-induced apoptosis that limits the yield of functional ß-cells from intact islets. | |||
T68398 |
MI-223
|
Others | Others |
MI-223 is an inhibitor of Mcl-1-stimulated homologous recombination (HR) DNA repair, which leads to sensitization of cancer cells to hydroxyurea- or olaparib-induced DNA replication stress. | |||
T68959 |
Fenobam hydrate
|
Others | Others |
Fenobam hydrate is a noncompetitive antagonist and inverse agonist of metabotropic glutamate receptor 5 (mGluR5). It inhibits intracellular calcium mobilization induced by the glutamate analog quisqualate and inhibits basal activity of mGluR5. Fenobam reduces stress-induced hyperthermia, exhibits anxiolytic-like activity, and may induce analgesia. | |||
T27107 |
CYM-5478
CYM 5478,CYM5478 |
Others | Others |
CYM-5478 is a potent and selective S1P2 agonist. Under nutrient-deprivation stress produced by serum-starvation, CYM-5478 induced a significant increase in the viability of C6 cells in a dose dependent manner at concentrations above 100 nM. | |||
T34811 |
Terrein
NSC 291308,土曲霉酮,Terrain,(+)Terrein,NSC291308,NSC-291308 |
Others | Others |
Terrain, also known as NSC 291308, is a fungal metabolite with diverse biological activities. Terrein reduces age-related inflammation induced by oxidative stress through Nrf2/ERK1/2/HO-1 signalling in aged HDF cells. (+)-terrein suppresses interleukin-6/ | |||
T25576 |
KF 392
KF392,KF-392 |
Others | Others |
KF 392 is antiulcer. It was found that KF-392 given orally to rats at 1.0 to 5.0 mg/kg had a marked suppression on the developments of Shay ulcer as well as the aspirin-, stress-, and reserpine-induced gastric lesions. | |||
T3689L |
Ruboxistaurin mesylate
LY-333531,LY333531,LY 333531,LY-333531 Mesylate |
Others | Others |
Ruboxistaurin is a PKC beta inhibitor. Ruboxistaurin reduces oxidative stress and attenuates left ventricular hypertrophy and dysfunction in rats with streptozotocin-induced diabetes. Ruboxistaurin attenuates diabetic nephropathy via modulation of TGF-β1/ | |||
T69068 |
Aspulvinone H
|
Others | Others |
Aspulvinone H is a natural inhibitor of glutamic oxaloacetate transaminase 1 (GOT1), suppressing glutamine metabolism, making PDAC cells sensitive to oxidative stress and inhibiting cell proliferation, exhibiting potent in vivo antitumor activity in an SW1990-cell-induced xenograft model. | |||
T73096 |
Z-LEVD-FMK
|
Others | Others |
Z-LEVD-FMK 是一种细胞渗透性的caspase-4抑制剂。 Z-LEVD-FMK 阻断 ER 应激诱导的癌细胞凋亡。 | |||
T84398 |
8,12-iso-iPF2α-VI
12-iso-5,6E,14Z-PGF2α,12-iso-5,6E,14Z-Prostaglandin F2α,8,12-iso-Isoprostane-F2α-VI |
Others | Others |
8,12-iso-iPF2α-VI, an isoprostane, arises from non-enzymatic, free radical-induced peroxidation of membrane lipids. It is the predominant isoprostane formed during lipid peroxidation and serves as a biomarker for oxidative stress. Detectable in hepatic tissue post CCl4-induced oxidative damage, 8,12-iso-iPF2α-VI levels are also elevated in the urine, blood, and cerebrospinal fluid of Alzheimer’s disease patients. | |||
T83050 |
Anti-inflammatory agent 62
|
Others | Others |
Anti-inflammatory agent 62 减轻乙酰氨基酚诱导的HepG2肝毒性,其机制是通过调节炎症和氧化应激途径。 | |||
T38228 |
R 121919 hydrochloride
|
Others | Others |
High affinity corticotropin releasing factor receptor1 (CRF1) antagonist (Ki = 3.5 nM). Reduces stress-induced elevations of plasma ACTH. Anxiolytic and antidepressant in vivo. Orally bioavailable. Chen and Grigoriadis (2005) NBI 30775 (R121919), an orally active antagonist of the corticotropin-releasing factor (CRF) type-1 receptor for the treatment of anxiety and depression. Drug Dev.Res. 65 216 |Jutkiewicz et al (2005) The effects of CRF antagonists, antalarmin, CP154,526, LWH234, and R121919... | |||
T36328 |
Termitomycamide B
|
Others | Others |
Endoplasmic reticulum (ER) stress, caused by accumulation of misfolded proteins and a disruption of calcium homeostasis, has been linked to several neuronal diseases including, Parkinson's, Alzheimer's, and prion diseases. A screen for protective activity against ER stress-dependent cell death identified termitomycamides, extracts from the fruiting bodies of T. titanicus, a notably large edible mushroom that is cultivated symbiotically in the nests of termites Termitomycamide B is a fatty acid i... | |||
T76195 |
Stresscopin-related peptide (human)
|
||
Stresscopin-related peptide (human) 是 2 型 CRH 受体的特异性配体。Stresscopin-related peptide (human) 抑制食物摄入,延迟胃排空,并减少热引起的水肿。Stresscopin-related peptide (human) 在应激后维持体内平衡,可用于应激相关疾病的研究。 | |||
T72543 |
BOLD-100 free base
NKP-1339 free base ; IT-139 free base ; KP-1339 free base,KP-1339 free base,NKP-1339 free base,IT-139 free base |
Others | Others |
BOLD-100 (NKP-1339; IT-139) free base 是一款钌基抗癌药物。作为GRP78应激诱导上调的抑制剂,它破坏内质网(ER)的稳态,从而诱发ER应激和未折叠蛋白反应(UPR)。此外,BOLD-100 free base 干预了内质网应激反应、溶酶体动力学以及细胞自噬(autophagy)间的复杂交互作用。 | |||
T35670 |
Miro1 Reducer
|
Others | Others |
Promotes proteasomal degradation of Miro1 (mitochondrial Rho GTPase 1). Reduces Miro1 levels in fibroblasts from Parkinson's disease (PD) patients (IC50 = 7.8 μM). Exhibits no significant effect on related outer mitochondrial membrane protein Mitofusin. Reduces stress-induced degeneration of dopaminergic neurons derived from PD patient iPSCs. Rescues age-dependent neuronal loss and prolongs lifespan in fly PD models. | |||
T81970 |
Kuwanon T
|
Others | Others |
Kuwanon T为一种源自桑树根皮的异戊二烯黄酮类化合物,能抵御t-BHP诱导的氧化应激,其EC50值为30.32 μM。 | |||
