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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T74814 |
PKM2/PDK1-IN-1
|
Others | Others |
PKM2/PDK1-IN-1 是一种紫草素硫醚衍生物,是PKM2/PDK1的双重抑制剂。 PKM2/PDK1-IN-1抑制NSCLC 细胞的增殖,并诱导细胞凋亡 (apoptosis)。 PKM2/PDK1-IN-1 诱导细胞间 ROS 产生,调节凋亡蛋白,参与线粒体和死亡受体通路。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T1125 |
Shikonin
NSC 252844,Isoarnebin 4,(+)-Shikonin,紫草素,Alkanna Red,C.I. 75535,Anchusa acid |
TNF; NF-κB; Chloride channel; HIV Protease; PKM | Apoptosis; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; NF-κB; Proteases/Proteasome |
Shikonin (Anchusa acid) 属于天然产物,是一种 TMEM16A 氯离子通道抑制剂 (IC50=6.5 μM) 和选择性 PKM2 抑制剂。Shikonin 具有抗肿瘤、抗炎和伤口愈合活性。 | |||
T2897 |
(Rac)-Shikonin
(±)-Shikonin,Alkanet extract,Anchusin,紫草素,Anchusa acid |
Others | Others |
(Rac)-Shikonin (Anchusin) 具有抗肿瘤作用。它能够诱导坏死死亡来绕过癌症耐药性。 | |||
T1121 |
Podofilox
鬼臼毒素,Podophyllotoxin,(+)-Shikonin |
Microtubule Associated; Topoisomerase | Cytoskeletal Signaling; DNA Damage/DNA Repair |
Podofilox ((+)-Shikonin) 是从八角莲中分离的一种木脂素,是微管组装和 DNA 拓扑异构酶 II 抑制剂。它对皮肤和粘膜有很强的刺激性,具有角质溶解作用,可用于治疗疣和角化病,具有潜在的抗肿瘤特性。 | |||
T5S2343 |
Acetylshikonin
乙酰紫草素,Acetyl shikonin |
Others; P450; AChE | Metabolism; Neuroscience; Others |
Acetylshikonin 来源于紫草根,具有抗癌、抗炎作用。它是一种 AChE 抑制剂,具有很强的抗凋亡活性。它是一种非选择性的细胞色素 P450抑制剂,对所有 P450 亚型抑制的 IC50值范围为 1.4-4.0 μM。 | |||
T4958 |
(-)-Alkannin
Alkannin,左旋紫草素,紫草素,Shikonin |
Apoptosis; PI3K | Apoptosis; PI3K/Akt/mTOR signaling |
(-)-Alkannin (Shikonin) 是从紫朱草中发现的一种天然产物,具有抗癌活性,可抑制细胞周期,诱导细胞凋亡,用作食品着色剂,在 Rho 激酶途径中可改善肝脏炎症。 | |||
TN2439 |
(2-Methylbutyryl)shikonin
|
Others | Others |
(2-Methylbutyryl)shikonin is a natural product from Lithospermum erythrorhizon Sieb. et Zucc. | |||
T5S2350 |
Beta-Acetoxyisovalerylshikonin
乙酰氧基异戊酰阿卡宁,Acetoxyisovalerylalkannin,β-乙酰氧基异戊酰阿卡宁 |
Others | Others |
Acetoxyisovalerylshikonin 是一种萘醌衍生物,提取自Arnebia euchroma 中。 | |||
TN1440 |
Beta-Hydroxyisovalerylshikonin
|
EGFR; Tyrosine Kinases; Prostaglandin Receptor; Src; AMPK; Fatty Acid Synthase | Angiogenesis; Chromatin/Epigenetic; GPCR/G Protein; Immunology/Inflammation; JAK/STAT signaling; Metabolism; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors |
Beta-hydroxyisovalerylshikonin 是分离自Lithospermium radix 的天然产物,具有抑制PTK 的作用, 对 EGFR 和 v-Src 受体作用的IC50分别为 0.7 μM 和 1 μM。它对多种肿瘤细胞系均有抑制作用,可以高效诱导 NCI-H522 和 DMS114 细胞的死亡。 | |||
TN2447 |
Isovalerylshikonin
|
Antibacterial | Microbiology/Virology |
Isovalerylshikonin 是太子参和紫草的天然产物。 | |||
TN1137 |
Isobutylshikonin
|
Others | Others |
Isobutylshikonin 是分离自Lithospermum canescens 毛状根培养的一种紫草素色素。 | |||
T3S2344 |
β,β-Dimethylacrylshikonin
β,β-二甲基丙烯酰紫草素,Dimethylacrylshikonin,β, β-Dimethylacrylshikonin |
ERK; HIF/HIF Prolyl-Hydroxylase | Chromatin/Epigenetic; MAPK; Metabolism |
β,β-Dimethylacrylshikonin (Dimethylacrylshikonin) 是一种萘醌衍生物,从 Arnebia nobilis 中提取得到。它利用 PI3K 通路诱导 eNOS、VEGF 和 HIF-1α 的表达,促进血管生成,具有抗肿瘤活性。 | |||
T5S2347 |
Deoxyshikonin
去氧紫草素,Arnebin 7 |
Others; HIF/HIF Prolyl-Hydroxylase; Antibacterial | Chromatin/Epigenetic; Metabolism; Microbiology/Virology; Others |
Deoxyshikonin (Arnebin 7) 是从紫草中分离的天然产物,具有抗肿瘤活性,在体外具有促血管生成作用。它和没食子酸十二烷基酯在体内外均与青霉素有显着的协同抗菌活性。 | |||
TN6458 |
Acetylshikonin
|
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Acetylshikonin can effectively inhibit tumor cells, it can be used to treat hepatocellular carcinoma cells expressing hepatitis B virus X protein (HBX) by inducing ER stress , an oncoprotein from hepatitis B virus. Acetylshikonin inhibits the production of eicosanoid, is due to the attenuation of cytosolic phospholipase A(2) membrane recruitment via the decrease in [Ca(2+)](i) and to the blockade of cyclooxygenase and 5-lipoxygenase activity. |