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Search Results for " smo "

Targets Recommended: Hedgehog/Smoothened Smo Hedgehog/Smoothened

75

抑制剂 & 化合物

28

天然产物

20

重组蛋白

3

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T63429	SMO-IN-2	Hedgehog/Smoothened	GPCR/G Protein; Stem Cells
	SMO-IN-2 是一种有效的 smoothened (SMO) 抑制剂，对 hedgehog (Hh) 信号传导有抑制作用。SMO-IN-2 对人髓母细胞瘤细胞系显示出抗增殖活性和抗癌活性。SMO-IN-2 可用于研究癌症。
T63387	SMO-IN-3	Others	Others
	SMO-IN-3 是 smoothened (SMO) 对有效抑制剂，能够作用于 hedgehog (Hh) 信号通路 (IC50: 34.09 nM)。SMO-IN-3 能够抑制人髓母细胞瘤细胞系 Daoy 的增殖，表现出抗癌作用。
T61897	SMO-IN-1	Others	Others
	SMO-IN-1 (Compound 15) 是口服有效的Smoothened (SMO)抑制剂， sonic Hh protein (shh) 的EC50值为 89 nM。
T3460	HhAntag	Hedgehog/Smoothened; Smo	GPCR/G Protein; Stem Cells
	HhAntag 是高效的、特异性的、具有口服活性的 Hh 通路的SMO 拮抗剂。
T23027	MRT-10	Hedgehog/Smoothened	GPCR/G Protein; Stem Cells
	MRT 10 是一种七跨膜平滑受体 (Smo) 拮抗剂，通过多种 Hedgehog (Hh) 测定，其IC50=0.65 μM。它与Smo 受体结合的位点是 Bodipycyclopamine。它可用于研究癌症。
T12109	MRT-83	Smo	Stem Cells
	MRT-83 是一种 Smo 拮抗剂，其IC50值在纳摩尔级别。它能够抑制 Hedgehog 信号通路。
T9531	MRT-14	Smo	Stem Cells
	MRT-14 是有效的 Smo 拮抗剂。Smo 是参与 Hedgehog 形态发生素信号转导的主要成分。MRT-14 在研究与异常 Hh 信号传导相关的多种癌症方面有价值。
T6891	MK-4101	Apoptosis; Hedgehog/Smoothened; Smo	Apoptosis; GPCR/G Protein; Stem Cells
	MK-4101 是一种 SMO 拮抗剂，对 293 细胞的 IC50为 1.1 µM。它也是一种 hedgehog 信号通路的有效抑制剂，对小鼠细胞和KYSE180 食管癌细胞的IC50分别为 1.5 µM 和 1 µM。它能抗肿瘤，抑制肿瘤细胞增殖并诱导细胞凋亡。
T2450	SANT-1 SANT 1	Hedgehog/Smoothened; Smo	GPCR/G Protein; Stem Cells
	SANT-1 是Smo 拮抗剂，能够抑制Hedgehog 通路，在 Shh-LIGHT2 和 SmoA1-LIGHT2 实验中，得到的IC50值分别为 20 nM 和 30 nM。
T14188	ALLO-2	Hedgehog/Smoothened; Smo	GPCR/G Protein; Stem Cells
	ALLO-2 是一种 Smo 耐药突变体的拮抗剂。在TM3-Gli-Luc 细胞中，它可抑制Smo 激动剂Hh-Ag1.5诱导的荧光素酶表达，其IC50=6 nM。
T6514	Glasdegib PF-04449913	Hedgehog/Smoothened; Smo	GPCR/G Protein; Stem Cells
	Glasdegib (PF-04449913) 是一种口服具有活力的 smoothened 抑制剂，能够结合到人 SMO(181-787氨基酸位点)，IC50=4 nM。
T24159	IHR-1 IHR 1	Smo	Stem Cells
	IHR-1 是一种Smo 拮抗剂，不能透过细胞膜。
T2666	Taladegib LY2940680	Hedgehog/Smoothened; Smo	GPCR/G Protein; Stem Cells
	Taladegib (LY2940680) 是smoothened 受体拮抗剂。
T1810	Purmorphamine Shh Signaling Antagonist VI	Hedgehog/Smoothened; Smo; Autophagy	Autophagy; GPCR/G Protein; Stem Cells
	Purmorphamine (Shh Signaling Antagonist VI) 是平滑受体激动剂，EC50为 1 μM。它阻止 BODIPY-cyclopamine 与 Smo 结合。它也是成骨细胞分化的诱导剂。
T1779	SAG Smoothened Agonist (SAG) HCl,Smoothened Agonist	Hedgehog/Smoothened; Smo	GPCR/G Protein; Stem Cells
	SAG (Smoothened Agonist) 是一种 Smo 受体激动剂 (EC50=3 nM)，具有细胞渗透性和选择性。SAG 可以直接结合 Smo 螺旋束调节 Smo 活性，可以活化 Hedgehog 信号通路。
T9532	MRT-81	Others; Hedgehog/Smoothened	GPCR/G Protein; Others; Stem Cells
	MRT-81 是一种人和啮齿动物 smoothened 受体的有效拮抗剂，能够抑制 hedgehog 的活性，在 Shh-light2 细胞中的IC50值为 41 nM。它可用于研究癌症。
T22814	GSA-10	Hedgehog/Smoothened	GPCR/G Protein; Stem Cells
	GSA-10是新型的喹啉甲酰胺衍生物，有效激动平滑受体剂，EC50为 1.2 μM。它作用于Smo，促进多能间充质干细胞分化为成骨细胞。它介导 Hedgehog 信号传导，这可能对癌症疾病的再生医学具有研究意义。