T24883 |
Tingenin B
22-Hydroxytingenone |
Others | Others |
Tingenin B is a potent anticancer agent due to its cytotoxic activity on cancer stem cells of breast cancer in vitro. Tingenin b was cytotoxic against MCF-7s (IC50: 2.38 μM for 48 h) by inducing apoptosis. Endoplasmic reticulum stress was also found to be | |||
T69990 |
Ruboxistaurin mesylate monohydrate
|
Others | Others |
Ruboxistaurin mesylate monohydrate is a PKC beta inhibitor potentially for the treatment of diabetic nephropathy and diabetic macular edema. Ruboxistaurin attenuates diabetic nephropathy via modulation of TGF-β1/Smad and GRAP pathways. Ruboxistaurin reduces oxidative stress and attenuates left ventricular hypertrophy and dysfunction in rats with streptozotocin-induced diabetes. Ruboxistaurin inhibits retinal neovascularization via suppression of phosphorylation of ERK1/2 and Akt. | |||
T70987 |
AT-1001
|
Others | Others |
AT-1001 is an α3β4 nAChR partial agonist. AT-1001 attenuates stress-induced reinstatement of nicotine seeking in a rat model of relapse and induces minimal withdrawal in dependent rats. AT-1001 also potently and reversibly blocks epibatidine-induced inward currents in HEK cells transfected with α3β4 nAChR. Importantly, AT-1001 potently and dose-dependently blocks nicotine self-administration in rats, without affecting food responding. When tested in a nucleus accumbens (NAcs) synaptosomal prepar... | |||
T63364 |
Nrf2 activator-5
|
Others | Others |
Nrf2 activator-5 是 Nrf2 的有效激活剂,能够减轻 BV-2 小胶质细胞中 H2O2诱导的氧化应激和 LPS 刺激的炎症,表现出抗氧化和抗炎活作用。 | |||
T75268 |
84-B10
|
Others | Others |
84-B10是一种3-苯基戊二酸衍生物,能够抑制cisplatin诱导的肾小管铁死亡,并减轻cisplatin引起的线粒体损伤和氧化应激,从而有效改善cisplatin诱导的急性肾损伤(AKI)。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3S0488 |
Syringaresinol diglucoside
Syringaresinol-di-O-glucoside,丁香树脂醇双葡萄糖苷 |
Others | Others |
Syringaresinol diglucoside (Syringaresinol-di-O-glucoside) 是一种提取自竹叶中的天然化合物。 | |||
T0632 |
3,4,5-Trimethoxybenzoic acid
Gallic acid trimethyl ether,Eudesmic acid,3,4,5-三甲氧基苯甲酸,Trimethylgallic Acid,Benzoic acid,Tri-O-methylgallic acid,没食子酸三甲醚 |
Antioxidant | oxidation-reduction |
3,4,5-Trimethoxybenzoic acid (Gallic acid trimethyl ether) 是一种苯甲酸衍生物,可用作医药和有机合成中的砌块。 | |||
T8704 |
4-hydroxyphenyl acetate
|
Nrf2 | Immunology/Inflammation |
4-hydroxyphenyl acetate 通过作为 NRF2 稳定剂防止 RPE 氧化应激诱导的坏死。 | |||
T5665 |
Geraniol
|
Others; Endogenous Metabolite; Antifungal | Metabolism; Microbiology/Virology; Others |
Geraniol 对糖尿病引起的心脏功能障碍起保护作用,抑制氧化应激。 | |||
TN1058 |
Pelargonidin chloride
|
NOS; Reactive Oxygen Species; Nrf2; NO Synthase | Immunology/Inflammation; Metabolism; NF-κB |
Pelargonidin chloride 是一种氧化氮自由基的清除剂,具有抗氧化作用。 | |||
T6S1768 |
Narcissin
水仙苷,Isorhamnetin 3-Rutinoside,Narcissoside |
Antioxidant | oxidation-reduction |
Narcissin (Isorhamnetin 3-Rutinoside) 是一种黄连糖苷,能够清除 ONOO-(IC50:3.5 μM)和 SIN-1 衍生的 ONOO-(IC50:9.6 μM),具有抗氧化作用。 | |||
TN1600 |
Eclalbasaponin I
|
Others | Others |
Eclalbasaponin I 分离自鳢肠中,具有抗肿瘤作用,能够抑制肝癌细胞 smmc-7721 的增殖(IC50:111.1703 μg/ml)。 | |||
TN1594 |
DL-Syringaresinol
(±)-Syringaresinol |
Antioxidant; Antifungal | Microbiology/Virology; oxidation-reduction |
DL-Syringaresinol ( (±)-Syringaresinol) 是一种来自与人参浆果的木质素,具有抗炎、抗氧化、镇痛活性和较弱的抗分枝杆菌活性。DL-Syringaresinol 可通过自噬延缓氧化应激诱导的皮肤老化,通过抑制炎症反应来缓解奥沙利铂诱导的神经性疼痛和脓毒症引起的心功能障碍。 | |||
T3860 |
Isoliquiritin apioside
|
MMP; p38 MAPK; NF-κB | MAPK; NF-κB; Proteases/Proteasome |
Isoliquiritin apioside 可抑制癌细胞和内皮细胞的侵袭和血管生成,显著降低 PMA 诱导的MMP9活性增加,并抑制 PMA 诱导的MAPK 和NF-κB 活化。 | |||
TN1461 |
(-)-Butin
Butin,漆黄素 ( 紫铆素) |
Akt; PI3K; Nrf2 | Cytoskeletal Signaling; Immunology/Inflammation; PI3K/Akt/mTOR signaling |
(-)-Butin (Butin) 是 Butin 的 S 对映体。其中 Butin 是一种分离自黄檀的心材中的生物活性黄酮类化合物,具有显著的抗血小板、抗氧化、抗炎作用。 | |||
T2S0690 |
Ecliptasaponin A
早莲苷 A,旱莲苷A,Echinocystic acid-3-o-glucoside |
Others | Others |
Ecliptasaponin A (Echinocystic acid-3-o-glucoside) 是一种墨旱莲 (Eclipta prostrate) 中分离得到的五环三萜皂苷。其中墨旱莲是一种具有多效作用的滋补草药,如抗炎、保肝、抗氧化和免疫调节。 | |||
T4868 |
gamma-Linolenic acid
gamolenic acid,γ-Linolenic acid,γ-亚麻酸 |
Endogenous Metabolite | Metabolism |
gamma-Linolenic acid (gamolenic acid) 是一种 omega-6 (n-6),18 碳 (18C-) 多不饱和脂肪酸 (PUFA),可以从人乳和植物种子油中提取。 | |||
TN1957 |
Mulberrofuran Q
MulberrofuranQ |
||
Mulberrofuran Q是一种有活性的化合物,可抑制12-羟基-5,8,10-十七碳三烯酸(HHT)和血栓烷B2(环加氧酶产物)的形成 ,可保护神经细胞免受缺氧-缺糖(OGD)诱导的氧化应激的影响。 | |||
T11685 |
Isolongifolene
异长叶烯,(-)-Isolongifolene |
Apoptosis; Others | Apoptosis; Others |
Isolongifolene ((-)-Isolongifolene) 是一种从调料九里香中分离的三环倍半萜烯,具有抗氧化,抗炎,抗癌和神经保护的特性。它通过调节 PI3K/AKT/GSK-3β 信号通路来减轻鱼藤酮诱导的氧化应激,线粒体功能障碍和细胞凋亡。 | |||
T6S1966 |
Curculigoside
Curculigoside A,仙茅苷 |
Antioxidant; NF-κB; JAK; STAT | Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; NF-κB; oxidation-reduction; Stem Cells |
Curculigoside (Curculigoside A) 是仙茅中的主要皂苷,具有显著的抗氧化、抗骨质疏松、抗抑郁和神经保护作用。它通过调节JAK/STAT/NF-κB 信号传导途径,具有抗关节炎作用。 | |||
T3395 |
Timosaponin AIII
Filiferin B,知母皂苷 A-III,AneMarsaponin A3,Timosaponin A3 |
AChE; mTOR | Neuroscience; PI3K/Akt/mTOR signaling |
Timosaponin AIII (Timosaponin A3) 是一种乙酰胆碱酯酶活性抑制剂,其IC50=35.4 μM。 | |||
T6S0221 |
Eriocitrin
eriodictyol 7-rutinoside,圣草次甙,Eriodictyol-7-O-Rutinoside,Eriodictioside,圣草次甙;圣草次苷,Eriodictyol glycoside |
Apoptosis; Carbonic Anhydrase | Apoptosis; Metabolism |
Eriocitrin (Eriodictyol-7-O-Rutinoside) 是从柠檬中分离出来的一种黄酮类天然产物,是强效的抗氧化剂。它通过激活线粒体涉及的内在信号传导途径来触发细胞凋亡。它通过上调 p53、cyclin A、cyclin D3 和 CDK6 使 S 期细胞周期停滞,从而抑制肝癌细胞的增殖。 | |||
TN1601 |
Effusol
灯心草菲酚,厄弗酚 |
