首页工具

登录

搜索结果

Search Results for " sirt3 "

Targets Recommended: Dehydrogenase Sirtuin HDAC p53 Autophagy

27

抑制剂 & 化合物

5

天然产物

1

重组蛋白

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name	Target	Signaling Pathways
T8480	Tenovin-6 Hydrochloride	Dehydrogenase; Sirtuin; HDAC; p53; Autophagy	Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism
	Tenovin-6 Hydrochloride 是 Tenovin-1 的类似物，能抑制二氢乳清酸脱氢酶。它是一种 p53转录活性的激活剂，抑制纯化人 SIRT1、SIRT2 和 SIRT3 蛋白脱乙酰酶活性，IC50分别为 21 μM、10 μM 和 67 μM。
T5124	SRT 1720 dihydrochloride[925434-55-5(free base)]	Sirtuin	Chromatin/Epigenetic; DNA Damage/DNA Repair
	SRT 1720 dihydrochloride[925434-55-5(free base)] 是 SIRT1 (EC1.5: 0.16 μM) 的选择性激活剂，对 SIRT2 (EC1.5: 37 μM) 和 SIRT3 (EC1.5: 300 μM) 的活性较低。
T4108	3-TYP 3-(1H-1,2,3-triazol-4-yl) pyridine	Sirtuin	Chromatin/Epigenetic; DNA Damage/DNA Repair
	3-TYP (3-(1H-1,2,3-triazol-4-yl) pyridine) 是选择性SIRT3抑制剂，IC50值为 16 nM。它对 SIRT1 和 SIRT2 的选择性强，IC50值分别为 88 和 92 nM。
T5096	SRT 1720 N-[2-[3-(1-哌嗪基甲基)咪唑并[2,1-B]噻唑-6-基]苯基]-2-喹喔啉甲酰胺	Sirtuin; Autophagy	Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair
	SRT 1720 是人 SIRT1 的选择性激活剂，EC1.5为 0.16 μM，对 SIRT2 和 SIRT3 的效力要低 230 倍以上。
T2412	SRT1720 hydrochloride SRT1720 HCl,SRT 1720 Hydrochloride	Sirtuin	Chromatin/Epigenetic; DNA Damage/DNA Repair
	SRT1720 hydrochloride (SRT1720 HCl) 是 SIRT1(EC1.5: 0.16 μM) 的选择性激活剂，对 SIRT2/SIRT3 (EC1.5s: 37 μM/300 μM) 的活性较低。
T22026	AGK7	Others; Sirtuin	Chromatin/Epigenetic; DNA Damage/DNA Repair; Others
	AGK7 是 sirtuin 2 (SIRT2) 抑制剂。它在体外和帕金森病果蝇模型中均能抑制多巴胺能细胞的凋亡。在帕金森病细胞模型中，它改善了 α-突触核蛋白毒性和修饰的包涵体形态
T3447	Thiomyristoyl	Sirtuin	Chromatin/Epigenetic; DNA Damage/DNA Repair
	Thiomyristoyl 是一种高效特异性SIRT2抑制剂，IC50值为28 nM。
T6371	AGK2 2-氰基-3-[5-(2,5-二氯苯基)-2-呋喃基]-N-5-喹啉基-2-丙烯酰胺	Apoptosis; Sirtuin	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair
	AGK2 是一种选择性SIRT2抑制剂，其IC50值为 3.5 μM。它抑制 SIRT1 和 SIRT3，IC50值分别为 30 和 91 μM。
T40891	ADTL-SA1215 ADTL-SA1215	Others	Others
	ADTL-SA1215 is a novel, highly selective small-molecule compound that acts as a specific activator of SIRT3, a protein known to play a crucial role in modulating autophagy. This compound holds great potential in the treatment of triple-negative breast cancer, as it effectively targets the molecular pathways associated with this subtype of cancer.
T1818	Tenovin-6 Tenovin 6	Dehydrogenase; Sirtuin; Autophagy	Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism
	Tenovin-6 是 Tenovin-1 的类似物，能抑制二氢乳清酸脱氢酶。它也抑制纯化人 SIRT1、SIRT2 和 SIRT3 蛋白脱乙酰酶活性，IC50分别为 21 μM、10 μM 和 67 μM。它是一种 p53转录活性的激活剂。
T21679	4'-bromo-Resveratrol	Sirtuin	Chromatin/Epigenetic; DNA Damage/DNA Repair
	4'-Bromo-resveratrol 是Sirtuin-1和Sirtuin-3的双重抑制剂。它通过线粒体代谢重编程，使黑色素瘤细胞的生长受到抑制。它通过代谢重编程、影响细胞周期以及细胞凋亡的信号传导，使其在黑色素瘤细胞中发挥抗增殖作用。
T12918	SIRT-IN-1	Sirtuin	Chromatin/Epigenetic; DNA Damage/DNA Repair
	SIRT-IN-1 是一种有效SIRT1/2/3抑制剂，IC50分别为 15，10，33 μM。
T35822	CAY10722	Others	Others
	CAY10722 is an inhibitor of sirtuin 3 (SIRT3), a class III HDAC (71% inhibition at 200 μM). SIRT3 is involved in modulating metabolic homeostasis as a NAD+-dependent protein deacetylase in the mitochondria. SIRT3 functions as either an oncogene or tumor suppressor, depending on cancer cell type. High SIRT3 expression in patient-derived esophageal cancer tissues is associated with shorter survival and, in mice, downregulation leads to a lower tumor load. In contrast, low SIRT3 expression in patie...
T79565	Sirt1/2-IN-4	Sirtuin	Chromatin/Epigenetic; DNA Damage/DNA Repair