T5465	PF-5274857 PF-5274857 freebase	Smo	Stem Cells
	PF-5274857 (PF-5274857 free base) freebase 是有效的、具有口服活性的、选择性的、可透过血脑屏障的 Smo 拮抗剂，其 IC50=5.8 nM，Ki=4.6 nM。它有用于包括激活的 Hh 途径驱动的脑肿瘤和脑转移在内的多种肿瘤的研究潜力。
T2299	BMS-833923 XL-139	Apoptosis; Hedgehog/Smoothened; Smo	Apoptosis; GPCR/G Protein; Stem Cells
	BMS-833923 (XL-139) 是一种口服生物可利用的 Smoothened 拮抗剂，以剂量依赖性方式抑制 BODIPY cyclopamine 与 SMO 的结合，IC50为21 nM。
T11838	LEQ506 NVP-LEQ506	Smo	Stem Cells
	LEQ506 是一种 Smo 抑制剂，对 hSmo 和 mSmo 的 IC50 分别为 2 nM 和 4 nM。
T1926	Sonidegib Erismodegib,NVP-LDE225,LDE225	Hedgehog/Smoothened; Smo	GPCR/G Protein; Stem Cells
	Sonidegib (Erismodegib) 是一种Smo 的选择性拮抗剂，能够抑制鼠 Smo (IC50:1.3 nM)和人 Smo (IC50:2.5 nM)。
T0107	Halcinonide Halcimat,Halciderm,哈西奈德,Halcinonida,氯氟舒松,SQ-18566	Glucocorticoid Receptor; Smo	Endocrinology/Hormones; Stem Cells
	Halcinonide (Halciderm) 是一种糖皮质激素，可用于局部皮肤感染的研究。
T2250	DY131 DY 131,GSK 9089,DY-131	Estrogen Receptor/ERR; Estrogen/progestogen Receptor; Smo	Endocrinology/Hormones; Stem Cells
	DY131 (DY-131) 是选择性的 ERRγ 和 ERRβ 激动剂，对 ERRα，ERα 和 ERβ 无效。它对Smo 的信号传导具有抑制作用。
T15727	Sonidegib diphosphate NVP-LDE 225 diphosphate,Erismodegib diphosphate,LDE225 diphosphate	Smo	Stem Cells
	Sonidegib diphosphate (LDE225 diphosphate) 是 Smo 的选择性拮抗剂，能够抑制鼠 Smo (IC50:1.3 nM)和人 Smo (IC50:2.5 nM)。
T5144	Desmopressin acetate (16679-58-6 free base) Desmopressin acetate,醋酸去氨加压素,DDAVP	Vasopressin Receptor	GPCR/G Protein
	Desmopressin acetate (16679-58-6 free base) (DDAVP) 是抗利尿激素精氨酸加压素的合成类似物。
T124384	Jasmonic acid (-)-Jasmonic acid
	Jasmonic acid (JA) 是一种植物激素，也是植物生长调节剂，参与植物迫防御和生长发育。Jasmonic acid 在信号传导过程中起着很重要的作用，诱导 MAP 激酶级联通路和钙通道发挥作用。
T2590	Vismodegib Erivedge,GDC-0449,RG 3616,维莫德吉	Hedgehog/Smoothened; ABC; Autophagy	Autophagy; GPCR/G Protein; Membrane transporter/Ion channel; Stem Cells
	Vismodegib (GDC-0449) 是一种刺猬抑制剂，IC50值为 3 nM。它还可抑制 P-gp 和ABCG2的活性，IC50值分别为 3.0 μM 和 1.4 μM。
T39910	Desmorpholinyl Navitoclax-NH-Me Desmorpholinyl ABT-263-NH-Me,Desmorpholinyl Navitoclax-NH-Me	BCL	Apoptosis
	Desmorpholinyl Navitoclax-NH-Me (Desmorpholinyl ABT-263-NH-Me) is a Bcl-xL inhibitor, which can be employed alongside a CRBN ligand to synthesize XZ739, a PROTAC BCL-XL degrader [1] [2].
T39818	Desmorpholinyl Quizartinib-PEG2-COOH Desmorpholinyl Quizartinib-PEG2-COOH	Others	Others
	Desmorpholinyl Quizartinib-PEG2-COOH is a compound featuring an FLT-3 ligand and a PEG-based PROTAC linker. It is employed in the synthesis of PROTAC FLT-3 degrader 1, which serves as a degrader for the FLT-3 internal tandem duplication (ITD) through PROTAC technology. The degrader exhibits an IC50 of 0.6 nM.
T131458	Acetyl-alpha-desmotroposantonin	Others	Others
	Acetyl-alpha-desmotroposantonin 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T131458。
TMAZ-0094A6	Anti-SMOC1 Monoclonal Antibody-AF647