Caspase | Apoptosis; Proteases/Proteasome |
Effusol 是一种从 Juncus effuses 中分离到的酚类物质,对 DPPH 自由基(IC50:79 μM) 及 ABTS 自由基(IC50:2.73 μM)具有较强的清除活性。它能挽救皮质酮减弱的 CA1 LTP,保护海马功能对抗应激诱导的认知能力下降。 | |||
T36051 |
Lipoxin A4
LXA4 |
Endogenous Metabolite; Interleukin | Immunology/Inflammation; Metabolism |
Lipoxin A4 (LXA4) 是一种内源性脂氧合酶衍生的类花生酸介质,具有抗炎作用。Lipoxin A4 通过抑制 Nrf2 来减弱 MSU 晶体诱导的 NLRP3 炎症小体激活,通过 FPR2-IRF 途径调节 M1/M2 巨噬细胞极化。Lipoxin 抑制氧化应激和炎症。 | |||
T3795 |
Corilagin
|
Apoptosis; TLR; Reverse Transcriptase; Antibacterial; Autophagy | Apoptosis; Autophagy; Immunology/Inflammation; Microbiology/Virology |
Corilagin 是一种鞣酸,有抑制 RNA 肿瘤病毒逆转录酶的活性。它抑制金黄色葡萄球菌的生长,MIC 为 25 μg/mL。它有抗肿瘤活性,可用于肝癌和卵巢癌。 | |||
T4001 |
Euxanthone
1,7-Dihydroxyxanthone |
Autophagy | Autophagy |
Euxanthone (1,7-Dihydroxyxanthone) 是一种从 Polygala tenuifolia Willd 的根中提取的氧杂蒽酮衍生物,具有抗肿瘤、神经保护和血管松弛活性,可通过诱导自噬 (autophagy) 来减弱 Aβ1-42 诱导的氧化应激和细胞凋亡。Euxanthone 可诱导神经母细胞瘤神经 2A (BU-1) 细胞的分化。 | |||
T3753 |
Sinapinic Acid
Sinapic acid,芥子酸,Synapoic acid |
Apoptosis; RAAS; Reactive Oxygen Species; HDAC | Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Endocrinology/Hormones; Immunology/Inflammation; Metabolism; NF-κB |
Sinapinic Acid (Synapoic acid) 是从 Hydnophytum formicarumJack. 根中分离到的酚类,是HDAC 抑制剂,对ACE-I 的活性也有抑制作用。它有抗肿瘤活性,诱导肿瘤细胞凋亡,具有抗氧化、抗糖尿病的作用。 | |||
T2909 |
Fraxetin
7,8-dihydroxy-6-methoxy coumarin,秦皮素,弗拉西汀 |
Apoptosis; Others | Apoptosis; Others |
Fraxetin (7,8-dihydroxy-6-methoxy coumarin) 是从秦皮中分离出来的一种天然产物,可诱导细胞凋亡,具有抗肿瘤、抗氧化作用和抗炎作用。 | |||
TN1464 |
Camellianin A
|
Apoptosis; RAAS | Apoptosis; Endocrinology/Hormones |
Camellianin A 是从 A. nitida 和 茶叶中提取得到的类黄酮列化合物,具有抗癌活性,抑制血管紧张素转换酶 (ACE) 活性,促进 Hep G2 和 MCF-7 细胞凋亡。Camellianin A 可预防CCl4-通过施加抗氧化应激、抗炎和抗细胞凋亡诱导肝损伤。 | |||
TWS1977 |
Kamebakaurin
尾叶香茶菜丙素,Kamebakaurine |
NF-κB | NF-κB |
Kamebakaurin (Kamebakaurine) 是一种提取自Isodon japonicus 中的天然产物,是一种NF-κB 的抑制剂,能够抑制 p50 的 DNA 结合活性。 | |||
T6S1572 |
Sauchinone
|
ERK; p38 MAPK; NF-κB | MAPK; NF-κB |
Sauchinone 是一种从Saururus chinensis 中获得的非对映异构的木脂素。它通过抑制I-κBα磷酸化和p65核易位来抑制 LPS 诱导的 iNOS,TNF-α 和 COX-2 表达。它具有抗炎和抗氧化活性。 | |||
TN1413 |
Atranorin
荔枝素,巴美灵,荔枝素 |
Endogenous Metabolite; NO Synthase; Ras | GPCR/G Protein; Immunology/Inflammation; MAPK; Metabolism |
Atranorin 是地衣的次生代谢产物,具有显着的抗伤害、抗炎和氧化还原活性,对 H(2)O(2) 诱导的氧化应激下的细胞具有细胞保护作用。 | |||
T2854 |
Phillyrin
Forsythin,连翘苷 |
P450; Influenza Virus; AMPK | Chromatin/Epigenetic; Metabolism; Microbiology/Virology; PI3K/Akt/mTOR signaling |
Phillyrin (Forsythin) 是从连翘中分离出来的一种天然产物,具有抗甲型流感病毒的活性,以及抗菌和消炎作用。 | |||
T40615 |
N,N'-Dimethylthiourea
N,N-二甲基硫脲,DMTU |
Antioxidant | oxidation-reduction |
N,N'-Dimethylthiourea (DMTU) 是一种分离自黑蒜的化合物。N,N'-Dimethylthiourea 具有口服活性的羟基自由基 (•OH) 的清除剂,通过活化的中性粒细胞在体外阻止 •OH 的产生。N,N'-Dimethylthiourea 通过发挥 •OH 清除和抗炎作用,防止水浸限制应激诱导的大鼠胃粘膜损伤。 | |||
T6S1784 |
Brazilin
Natural Red 24,巴西苏木素;苏枋精,Braziletto,Brasilin,Superbresiline,巴西苏木素 |
Apoptosis; Others; AMPK; Autophagy | Apoptosis; Autophagy; Chromatin/Epigenetic; Others; PI3K/Akt/mTOR signaling |
Brazilin (Braziletto) 是来自几种热带硬木的心材的一种红色染料前体,有软骨保护和抗炎活性。它抑制细胞增殖,促进细胞凋亡并通过 AMPK/mTOR 途径诱导自噬。 | |||
T4S2326 |
Cornuside
7-Galloylsecologanol,7-O-Galloylsecologanol,山茱萸新苷,Comuside |
ERK; p38 MAPK; NF-κB; JNK | MAPK; NF-κB |
Cornuside (Comuside) 是从山茱萸的果实中分离出的环烯醚萜苷,可用于炎症疾病的研究和促进血液循环。 它通过下调 MAPK 和 NF-κB 信号通路抑制肥大细胞介导的过敏反应,用于炎性过敏性疾病中的潜能。 | |||
T5S1805 |
5,7-Dihydroxychromone
5,7-Dihydroxy-4H-Chromen-4-One,5,7-二羟基色酮,5,7-二羟基色原酮 |
Others; Virus Protease; PARP; Caspase; Nrf2 | Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Immunology/Inflammation; Microbiology/Virology; Others; Proteases/Proteasome |
5,7-Dihydroxychromone (5,7-Dihydroxy-4H-Chromen-4-One) 是一种Cudrania tricuspidata 的提取物,通过激活 Nrf2/ARE 信号对 6-OHDA 诱导的氧化应激和细胞凋亡发挥神经保护作用。它抑制 6-OHDA 诱导的 SH-SY5Y 细胞中活化的caspase-3,caspase-9以及切割的PARP 表达。 | |||
T3414 |
Morroniside
莫诺苷,奎宁树 |
Apoptosis; MMP; Pyroptosis | Apoptosis; Immunology/Inflammation; Proteases/Proteasome |
Morroniside 通过抑制神经元凋亡和 MMP9/2 的表达从而发挥神经保护作用,可作为 db/db 小鼠肝脏炎症反应和脂质代谢的调节剂。它通过抑制高血糖和氧化应激表现出对糖尿病肾损伤和人脐静脉内皮细胞的保护作用。 | |||
T4719 |
1,4-D-Gulonolactone
D-Gulonic acid γ-lactone,D-(-)-古洛糖酸-1,4-内酯 |
Others; Endogenous Metabolite | Metabolism; Others |
1,4-D-Gulonolactone (D-Gulonic acid γ-lactone) (也称为还原性抗坏血酸,RAA) 是 L-gulono-1,4-lactone oxidoreductase (EC 1.1.3.8)的底物,催化植物和动物中l -抗坏血酸(维生素C)生物合成的最后一步。enzyme L-Gulono-1,4-lactone oxidase 在容易患坏血病、缺乏维生素c的动物(如人类)中缺失。1,4-D-Gulonolactone 存在于人体血液中,并被用作比较运动引起的氧化应激变化的标志物之一。 | |||
T6S0735 |
Flavokawain B
黄卡瓦胡椒素B,Flavokavain B,Flavokawin B,2'-Hydroxy-4',6'-Dimethoxychalcone |
Apoptosis; Others | Apoptosis; Others |
Flavokawain B (Flavokavain B) 是从卡瓦醉椒的根提取物中,分离出的查尔酮。它是一种凋亡诱导剂,可抑制各种癌细胞株生长。它以极低的无毒浓度抑制人脑内皮细胞的迁移和血管形成,具有抗血管生成活性。 | |||
T3779 |
Crocin II
Crocin 2,西红花苷II,Crocetin gentiobiosylglucosyl ester,藏红花,Tricrocin,Crocin B |
Caspase; COX; NO Synthase | Apoptosis; Immunology/Inflammation; Neuroscience; Proteases/Proteasome |
Crocin II (Crocetin gentiobiosylglucosyl ester) 是从栀子果实中分离出来的一种天然产物,具有抗氧化、抗癌和抗抑郁活性。它抑制 iNOS 和 COX-2的蛋白质和 m-RNA 的表达,还抑制NO 产生,IC50值为 31.1 μM。 | |||
T4S0969 |
Obtusifolin
决明蒽醌,决明蒽醌;美决明子素 |
Antioxidant; NF-κB | NF-κB; oxidation-reduction |
Obtusifolin 是分离自决明子的种子中,能够抑制NF-kB 通路,调节气道上皮细胞中 MUC5AC 粘蛋白的基因表达和产生。它通过靶向甲状旁腺激素相关蛋白来抑制邻苯二甲酸酯诱导的乳腺癌骨转移。 | |||
TN1163 |
2'-Hydroxychalcone
|
Others | Others |
2'-Hydroxychalcone 是一种药物合成中间体,可用于合成黄酮类化合物。负载在纳米乳液中的2'-Hydroxychalcone 在Danio rerio 模型对副球孢子菌显示出杀真菌活性。2'-Hydroxychalcone 通过负载脂质的Hepg2细胞中的氧化应激诱导细胞毒性。2'-Hydroxychalcone 抑制通过逆转录聚合酶链反应确定的肿瘤坏死因子-α诱导ICAM-1,VCAM-1和E-选择素的稳态转录水平,因此可能会干扰其基因的转录。 | |||