	Sirt1/2-IN-4（compound PS3）为SIRT1/2/3抑制剂，其IC50分别为1.2 μM (SIRT1)、1.9 μM (SIRT2) 和2.0 μM (SIRT3)。该化合物能完全阻制p53脱乙酰化作用，显示出潜在的抗癌活性。
T35821	CAY10721	Others	Others
	CAY10721 is an inhibitor of sirtuin 3 (SIRT3), a class III HDAC (39% SIRT3 inhibition at 200 μM). Upregulation of SIRT3 transcription is associated with oral squamous cell carcinoma (OSCC) and breast cancer with lymph node involvement, while SIRT3 down-regulation inhibits the growth of OSCC cells and sensitizes them to radiation and chemotherapy.
T72238	SRT 1720 dihydrochloride	Others	Others
	SRT 1720 dihydrochloride 是选择性的和具有口服活性的 SIRT1激活剂，EC50为 0.10 μM，对 SIRT2和 SIRT3的作用较弱。
T12919	SIRT-IN-2	Sirtuin	Chromatin/Epigenetic; DNA Damage/DNA Repair
	SIRT-IN-2 是一种 SIRT1/2/3 有效抑制剂，IC50 分别为 4、1和 7 μM。
T16667	PROTAC Sirt2 Degrader-1	Sirtuin; PROTACs	Chromatin/Epigenetic; DNA Damage/DNA Repair; PROTAC
	PROTAC Sirt2 Degrader-1 is a SirReal-based PROTAC, acts as a Sirt2 degrader, composed of a highly potent and isotype-selective Sirt2 inhibitor, a linker, and a bona fide cereblon ligand for E3 ubiquitin ligase. PROTAC Sirt2 Degrader-1 shows an IC50 of 0.25 μM for Sirt2, with no effect on Sirt1/Sirt3 (IC50s > 100 μM)[1].
T60257	SIRT-IN-3	Others	Others
	SIRT-IN-3 是一种有效的SIRT 抑制剂，对 SIRT1 的IC50为 17 μM。SIRT-IN-3 对 SIRT1 的选择性分别是 SIRT-2 和 SIRT3 的 4 倍和 14 倍，其对 SIRT2的IC50为74 μM；对SIRT3的IC50为235 μM。
T74894	SIRT1/2/3-IN-1	Others	Others
	SIRT1/2/3-IN-1 (compound 10) 为高效、选择性并具细胞渗透性的 SIRT1/2/3 抑制剂，其对 SIRT1、SIRT2 和 SIRT3 的 IC50 值分别为 0.54、0.253、0.72 μM，适用于癌症研究。
T72484	SIRT6 activator 12q	Others	Others
	SIRT6 activator12q是一种有效、选择性且口服活性SIRT6激活剂，其对SIRT1、SIRT2、SIRT3、SIRT5、SIRT6的IC50值依次为171.20、>200、>200、>200、0.58 μM。该化合物能够抑制细胞增殖和迁移，同时诱导细胞凋亡(Apoptosis)及在G2期引起细胞周期停滞，展现了其抗癌潜力。
T40059	Nicotinamide riboside tartrate	Others	Others
	Nicotinamide riboside tartrate (NRT) is an oral NAD+ precursor that raises NAD+ levels, activates SIRT1 and SIRT3, and serves as a vitamin B3 (niacin) source. NRT also improves oxidative metabolism and protects against metabolic abnormalities induced by a high-fat diet. Furthermore, NRT mitigates cognitive decline in a transgenic mouse model of Alzheimer's disease.
T40060	Nicotinamide riboside malate	Others	Others
	Nicotinamide riboside malate is an orally active NAD+ precursor that elevates NAD+ levels and stimulates the activity of SIRT1 and SIRT3. Functioning as a vitamin B3 (niacin) source, it augments oxidative metabolism and provides protection against metabolic abnormalities induced by a high-fat diet. Additionally, Nicotinamide riboside malate mitigates cognitive decline in a genetically modified mouse model of Alzheimer's disease.
T79601	SPC-180002	Sirtuin	Chromatin/Epigenetic; DNA Damage/DNA Repair
	SPC-180002是一种针对SIRT1/3的双重抑制剂，IC50值分别为1.13 μM和5.41 μM。该化合物可通过诱导ROS产生干扰氧化还原平衡，进而增强p21蛋白的稳定性并引起线粒体功能障碍，同时显著抑制细胞周期进程及癌细胞的增殖，并能激活Nrf2信号通路。
T62240	Sirt1/2-IN-1	Others	Others
	Sirt1/2-IN-1 (Compound 7) 是一种 SIRT1 和 SIRT2 的抑制剂，能够作用于 SIRT1 (IC50: 1.81 μg/mL)、SIRT2 (IC50: 2.10 μg/mL) 和 SIRT3 (IC50: 20.5 μg/mL)，并具有α-微管蛋白的超乙酰化活性 (IC50: 32.05 μg/mL)。Sirt1/2-IN-1 表现出显著的抗癌作用。
T33663	Nicotinamide Riboside Triflate SRT 647 Triflate,SRT 647,Nicotinamide Riboside,Nicotinamide Ribose,SRT-647,SRT647,SRT647 Triflate,SRT-647 Triflate	Sirtuin	Chromatin/Epigenetic; DNA Damage/DNA Repair
	Nicotinamide Riboside Triflate (SRT647 Triflate) 是一种天然NAD前体，可增加NAD水平，可增强氧化代谢并防止高脂肪饮食引起的肥胖，KE 激活SIRT3可防止噪音引起的听力损失,可用于研究肌肉萎缩。
T27004	CHIC35 CHIC-35,CHIC 35	Others	Others
	CHIC-35 is a selective deacetylase SIRT1 inhibitor.