T40880	(±)-Jasmonic acid	Others	Others
	(±)-Jasmonic acid, a plant growth regulator and derivative of α-linolenic acid, exhibits chlorophyll-lowering effects in green and etiolated barley leaf segments, while also inhibiting the elongation of rice seedlings.
TMAZ-0094A4	Anti-SMOC1 Monoclonal Antibody-AF488

T31472	Dihydrojasmone lactone gamma-Methyldecalactone,gamma-Methyl decalactone,4-Methyldecanolide	Others	Others
	Dihydrojasmone lactone is a biochemical.
T36941	Sporidesmolide III	Others	Others
	Sporidesmolide III is a cyclodepsipeptide originally isolated from P. chartarum.
T131459	alpha-Desmotroposantonin methylether	Others	Others
	alpha-Desmotroposantonin methylether 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T131459。
T32269	Jasmone, (E)- EINECS 228-410-7	Others	Others
	Jasmone, (E)- is a type of perfuming agent.
T1503	Esmolol hydrochloride ASL8052,Esmolol HCl,盐酸艾司洛尔	Mitophagy; Adrenergic Receptor; Autophagy	Autophagy; GPCR/G Protein; Neuroscience
	Esmolol hydrochloride 是一种心脏选择性β受体阻滞剂，用于治疗心律失常和严重高血压。
TMAZ-0094A	Anti-SMOC1 Monoclonal Antibody-APC

TMAZ-0094A5	Anti-SMOC1 Monoclonal Antibody-AF555

T13523	Bronchospasmolytic agent 1	Others	Others
	Bronchospasmolytic agent 1 is a flutropium bromide compound and acts as a bronchospasmolytic agent.
T74190	(-)-Jasmonoyl-L-isoleucine	Others	Others
	(-)-Jasmonoyl-L-isoleucine ((-)-JA-L-Ile)，为(+)-JA-L-Ile的对映体，是一种无活性的内源性激素。
T65308	Methyl jasmonate	Others	Others
	Methyl jasmonate 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T65308，CAS号为 1211-29-6。
TMAZ-0094P	Anti-SMOC1 Monoclonal Antibody-PE

T23769	AZSMO-23 AZSMO 23	Others	Others
	AZSMO-23 is the human ether-a-go-go-related gene (hERG)-encoded potassium channel activator that acts by blocking hKv4.3-hKChIP2.2, hCav3.2, and hKv1.5 and activating hCav1.2/β2/α2δ.
TMAZ-0094B	Anti-SMOC1 Monoclonal Antibody-Biotin

T40465	SAG dihydrochloride	Hedgehog/Smoothened	GPCR/G Protein; Stem Cells
	SAG dihydrochloride 是一种强效的 Smoothened（Smo）受体激动剂（EC 50 =3 nM；K d =59 nM）。SAG dihydrochloride 可激活刺猬信号通路并抵消环丙胺对 Smo 的抑制。
T24754	Hh-Ag1.5 SAG-1.5,SAG1.5,SAG 1.5	Hedgehog/Smoothened	GPCR/G Protein; Stem Cells
	Hh-Ag1.5 (SAG-1.5) 是一种高效的 Hedgehog (Hh) 激动剂(EC50： 1 nM)和Smoothened (Smo)受体激动剂，对Smo的 EC50 为 1 nM、 Ki值在 0.5 和 2.3 nM 之间。Hh-Ag1.5 介导的重编程打破了非损伤肝脏干细胞的静止状态，从而挽救了肝衰竭。Hh-Ag1.5 诱导 hiPSCs 分化为皮肤前体细胞、脊髓运动神经元和脊髓感觉神经元。
T4211	SAG hydrochloride (912545-86-9(free base)) Smoothened Agonist HCl	Hedgehog/Smoothened	GPCR/G Protein; Stem Cells
	SAG hydrochloride (912545-86-9(free base)) (Smoothened Agonist HCl) 可作为 SMO 激动剂。
T64351	GI-560192 RL-0070933	Smo	Stem Cells
	GI-560192 (RL-0070933) 是一种有效的纤毛调节剂。GI-560192 通过 hedgehog 信号通路调节 smoothed (Smo) 向初级纤毛的易位和/或积累。

化合物

Cat.No: T63429

Target: Hedgehog/Smoothened

Cat.No: T63387

Target: Others

Cat.No: T61897

Target: Others

Cat.No: T3460

Target: Hedgehog/Smoothened, Smo

Cat.No: T23027

Target: Hedgehog/Smoothened

Cat.No: T12109

Target: Smo

Cat.No: T9531

Target: Smo

Cat.No: T6891

Target: Apoptosis, Hedgehog/Smoothened, Smo

Cat.No: T2450

Synonym: SANT 1

Target: Hedgehog/Smoothened, Smo

Cat.No: T14188

Target: Hedgehog/Smoothened, Smo

Cat.No: T6514

Synonym: PF-04449913

Target: Hedgehog/Smoothened, Smo

Cat.No: T24159

Synonym: IHR 1

Target: Smo

Cat.No: T2666

Synonym: LY2940680

Target: Hedgehog/Smoothened, Smo

Cat.No: T1810

Synonym: Shh Signaling Antagonist VI

Target: Hedgehog/Smoothened, Smo, Autophagy

Cat.No: T1779

Synonym: Smoothened Agonist (SAG) HCl,Smoothened Agonist

Target: Hedgehog/Smoothened, Smo

Cat.No: T9532

Target: Others, Hedgehog/Smoothened

Cat.No: T22814

Target: Hedgehog/Smoothened

Cat.No: T5465

Synonym: PF-5274857 freebase

Target: Smo

Cat.No: T2299

Synonym: XL-139

Target: Apoptosis, Hedgehog/Smoothened, Smo

Cat.No: T11838

Synonym: NVP-LEQ506

Target: Smo

Cat.No: T1926

Synonym: Erismodegib,NVP-LDE225,LDE225

Target: Hedgehog/Smoothened, Smo

Cat.No: T0107

Synonym: Halcimat,Halciderm,哈西奈德,Halcinonida,氯氟舒松,SQ-18566

Target: Glucocorticoid Receptor, Smo

Cat.No: T2250

Synonym: DY 131,GSK 9089,DY-131

Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor, Smo

Sonidegib diphosphate

Cat.No: T15727

Synonym: NVP-LDE 225 diphosphate,Erismodegib diphosphate,LDE225 diphosphate

Target: Smo

Desmopressin acetate (16679-58-6 free base)