T37512 |
cis-4-Hydroxy-L-proline
|
Endogenous Metabolite | Metabolism |
cis-4-Hydroxy-L-proline 是脯氨酸的一种类似物,抑制胶原蛋白的产生。它通过阻止三层螺旋胶原在细胞层上的沉积从而抑制成纤维细胞的生长。它还可抑制原发性N-亚硝基甲基脲诱导的大鼠乳腺肿瘤的生长。 | |||
TN1581 |
Dihydroguaiaretic acid
二氢愈创木酸 |
COX; DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Immunology/Inflammation; Neuroscience |
Dihydroguaiaretic acid has antioxidative activity, can significantly protect primary cultured neuronal cells against glutamate-induced oxidative stress. | |||
T19576 |
Tetrahydrocortisone
|
Others | Others |
Tetrahydrocortisone, a stress-induced hormone and a urinary metabolite of Cortisone, originates from the reduction of Cortisone facilitated by 5-reductase. | |||
TN4941 |
Sanggenon N
|
Others | Others |
Sanggenon N shows protective effects on t-BHP-induced oxidative stress with the EC50 value of 23.45 ± 4.72 uM. It inhibits lipopolysaccharide-induced nitric oxide production in RAW 264.7 macrophages. | |||
T24025 |
Eckol
|
Others | Others |
Eckol inhibits ultraviolet B-induced cell damage by a decrease in oxidative stress in human keratinocytes.This compound is unstable in powder form and other related salt forms are recommended. | |||
TN1542 |
Cycloheterophyllin
|
NADPH-oxidase; PKA; PKC | Chromatin/Epigenetic; Cytoskeletal Signaling; Immunology/Inflammation; Tyrosine Kinase/Adaptors |
Cycloheterophyllin has an antioxidant effect, it is a photoprotective agent that inhibits ultraviolet A (UVA)-induced oxidative stress and damage, and could be used in the research on and prevention of skin photoaging. | |||
T71479 |
Kahweol oleate
|
Others | Others |
Kahweol oleate is emi-syntetic derivative of kahweol, a natural product found in coffee beans. It exhibits a wide variety of biological activities, including inhibiting RANKL-induced osteoclast generation, inducing cell cycle arrest and apoptosis in oral squamous cell carcinoma cells, preventing aflatoxin B1 induced DNA adduct formation, and suppressing H2O2-induced DNA damage and oxidative stress. | |||
TN3618 |
Cedrin
|
Beta Amyloid; BCL; Caspase | Apoptosis; Neuroscience; Proteases/Proteasome |
Cedrin has protective effects on PC12 cells against the neurotoxicity induced by amyloid β1-42, the protective effect is related to the inhibition of oxidative stress, improvement of mitochondrial dysfunction and suppression of apoptosis. | |||
T68642 |
Kahweol palmitate
|
Others | Others |
Kahweol palmitate is a semi-synthetic derivative of kahweol, a natural product found in coffee beans. It exhibits a wide variety of biological activities, including inhibiting RANKL-induced osteoclast generation, inducing cell cycle arrest and apoptosis in oral squamous cell carcinoma cells, preventing aflatoxin B1-induced DNA adduct formation, and suppressing H2O2-induced DNA damage and oxidative stress. | |||
TN2287 |
Turkesterone
|
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Turkesterone is a phytoecdysteroid possessing an 11alpha-hydroxyl group, also is an analogue of the insect steroid hormone 20-hydroxyecdysone. It has immunomodulating and antistress activity, can increase the adaptation capacity of mice under immobilization-induced stress conditions. | |||
TN3473 |
Axillarin
|
||
Axillarin has antioxidant activity, it shows xanthine oxidase inhibitory activity ( IC(50) :36.0 uM). Axillarin can strongly protect primary cultured neurons against glutamate-induced oxidative stress. | |||
T71478 |
Kahweol stearate
|
Others | Others |
Kahweol stearate is a semi-synthetic derivative of kahweol, a natural product found in coffee beans. It exhibits a wide variety of biological activities, including inhibiting RANKL-induced osteoclast generation, inducing cell cycle arrest and apoptosis in oral squamous cell carcinoma cells, preventing aflatoxin B1-induced DNA adduct formation, and suppressing H2O2-induced DNA damage and oxidative stress. | |||
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Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPJ-00433 |
VSIR Protein, Cynomolgus, Recombinant (His)
Stress-induced secreted protein-1,Platelet... |
Cynomolgus | HEK293 Cells |
platelet receptor Gi24 is a single-pass type I membrane protein, and located at the cell surface. The protein can be cleaved by MMP14, and stimulate MMP14-mediated MMP2 activation. It is participated in the BMP signaling pathway. It also regulates the CD4-pasitive, alpha-beta T cell proliferation, and T cell cytokine production negatively. However, the protein can regulate stem cell differentiation positively. | |||
TMPH-00774 |
SAM22 Protein, Glycine max, Recombinant (His)
Pathogenesis-related protein 10,PR-10,Stress-in... |
Glycine max | P. pastoris (Yeast) |
Involved in disease resistance. SAM22 Protein, Glycine max, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 18.8 kDa and the accession number is P26987. | |||
TMPH-03072 |
MPK5 Protein, Japonica rice, Recombinant (His & Myc)
MPK5,Multiple stress-responsive MAP kinase 2,MAP ki... |
Rice | E. coli |
MPK5 Protein, Japonica rice, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 48.0 kDa and the accession number is Q10N20. | |||
TMPJ-01372 |
Cornulin Protein, Human, Recombinant (His)
Tumor-Related Protein,58 kDa Heat Shock Protein,PDRC1,C1orf1... |
Human | E. coli |