化合物

Tenovin-6 Hydrochloride

Cat.No: T8480

Target: Dehydrogenase, Sirtuin, HDAC, p53, Autophagy

SRT 1720 dihydrochloride[925434-55-5(free base)]

Cat.No: T5124

Target: Sirtuin

Cat.No: T4108

Synonym: 3-(1H-1,2,3-triazol-4-yl) pyridine

Target: Sirtuin

Cat.No: T5096

Synonym: N-[2-[3-(1-哌嗪基甲基)咪唑并[2,1-B]噻唑-6-基]苯基]-2-喹喔啉甲酰胺

Target: Sirtuin, Autophagy

SRT1720 hydrochloride

Cat.No: T2412

Synonym: SRT1720 HCl,SRT 1720 Hydrochloride

Target: Sirtuin

Cat.No: T22026

Target: Others, Sirtuin

Cat.No: T3447

Target: Sirtuin

Cat.No: T6371

Synonym: 2-氰基-3-[5-(2,5-二氯苯基)-2-呋喃基]-N-5-喹啉基-2-丙烯酰胺

Target: Apoptosis, Sirtuin

Cat.No: T40891

Synonym: ADTL-SA1215

Target: Others

Cat.No: T1818

Synonym: Tenovin 6

Target: Dehydrogenase, Sirtuin, Autophagy

4'-bromo-Resveratrol

Cat.No: T21679

Target: Sirtuin

Cat.No: T12918

Target: Sirtuin

Cat.No: T35822

Target: Others

Cat.No: T79565

Target: Sirtuin

Cat.No: T35821

Target: Others

SRT 1720 dihydrochloride

Cat.No: T72238

Target: Others

Cat.No: T12919

Target: Sirtuin

PROTAC Sirt2 Degrader-1

Cat.No: T16667

Target: Sirtuin, PROTACs

Cat.No: T60257

Target: Others

SIRT1/2/3-IN-1

Cat.No: T74894

Target: Others

SIRT6 activator 12q

Cat.No: T72484

Target: Others

Nicotinamide riboside tartrate

Cat.No: T40059

Target: Others

Nicotinamide riboside malate

Cat.No: T40060

Target: Others

Cat.No: T79601

Target: Sirtuin

Cat.No: T62240

Target: Others

Nicotinamide Riboside Triflate

Cat.No: T33663

Synonym: SRT 647 Triflate,SRT 647,Nicotinamide Riboside,Nicotinamide Ribose,SRT-647,SRT647,SRT647 Triflate,SRT-647 Triflate