Cat.No: T5144

Synonym: Desmopressin acetate,醋酸去氨加压素,DDAVP

Target: Vasopressin Receptor

Cat.No: T124384

Synonym: (-)-Jasmonic acid

Cat.No: T2590

Synonym: Erivedge,GDC-0449,RG 3616,维莫德吉

Target: Hedgehog/Smoothened, ABC, Autophagy

Desmorpholinyl Navitoclax-NH-Me

Cat.No: T39910

Synonym: Desmorpholinyl ABT-263-NH-Me,Desmorpholinyl Navitoclax-NH-Me

Target: BCL

Desmorpholinyl Quizartinib-PEG2-COOH

Cat.No: T39818

Synonym: Desmorpholinyl Quizartinib-PEG2-COOH

Target: Others

Acetyl-alpha-desmotroposantonin

Cat.No: T131458

Target: Others

Anti-SMOC1 Monoclonal Antibody-AF647

Cat.No: TMAZ-0094A6

(±)-Jasmonic acid

Cat.No: T40880

Target: Others

Anti-SMOC1 Monoclonal Antibody-AF488

Cat.No: TMAZ-0094A4

Dihydrojasmone lactone

Cat.No: T31472

Synonym: gamma-Methyldecalactone,gamma-Methyl decalactone,4-Methyldecanolide

Target: Others

Sporidesmolide III

Cat.No: T36941

Target: Others

alpha-Desmotroposantonin methylether

Cat.No: T131459

Target: Others

Cat.No: T32269

Synonym: EINECS 228-410-7

Target: Others

Esmolol hydrochloride

Cat.No: T1503

Synonym: ASL8052,Esmolol HCl,盐酸艾司洛尔

Target: Mitophagy, Adrenergic Receptor, Autophagy

Anti-SMOC1 Monoclonal Antibody-APC

Cat.No: TMAZ-0094A

Anti-SMOC1 Monoclonal Antibody-AF555

Cat.No: TMAZ-0094A5

Bronchospasmolytic agent 1

Cat.No: T13523

Target: Others

(-)-Jasmonoyl-L-isoleucine

Cat.No: T74190

Target: Others

Methyl jasmonate

Cat.No: T65308

Target: Others

Anti-SMOC1 Monoclonal Antibody-PE

Cat.No: TMAZ-0094P

Cat.No: T23769

Synonym: AZSMO 23

Target: Others

Anti-SMOC1 Monoclonal Antibody-Biotin

Cat.No: TMAZ-0094B

SAG dihydrochloride

Cat.No: T40465

Target: Hedgehog/Smoothened

Cat.No: T24754

Synonym: SAG-1.5,SAG1.5,SAG 1.5

Target: Hedgehog/Smoothened

SAG hydrochloride (912545-86-9(free base))