Cornulin is a member of the fused gene family of molecular chaperones. Human Cornulin contains N-terminus EF-hand domains and Ca2+ binding domains, and two glutamine- and threonine-rich 60 amino acid repeats in its C-terminus. Cornulin involves in the mucosal/epithelial immune response and epidermal differentiation. Cornulin is a survival factor that participates in the clonogenicity of squamous esophageal epithelium cell lines, attenuates deoxycholic acid (DCA)-induced apoptotic cell death and ... | |||
TMPJ-01382 |
HSPB8 Protein, Human, Recombinant (His)
Small stress protein-like protein HSP22,CRYAC,E2IG1... |
Human | E. coli |
Heat shock protein beta-8 (HSPB8) belongs to the small heat shock protein (HSP20) family. This protein can be inducted by 17-beta-estradiol, and is predominantly expressed in skeletal muscle and heat, mainly located in the cytoplasm and nucleus. HSPB8 usually exists in monomer, it can interact with HSPB1 and DNAJB6. HSPB8 displays temperature-dependent chaperone activity,appears to be involved in regulation of cell proliferation, apoptosis, and carcinogenesis, and mutations in this gene have bee... | |||
TMPY-04396 |
C-ABL/ABL1 Protein, Human, Recombinant (GST)
v-abl,ABL,JTK7,ABL proto-oncogene 1, non-receptor tyrosine k... |
Human | Baculovirus Insect Cells |
c-Abl belongs to the class of tyrosine kinases and is the prototype of a subfamily which includes two members, c-Abl and Arg (Abl-related gene). Both proteins are localized at the cell membrane, actin cytoskeleton and cytosol, and c-Abl is present in the nucleus as well. c-Abl is a non-receptor tyrosine kinase that participates in multiple signaling pathways linking the cell surface, cytoskeleton, and the nucleus. Recent in vitro studies have also linked c-Abl to amyloid-beta-induced toxicity an... | |||
TMPH-02298 |
Urocortin-3 Protein, Human, Recombinant (His & SUMO)
UCN3,Stresscopin,Urocortin III,Urocortin-3 |
Human | E. coli |
Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress. | |||
TMPH-02587 |
CIRBP Protein, Mouse, Recombinant (His)
CIRP,A18 hnRNP,Glycine-rich RNA-binding protein CIRP,CIRBP,C... |
Mouse | E. coli |
Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Promotes assembly of stress granules (SGs), when overexpressed. Seems to play an essential role in cold-induced suppression of cell proliferation. Acts as a translational repressor. Acts as a translational activator. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. | |||
TMPH-02681 |
GPX7 Protein, Mouse, Recombinant (His & Myc)
Glutathione peroxidase 7,Gpx7 |
Mouse | E. coli |
It protects esophageal epithelia from hydrogen peroxide-induced oxidative stress. It suppresses acidic bile acid-induced reactive oxigen species (ROS) and protects against oxidative DNA damage and double-strand breaks. GPX7 Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 26.7 kDa and the accession number is Q99LJ6. | |||
TMPH-00731 |
RpoS Protein, E. coli, Recombinant
RNA polymerase sigma factor RpoS,rpoS,Sigma S,Sigma-38 |
E. coli | E. coli |
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response. Controls, positively or negatively, the expression of several hundred genes, which are mainly involved in metabolism, transport, regulation and stress management.; Protects stationary phase cells from killing induced by endoribonuclease MazF. | |||
TMPH-00730 |
RpoS Protein, E. coli, Recombinant (His)
Sigma S,rpoS,RNA polymerase sigma factor RpoS,Sigma-38 |
E. coli | E. coli |
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response. Controls, positively or negatively, the expression of several hundred genes, which are mainly involved in metabolism, transport, regulation and stress management.; Protects stationary phase cells from killing induced by endoribonuclease MazF. | |||
TMPH-01502 |
Humanin Protein, Human, Recombinant (GST)
Humanin,Humanin mitochondrial,MT-RNR2 |
Human | E. coli |
Plays a role as a neuroprotective factor. Protects against neuronal cell death induced by multiple different familial Alzheimer disease genes and amyloid-beta proteins in Alzheimer disease. Mediates its neuroprotective effect by interacting with a receptor complex composed of IL6ST/GP130, IL27RA/WSX1 and CNTFR. Also acts as a ligand for G-protein coupled receptors FPR2/FPRL1 and FPR3/FPRL2. Inhibits amyloid-beta protein 40 fibril formation. Also inhibits amyloid-beta protein 42 fibril formation.... | |||
TMPH-01503 |
Humanin Protein, Human, Recombinant (hFc)
MT-RNR2,Humanin,Humanin mitochondrial |
Human | HEK293 Cells |
Plays a role as a neuroprotective factor. Protects against neuronal cell death induced by multiple different familial Alzheimer disease genes and amyloid-beta proteins in Alzheimer disease. Mediates its neuroprotective effect by interacting with a receptor complex composed of IL6ST/GP130, IL27RA/WSX1 and CNTFR. Also acts as a ligand for G-protein coupled receptors FPR2/FPRL1 and FPR3/FPRL2. Inhibits amyloid-beta protein 40 fibril formation. Also inhibits amyloid-beta protein 42 fibril formation.... | |||
TMPY-02390 |
SSPA Protein, E. coli, Recombinant (His)
ssp,pog |
E. coli | E. coli |
Stringent starvation protein A (ssPA), a member of the GST superfamily, is an RNA polymerase-associated transcriptional activator for the lytic development of phage P1 and is essential for stationary phase-induced acid tolerance of E. coli. It indicates that the flexible regions are not critical for SspA function, whereas the surface pocket is important for both transcriptional activation of the phage P1 late promoter and acid resistance of E. coli. SspA is known to be implicated in survival dur... | |||