Target: Sirtuin

Cat.No: T27004

Synonym: CHIC-35,CHIC 35

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T2S0731	Trilobatin 三叶苷,三叶甙,P-Phlorizin	Amylase	Metabolism
	Trilobatin (P-Phlorizin) 是源自Lithocarpus polystachyusRehd 的甜味剂，是一种HIV-1抑制剂，靶向 Gp41 包膜蛋白，具有神经保护作用。它还是SGLT1/2抑制剂，可选择性诱导人肝母细胞瘤细胞增殖。
T13795	Nicotinamide riboside	Sirtuin	Chromatin/Epigenetic; DNA Damage/DNA Repair
	Nicotinamide riboside 是维生素 B3 的来源，可以增强氧化代谢并防止高脂肪饮食诱导的代谢异常。它是具有口服活性的 NAD+的前体，增加 NAD+水平并激活SIRT1和SIRT3，可用于研究阿尔茨海默氏病的认知退化。
T5S1133	Ganoderic acid D 灵芝酸D,灵芝酸 D	Apoptosis; Sirtuin	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair
	Ganoderic acid D 是高度氧化的四环三萜，是灵芝的主要活性成分，可诱导 HeLa 人宫颈癌细胞凋亡。它上调 SIRT3的蛋白质表达并通过 SIRT3 诱导脱乙酰化的亲环蛋白 D 。它抑制结肠癌细胞的能量重编程，包括结肠癌细胞中的葡萄糖摄取，乳酸、丙酮酸和乙酰辅酶的产生。
T3S0175	Gardenia yellow alpha-Crocin,Crocin I,Crocine,西红花苷 I,西红花苷I,藏红花	Sirtuin	Chromatin/Epigenetic; DNA Damage/DNA Repair
	Gardenia yellow (Crocin I) 是藏红花素家族的一员，作为可口服的抗抑郁剂，能增强 SIRT3的 mRNA 的表达，具有抗动脉粥样硬化和降血脂作用。
T6220	Nicotinamide riboside chloride 烟酰胺核糖氯酸盐,烟酰胺核苷	Sirtuin; Endogenous Metabolite	Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism
	Nicotinamide riboside Chloride 是维生素 B3 的来源，可以增强氧化代谢并防止高脂肪饮食诱导的代谢异常。它是具有口服活性的 NAD+的前体，增加 NAD+水平并激活SIRT1和SIRT3，可用于研究阿尔茨海默氏病的认知退化。

天然产物

Cat.No: T2S0731

Synonym: 三叶苷,三叶甙,P-Phlorizin

Target: Amylase

Nicotinamide riboside

Cat.No: T13795

Target: Sirtuin

Ganoderic acid D

Cat.No: T5S1133

Synonym: 灵芝酸D,灵芝酸 D

Target: Apoptosis, Sirtuin

Gardenia yellow

Cat.No: T3S0175

Synonym: alpha-Crocin,Crocin I,Crocine,西红花苷 I,西红花苷I,藏红花

Target: Sirtuin

Nicotinamide riboside chloride

Cat.No: T6220

Synonym: 烟酰胺核糖氯酸盐,烟酰胺核苷

Target: Sirtuin, Endogenous Metabolite

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-02798	SIRT3 Protein, Mouse, Recombinant (His & Myc) Regulatory protein SIR2 homolog 3,Sirt...	Mouse	E. coli
	SIRT3 Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 36.3 kDa and the accession number is Q8R104.

重组蛋白

SIRT3 Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02798

Species: Mouse

Expression System: E. coli

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

Copyright © 2015-2024 TargetMol Chemicals Inc. All rights reserved. 沪ICP备20019793号-4

沪公网安备 31010602006700号

沪公网安备 31010602006700号

TargetMol Loading

联系我们

电话：

400-820-0310

邮箱：

service@tsbiochem.com

QQ：

2881945090（终端用户）

2885109491（经销商）

经销：

终端：

地址：

上海市静安区江场三路238号8楼