Cat.No: T4211

Synonym: Smoothened Agonist HCl

Target: Hedgehog/Smoothened

Cat.No: T64351

Synonym: RL-0070933

Target: Smo

Cat. No.	Product Name	Target	Signaling Pathways
T2825	Cyclopamine 环巴胺,11-Deoxojervine	Hedgehog/Smoothened; Endogenous Metabolite; Smo	GPCR/G Protein; Metabolism; Stem Cells
	Cyclopamine (11-Deoxojervine) 是Hedgehog 通路的拮抗剂，细胞实验中IC50=46 nM。它还是选择性Smo 抑制剂。
T3363	Jervine 蒜黎芦碱,Iervin,11-Ketocyclopamine,Jerwiny	Hedgehog/Smoothened; Smo	GPCR/G Protein; Stem Cells
	Jervine (Jerwiny) 是一种有效的刺猬 (Hh) 抑制剂(IC50:500-700 nM)。它是一种天然致畸性甾体生物碱，来自于 Veratrumalbum 的根茎，具有抗炎和抗氧化作用。
T3912	Saikosaponin B1 柴胡皂苷B1,柴胡皂苷 B1	Others	Others
	Saikosaponin B1 是柴胡的生物活性成分，具有抗癌作用。它能够靶向SMO 抑制 Hedgehog 通路，显著抑制髓母细胞瘤模型中的肿瘤生长。
T7220	Prohydrojasmon racemate Propyl dihydrojasmonate,茉莉酮,Prohydrojasmon	Others	Others
	Prohydrojasmon racemate (Propyl dihydrojasmonate) 是 Prohydrojasmon 的外消旋体。其中Prohydrojasmon 是合成的植物生长调节剂。
TJS0161	Eudesmol β-Eudesmol,桉叶醇,Β-桉叶醇	Others	Others
	β-Eudesmol (β-Eudesmol) 是一种倍半萜类化合物，由Streptomyces tendae 产生。
T8077	Dihydrojasmone	Others	Others
	Dihydrojasmone 是一种重要的香料成分，是佛手柑油的成分。
T4900	(±)-Methyl Jasmonate (±)-茉莉酸甲酯,甲基茉莉酮酸酯,(±)-Jasmonic Acid methyl ester,Methyl 2-(3-oxo-2-(pent-2-en-1-yl)cyclopentyl)acetate	Others; Endogenous Metabolite	Metabolism; Others
	Methyl 2-(3-oxo-2-(pent-2-en-1-yl)cyclopentyl)acetate ((±)-Jasmonic Acid methyl ester) 是内源性代谢产物的一种。
T3865	beta-Eudesmol β-桉叶醇,Beta-Selinenol,beta-桉叶醇	TRP/TRPV Channel; AChR	Membrane transporter/Ion channel; Neuroscience
	beta-Eudesmol (Beta-Selinenol) 是天然的含氧倍半萜烯，可激活hTRPA1，EC50值为 32.5 μM。Beta-Eudesmol 有增加食欲的功效。
T8076	cis-Jasmone 茉莉酮,Jasmone,顺式茉莉酮	Others	Others
	cis-Jasmone 是一种来源于植物中的天然产物。它由许多花组成型释放，有时通过叶子作为传粉者的引诱剂或作为昆虫花食草动物宿主定位的化学提示。它处理作物可以诱导对食草动物的直接防御，并能够释放吸收天敌的挥发性化合物来诱导间接防御。
T6S2247	Alismoxide (+)-Alismoxide,环氧泽泻烯	Others	Others
	Alismoxide ((+)-Alismoxide) 一种具有抗炎作用的天然化合物。
T2783	Methyl dihydrojasmonate Methyl Dihydrojasmonate,Kharismal,Hedione,二氢茉莉酮酸甲酯	Others	Others
	Methyl dihydrojasmonate (Kharismal) 是一种香料成分，具有茉莉花香气，常用于许多香料混合物中。
T19711	Desmosterol Desmesterol,24-Dehydrocholesterol	Endogenous Metabolite	Metabolism
	Desmosterol(24-Dehydrocholesterol) 是一种胆固醇生物合成中间体，抑制巨噬细胞炎症小体活化，防止血管炎症和动脉粥样硬化。
TN5801	12-Hydroxyjasmonic acid
	12-Hydroxyjasmonic acid glucoside is a COI1-JAZ-independent activator of leaf-closing movement in samanea saman.
TN3962	epi-Eudesmol	Others	Others
	epi-Eudesmol is a natural product from Laggera alata var. montana C. D. Adams.
T40450	Dihydrojasmonic acid	Others	Others
	Dihydrojasmonic acid is a plant growth regulator.
TN1367	Alismol 泽泻醇	Potassium Channel; Calcium Channel; PI3K	Membrane transporter/Ion channel; Metabolism; PI3K/Akt/mTOR signaling
	Alismol has antihypertensive action, it decreases cardiac output, heart rate and left ventricular pressure, but it increases coronary flow, it has been used for the prevention of anginal attacks.
TN5377	Nardoeudesmol A
	Nardoeudesmol A 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN5377，CAS号为 1445952-30-6。
TN2668	1beta-Hydroxy-beta-eudesmol	Others	Others
	1beta-Hydroxy-beta-eudesmol is a natural product from Cymbopogon proximus STAPF.
T19782	Antidesmone	Others	Others
	Antidesmone is one compound mainly isolated from Ajugade cumbers Thunb (Labiatae). Antidesmone prevents acute lung injury via regulating MAPK and NF-κB activities.
T83460	11-O-β-D-glucopyranosyl thamnosmonin
	11-O-β-D-glucopyranosyl thamnosmonin是一种香豆素苷，能够从Angelica apaensis根部提取。该化合物对PAF、AA和ADP诱发的兔血小板聚集表现出轻度的抑制效果。
TN4351	Jasmoside	Others	Others
	Jasmoside is a natural product from Jasminum mesnyi.
TSP-41868968	alpha-Desmotroposantonin	Others	Others
	alpha-Desmotroposantonin 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 TSP-41868968。
T81113	Sporidesmolide V
	Sporidesmolide V为从Pithornyces chartarum培养物中分离得到的环缩肽类化合物。
TN7273	(±)7-epi Jasmonic Acid 2-iso Jasmonic Acid	Others	Others
	(±)-7-epiJasmonic acid, the primary metabolite in the 12-oxo phytodienoic acid pathway of 13(S)-hydroperoxy linolenic acid metabolism in plants, is synthesized initially as the more active (+)-7-epijasmonic acid. It quickly epimerizes to the more stable (−)-7-jasmonic acid isomer, demonstrating its biological relevance. Acting as a plant growth regulator, (±)-7-epiJasmonic acid triggers various signal transduction pathways, which can either promote growth or inhibit it, likely as a response to s...
TN2585	11-Hydroxyjasmonic acid	Others	Others
	11-Hydroxyjasmonic acid是一种天然产物，属于防己科千金藤属，其产品编号为 TN2585，CAS号为 140447-14-9。11-Hydroxyjasmonic acid可用作对照参考。
TN5886	Thamnosmonin
	Thamnosmonin is a natural product from Citrus sinensis.
T21296	Desmopressin acetate trihydrate Desmogalen,Adiuretin,Deamino Arginine Vasopressin,Vasopressin 1-Desamino-8-arginine
	Desmopressin acetate is a synthetic replacement for vasopressin, which reduces urine production. Medical use of Desmopressin acetate includes: (a) bed wetting; (b) diabetes insipidus; (c) nighttime urination; (d) clotting disorders.
T10085	20(S)-Hydroxycholesterol 20α-Hydroxycholesterol	Smo	Stem Cells
	20(S)-Hydroxycholesterol (20α-Hydroxycholesterol) 是平滑 (smo) 癌蛋白的变构激活剂。