TMPH-03443 |
GPX2 Protein, S. cerevisiae, Recombinant (His & Myc)
Glutathione peroxidase homolog 2,Glutathione peroxidase-like... |
Saccharomyces cerevisiae | E. coli |
Glutathione peroxidase-like protein that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress. Plays an important role in the oxidative stress-induced response in the presence of Ca(2+). Has peroxidase activity using preferentially thioredoxin as a reducing power. The redox state of the mitochondrial GPX2 is regulated by TRX1 and TRX2 (cytoplasmic thioredoxin), and by TRX3 (mitochondrial matrix thioredoxin). Involved in sporulation. GPX2 Protein, ... | |||
TMPH-00085 |
SIZ1 Protein, Arabidopsis thaliana, Recombinant (His)
E3 SUMO-protein ligase SIZ1,SIZ1,E3 SUMO-protein transferase... |
Arabidopsis thaliana | E. coli |
E3 SUMO protein ligase involved in regulation processes. Mediates SUMO/ attachment to PHR1, a MYB transcriptional activator controlling the phosphate deficiency responses. Functions as an upstream negative regulator of salicylic acid (SA) accumulation and subsequent SA-mediated systemic acquired resistance (SAR) signaling. Probably not involved in jasmonic acid (JA)-mediated defense response. Participates in abiotic stress-induced sumoylation. Controls heat shock-induced SUMO1 and SUMO2 conjugat... | |||
TMPH-02135 |
SPRED1 Protein, Human, Recombinant (His & Myc & SUMO)
SPRED1,Sprouty-related, EVH1 domain-containing protein 1 |
Human | E. coli |
Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase. Negatively regulates hematopoiesis of bone marrow. Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2. Attenuates actin stress fiber formation via inhibition of TESK1-mediated phosphorylation of cofilin. Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells. SPRED1 Protein, Human, Reco... | |||
TMPH-01313 |
EIF4G1 Protein, Human, Recombinant (His)
EIF4G,eIF-4-gamma 1,Eukaryotic translation initiation factor... |
Human | P. pastoris (Yeast) |
Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. As a member of the eIF4F complex, required for endoplasmic reticulum stress-induced ATF4 mRNA translation. EIF4G1 Protein, Human, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 41.6 kDa and the accession number is Q04637. | |||
TMPY-02072 |
HSF1 Protein, Human, Recombinant (His)
HSTF1,heat shock transcription factor 1 |
Human | E. coli |
Heat shock factor protein 1, also known as heat shock transcription factor 1, HSF1, and HSTF1, is a cytoplasm and nucleus protein that belongs to the HSF family. HSF1 is the major transcription factor of HSPs (heat shock proteins) in response to various stresses. Wild type HSF1 (heat shock transcriptional factor 1) is normally inactive. HSF1 / HSTF1 is a DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable... | |||
TMPJ-00754 |
CRYAA Protein, Human, Recombinant (His)
Heat Shock Protein Beta-4,CRYA1,α-Crystallin A Chain,HSPB4,S... |
Human | E. coli |
Alpha-Crystallin A Chain (CRYAA) belongs to the small heat shock protein (HSP20) family and can be induced by heat shock. The expression of CRYAA is preferentially restricted to the lens cell. CRYAA may contribute to the transparency and refractive index of the lens. CRYAA has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. Two additional functions of CRYAA are an autokinase activity and participation in the intracellular architecture. | |||
TMPH-01312 |
EIF4G1 Protein, Human, Recombinant (B2M & His & JD & Myc)
eIF-4G 1,EIF4G,Eukaryotic translation initiation factor 4 ga... |
Human | E. coli |
Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. As a member of the eIF4F complex, required for endoplasmic reticulum stress-induced ATF4 mRNA translation. EIF4G1 Protein, Human, Recombinant (B2M & His & JD & Myc) is expressed in E. coli expression system with N-10xHis-B2M-JD and C-Myc tag. The predicted molecular weight is 46.6 kDa and the accession nu... | |||
TMPK-00247 |
MICB Protein, Human, Recombinant (hFc)
MIC-B,PERB11.2,MICB |
Human | HEK293 Cells |
MICB (MHC class I chain-related gene B) is a transmembrane glycoprotein that functions as a ligand for NKG2D. A closely related protein, MICA, shares 85% amino acid identity with MICB.MICB Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis. MICB Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted ... | |||
TMPK-00245 |
MICB Protein, Human, Recombinant (His & Avi)
PERB11.2,MICB,MIC-B |
Human | HEK293 Cells |
MICB (MHC class I chain-related gene B) is a transmembrane glycoprotein that functions as a ligand for NKG2D. A closely related protein, MICA, shares 85% amino acid identity with MICB.MICB Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis. MICB Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The ... | |||
TMPK-00246 |
MICB Protein, Human, Recombinant (His & Avi), Biotinylated
MIC-B,MICB,PERB11.2 |
Human | HEK293 Cells |
MICB (MHC class I chain-related gene B) is a transmembrane glycoprotein that functions as a ligand for NKG2D. A closely related protein, MICA, shares 85% amino acid identity with MICB.MICB Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis. MICB Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His... | |||
TMPY-04425 |
PRAK/MAPKAPK5 Protein, Human, Recombinant (His & GST)
PRAK,MAPKAP-K5,MK-5,mitogen-activated protein kinase-activat... |