天然产物

Cat.No: T2825

Synonym: 环巴胺,11-Deoxojervine

Target: Hedgehog/Smoothened, Endogenous Metabolite, Smo

Cat.No: T3363

Synonym: 蒜黎芦碱,Iervin,11-Ketocyclopamine,Jerwiny

Target: Hedgehog/Smoothened, Smo

Saikosaponin B1

Cat.No: T3912

Synonym: 柴胡皂苷B1,柴胡皂苷 B1

Target: Others

Prohydrojasmon racemate

Cat.No: T7220

Synonym: Propyl dihydrojasmonate,茉莉酮,Prohydrojasmon

Target: Others

Cat.No: TJS0161

Synonym: β-Eudesmol,桉叶醇,Β-桉叶醇

Target: Others

Cat.No: T8077

Target: Others

(±)-Methyl Jasmonate

Cat.No: T4900

Synonym: (±)-茉莉酸甲酯,甲基茉莉酮酸酯,(±)-Jasmonic Acid methyl ester,Methyl 2-(3-oxo-2-(pent-2-en-1-yl)cyclopentyl)acetate

Target: Others, Endogenous Metabolite

Cat.No: T3865

Synonym: β-桉叶醇,Beta-Selinenol,beta-桉叶醇

Target: TRP/TRPV Channel, AChR

Cat.No: T8076

Synonym: 茉莉酮,Jasmone,顺式茉莉酮

Target: Others

Cat.No: T6S2247

Synonym: (+)-Alismoxide,环氧泽泻烯

Target: Others

Methyl dihydrojasmonate

Cat.No: T2783

Synonym: Methyl Dihydrojasmonate,Kharismal,Hedione,二氢茉莉酮酸甲酯

Target: Others

Cat.No: T19711

Synonym: Desmesterol,24-Dehydrocholesterol

Target: Endogenous Metabolite

12-Hydroxyjasmonic acid

Cat.No: TN5801

Cat.No: TN3962

Target: Others

Dihydrojasmonic acid

Cat.No: T40450

Target: Others

Cat.No: TN1367

Synonym: 泽泻醇

Target: Potassium Channel, Calcium Channel, PI3K

Nardoeudesmol A

Cat.No: TN5377

1beta-Hydroxy-beta-eudesmol

Cat.No: TN2668

Target: Others

Cat.No: T19782

Target: Others

11-O-β-D-glucopyranosyl thamnosmonin

Cat.No: T83460

Cat.No: TN4351

Target: Others

alpha-Desmotroposantonin

Cat.No: TSP-41868968

Target: Others

Sporidesmolide V

Cat.No: T81113

(±)7-epi Jasmonic Acid

Cat.No: TN7273

Synonym: 2-iso Jasmonic Acid

Target: Others

11-Hydroxyjasmonic acid

Cat.No: TN2585

Target: Others

Cat.No: TN5886

Desmopressin acetate trihydrate

Cat.No: T21296

Synonym: Desmogalen,Adiuretin,Deamino Arginine Vasopressin,Vasopressin 1-Desamino-8-arginine