Human | Baculovirus Insect Cells |
MAPKAPK5 contains 1 protein kinase domain and belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family. MAPKAPK5 has significant sequence homology to mitogen-activated protein kinase (MAPK)-activated protein kinase (MAPKAPK). It is widely distributed. MAPKAPK5 can be phosphorylated by an extracellular-regulated kinase (ERK), and p38 kinase but not by c-jun N-terminal kinase (JNK)in vitro. Recombinant GST-MAPKAPK5 protein can phosphorylate a peptide derived from the regulator... | |||
TMPY-02299 |
ALDH3A1 Protein, Human, Recombinant (His)
ALDHIII,aldehyde dehydrogenase 3 family, member A1,ALDH3 |
Human | Baculovirus Insect Cells |
Aldehyde dehydrogenase 3A1 (ALDH3A1) is a metabolic enzyme that catalyzes the oxidation of various aldehydes. Certain types of epithelial tissues in mammals, especially those continually exposed to environmental stress (e.g., corneal epithelium), express ALDH3A1 at high levels and its abundance in such tissues is perceived to help to maintain cellular homeostasis under conditions of oxidative stress. Metabolic as well as non-metabolic roles for ALDH3A1 have been associated with its mediated resi... | |||
TMPY-02150 |
GADD45A Protein, Human, Recombinant (His & GST)
GADD45,growth arrest and DNA-damage-inducible, alpha,growth ... |
Human | Baculovirus Insect Cells |
GADD45A is a member of the GADD45 Family, and has been found to associate with several cytoplasmic and nuclear factors and has been implicated in several cellular functions, including MAPK signaling, cell cycle regulation, DNA repair and genomic stability, apoptosis, and immune responses. The GADD45 Family of genes is rapidly induced by different stressors, including differentiation-inducing cytokines, and there is a large body of evidence that their cognate proteins are key players in cellular ... | |||
TMPY-04378 |
MAPKAPK3 Protein, Human, Recombinant (GST)
mitogen-activated protein kinase-activated protein kinase 3,... |
Human | Baculovirus Insect Cells |
The MAPKAP kinases are a group of MAP kinase substrates that are themselves kinases. In response to activation, the MAP kinases phosphorylate downstream components on a consensus Pro-X-Ser/Thr-Pro motif. Several kinases that contain this motif have been identified and serve as substrates for the ERK and p38 MAP kinases. Mitogen-activated protein (MAP) kinase-activated protein kinase 3, also known as MAPKAPK-3 and 3pK, is a member of the Ser/Thr protein kinase family. It is widely expressed in hu... | |||
TMPY-04122 |
ATOX1 Protein, Human, Recombinant (His)
HAH1,ATX1,antioxidant 1 copper chaperone |
Human | E. coli |
ATOX1 is a cytoplasmic copper chaperone that interacts with the copper-binding domain of the membrane copper transporters ATP7A and ATP7B. ATOX1 has also been suggested to have a potential anti-oxidant activity. As the trace element copper is essential, but extremely toxic in high concentrations, intracellular copper concentrations are tightly controlled. Once in the cell, copper is distributed by metallochaperones, including the small cytoplasmic protein ATOX1. ATOX1 plays an important role in ... | |||
TMPY-02131 |
Acid Phosphatase/ACP1 Protein, Human, Recombinant (GST)
acid phosphatase 1, soluble,HAAP |
Human | E. coli |
The low molecular weight phosphotyrosine phosphatase (LMW-PTP), also known as Acid phosphatase 1 (ACP1), belongs to the low molecular weight phosphotyrosine protein phosphatase family are involved in the regulation of important physiological functions, including stress resistance and synthesis of the polysaccharide capsule. ACP1/LMW-PTP is an enzyme involved in platelet-derived growth factor-induced mitogenesis and cytoskeleton rearrangement. LMW-PTP is able to specifically bind and dephosphoryl... | |||
TMPJ-01411 |
HSPB11 Protein, Human, Recombinant (His)
PP25,Placental Protein 25,Heat Shock Protein β-11,Heat Shock... |
Human | E. coli |
Heat Shock Protein β-11 (HSPB11) is a stress-responsive protein that is required to deal with proteotoxic stresses. HSPB11 is composed of an IFT complex B composed of IFT88, IFT57, TRAF3IP1, IFT52, IFT27, HSPB11 and IFT20 and is detected in placenta. HSPB11 has beeb shown to form oligomeric complexes and prevent the aggregation of in vitro denaturated aldolase and glyceraldehyde-3-phosphate dehydrogenase in accordance with the chaperone model of HSPB1 and HSPB5. HSPB11 overexpression protected a... | |||
TMPJ-00886 |
ATF1 Protein, Human, Recombinant (His)
Cyclic AMP-dependent transcription factor ATF-1,Activating t... |
Human | E. coli |
Cyclic AMP-dependent transcription factor ATF-1(ATF1) which contains 1 bZIP (basic-leucine zipper) domain and 1 KID (kinase-inducible) domain, belongs to the bZIP family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. ATF1 binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. It also binds to the ... | |||
TMPY-04550 |
JNK2 Protein, Human, Recombinant (His)
JNK2α,SAPK1a,PRKM9,JNK2β,JNK2,SAPK,JNK2BETA,mitogen-activate... |
Human | Baculovirus Insect Cells |
Mitogen-activated protein kinase 9 (MAPK9), also well known as c-Jun N-terminal kinase (JNK2), is a member of the MAP kinase subfamily belonging to the protein kinase superfamily. MAPK9 responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating some transcription factors, such as c-Jun and ATF2. The crystal structure of human JNK2 complexed with an indazole inhibitor by applying a high-throughput protein engineering and surface-site mutagenesis approach. A n... | |||