20(S)-Hydroxycholesterol

Cat.No: T10085

Synonym: 20α-Hydroxycholesterol

Target: Smo

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-03143	PFD0110w Protein, Plasmodium falciparum, Recombinant Normocyte-binding protein 1,Reticulocyte-binding protein hom...	Plasmodium falciparum	E. coli
	PFD0110w Protein, Plasmodium falciparum, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 30.1 kDa and the accession number is P86148.
TMPY-03370	Desmocollin 2/DSC2 Protein, Rat, Recombinant (His) desmocollin 2	Rat	HEK293 Cells
	Desmocollin 2/DSC2 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 76.1 kDa and the accession number is Q3T1K6.
TMPH-03144	SEY1 Protein, Plasmodium knowlesi, Recombinant (His) SEY1,Protein SEY1 homolog	Plasmodium knowlesi	E. coli
	Probable GTP-binding protein that may be involved in cell development. SEY1 Protein, Plasmodium knowlesi, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 103.5 kDa and the accession number is B3LAJ9.
TMPY-01892	Desmocollin 2/DSC2 Protein, Human, Recombinant (His) ARVD11,desmocollin 2,DGII/III,DSC3,DG2,CDHF2	Human	HEK293 Cells
	Desmocollin 2/DSC2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 75 kDa and the accession number is Q02487-1.
TMPK-00736	DSG-2/Desmoglein-2 Protein, Mouse, Recombinant (His) MGC117036,HDGC,Desmoglein-2,CDHF5,DSG2,MGC117037,AR...	Mouse	HEK293 Cells
	Desmoglein-2 (DSG-2) as the primary high-affinity receptor used by adenoviruses Ad3, Ad7, Ad11 and Ad14. These serotypes represent key human pathogens causing respiratory and urinary tract infections. In epithelial cells, adenovirus binding of DSG-2 triggers events reminiscent of epithelial-to-mesenchymal transition, leading to transient opening of intercellular junctions. DSG-2/Desmoglein-2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted mo...
TMPH-03138	GST Protein, Plasmodium falciparum, Recombinant (His)	Plasmodium falciparum	P. pastoris (Yeast)
	Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. May also function as a storage protein or ligandin for parasitotoxic ferriprotoporphyrin IX (hemin). GST Protein, Plasmodium falciparum, Recombinant (His) is expressed in yeast with N-10xHis tag. The predicted molecular weight is 27.3 kDa and the accession number is Q8MU52.
TMPH-03137	PFS230 Protein, Plasmodium falciparum, Recombinant PFS230,Gametocyte surface protein P230	Plasmodium falciparum	E. coli
	Gametocyte surface protein required for male/female gamete fusion. Also required for male gamete exflagellation and interaction with erythrocytes. PFS230 Protein, Plasmodium falciparum, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 15.9 kDa and the accession number is P68874.
TMPH-03061	Osmotin Protein, Nicotiana tabacum, Recombinant (His & SUMO) AP24,Osmotin	Nicotiana tabacum	E. coli
	Osmotin Protein, Nicotiana tabacum, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 40.3 kDa and the accession number is P14170.
TMPH-03141	Plasmepsin-2 Protein, Plasmodium falciparum, Recombinant (His & Myc) Plasmepsin II,Aspartic hemoglobinase II,PMII,Plasmepsin 2,Pf...	Plasmodium falciparum	Baculovirus Insect Cells
	During the asexual blood stage, participates in initial cleavage of native host hemoglobin (Hb) resulting in Hb denaturation. May cleave preferentially denatured hemoglobin that has been cleaved by PMI. Digestion of host Hb is an essential step which provides the parasite with amino acids for protein synthesis, and regulates osmolarity (Probable). Plasmepsin-2 Protein, Plasmodium falciparum, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predict...
TMPH-03136	L-lactate dehydrogenase Protein, Plasmodium berghei, Recombinant (His & Myc) LDH,L-lactate dehydrogenase	Plasmodium berghei	E. coli
	N/A. L-lactate dehydrogenase Protein, Plasmodium berghei, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 39.4 kDa and the accession number is Q7SI97.
TMPH-02128	SMOC1 Protein, Human, Recombinant (GST & His) SMOC1,Secreted modular calcium-binding protein 1,SP...	Human	E. coli
	Plays essential roles in both eye and limb development. Probable regulator of osteoblast differentiation.
TMPY-04642	Desmocollin 2/DSC2 Protein, Rat, Recombinant (hFc) desmocollin 2	Rat	HEK293 Cells
	Desmocollin 2/DSC2 Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 101.6 kDa and the accession number is Q3T1K6.
TMPH-03139	MDR1 Protein, Plasmodium falciparum, Recombinant (His & SUMO) Chloroquine resistance protein,MDR1,Multidrug resistance pro...	Plasmodium falciparum	E. coli
	Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells. MDR1 Protein, Plasmodium falciparum, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 54.2 kDa and the accession number is P13568.
TMPY-01783	SMOC1 Protein, Human, Recombinant (His) OAS,SPARC related modular calcium binding 1	Human	HEK293 Cells
	SPARC-related modular calcium-binding protein 1, also known as secreted modular calcium-binding protein 1 and SMOC1, is a member of the SPARC family. SMOC1 is widely expressed in many tissues with a strongest signal in ovary. It contains two EF-hand domains, one Kazal-like domain and two thyroglobulin type-1 domains. Extracellular matrix proteins have been implicated in the regulation of osteoblast differentiation of bone marrow-derived mesenchymal stem cells (BMSCs) through paracrine or autocri...
TMPK-00967	DSG-2/Desmoglein-2 Protein, Human, Recombinant (His) CMD1BB,Desmoglein-2,ARVC10,CDHF5,MGC117037,MGC11703...	Human	HEK293 Cells
	Desmoglein-2 (DSG-2) as the primary high-affinity receptor used by adenoviruses Ad3, Ad7, Ad11 and Ad14. These serotypes represent key human pathogens causing respiratory and urinary tract infections. In epithelial cells, adenovirus binding of DSG-2 triggers events reminiscent of epithelial-to-mesenchymal transition, leading to transient opening of intercellular junctions. DSG-2/Desmoglein-2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted mo...
TMPH-03142	Plasmepsin-2 Protein, Plasmodium falciparum, Recombinant (E. coli, His & Myc) PMII,PfAPD,Plasmepsin 2,PfPM1,Aspartic hemoglobinase II,Plas...	Plasmodium falciparum	E. coli
	During the asexual blood stage, participates in initial cleavage of native host hemoglobin (Hb) resulting in Hb denaturation. May cleave preferentially denatured hemoglobin that has been cleaved by PMI. Digestion of host Hb is an essential step which provides the parasite with amino acids for protein synthesis, and regulates osmolarity (Probable). Plasmepsin-2 Protein, Plasmodium falciparum, Recombinant (E. coli, His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. T...
TMPH-03140	Plasmepsin-1 Protein, Plasmodium falciparum, Recombinant (His) Plasmepsin I,Aspartic hemoglobinase I,Plasmepsin 1,PMI	Plasmodium falciparum	E. coli
	During the asexual blood stage, catalyzes the initial cleavage of native host hemoglobin (Hb) resulting in Hb denaturation; specifically cleaves between Phe-33 and Leu-34 of Hb alpha-chain. Digestion of host Hb is an essential step which provides the parasite with amino acids for protein synthesis, and regulates osmolarity (Probable). Plasmepsin-1 Protein, Plasmodium falciparum, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 41.0 k...
TMPH-02540	GRK2 Protein, Mouse, Recombinant (His & SUMO) Beta-adrenergic receptor kinase 1,Grk2,G-protein-coupled rec...	Mouse	E. coli
	Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner. Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by facilitating the trafficking of SMO into the cilium and...
TMPH-01528	IHH Protein, Human, Recombinant (His) HHG-2,IHH,Indian hedgehog protein	Human	E. coli
	Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification: may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP).
TMPY-01165	FZD1/Frizzled 1 Protein, Mouse, Recombinant (His) Fzd1,AW227548,frizzled class receptor 1,FZ-1,Fz1	Mouse	HEK293 Cells
	Frizzled-1, also known as FZD1, belongs to theG-protein coupled receptor Fz/Smo family. FZD1 contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, 7 transmembrane domains, and a C-terminal PDZ domain-binding motif. FZD1 is expressed in adult heart, placenta, lung, kidney, pancreas, prostate, and ovary and in fetal lung and kidney. Frizzled is a family of G protein-coupled receptor proteins that serve as receptors in the Wnt signaling pathway and other signalin...

重组蛋白

PFD0110w Protein, Plasmodium falciparum, Recombinant

Cat.No: TMPH-03143

Species: Plasmodium falciparum

Expression System: E. coli

Desmocollin 2/DSC2 Protein, Rat, Recombinant (His)

Cat.No: TMPY-03370

Species: Rat

Expression System: HEK293 Cells

SEY1 Protein, Plasmodium knowlesi, Recombinant (His)

Cat.No: TMPH-03144

Species: Plasmodium knowlesi

Expression System: E. coli

Desmocollin 2/DSC2 Protein, Human, Recombinant (His)

Cat.No: TMPY-01892

Species: Human

Expression System: HEK293 Cells

DSG-2/Desmoglein-2 Protein, Mouse, Recombinant (His)

Cat.No: TMPK-00736

Species: Mouse

Expression System: HEK293 Cells

GST Protein, Plasmodium falciparum, Recombinant (His)

Cat.No: TMPH-03138

Species: Plasmodium falciparum

Expression System: P. pastoris (Yeast)

PFS230 Protein, Plasmodium falciparum, Recombinant

Cat.No: TMPH-03137

Species: Plasmodium falciparum

Expression System: E. coli

Osmotin Protein, Nicotiana tabacum, Recombinant (His & SUMO)

Cat.No: TMPH-03061

Species: Nicotiana tabacum

Expression System: E. coli

Plasmepsin-2 Protein, Plasmodium falciparum, Recombinant (His & Myc)

Cat.No: TMPH-03141

Species: Plasmodium falciparum

Expression System: Baculovirus Insect Cells

L-lactate dehydrogenase Protein, Plasmodium berghei, Recombinant (His & Myc)

Cat.No: TMPH-03136

Species: Plasmodium berghei

Expression System: E. coli

SMOC1 Protein, Human, Recombinant (GST & His)

Cat.No: TMPH-02128

Species: Human

Expression System: E. coli

Desmocollin 2/DSC2 Protein, Rat, Recombinant (hFc)

Cat.No: TMPY-04642

Species: Rat

Expression System: HEK293 Cells

MDR1 Protein, Plasmodium falciparum, Recombinant (His & SUMO)

Cat.No: TMPH-03139

Species: Plasmodium falciparum

Expression System: E. coli

SMOC1 Protein, Human, Recombinant (His)

Cat.No: TMPY-01783

Species: Human

Expression System: HEK293 Cells

DSG-2/Desmoglein-2 Protein, Human, Recombinant (His)

Cat.No: TMPK-00967

Species: Human

Expression System: HEK293 Cells

Plasmepsin-2 Protein, Plasmodium falciparum, Recombinant (E. coli, His & Myc)

Cat.No: TMPH-03142

Species: Plasmodium falciparum

Expression System: E. coli

Plasmepsin-1 Protein, Plasmodium falciparum, Recombinant (His)

Cat.No: TMPH-03140

Species: Plasmodium falciparum

Expression System: E. coli

GRK2 Protein, Mouse, Recombinant (His & SUMO)

Cat.No: TMPH-02540

Species: Mouse

Expression System: E. coli

IHH Protein, Human, Recombinant (His)

Cat.No: TMPH-01528

Species: Human

Expression System: E. coli

FZD1/Frizzled 1 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-01165

Species: Mouse

Expression System: HEK293 Cells

Cat. No.	Product Name	Target	Signaling Pathways
TMIJ-0276	Vismodegib-d4
	Vismodegib-d4 是 Vismodegib 的氘代化合物。Vismodegib 的 CAS 号为 879085-55-9。Vismodegib 是一种刺猬抑制剂，IC50值为 3 nM。它还可抑制P-gp和ABCG2的活性，IC50值分别为 3.0 μM 和 1.4 μM。
TMID-0198	Esmolol-d7 HCl
	Esmolol-d7 HCl 是 Esmolol HCl 的氘代化合物。Esmolol HCl 的 CAS 号为 81161-17-3。Esmolol hydrochloride 是一种心脏选择性β受体阻滞剂，用于治疗心律失常和严重高血压。
TMIJ-0277	Vismodegib-d7
	Vismodegib-d7 是 Vismodegib 的氘代化合物。Vismodegib 的 CAS 号为 879085-55-9。Vismodegib 是一种刺猬抑制剂，IC50值为 3 nM。它还可抑制P-gp和ABCG2的活性，IC50值分别为 3.0 μM 和 1.4 μM。

同位素标记化合物

Cat.No: TMIJ-0276

Cat.No: TMID-0198

Cat.No: TMIJ-0277

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