TMPY-02084 |
Thioredoxin 2/TRX2 Protein, Human, Recombinant (His)
MT-TRX,RP5-1119A7. 13-005,TRX2,MTRX,thioredoxin 2 |
Human | E. coli |
Thioredoxin-2, also known as TXN2, MTRX and TRX2, is a member of the thioredoxin family. Tryparedoxins (TXN) are thioredoxin-related proteins which, as trypanothione:peroxiredoxin oxidoreductases, constitute the trypanothione-dependent antioxidant defense and may also serve as substrates for ribonucleotide reductase in trypanosomatids. Thioredoxin-2 / TXN2 contains one thioredoxin domain. It is widely expressed in adult (at protein level) and fetal tissues. Human Thioredoxin-2 / TXN2 is a small ... | |||
TMPY-04357 |
RSK4 Protein, Human, Recombinant (GST)
RSK4,ribosomal protein S6 kinase, 90kDa, polypeptide 6,PP90R... |
Human | Baculovirus Insect Cells |
Ribosomal protein S6 kinase alpha-6, also known as Ribosomal S6 kinase 4, 9 kDa ribosomal protein S6 kinase 6,RSK-4, RSK4 and RPS6KA6, is a protein that belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family and S6 kinase subfamily. RPS6KA6 contains one AGC-kinase C-terminal domain and two protein kinase domains. RPS6KA6 forms a complex with either ERK1 or ERK2 in quiescent cells. RPS6KA6 shows a high level of homology to three isolated members of the human RSK family. RSK2... | |||
TMPY-04392 |
RSK3 Protein, Human, Recombinant (GST)
HU-2,ribosomal protein S6 kinase, 90kDa, polypeptide 2,S6K-α... |
Human | Baculovirus Insect Cells |
Ribosomal protein S6 kinase alpha-2, also known as 9 kDa ribosomal protein S6 kinase 2, MAP kinase-activated protein kinase 1c, MAPK-activated protein kinase 1c, Ribosomal S6 kinase 3, RSK-3, RPS6KA2 and MAPKAPK1C, is a nucleus protein that belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family and S6 kinase subfamily. RPS6KA2 / RSK-3 is expressed in many tissues. Highest expression is in lung and skeletal muscle. The expression of RPS6KA2 reduced proliferation, caused G1 a... | |||
TMPH-03264 |
p53 Protein, Rat, Recombinant (His)
Tumor suppressor p53,Tp53,Cellular tumor antigen p53 |
Rat | E. coli |
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 ex... | |||
TMPH-02574 |
p53 Protein, Mouse, Recombinant (His & SUMO)
Tp53,Cellular tumor antigen p53,Tumor suppressor p53 |
Mouse | E. coli |
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 ex... | |||
TMPH-02631 |
PRKN Protein, Mouse, Recombinant (GST)
E3 ubiquitin-protein ligase parkin,Prkn,Parkin RBR E3 ubiqui... |
Mouse | E. coli |
Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Substrates include SYT11 and VDAC1. Other substrates are BCL2, CCNE1, GPR37, RHOT1/MIRO1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, MIRO1 and AIMP2. Mediates monoubiquitination as well as 'Lys-6', 'Lys-11', 'Lys-48'-linked and 'Lys-63'-linked polyubiquitination of substrates depending on the context. Participates in the removal and/or det... | |||
TMPH-01263 |
PRKN Protein, Human, Recombinant (His & SUMO)
PRKN,Parkin RBR E3 ubiquitin-protein ligase,E3 ubiquitin-pro... |
Human | E. coli |
Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Substrates include SYT11 and VDAC1. Other substrates are BCL2, CCNE1, GPR37, RHOT1/MIRO1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, MIRO1 and AIMP2. Mediates monoubiquitination as well as 'Lys-6', 'Lys-11', 'Lys-48'-linked and 'Lys-63'-linked polyubiquitination of substrates depending on the context. Participates in the removal and/or det... | |||
TMPY-01416 |
OLFM4 Protein, Human, Recombinant (His)
hGC-1,GC1,OLM4,bA209J19.1,GW112,olfactomedin 4,OlfD,hOLfD,UN... |
Human | HEK293 Cells |
Olfactomedin-4, also known as G-CSF-stimulated clone 1 protein, Antiapoptotic protein GW112, and OLFM4, is a secreted protein that contains one olfactomedin-like domain. The OLFM4 gene was recently reported to inhibit various apoptotic pathways and promote the proliferation of cancer cells, suggesting that OLFM4 might serve as a diagnostic marker for human cancers. Thus, OLFM4 mRNA might be a useful tool to support the diagnosis of cancer, irrespective of the clinical stages. It is overexpressed... |
Cat. No. | Product Name | Target | Signaling Pathways |
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T70174 |
Pirlindole-d4 HCl
|
||
Pirlindole-d4 is intended for use as an internal standard for the quantification of pirlindole by GC- or LC-MS. Pirlindole is a selective and reversible monoamine oxidase A (MAO-A) inhibitor. It is selective for MAO-A over MAO-B. In rats, it reverses the depressive-like effects induced by chronic mild stress (CMS), increases proliferation of hippocampal neural progenitor cells, and reverses dendritic atrophy in granule neurons. Pirlindole is also an inhibitor of enterovirus-D68 and coxsackieviru... | |||
T35775 |
HT-2 Toxin-13C22
HT-2 Toxin-13C22 |
||
HT-2 toxin-13C22is intended for use as an internal standard for the quantification of HT-2 toxin by GC- or LC-MS. HT-2 toxin is a type A trichothecene mycotoxin and an active, deacetylated metabolite of the trichothecene mycotoxin T-2 toxin .1,2Like T-2 toxin, HT-2 toxin inhibits protein synthesis and cell proliferation in plants.2HT-2 toxin also reduces viability of HepG2, A549, HEp-2, Caco-2, A-204, U937, Jurkat, and RPMI-8226 cancer cells with IC50values ranging from 3.1 to 23 ng/ml and human... |